TRADEMARK LICENSE
AGREEMENT
This TRADEMARK
LICENSE AGREEMENT (this “ Agreement ”), dated as
of February 15, 2007 (the “ Effective Date ”),
is made by and between Inspire Pharmaceuticals, Inc., a Delaware
corporation having its principal office at 4222 Emperor Blvd.,
Suite 200, Durham, NC 27703 (“ Inspire ”), and
InSite Vision Incorporated, a Delaware corporation having its
principal office at 965 Atlantic Ave., Alameda, CA 94501 (“
InSite ”). Inspire and InSite are each sometimes
referred to individually as a “ Party ” and
together as the “ Parties .”
RECITALS
WHEREAS, InSite and Inspire are entering into a
license agreement (the “ License Agreement ”)
contemporaneously with this Agreement, under which InSite is
granting to Inspire the exclusive rights in the Territory to
certain patents, know-how and regulatory filings for the
commercialization of Subject Products;
WHEREAS, InSite owns and has the right to grant
a license to the InSite Trademarks and the Domain Names described
on Schedule 1 attached hereto; and
WHEREAS, Inspire desires to obtain from InSite,
and InSite desires to grant to Inspire, rights and licenses to use
the InSite Trademarks and the Domain Names in connection with the
marketing, commercialization and sale of Subject Products in the
Territory under the License Agreement.
NOW, THEREFORE, in consideration of the
foregoing premises, the rights and benefits that they will each
receive in connection with the License Agreement, and the mutual
representations, covenants and agreements contained herein, Inspire
and InSite, intending to be legally bound, hereby agree as
follows:
ARTICLE
1
DEFINITIONS
1.1
Incorporated
Definitions . Capitalized
terms that are used in this Agreement but are not otherwise defined
in this Agreement will have the respective meaning ascribed to such
terms in the License Agreement.
1.2
Additional Definitions
. When used in this Agreement,
whether in the singular or plural, each of the following
capitalized terms shall have the meanings set forth in this Section
1
(a) “ AzaSite Trademark ” means
the trademark AzaSite™.
(b) “ Domain Names ” means the
internet domain names set forth in Schedule 1 , such domain
names being owned and registered by InSite.
(c) “ Independent Sublicensee ”
has the meaning set forth in Section 4.4.
(d) “ InSite Trademarks ” means
the trademarks set forth in Schedule 1 , such marks being
owned and registered by InSite. From and after the effective date
of the assignment of the AzaSite Trademark by InSite to Inspire
pursuant to Section 2.3(b) of the License Agreement, the term
“InSite Trademarks” shall not include the AzaSite
Trademark for any purpose under this Agreement.
(e) “ Term ” has the meaning set
forth in Section 4.1.
ARTICLE
2
LICENSES AND
EXCLUSIVITY
(a) Subject to the terms and conditions of this
Agreement, InSite hereby grants to Inspire a royalty-free,
exclusive (even as to InSite and its Affiliates) right and license,
with the right to grant sublicenses, to use the AzaSite Trademark
and the Domain Names in connection with the marketing,
commercialization and sale of Subject Products in the Field in the
Territory under the License Agreement. In connection with such
license, InSite agrees immediately to cease any and all use of the
Domain Names and to execute and deliver such further and other
documents and to perform such actions as may be necessary to enable
Inspire to access and use the Domain Names under such
license.
(b) Subject to the terms and conditions of this
Agreement, InSite hereby grants to Inspire a royalty-free,
non-exclusive right and license, with the right to grant
sublicenses, to use the InSite Trademarks (other than the AzaSite
Trademark) in connection with the marketing, commercialization and
sale of Subject Products in the Field in the Territory under the
License Agreement. Notwithstanding the non-exclusive nature of the
foregoing grant, InSite hereby expressly covenants that it shall
not, and shall cause its Affiliates and licensees not to, directly
or indirectly: (x) use the InSite Trademarks in connection with the
marketing, commercialization or sale of Subject Products in the
Field in the Territory; or (y) grant to any Third Party any right
or license under the InSite Trademarks to conduct any of the
activities set forth in the foregoing clause (x).
2.2
Sublicenses
. Inspire may sublicense the rights
granted under Section 2.1 only to sublicensees who will use the
InSite Trademarks and the Domain Names in connection with the
marketing, commercialization and sale of Subject Products in the
Field in the Territory under the License Agreement. All sublicenses
granted hereunder must be in writing and must contain provisions
that are not inconsistent with the terms and conditions of this
Agreement. All sublicenses shall include quality control standards
at least as protective as those referenced under Section 3.1.
2.3
Use of Affiliates and Third Party
Contractors . The
licenses granted under Section 2.1 include the right of
Inspire to engage its Affiliates and Third Party contractors in
exercising such rights and in carrying out its activities and
obligations under this Agreement, provided that (i) all such
agreements with Third Party contractors must be in writing and must
contain provisions that are not inconsistent with the terms and
conditions of this Agreement and (ii) Inspire remains
responsible for the compliance with this Agreement by such
Affiliates or Third Party contractors.
2.4
No Implied Grants
. Except as expressly licensed
hereunder, neither Party grants any rights to the other Party under
this Agreement, by implication or estoppel, under any of its
intellectual property rights.
2.5
Registration of
License . Notwithstanding
anything to the contrary in Section 5.1, Inspire, at its expense,
may register the licenses granted under this Agreement in any
country of the Territory. Upon request by Inspire, InSite agrees
promptly to execute any “short form” licenses
consistent with the terms and conditions of this Agreement
submitted to it by Inspire reasonably necessary to effect the
foregoing registration in such country.
2.6
Notice . In connection with the use of the InSite
Trademarks, Licensee will mark the first prominent use of the
InSite Trademark with the appropriate trademark symbol
(“TM” or “®”, as set forth in
Schedule 1 or as otherwise reasonably instructed by InSite
in writing) and will include the following legend in connection
with such use: “[InSite Trademark] is the trademark of InSite
Vision Incorporated and is being used by
permission.”
ARTICLE
3
QUALITY CONTROL AND RELATED
MATTERS
3.1
Quality Control and
Standards . Inspire shall
adhere to such reasonable quality control standards that InSite may
from time to time promulgate and communicate to Inspire in writing
with respect to the InSite Trademarks, and shall comply materially
with all federal, state and local laws and regulations governing
the use of the InSite Trademarks in connection with the provision
of Inspire Licensed Products. In order to confirm that
Inspire’s use of the InSite Trademarks complies with this
Section 3.1, InSite shall have the right upon written notice
to require that Inspire submit to InSite a reasonable number of
representative samples of any Inspire Licensed Products or related
materials bearing the InSite Trademarks.
3.2
Protection of the InSite
Trademarks . Inspire
hereby acknowledges InSite’s rights in the InSite Trademarks
and shall not at any time do or authorize to be done any action
that would prejudice the validity or registration of the InSite
Trademarks or the good will associated therewith, including filing
for, using or authorizing the use of any trademark (i) likely
to cause consumer confusion with respect to the InSite Trademarks
or (ii) containing “SITE” as a part. It is
understood that neither Inspire nor any of its Affiliates shall
acquire or claim any independent right, title or interest in or to
the InSite Trademarks by virtue of Inspire’s use of the
InSite Trademarks as provided in this Agreement, it being the
intention of the Parties that all use of the InSite Trademarks by
Inspire, and all goodwill associated therewith, shall at all times
inure to the exclusive benefit of InSite.
ARTICLE
4
TERM AND
TERMINATION
4.1
Term . Except as set forth in