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PREFERRED STOCK WARRANT

Warrant Agreement

PREFERRED STOCK WARRANT | Document Parties: ALSIUS CORP | Oxford Finance Corporation You are currently viewing:
This Warrant Agreement involves

ALSIUS CORP | Oxford Finance Corporation

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Title: PREFERRED STOCK WARRANT
Governing Law: Virginia     Date: 4/26/2006

PREFERRED STOCK WARRANT, Parties: alsius corp , oxford finance corporation
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                                                                     Exhibit 4.5

                             PREFERRED STOCK WARRANT

NEITHER THIS WARRANT NOR THE SECURITIES ISSUABLE UPON EXERCISE OF THIS WARRANT
HAVE BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. NO SALE OR
DISPOSITION MAY BE EFFECTED EXCEPT IN COMPLIANCE WITH RULE 144 UNDER SAID ACT OR
WITHOUT AN EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR AN OPINION OF
COUNSEL FOR THE HOLDER, SATISFACTORY TO THE COMPANY, THAT SUCH REGISTRATION IS
NOT REQUIRED UNDER THE ACT OR RECEIPT OF A NO-ACTION LETTER FROM THE SECURITIES
AND EXCHANGE COMMISSION.

             WARRANT TO PURCHASE SHARES OF SERIES F PREFERRED STOCK

                                                              Dated: May 31, 2005

THIS CERTIFIES THAT, for value received, Oxford Finance Corporation, ("Holder")
is entitled to subscribe for and purchase that number of shares as set forth in
paragraph 1 below of the fully paid and non-assessable Series F Preferred Stock
(the "Shares" or the "Preferred Stock") of Alsius Corporation, a California
corporation (the "Company"), at the Warrant Price (as hereinafter defined),
subject to the provisions and upon the terms and conditions hereinafter set
forth. As used herein, the term "Series F Preferred Stock" shall mean the
Company's presently authorized Series F Preferred Stock, and any stock into
which such Series F Preferred Stock may hereafter be exchanged.

1. Warrant Price. The Warrant Price shall initially be the lower of (i) Three
Dollars ($3.00) per share and (ii) the lowest effective price per share (on a
common stock equivalent basis and taking into account any securities issued
together with the preferred stock) at which shares of the Company's convertible
preferred stock are sold in the next Qualified Financing; provided, however, if
the Qualified Financing has not closed prior to the exercise of this Warrant,
then the Warrant Price shall be Three Dollars ($3,00) per share. A "Qualified
Financing" shall mean the sale of the convertible preferred stock of the Company
to purchasers which include venture capital investors in an aggregate gross cash
amount not less than $2,000,000 (excluding any bridge debt actually converted
into equity.). The number of shares for which this Warrant is exercisable shall
be the nearest whole number determined by dividing $350,000 by the Warrant Price
determined pursuant to this paragraph

2. Conditions to Exercise. The purchase right represented by this Warrant may be
exercised at any time, or from time to time, in whole or in part during the term
commencing on the date hereof and ending on the earlier of:

     (a)   5:00 P.M. Eastern Standard time on the eighth annual anniversary of
          this Warrant Agreement; or

     (b)   the earlier termination of this Warrant pursuant to Section 3(e).

     In the event that, although the Company shall have given notice of a
transaction pursuant to subparagraph [3(e)] hereof, the transaction does not
close within 60 days of the day specified by the Company, unless otherwise
elected by the Holder any exercise of the Warrant subsequent to the giving of
such notice shall be rescinded and the Warrant shall again be exercisable until
terminated in accordance with this Paragraph 2.

3. Method of Exercise; Payment; Issuance of Shares; Issuance of New Warrant.

     (a)   Cash Exercise. Subject to Section 2 hereof, the purchase right
          represented by this Warrant may be exercised by the Holder hereof, in
          whole or in part, by the surrender of this Warrant (with a duly
          executed Notice of Exercise in the form attached hereto) at the
          principal office of the Company (as set forth in Section 18 below) and
          by payment to the Company, by check, of an amount equal to the then
          applicable Warrant Price per share multiplied by the number of shares
          then being purchased. In the event of any exercise of the rights
          represented by this Warrant, certificates for the shares of stock so
           purchased shall be in the name of, and delivered to, the Holder
          hereof, or as such Holder may direct (subject to the terms of transfer
          contained herein and upon payment by such Holder hereof of any
          applicable transfer taxes). Such delivery shall be made within 10
          business days after exercise of the Warrant and at the Company's
          expense and, unless this Warrant


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                             PREFERRED STOCK WARRANT

          has been fully exercised or expired, a new Warrant having terms and
          conditions substantially identical to this Warrant and representing
          the portion of the Shares, if any, with respect to which this Warrant
           shall not have been exercised, shall also be issued to the Holder
          hereof within 10 business days after exercise of the Warrant.

     (b)   Net Issue Exercise. In lieu of exercising this Warrant pursuant to
          Section 3(a), Holder may elect to receive shares equal to the value of
          this Warrant (or of any portion thereof remaining unexercised) by
          surrender of this Warrant at the principal office of the Company
          together with notice of such election, in which event the Company
          shall issue to Holder the number of shares of the Company's Series ___
          Preferred Stock computed using the following formula:

              Y (A-B)
          X = -------
                 A

          Where X = the number of shares of Series F Preferred Stock to be
          issued to Holder.

          Y = the number of shares of Series F Preferred Stock purchasable under
          this Warrant (at the date of such calculation).

          A = the Fair Market Value of one share of the Company's Series F
          Preferred Stock (at the date of such calculation).

          B = Warrant Exercise Price (as adjusted to the date of such
          calculation).

     (c)   Fair Market Value. For purposes of this Section 3, Fair Market Value
          of one share of the Company's Series F Preferred Stock shall mean:

          (i)   If the Common Stock is traded on NASDAQ or Over-The-Counter or on
               an exchange, the per share Fair Market Value for the Series F
                Preferred Stock will be the average of the closing bid and asked
               prices of the Common Stock quoted in the Over-The-Counter Market
               Summary or the closing price quoted on any exchange on which the
               Common Stock is listed, whichever is applicable, as published in
               the Western Edition of The Wall Street Journal for the ten (10)
               trading days prior to the date of determination of Fair Market
               Value multiplied by the number of shares of Common Stock into
               which each share of Series F Preferred Stock is then convertible;
               or

          (ii) In the event of an exercise in connection with a merger,
               acquisition or other consolidation in which the Company is not
               the surviving entity, the per share Fair Market Value for the
               Series F Preferred Stock shall be the value to be received per
               share of Series F Preferred Stock by all Holders of the Series F
               Preferred Stock in such transaction as determined by the Board of
               Directors; or

          (iii) In any other instance, the per share Fair Market Value for the
               Series F Preferred Stock shall be as determined in good faith by
               the Company's Board of Directors unless Holder elects to have
               such fair market value determined by an appraiser, which election
               must be made by Holder within ten (10) business days of the date
               the Company notifies Holder of the fair market value as
               determined by its Board of Directors. In the event of such an
               appraisal, the cost thereof shall be borne by the Holder unless
               such appraisal results in a fair market value in excess of 115%
               of that determined by the Company's Board of Directors, in which
               event the Company shall bear the cost of such appraisal.

               In the event of 3(c)(ii) or 3(c)(iii), above, the Company's Board
          of Directors shall prepare a certificate, to be signed by an
          authorized Officer of the Company, setting forth in reasonable detail
          the basis for and method of determination of the per share Fair Market
          Value of the Series Preferred Stock. The Board will also certify to
          the Holder that this per share Fair Market Value


                                   Page 2 of 9

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                             PREFERRED STOCK WARRANT

          will be applicable to all holders of the Company's Series F Preferred
          Stock. Such certification must be made to Holder at least fifteen (15)
          business days prior to the proposed effective date of the merger,
          consolidation, sale, or other triggering event as defined in 3(c)(ii)
          and 3(c)(iii).

     (d)   Automatic Exercise. To the extent this Warrant is not previously
          exercised, it shall be automatically exercised in accordance with
          Sections 3(b) and 3(c) hereof (even if not surrendered) immediately
          before its expiration.

     (e)   Treatment of Warrant Upon Acquisition of Company.

          (i)   Upon the written request of the Company, Holder agrees that, in
               the event of an Acquisition (as defined below) in which the sole
               consideration is cash, either (a) Holder shall exercise its
               conversion or purchase right under this Warrant and such exercise
               will be deemed effective immediately prior to the consummation of
               such Acquisition or (b) if Holder elects not to exercise the
               Warrant, this Warrant will expire upon the consummation of such
               Acquisition. The Company shall provide the Holder with written
               notice of its request relating to the foregoing (together with
               such reasonable information as the Holder may request in
               connection with such contemplated Acquisition giving rise to such
                notice), which is to be delivered to Holder not less than ten
               (10) days prior to the closing of the proposed Acquisition.

          (ii) Upon written request of the Company, Holder agrees that, in the
               event of a stock for stock Acquisition of the Company by a
               publicly traded acquirer if, on the record date for the
               Acquisition, the fair market value of the Shares (or other
               securities issuable upon exercise of this Warrant) is equal to or
               greater than four [4] times the Warrant Price, Company may
               require the Warrant to be deemed automatically exercised and the
               Holder shall participate in the Acquisition as a holder of the
                Shares (or other securities issuable upon exercise of the
               Warrant) on the same terms as other holders of the same class of
               securities of the Company.

          (iii) Upon the closing of any Acquisition other than those
                particularly described in subsections (i) or (ii) above, the
               successor entity shall assume the obligations of the Warrant, and
               the Warrant shall be exercisable for the same securities, cash,
               and property as would be payable for the Shares issuable upon
               exercise of the unexercised portion of this Warrant as if such
               Shares were outstanding on the record date for the Acquisition
               and subsequent closing. The Warrant Price and/or number of Shares
               shall be adjusted accordingly.

          (iv) For the purpose of this Warrant, "Acquisition" means any sale,
               license, or other disposition of all or substantially all of the
               assets of the Company, or any reorganization, consolidation, or
               merger of the Company where the holders of the Company's
               securities before the transaction beneficially own less than 50%
               of the outstanding voting securities of the surviving entity
               after the transaction, other than in connection with an initial
               public offering.

4. Representations and Warranties of Holder and Restrictions on Transfer Imposed
by the Securities Act of 1933.

     (a)   Representations and Warranties by Holder. The Holder represents and
          warrants to the Company with respect to this purchase as follows:

          (i)   The Holder has substantial experience in evaluating and investing
               in private placement transactions of securities of companies
               similar to the Company so that the Holder is capable of
               evaluating the merits and risks of its investment in the Company
               and has the capacity to protect its interests.


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                             PREFERRED STOCK WARRANT

          (ii) The Holder is acquiring the Warrant and the Shares of Series F
               Preferred Stock issuable upon exercise of the Warrant and Common
               Stock issuable upon conversion thereof (collectively the
               "Securities") for investment for its own account and not with a
               view to, or for resale in connection with, any distribution
               thereof. The Holder understands that the Securities have not been
               registered under the Securities Act of 1933, as amended (the
               "Act") by reason of a specific exemption from the registration
               provisions of the Act, which depends upon, a


 
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