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ADDENDUM TO SUPPLY AGREEMENT

Supply Agreement

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Title: ADDENDUM TO SUPPLY AGREEMENT
Date: 1/18/2006
Industry: Biotechnology and Drugs     Sector: Healthcare

ADDENDUM TO SUPPLY AGREEMENT, Parties:
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                                                                   EXHIBIT 10.10

                                    ADDENDUM
                   TO SUPPLY AGREEMENT DATED MARCH 25TH, 2004

             ENTERED INTO AND SIGNED ON THIS 30TH DAY OF JUNE, 2004

BY AND BETWEEN:         OMRIX BIOPHARMACEUTICALS LTD.
                       whose address for the purposes hereof is:
                       MDA Blood center
                       Tel Hasbomer Hospital
                       Kiryat Ono Israel
                        (Hereinafter referred to as: "OMRIX")

                                                              OF THE FIRST PART;

                                       AND

                       PLASTMED LTD. REG. NO. 51-352193-7
                        a company registered in Israel,
                       whose address for the purposes hereof is
                       at 5 Beit Harishomm St.
                       Emek Hefer Industrial Zone 388 00
                       (Hereinafter referred to as: "PLASTMED")

                                                             OF THE SECOND PART:

WHEREAS:     The Parties have entered on March 25th, 2004
            into a manufacture and supply AGREEMENT (hereinafter the
            "AGREEMENT") of Quixil application Devices (as defined in the
            Agreement); and

WHEREAS:     The parties wish to amend certain provisions of the
            Agreement relating to the molds required for the manufacture
            of the Devices and terms of payment relating thereto, as more fully
            set forth in this Addendum to the Agreement (the "ADDENDUM").

NOW THEREFORE IT IS AGREED, DECLARED AND STIPULATED BETWEEN THE PARTIES AS
FOLLOWS:

1.     The Preamble to this Addendum forms an integral part hereof and shall be
      binding upon the parties as the Addendum itself.

2.     This Addendum forms an integral part of the Agreement, and unless
      specifically amended herewith, the provisions of the Agreement shall be
      binding upon the parties hereto and shall remain in full force and effect.

3.     Without prejudice to the provisions of Section 5.2 of the
      Agreement and notwithstanding any other provision or the Agreement or the
      contrary, it is agreed that PlastMed is solely and fully responsible for
      the design and planning of the mold, and that the molds will be ready for
      manufacture of the Devices in not later than 7 (seven) months as of the
      signing date of the Agreement.


      PORTIONS OF THIS EXHIBIT MARKED BY AN *** HAVE BEEN OMITTED PURSUANT
       TO A REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE
                      SECURITIES AND EXCHANGE COMMISSION.

<PAGE>

                                       2

      In view of the passage of time since the date the Agreement was executed
      by the Parties, the Parties hereby agree that all dates and periods
      mentioned therein shall be deemed as postponed and delayed by six weeks.

4.     Payment terms of the amount of (euro) *** (*** Euro) described in
      Section 5.2 of the Agreement are hereby replaced with the following terms:

      4.1.   (euro) *** (*** Euro) designated to cover setup and local expenses,
            shall be paid in advance upon the signing of this Addendum.

      4.2.   The balance in the amount of (euro) *** (*** Euro) shall be paid
            within 30 days of signature hereof (the "BALANCE PAYMENT DATE"),
            against the receipt of" autonomous bank guaranties, as
            stipulated below, issued by one of the leading bank in Israel, in
            the form attached as ANNEX A hereto:

            4.2.1.A Bank Guarantee, in the form attached as ANNEX A hereto
                  (hereinafter: a "BANK GUARANTY"), in the amount of (euro)
                  *** (*** Euro), valid for a period of 20 (TWENTY) WEEKS
                  commencing upon the Balance Payment Date.

                  Without prejudice to the autonomous nature of this Bank
                  Guaranty, Omrix may exercise this Bank Guaranty in the event
                  of failure by PlastMed to supply Omrix detailed design
                  drawings for the following molds Vial Cup 2.5 ml, Vial holder,
                  syringe body and valve care within 14 (fourteen) weeks of the
                   date hereof all in accordance with the amended provisions of
                  the Agreement and the Technical Specifications, attached as
                  Annex A thereto.

                  In the event the above design drawings were delivered on time,
                  Omrix shall have a period of 2 (two) weeks from receipt of
                  such detailed design drawings, to approve or disapprove
                  whether they comply with the Technical Specifications
                  attached as Annex A to the Agreement.

                  In the event of an approval notice, Omrix shall return
                  immediately the Guaranty to PlastMed. In the event of a
                  disapproval notice Omrix shall give written details as to the
                  nature of the disapproval including any and all defect
                  and / or flaws ("DETAILS OF DISAPPROVAL) and PlastMed shall
                  take all actions required in order to correct and amend same
                  within a period of 4 (four) weeks commencing upon the receipt
                  of the Details of Disapproval. Upon the end of such 4 (four)
                  weeks period Omrix shall be entitled to exercise this Bank
                  Guaranty only if PlastMed failed to amend the defects and / or
                  flaws. In any other event, Omrix shall return the Bank
                  Guaranty immediately to PlastMed.
<PAGE>

                                       3

            4.2.2.       A Bank Guarantee in the amount of (euro) *** (*** Euro),
                        valid for a period of 20 (TWENTY) WEEKS commencing upon
                        the Balance Payment Date.

                        Without prejudice to the autonomous nature of this Bank
                         Guaranty, Omrix may exercise this Bank Guaranty in the
                        event of failure by PlastMed to supply detailed design
                        drawings for the syringe holder molds within 14
                        (fourteen) weeks of the date hereof all in accordance
                        with the amended provisions of the Agreement and the
                        Technical Specifications attached as Annex A thereto.

                        In the event the above design drawings were delivered on
                        time, Omrix shall have a period of 2 (two) weeks of
                        receipt of such detailed design drawings, to approve or
                        disapprove whether they comply with the Technical
                        Specifications attached as Annex A to the Agreement.

                        In the event of an approval notice, Omrix shall return
                        immediately the Guaranty to PlastMed. In the event of a
                         disappro


 
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