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WARRANT TO PURCHASE 471 SHARES OF COMMON STOCK

Warrant Agreement

WARRANT TO PURCHASE 471 SHARES OF COMMON STOCK
 | Document Parties: COMBINATORX, INC | GENERAL ELECTRIC CAPITAL CORPORATION You are currently viewing:
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COMBINATORX, INC | GENERAL ELECTRIC CAPITAL CORPORATION

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Title: WARRANT TO PURCHASE 471 SHARES OF COMMON STOCK
Governing Law: Connecticut     Date: 3/20/2006
Industry: Biotechnology and Drugs    

WARRANT TO PURCHASE 471 SHARES OF COMMON STOCK
, Parties: combinatorx  inc , general electric capital corporation
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                                                                     EXHIBIT 4.5

NEITHER THIS WARRANT NOR THE SECURITIES ISSUABLE UPON EXERCISE OF THIS WARRANT
HAVE BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. NO SALE OR
DISPOSITION MAY BE EFFECTED EXCEPT IN COMPLIANCE WITH RULE 144 UNDER SAID ACT OR
WITHOUT AN EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR (IF REASONABLY
REQUIRED BY THE COMPANY) AN OPINION OF COUNSEL FOR THE HOLDER, SATISFACTORY TO
THE COMPANY, THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE ACT OR RECEIPT OF
A NO-ACTION LETTER FROM THE SECURITIES AND EXCHANGE COMMISSION.

                 WARRANT TO PURCHASE 471 SHARES OF COMMON STOCK

                                  June 28, 2005

THIS CERTIFIES THAT, for value received, GENERAL ELECTRIC CAPITAL CORPORATION
("HOLDER") is entitled to subscribe for and purchase FOUR HUNDRED SEVENTY
ONE(471) shares of the fully paid and nonassessable Common Stock (the "SHARES"
or the "STOCK") of COMBINATORX, INC., a Delaware corporation (the "COMPANY"), at
the Warrant Price (as hereinafter defined), subject to the provisions and upon
the terms and conditions hereinafter set forth.

1.   WARRANT PRICE. The Warrant Price shall initially be $6.75 per share, subject
to adjustment as provided in Section 7 below.

2.   CONDITIONS TO EXERCISE. The purchase right represented by this Warrant may
be exercised at any time, or from time to time, in whole or in part during the
term commencing on the date hereof and ending at 5:00 P.M. Eastern time on the
tenth anniversary of the date of this Warrant.

3.   METHOD OF EXERCISE; PAYMENT; ISSUANCE OF SHARES; ISSUANCE OF NEW WARRANT.

(a) CASH EXERCISE. Subject to Section 2 hereof, the purchase right represented
by this Warrant may be exercised by the Holder hereof, in whole or in part, by
the surrender of this Warrant (with a duly executed Notice of Exercise in the
form attached hereto) at the principal office of the Company (as set forth in
Section 18 below) and by payment to the Company, by check, of an amount equal to
the then applicable Warrant Price per share multiplied by the number of shares
then being purchased. In the event of any exercise of the rights represented by
this Warrant, certificates for the shares of stock so purchased shall be in the
name of, and delivered to, the Holder hereof, or as such Holder may direct
(subject to the terms of transfer contained herein and upon payment by such
Holder hereof of any applicable transfer taxes). Such delivery shall be made
within 30 days after exercise of the Warrant and at the Company's expense and,
unless this Warrant has been fully exercised or expired, a new Warrant having
terms and conditions substantially identical to this Warrant and representing
the portion of the Shares, if any, with respect to which this Warrant shall not
have been exercised, shall also be issued to the Holder hereof within 30 days
after exercise of the Warrant.

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(b) NET ISSUE EXERCISE. Holder may also elect to receive shares equal to the
value of this Warrant (or of any portion thereof remaining unexercised) by
surrender of this Warrant at the principal office of the Company together with
notice of such election, in which event the Company shall issue to Holder the
number of shares of the Company's Common Stock computed using the following
formula:

     X = Y (A-B)
         ------
            A
     Where X = the number of shares of Stock to be issued to Holder.
     Y = the number of shares of Stock purchasable under this Warrant (at the
            date of such calculation).
     A = the Fair Market Value of one share of the Company's Common Stock (at
            the date of such calculation).
     B = Warrant Price (as adjusted to the date of such calculation).

(c) FAIR MARKET VALUE. For purposes of this Section 3, Fair Market Value of one
share of the Company's Stock shall mean:

     (i)     In the event of an exercise in connection with an Initial Public
     Offering, the per share Fair Market Value for the Stock shall be the
     Offering Price at which the underwriters initially sell Common Stock to
     the; or
     (ii)    The average of the closing bid and asked prices of Common Stock
     quoted in the Over-The-Counter Market Summary or the last reported sale
     prices quoted on the Nasdaq National Market ("NNM") or on any exchange on
     which the Common Stock is listed, whichever is applicable, as published in
     the Western Edition of the WALL STREET JOURNAL for the 21 trading days
     prior to the date of determination of Fair Market Value; or
      (iii)   In the event of an exercise in connection with a merger, acquisition
     or other consolidation in which the Company is not the surviving entity,
     the per share Fair Market Value for the Stock shall be the value to be
     received per share of Common Stock by all holders of the Common Stock in
     such transaction as determined by the Board of Directors; or
     (iv)    In any other instance, the per share Fair Market Value for the Stock
     shall be as determined in good faith by the Company's Board of Directors.
     In the event of 3(c)(iii) or 3(c)(iv), above, the Company's Board of
     Directors shall prepare a certificate, to be signed by an authorized
     officer of the Company, setting forth in reasonable detail the basis for
      and method of determination of the per share Fair Market Value of the
     Stock. In the event of 3(c)(iii) above, the Board will also certify to the
     Holder that this per share Fair Market Value will be applicable to all
     holders of the Company's Common Stock. Such certification must be made to
     Holder at least ten business days prior to the proposed effective date of
     the merger, consolidation, sale, or other triggering event as defined in
     3(c)(iii).

(d) AUTOMATIC EXERCISE. To the extent this Warrant is not previously exercised,
it shall be automatically exercised in accordance with Sections 3(b) and 3(c)
hereof (even if not surrendered) immediately before its expiration, involuntary
termination or cancellation.

(e) MANDATORY REDEMPTION. At any time, prior to the exercise of this warrant,
the Holder may at its option require the Company to redeem this Warrant for a
price of $XX (the "REDEMPTION PRICE"). Company shall remit the Redemption Price
to the Holder in immediately available funds

                                      - 2 -
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within ten days of receiving written demand of such redemption. Upon Holder
receiving the Redemption Price, this Warrant, and the all rights of Holder under
this Warrant to purchase any Shares of the Company shall terminate.

4.   REPRESENTATIONS AND WARRANTIES OF HOLDER AND THE COMPANY.

(a) Representations and Warranties by Holder.   The Holder represents and
warrants to the Company with respect to this purchase as follows:

     (i)     The Holder has substantial experience in evaluating and investing in
     private placement transactions of securities of companies similar to the
     Company so that the Holder is capable of evaluating the merits and risks of
     its investment in the Company and has the capacity to protect its
     interests.

     (ii)    Except for transfers to a Holder's affiliates, the Holder is
     acquiring the Warrant and the Shares of Stock issuable upon exercise of the
     Warrant (collectively the "SECURITIES") for investment for its own account
     and not with a view to, or for resale in connection with, any distribution
     thereof. The Holder understands that the Securities have not been
     registered under the Securities Act of 1933, as amended (the "ACT") by
      reason of a specific exemption from the registration provisions of the Act
     which depends upon, among other things, the bona fide nature of the
     investment intent as expressed herein.

     (iii)   The Holder acknowledges that the Securities must be held
     indefinitely unless subsequently registered under the Act or an exemption
     from such registration is available. The Holder is aware of the provisions
     of Rule 144 promulgated under the Act.

     (iv)    The Holder is an "accredited investor" within the meaning of
     Regulation D promulgated under the Act.

     (v)     The Holder has had an opportunity to discuss the Company's business,
     management and financial affairs with its management and an opportunity to
     review the Company's facilities. The Holder understands that such
     discussions, as well as the written information issued by the Company, were
     intended to describe the aspects of the Company's business and prospects
     which the Company believes to be material but were not necessarily a
     thorough or exhaustive description.

(b) Company hereby represents and warrants to Holder that, except as set forth
in the schedule attached to this Warrant as EXHIBIT A (the "DISCLOSURE
SCHEDULE"), the statements in the following paragraphs of this Section 4(b) are
true and correct (x) as of the date hereof and (y) except where any such
representation and warranty relates specifically to an earlier date, as of the
date of any exercise of this Warrant.

            (i)     CORPORATE ORGANIZATION AND AUTHORITY. Company (a) is a
corporation duly organized, validly existing, and in good standing in its
jurisdiction of incorporation, (b) has the corporate power and authority to own
and operate its properties and to carry on its business as now conducted and as
proposed to be conducted; and (c) is qualified as a foreign corporation in all
jurisdictions where such qualification is required.

                                      - 3 -
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            (ii)    CORPORATE POWER.   Company has all requisite legal and
corporate power and authority to execute, issue and deliver the Warrant, to
issue the Common Stock issuable upon exercise or conversion of the Warrant, and
to carry out and perform its obligations under the Warrant and any related
agreements.

            (iii)   AUTHORIZATION; ENFORCEABILITY. All corporate action on the
part of Company, its officers, directors and shareholders necessary for the
authorization, execution, delivery and performance of its obligations under this
Warrant and for the authorization, issuance and delivery of the Warrant and
Stock issuable upon exercise of the Warrant has been taken and this Warrant
constitutes the legally binding and valid obligation of Company enforceable in
accordance with its terms.

            (iv)    VALID ISSUANCE OF WARRANT AND COMMON STOCK The Warrant has
been validly issued and is free of restrictions on transfer other than
restrictions on transfer set forth herein and under applicable state and federal
securities laws. The Common Stock issuable upon conversion of this Warrant, when
issued, sold and delivered in accordance with the terms of this Warrant for the
consideration expressed herein, will be duly and validly issued, fully paid and
nonassessable, and will be free of restrictions on transfer other than
restrictions on transfer under this Warrant and under applicable state and
federal securities laws. Subject to applicable restrictions on transfer, the
issuance and delivery of the Warrant and the Common Stock issuable upon
conversion of the Warrant are not subject to any preemptive or other similar
rights or any liens or encumbrances except as specifically set forth in
Company's Certificate of Incorporation or this Warrant. The offer, sale and
issuance of the Warrant and Common Stock, as contemplated by this Warrant, are
exempt from the prospectus and registration requirements of applicable United
States federal and state security laws, and neither Company nor any authorized
agent acting on its behalf has or will take any action hereafter that would
cause the loss of such exemption.

            (v)     NO CONFLICT WITH OTHER INSTRUMENTS. The execution, delivery,
and performance of this Warrant will not result in any violation of, be in
conflict with,

                                       - 4 -
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            or constitute a default under, with or without the passage of time
or the giving of notice (a) any provision of Company's Certificate of
Incorporation or by-laws; (b) any provision of any judgment, decree, or order to
which Company is a party or by which it is bound or an event which results in
the creation of any material lien, charge or encumbrance upon any material
assets of Company; (c) any contract, obligation, or commitment to which Company
is a party or by which it is bound; or (d) any statute, rule, or governmental
regulation applicable to Company.

            (vi)    CAPITALIZATION.   As of June 28, 2005 the authorized capital
stock of Company consists of 32,000,000 shares of Common Stock, $0.001 par
value, of which 993,032 were issued and outstanding, and 23,162,386 shares of
Preferred Stock, $0.001 par value, of which 22,907,015 were issued and
outstanding. The outstanding shares have been duly authorized and validly issued
(including, without limitation, issued in compliance with applicable federal and
state securities laws), are fully paid and nonassessable. Company has reserved
471 shares of Common Stock for issuance upon exercise of this Warrant. Except as
set forth in Section 4(b) of the Disclosure Schedule, there are no outstanding
warrants, options, conversion privileges, preemptive rights or other rights or
agreements to purchase or otherwise acquire or issue any equity securities or
convertible Securities of Company, nor has the issuance of any of the aforesaid
rights to acquire securities of Company been authorized.

           ( vii ) GOVERNMENTAL CONSENTS. No consent, approval, order or
authorization of, or registration, qualification, designation, declaration or
filing with, any federal, state or local governmental authority on the part of
Company is required in connection with the offer, sale or issuance of the
Warrant (and the Stock issuable upon the exercise of this Warrant), or the
consummation of any other transaction contemplated hereby, except for the
following: (a) the filing of a notice on Form D under the Act and b) the
compliance with other applicable state securities laws, which compliance will
have occurred within the appropriate time periods therefore. The offer, sale and
issuance of the Warrant and the shares of Stock in conformity with the terms of
this Warrant are exempt from the registration requirements of the Act and any
applicable state laws.

5.   LEGENDS.

(a) Each certificate representing the Securities shall be endorsed with the
following legend:

            THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT
            OF 1933 AND MAY NOT BE TRANSFERRED UNLESS COVERED BY AN EFFECTIVE
            REGISTRATION STATEMENT UNDER SAID ACT, A "NO ACTION" LETTER FROM THE
             SECURITIES AND EXCHANGE COMMISSION WITH RESPECT TO SUCH TRANSFER, A
            TRANSFER MEETING THE REQUIREMENTS OF RULE 144 OF THE SECURITIES AND
            EXCHANGE COMMISSION, OR (IF REASONABLY REQUIRED BY THE COMPANY) AN
            OPINION OF COUNSEL SATISFACTORY TO THE ISSUER TO THE EFFECT THAT ANY
            SUCH TRANSFER IS EXEMPT FROM SUCH REGISTRATION.

The Company need not enter into its stock records a transfer of Securities
unless the conditions specified in the foregoing legend are satisfied. The
Company may also instruct its transfer agent

                                      - 5 -
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not to allow the transfer of any of the Shares unless the conditions specified
in the foregoing legend are satisfied.

(b) REMOVAL OF LEGEND AND TRANSFER RESTRICTIONS. The legend relating to the Act
endorsed on a certificate pursuant to paragraph 5(a) of this Warrant shall be
removed and the Company shall issue a certificate without such legend to the
Holder of the Securities if (i) the Securities are registered under the Act and
a prospectus meeting the requirements of Section 10 of the Act is available or
(ii) the Holder provides to the Company an opinion of counsel for the Holder
reasonably satisfactory to the Company, a no-action letter or interpretive
opinion of the staff of the SEC reasonably satisfactory to the Company, or other
evidence reasonably satisfactory to the Company, to the effect that public sale,
transfer or assignment of the Securities may be made without registration and
without compliance with any restriction such as Rule 144.

6. CONDITION OF TRANSFER OR EXERCISE OF WARRANT. It shall be a condition to any
transfer or exercise of this Warrant that at the time of such transfer or
exercise, the Holder shall provide the Company with a representation in writing
that the Holder or transferee is acquiring this Warrant and the shares of Stock
to be issued upon exercise for investment purposes only and not with a view to
any sale or distribution. As a further condition to any transfer of this Warrant
or any or all of the shares of Stock issuable upon exercis


 
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