MODIFIED PRODUCT AGREEMENT

Supply Agreement

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This Supply Agreement involves

ev3 Inc. | SurModics, Inc. | Microvena Corporation

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Title: MODIFIED PRODUCT AGREEMENT
Date: 4/5/2005

MODIFIED PRODUCT AGREEMENT, Parties: ev3 inc. , surmodics inc. , microvena corporation

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Exhibit 10.46

ATTACHMENT A3
February 21,2002 SurModics-Modified Product Agreement
between
SurModics, Inc. and ev3 Inc., successor in interest to Microvena Corporation

1. Quantity of Medical Product. ev3 will supply SURMODICS with up to 50,000 units of Medical Product (double-ended catheters for the delivery and retrieval of ev3's debris collection system), at no charge, to be modified at SURMODICS' facility. In addition, ev3 acknowledges that all units of Medical Product supplied to SURMODICS will not be returned in that some units of Medical Product may be (i) lost to scrap, or (ii) consumed in the performance of quality procedures, or (iii) kept by SURMODICS as retained samples.

2. Delivery of SurModics-Modified Medical Product to ev3. SURMODICS anticipates that the SurModics-Modified Medical Products will be returned to ev3 within two weeks of receipt of Medical Products by SURMODICS provided that (a) ev3 submits batches containing 250 units or

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