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<PAGE>
EXHIBIT 10.37
CONFIDENTIAL TREATMENT REQUESTED. CONFIDENTIAL PORTIONS
OF
THIS DOCUMENT MARKED [****] HAVE BEEN REDACTED AND HAVE BEEN
FILED
SEPARATELY WITH THE U.S. SECURITIES AND EXCHANGE
COMMISSION.
TRANSITION SERVICES AGREEMENT
BY AND BETWEEN
IPR PHARMACEUTICALS, INC.
AND
ATHEROGENICS, INC.
DATE: DECEMBER 22, 2005
<PAGE>
TABLE OF CONTENTS
<TABLE>
<S>
<C>
1
Definitions.................................................
1
2
Construction................................................
6
3
Amendment...................................................
6
4 Transition
Assistance....................................... 6
5
Fees........................................................
8
6 Invoicing,
Payment, Recordkeeping and Audits................ 11
7
Representations and Warranties..............................
12
8
Indemnification.............................................
13
9 Force
Majeure............................................... 17
10
Term and Termination........................................
17
11
Confidentiality.............................................
19
12
Use of Name.................................................
21
13
Notices.....................................................
21
14
Relationship of the Parties.................................
22
15
Rights Of Third Parties.....................................
23
16
Assignment..................................................
23
17
Entire Agreement............................................
23
18
Expenses....................................................
23
19
Waiver and Non-Exclusion of Remedies........................
24
20
Severability................................................
24
21
Governing Law and Disputes..................................
24
22
Equitable Relief............................................
24
23
Environmental Provisions....................................
25
24
Counterparts................................................
25
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EXHIBITS
Exhibit 1 -- Process Improvements
Exhibit 2 -- Estimated Spray Drying Capital Expenditure
Exhibit 3 -- Estimated Manufacturing Start-Up and Other Costs
Exhibit 4 -- Existing Agreements
Exhibit 5 -- Dow Consent to Assignment
(i)
<PAGE>
TRANSITION SERVICES AGREEMENT
This
Transition Services Agreement (the "AGREEMENT") is made as of
December 22, 2005 and shall be effective as of the Effective Date
(as defined
herein) by and between
(1) IPR
Pharmaceuticals, Inc., a company organized and existing under the
laws
of Puerto
Rico with an address at CARR 188 LOTE 17 SAN ISIDRO INDUSTRIAL
PARK,
CANOVANAS, PR 00729 ("ASTRAZENECA"); and
(2)
AtheroGenics, Inc., a Georgia corporation with principal executive
offices
at 8995
Westside Parkway, Alpharetta, Georgia 30004 (the "AGIX").
RECITALS
(A) WHEREAS,
AstraZeneca desires to receive certain transition services from
AGIX to
facilitate AstraZeneca's exercise of the manufacturing rights
granted
pursuant to the License Agreement; and
(B) WHEREAS,
AGIX is willing to provide such transition services on the
terms
and
conditions set forth herein.
AGREEMENT
NOW, THEREFORE, in consideration of the mutual covenants contained
in this
Agreement, and other good and valuable consideration, the receipt
and
sufficiency of which are hereby acknowledged, the Parties,
intending to be
legally bound, agree as follows:
1
DEFINITIONS
Unless otherwise specifically provided in this Agreement, the
following terms
shall have the following meanings:
1.1 "AFFILIATE"
means any Person that directly (or indirectly through one or
more
intermediaries) controls, is controlled by, or is under common
control
with a Party. For purposes of this definition only, the terms
"controls," "controlled," and "control" means (i) the direct or
indirect
ability or
power to direct or cause the direction of the management and
policies
of an entity or otherwise direct the affairs of such entity,
whether
through ownership of equity, voting securities, or beneficial
interest,
by contract, or otherwise, or (ii) the ownership, directly or
indirectly, of at least 50% of the voting securities (or other
comparable
ownership
interest for an entity other than a corporation) of a Party.
1.2 "AGIX
INDEMNITEES" has the meaning set forth in Section 8.2.
1
<PAGE>
1.3 "AGIX
INFORMATION" means all data and information related to or
comprised
in
Intellectual Property Rights and Know-How, as well as other
information
in
relation to AGIX's general business operations, SDD, a SDD
Manufacturing Process, the Final Commercial Products, a
Manufacturing
Process,
an SDD Process Improvement, or a Process Improvement, which is
owned by
AGIX.
1.4 "APPLICABLE
LAWS AND REGULATIONS" mean all applicable statutes,
ordinances, regulations, rules, or orders of any kind whatsoever of
any
Governmental Authority, including, without limitation, the Food,
Drug and
Cosmetic
Act, Prescription Drug Marketing Act, Generic Drug Enforcement
Act of
1992 (21 U.S.C. Section 335a et seq.), and Anti-Kickback
Statute
(42 U.S.C.
Section 1320a-7b et seq.), all as amended from time to time.
1.5 "ASTRAZENECA
INFORMATION" means all data and information related to or
comprised
in Intellectual Property Rights and Know-How, as well as other
information in relation to AstraZeneca's general business
operations, SDD,
a SDD
Manufacturing Process, the Final Commercial Products, a
Manufacturing Process, or a Process Improvement, which data and
information is owned by AstraZeneca.
1.6 "CAPACITY
RESERVE FEE" shall have the meaning set forth in the Dow
Agreement.
1.7 "COMBINATION
PRODUCT" means a Product in final form that includes one or
more
pharmaceutically active ingredients other than the Compound, in
combination with the Compound, that are sold as a fixed dose or
separate
doses in a
single package and priced as one item. All references to
Product in
this Agreement shall be deemed to include Combination
Product(s).
1.8 "COMPOUND"
means AGI-1067, which is chemically defined as [****],
including
its pharmacologically acceptable salts, solvates, hydrates,
hemihydrates, polymorphs, metabolites, free base forms, pro-drugs,
esters,
tautomers,
and if applicable, any isomers, stereoisomers, racemates,
enantiomers and all optically active forms thereof.
1.9
"CONFIDENTIAL INFORMATION" has the meaning set forth in Section
11.1.1
hereof.
1.10 "CONTROL" or
"CONTROLLED" means with respect to any Intellectual Property
Right,
that the Party owns or has a license to such Intellectual
Property
Right or
Information and has the ability to grant access, a license, or
a
sublicense
to such Intellectual Property Right to the other Party as
provided
for in this Agreement without violating an agreement with, or
infringing
any rights of, a Third Person as of the time such person would
be first
required under this Agreement to grant the other person such
access,
license or sublicense.
1.11 "DISCLOSING
PARTY" means the Party disclosing Confidential Information.
1.12 "DOW AGREEMENT"
means that "Commercial Supply Agreement for Production of
AGI-1067
and Probucol between The Dow Chemical Company ("DOW") and
-------
[****] indicates that certain confidential information contained in
this
document has been omitted pursuant to a request for confidential
treatment and
filed separately with the Securities and Exchange Commission.
2
<PAGE>
AtheroGenics, Inc." dated as of October 6, 2005, excluding any
amendments
thereto
entered into after the Effective Date.
1.13 "EFFECTIVE DATE"
means the Effective Date of the License Agreement.
1.14 "EXISTING
AGREEMENTS" means the Dow Agreement and the other agreements
set
forth on Exhibit
4.
1.15 "FDA" means the
United States Food and Drug Administration, or any
successor
federal agency having responsibility over United States
Regulatory
Approvals.
1.16 "FINAL COMMERCIAL
PRODUCT" means a pharmaceutical product in
ready-for-sale form, packaged and labeled dosage form marketed by
or on
behalf of
AstraZeneca, its Affiliates or Sublicensees, now or in the
future,
that comprises or utilizes SDD or the Compound in its
manufacture.
1.17 "FORCE MAJEURE"
has the meaning set forth in Section 9.1.
1.18 "GOVERNMENTAL
AUTHORITY" means any court, tribunal, arbitrator, agency,
commission, official or other instrumentality of any federal,
state, or
other
political subdivision, or supranational body, domestic or
foreign.
1.19 "INDIRECT TAXES"
means value added taxes, sales taxes, consumption taxes
and other
similar taxes.
1.20 "INFORMATION"
means any information Controlled by either Party, including,
but not
limited to: (a) any and all inventions (whether or not
patentable), Know-How, developments, materials, data, analyses, and
the
like,
regardless of whether the information is stored or transmitted
in
oral,
documentary, or electronic form; (b) information relating to
research
and development plans, experiments, results, compounds,
therapeutic leads, candidates and products, clinical and
preclinical data,
trade
secrets and manufacturing, marketing, financial, regulatory,
personnel
and other business information and plans, and all scientific,
clinical,
regulatory, marketing, financial and commercial information or
data; (c)
AstraZeneca Information; and (d) AGIX Information.
1.21 "INTELLECTUAL
PROPERTY RIGHTS" means trade secrets, patent rights,
trademarks, service marks, trade names, design rights,
copyrights
(including
rights in computer software) and any rights or property similar
to any of
the foregoing in any part of the world, whether registered or
not, together
with the right to apply for the registration of any such
rights,
and all rights or forms of protection having equivalent or
similar
effect, in
any part of the world.
1.22 "INVOICE
CURRENCY" means United States dollars.
1.23 "KNOW-HOW" means
all technical information or data relating to SDD,
whether
protected by Intellectual Property Rights or not, including,
but
not
limited to technology, processes, specifications, formulas,
procedures, techniques, SHE
3
<PAGE>
Information, practices and instructions of, and scientific,
analytical and
technical
data regarding the synthesis, manufacturing and pharmaceutical
processing
of SDD or the Compound.
1.24 "LICENSE
AGREEMENT" means the License and Collaboration Agreement
between
AstraZeneca and AGIX, dated as of December 22, 2005, as the same
shall be
amended
from time to time.
1.25 "LOSSES" means
any and all liabilities, claims, demands, causes of action,
damages,
loss and expenses incurred directly in connection with this
Agreement,
including interest, penalties, and reasonable lawyers' fees and
disbursements.
1.26 "MANUFACTURING
PROCESS" means any process (or any step in or portion of
any
process) used or developed by AGIX, Third Party Suppliers, or
AstraZeneca (or any of their Affiliates) as of the Effective Date
or at
any time
thereafter, in manufacturing SDD or Final Commercial Product.
1.27 "MANUFACTURING
START-UP AND OTHER COSTS" shall mean such expenditures
estimated
by AGIX as all reasonably necessary expenditures for the start
up and
launch of manufacture of SDD (other than those expenditures
described
as Spray Dried Capital Expenditures) as set forth in Exhibit 3.
1.28 "PARTIES" means
AstraZeneca and AGIX and "PARTY" means either AstraZeneca
or
AGIX.
1.29 "PERSON" means a
natural person, a corporation, a partnership, a trust, a
joint
venture, a limited liability company, any Governmental Authority
or
any other
entity or organization.
1.30 "PROCESS
IMPROVEMENT" has the meaning set forth in Section 5.3.1.
1.31 "PRODUCT" means a
pharmaceutical product that contains or incorporates the
Compound,
whether in development or approved by any Regulatory Authority,
including
all formulations, line extensions and modes of administration
(including, without limitation, all delivery devices, dosage forms
or
other
peripherals and consumables), including, without limitation,
Combination Products.
1.32 "RECEIVING PARTY"
means the Party to whom Confidential Information is
disclosed.
1.33 "REGULATORY
APPROVAL" means any and all approvals (including pricing
approvals
to the extent necessary), licenses, registrations or
authorizations of any Regulatory Authority, necessary for the
development,
manufacture and commercialization of a Final Commercial
Product.
1.34 "REGULATORY
AUTHORITY" means, in a particular country or jurisdiction, any
applicable
government regulatory authorities involved in granting
Regulatory
4
<PAGE>
Approval
and/or, to the extent required in such country or jurisdiction,
pricing
approval of Final Commercial Product in such country or
jurisdiction, including without limitation, (a) in the United
States, the
FDA, and
any other applicable governmental or regulatory authority in
the
United
States having jurisdiction over Final Commercial Product, and
any
successor
government authority having substantially the same function,
and
(b) any
foreign equivalent thereof.
1.35 "SAVINGS" has the
meaning set forth in Sections 5.3.5 and 5.3.6,
respectively.
1.36 "SAVINGS TRIGGER
DATE" has the meaning set forth in Section 5.3.3.
1.37 "SHE INFORMATION"
means to the extent applicable and available, and as
agreed to
by the Parties, safety, health and environmental information as
it relates
to SDD and SDD Manufacturing Process including, without
limitation: safety data sheets, chemical hazard assessments,
operational
hazard
test results and environmental assessments.
1.38 "SPRAY DRIED
DISPERSION" or "SDD" means the Compound in spray-dried form.
1.39 "SDD
MANUFACTURING PROCESS" means any process (or any step in or
portion
of any
process) used or developed by a Party (or any of its Affiliates
or
Third
Party Suppliers) as of the Effective Date or at any time
thereafter,
in
manufacturing SDD.
1.40 "SPRAY DRYING
CAPITAL EXPENDITURE" shall mean such capital expenditures
estimated
by AGIX as being all reasonably necessary capital expenditures
relating
directly to the spray drying process to manufacture SDD, which
expenditures are estimated in Exhibit 2.
1.41 "SUBLICENSEE"
means any Third Person (including, without limitation, a
distributor) to which AstraZeneca or any of its Affiliates grants
any
right to
make, use, market, or import and sell a Final Commercial
Product
in
accordance with the License Agreement. A Third Person who is
granted
only the
right to distribute or promote a Final Commercial Product (such
as a
contract sales organization) shall not be considered a
Sublicensee.
1.42 "TERM" means the
period beginning on the Effective Date and continuing
until the
date upon which this Agreement is terminated in accordance with
Article
10.
1.43 "THIRD PARTY" or
"THIRD PERSON" means any Person other than AGIX or
AstraZeneca and their respective Affiliates.
1.44 "THIRD PARTY
SUPPLIER" means a Person engaged by a Party, including,
without
limitation, Dow, for the supply of SDD or any aspect of the
supply,
manufacture or warehousing of SDD, its constituents or raw
materials
(such as Probucol), including the performance of a SDD
Manufacturing Process.
5
<PAGE>
1.45 "TRANSITION
PERIOD" means the period commencing on the Effective Date and
continuing
until the receipt of the first Regulatory Approval for the
Product.
2
CONSTRUCTION
2.1 Except where
the context requires otherwise, whenever used the singular
includes
the plural, the plural includes the singular, the use of any
gender is
applicable to all genders and the word "or" has the inclusive
meaning
represented by the phrase "and/or." Whenever this Agreement
refers
to a
number of days, unless otherwise specified, such number refers
to
calendar
days. The headings of this Agreement are for convenience of
reference
only and do not define, describe, extend or limit the scope or
intent of
this Agreement or the scope or intent of any provision
contained
in this
Agreement. The term "including" or "includes" as used in this
Agreement
means including, without limiting the generality of any
description preceding such term. The wording of this Agreement
shall be
deemed to
be the wording mutually chosen by the Parties and no rule of
strict
construction shall be applied against any Party.
2.2 References
to Articles, Sections, Exhibits and Schedules refer to the
Articles,
Sections, Exhibits and Schedules of and to this Agreement.
2.3 The Exhibits
and the Schedules (as amended from time to time by agreement
of the
Parties in writing) form part of this Agreement and have the
same
force and
effect as if expressly set out in the body of the Agreement.
Any
reference
to the Agreement includes the Exhibits and the Schedules. Any
breach of
the Exhibits or Schedules shall be deemed as a breach of this
Agreement.
3
AMENDMENT
Any
amendment or modification of this Agreement (including any
amendment
of any
Exhibit or Schedule hereto) must be in writing and signed by
authorized
representatives of both Parties.
4
TRANSITION ASSISTANCE
4.1 Transition
Assistance. Following the Effective Date and continuing
throughout
the Transition Period, AGIX shall cooperate with AstraZeneca
and
provide AstraZeneca with all reasonable assistance as
reasonably
requested
by AstraZeneca to facilitate manufacturing of the Final
Commercial
Product and Compound, including, without limitation, assistance
regarding
the Process Improvements. Such technical assistance shall
include,
without limitation, (i) transitioning to AstraZeneca
relationships with Third Party Suppliers, vendors and contractors
relating
to the
manufacture of raw materials, Compound and Spray Dried
Dispersion
and (ii)
transferring to AstraZeneca financial, business, regulatory,
technical
and all other necessary or useful information relating to the
manufacture and supply of raw materials, Compound and Spray
Dried
Dispersion.
4.2
Manufacturing Timelines. [****]
-------
[****] indicates that certain confidential information contained in
this
document has been omitted pursuant to a request for confidential
treatment and
filed separately with the Securities and Exchange Commission.
6
<PAGE>
4.3 Assignment
of Contracts and Other Rights. AGIX shall use commercially
reasonable
efforts to assign to AstraZeneca and, upon such assignment,
AstraZeneca shall assume all rights and obligations of AGIX under
the Dow
Agreement
and the other Existing Agreements, provided, however that
AstraZeneca will, at AGIX's option, use commercially reasonable
efforts to
assign to
AGIX such agreements, to the extent then still in effect, and
any new
agreements entered into by AstraZeneca relating to the
manufacture
of raw
materials, Compound and Spray Dried Dispersion together with
any
equipment
funded under Section 5.2 and used in connection with the
manufacture thereof, and the right to the use thereof in the event
that
AstraZeneca terminates the License Agreement pursuant to Sections
13.3(a),
13.3(b),
13.3(c) or 13.3(d) of the License Agreement or AGIX terminates
the
License Agreement pursuant to Section 13.4 thereof, provided,
however,
that in
the event that AGIX elects to have an agreement, equipment or
the
use
thereof assigned to AGIX pursuant to this Section 4.3,
AstraZeneca
shall be
relieved of its obligation pursuant to Section 13.5(b)(vi) of
the
License
Agreement to supply Products and/or Compounds to AGIX. AGIX and
AstraZeneca shall use commercially reasonable efforts to obtain any
third
party
consents that may be necessary to effect the assignments required
by
this
Section 4.3. Immediately following the execution of this
Agreement,
AGIX shall
contact Niro to obtain Niro's consent to the assignment of
PO#B24579
set forth on Exhibit 4 to AstraZeneca. In the event AGIX is
unable to
obtain Niro's consent, AGIX shall lease or, at AstraZeneca's
option,
assign the equipment purchased thereunder to AstraZeneca, for
no
addition
consideration beyond that set forth herein, and shall pass
through to
AstraZeneca all warranties set forth in such purchase order.
4.4 Assistance
Following Transition Period. Following the Transition Period,
AGIX shall
continue to provide such reasonable additional technical and
regulatory
assistance as reasonably requested by AstraZeneca, at
AstraZeneca's expense. Such assistance may be provided by
telephone, video
conference
or in-person at AstraZeneca's facility or at any third party's
facility,
as mutually agreed; provided that, the Parties reasonably agree
to the
scheduling of any such assistance.
4.5 Certain
Additional Covenants. Following the date hereof, AGIX (i) will
not
enter into
any contracts related to the manufacture or supply of Spray
Dried
Dispersion without the prior written consent of AstraZeneca,
except
that AGIX
may take any of the foregoing actions in the ordinary course
prior to
the Effective Date without AstraZeneca's consent; (ii) will not
terminate,
take any action likely to result in a breach of or prepay any
contract
or obligation related to the manufacture or supply of Spray
Dried
Dispersion
without the prior written consent of AstraZeneca; and (iii)
will cause
each of its Affiliates to comply with this Section 4.5.
4.6 Meetings.
During the Transition Period, AstraZeneca shall notify AGIX
promptly
of any material developments with respect to, and shall keep
AGIX
informed
on an ongoing basis regarding, the manufacture and supply of
the
SDD, the
Compound and materials, and regulatory matters. During the
Transition
Period,
7
<PAGE>
the
Parties shall meet no less than monthly regarding the
manufacturing,
supply and
regulatory filings related to the SDD, the Compound and
materials.
5
FEES
5.1 Costs of
Transitional Assistance. AstraZeneca shall reimburse AGIX for
all
costs and
expenses reasonably incurred by AGIX in providing transition
assistance
hereunder. Promptly following the Effective Date, the Parties
will agree
on a process and rates for determining such costs and expenses.
5.2
Reimbursement for Capital and Other Expenses.
5.2.1
AstraZeneca shall reimburse AGIX for [****] of the capital and
other
expenses set forth on Exhibits 2 and 3 incurred by AGIX prior to
the
Effective Date.
5.2.2
After the Effective Date, AGIX shall reimburse AstraZeneca for
[****] of the capital and other expenses set forth on Exhibits 2
and
3 incurred by AstraZeneca, up to the maximum AGIX payment
levels
specified on such Exhibits.
5.2.3
AstraZeneca shall pay to AGIX, within thirty (30) days following
the
last date that AstraZeneca is no longer entitled to elect to
terminate the License Agreement pursuant to Sections 13.3(a),
13.3(b) or 13.3(c) (and has not exercised any such election to
terminate the License Agreement), or prior to such last date,
AGIX
terminates the License Agreement pursuant to Section 13.4
thereof,
an amount equal to (a) the capital and other expenses set forth
on
Exhibits 2 and 3 incurred by AGIX prior to the Effective Date
and
not previously reimbursed by AstraZeneca pursuant to Section
5.2.1
plus (b) any amounts paid by AGIX pursuant to Section 5.2.2
above.
5.2.4 All
amounts payable pursuant to this Section 5.2 shall be made
within thirty (30) days after receipt of an invoice therefor,
accompanied by evidence of payment of such expenses.
5.3 Process
Improvements.
5.3.1 As
of the Effective Date, AGIX has proposed the following
improvements to the manufacturing process, as more fully
described
in Exhibit 1 (the "PROCESS IMPROVEMENTS"):
(a) [****] (Part A, Exhibit 1);
(b) [****] (Part B, Exhibit 1);
(c) [****] (Part C, Exhibit 1); and
(d) [****] (Part D, Exhibit 1).
-------
[****] indicates that certain confidential information contained in
this
document has been omitted pursuant to a request for confidential
treatment and
filed separately with the Securities and Exchange Commission.
8
<PAGE>
5.3.2
AstraZeneca shall have the right to determine which of the
Process
Improvements to implement and shall pay all costs associated
with
implementing any such Process Improvements. The Process
Improvements
described in Sections 5.3.1(a)-(c) shall be considered to have
been
implemented on the date that the price paid by AstraZeneca to
any
Third Party Supplier for SDD or the Compound is reduced to
reflect
such implementation (the "PROCESS IMPLEMENTATION DATE").
5.3.3 AGIX
shall not be entitled to receive Savings, if any, from any
Process Improvement until the earlier of: (a) the date on which
[****] of the Final Commercial Product sold by AstraZeneca, its
Affiliates and Sublicensees in two consecutive calendar quarters
is
in the form of a 300mg tablet or (b) [****] from the First
Commercial Sale (as defined in the License Agreement) of the
Product. The earlier of such dates is referred to herein as the
"SAVINGS TRIGGER DATE."
5.3.4 With
respect to each of the Process Improvements set forth in
Section 5.3.1(a)-(c), beginning on the Savings Trigger Date and
continuing throughout the term of the License Agreement,
AstraZeneca
shall pay to AGIX on a quarterly basis, [****] of any Savings
from
such Process Improvement (as calculated in accordance with
Sections
5.3.5 and 5.3.6 below) times the number of kilograms of
Compound
purchased by AstraZeneca, its Affiliates and Sublicensees
(other
than Third Party Suppliers) during such calendar quarter.
5.3.5 With
respect to the Process Improvements set forth in Section
5.3.1(b) and (c) the term "SAVINGS" shall mean the difference
between the per kilogram price of the Compound to AstraZeneca
and
its Affiliates and Sublicensees prior to the Process
Implementation
Date and the per kilogram price of the Compound to AstraZeneca
and
its Affiliates and Sublicensees immediately after the Process
Implementation Date for such Process Improvement to the extent
that
any such reduction in price is attributable to the implementation
of
such Process Improvement.
5.3.6 With
respect to the Process Improvement set forth in Section
5.3.1(a), the term "SAVINGS" shall mean (i) for the number of
kilograms of Compound actually purchased by AstraZeneca, its
Affiliates and Sublicensees, the difference between the per
kilogram
price of Compound prior to the Process Implementation Date and
the
per kilogram price of Compound to AstraZeneca, its Affiliates
and
Sublicensees, after the Process Implementation Date for such
Process
Improvement (both such prices as set forth specifically in the
Dow
Agreement) plus, (ii) for the number of kilograms of Probucol
actually purchased by AstraZeneca, its Affiliates and
Sublicensees,
the cost reduction per kilogram as a result of reduced Probucol
consumption, which cost reduction shall equal the average per
kilogram price of Probucol during a calendar year times the
fraction, where the numerator is the difference between the
number
of Probucol
-------
[****] indicates that certain confidential information contained in
this
document has been omitted pursuant to a request for confidential
treatment and
filed separately with the Securities and Exchange Commission.
9
<PAGE>
kilograms required per kilogram of Compound prior to the
Implementation Date and the number of Probucol kilograms
required
per kilo of Compound after the Process Implementation Date and
the
denominator is the number of Probucol kilograms required per
kilogram of Compound after the Process Implementation Date.
5.3.7 The
Parties acknowledge and agree that the calculations of Savings
are based on the financial structure currently set forth in the
Dow
Agreement as






