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2004 SECURITYHOLDER AGREEMENT

Shareholder Agreement

2004 SECURITYHOLDER AGREEMENT | Document Parties: VANDA PHARMACEUTICALS INC. | CARE CAPITAL INVESTMENTS II, LP | CARE CAPITAL OFFSHORE INVESTMENTS II, LP | BIOMEDICAL SCIENCES INVESTMENT FUND PTE LTD | DOMAIN PARTNERS VI, LP | DP VI ASSOCIATES, L.P. | PROSPECT VENTURE PARTNERS II, L.P. | PROSPECT ASSOCIATES II, L.P. | RHO VENTURES IV, L.P. | RHO VENTURES IV GMBH & CO You are currently viewing:
This Shareholder Agreement involves

VANDA PHARMACEUTICALS INC. | CARE CAPITAL INVESTMENTS II, LP | CARE CAPITAL OFFSHORE INVESTMENTS II, LP | BIOMEDICAL SCIENCES INVESTMENT FUND PTE LTD | DOMAIN PARTNERS VI, LP | DP VI ASSOCIATES, L.P. | PROSPECT VENTURE PARTNERS II, L.P. | PROSPECT ASSOCIATES II, L.P. | RHO VENTURES IV, L.P. | RHO VENTURES IV GMBH & CO

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Title: 2004 SECURITYHOLDER AGREEMENT
Governing Law: New York     Date: 4/7/2006
Industry: Biotechnology and Drugs     Sector: Healthcare

2004 SECURITYHOLDER AGREEMENT, Parties: vanda pharmaceuticals inc. , care capital investments ii  lp , care capital offshore investments ii  lp , biomedical sciences investment fund pte ltd , domain partners vi  lp , dp vi associates  l.p. , prospect venture partners ii  l.p. , prospect associates ii  l.p. , rho ventures iv  l.p. , rho ventures iv gmbh & co
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                                                                     EXHIBIT 4.1

                           VANDA PHARMACEUTICALS INC.

                         2004 SECURITYHOLDER AGREEMENT

            THIS 2004 SECURITYHOLDER AGREEMENT (the "AGREEMENT") is entered into
as of September 28, 2004 among VANDA PHARMACEUTICALS INC., a Delaware
corporation (the "COMPANY"), and each of the other parties signatory hereto.

                                    RECITALS

            A.     The Company, the Care Capital Securityholder and the EDB
Securityholder previously entered into that certain Securityholder Agreement
dated as of March 12, 2003 (the "ORIGINAL SECURITYHOLDER AGREEMENT").

            B.     The Securityholders are purchasing shares of the Company's
Series B Preferred Stock pursuant to that certain Series B Preferred Stock
Purchase Agreement dated as of September 28, 2004 (the "2004 PURCHASE
AGREEMENT").

            C.     The obligations in the 2004 Purchase Agreement are conditioned
upon the execution and delivery of this Agreement.

            D.     The Company and the Securityholders now desire to amend and
restate the Original Securityholder Agreement in its entirety.

            NOW, THEREFORE, in consideration of the foregoing and the mutual
agreements herein contained, the parties hereto agree:

SECTION 1. CERTAIN DEFINITIONS.

            1.1    DEFINITIONS. For the purposes of this Agreement, the following
terms have the following meanings:

            "AFFILIATE", with respect to any Person, means any other Person
      directly or indirectly controlling, controlled by or under common control
      with, such Person. For purposes of this definition, "control" (including
      with correlative meanings, the terms "controlling", "controlled by" or
      "under common control with"), as used with respect to any Person, shall
      mean the possession, directly or indirectly, of the power to direct or
      cause the direction of the management and policies of such Person, whether
      through the ownership of voting securities or by contract or otherwise.

            "AFFILIATED GROUP", with respect to any Person, means such Person
      and each Affiliate and Associate of such Person and each other Person with
      whom such Person is acting "as a partnership, limited partnership,
      syndicate, or other group for the purpose of acquiring, holding, or
      disposing of" Shares (within the meaning of Section 13(d)(3) of the 1934
      Act, regardless of whether the Company shall at any time be subject to the
      requirements of the 1934 Act).

            "ASSOCIATE" has the meaning given such term in Rule 12b-2 under the
      1934 Act.

            "BENEFICIAL OWNER" or "BENEFICIALLY OWN" has the meaning given such
      term in Rule 13d- 3 under the 1934 Act, and, with respect to any options
      or rights to acquire any Security, shall be determined without regard to
      whether any such Security is "in the money."

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            "BOARD OF DIRECTORS" means the Board of Directors of the Company.

            "BUSINESS DAY" means any day other than a Saturday, Sunday or other
      day on which commercial banks are authorized or obligated to be closed in
      New York City.

            "CARE CAPITAL SECURITYHOLDER" means Care Capital Investments II, LP,
      a Delaware limited partnership, and Care Capital Offshore Investments II,
      LP, a Cayman Islands exempted limited partnership.

            "CAUSE" means, with respect to any individual, (i) any willful
      violation of any federal, state, foreign or other law or regulation
      applicable to the business or affairs of the Company or any of its
      subsidiaries or Affiliates, or the commission of any felony or other crime
      involving moral turpitude, or any willful perpetration of a common law
      fraud; or (ii) any other misconduct that is materially injurious to the
      financial condition or business reputation of, or is otherwise materially
      injurious to, the Company or any of its subsidiaries or Affiliates.

            "CERTIFICATE" means the Certificate of Incorporation of the Company,
      as amended from time to time.

            "CODE" means the Internal Revenue Code of 1986, as amended.

            "COMMISSION" means the Securities and Exchange Commission, and any
      successor commission or agency having similar powers.

            "COMMON SHARE" means any share of Common Stock.

            "COMMON STOCK" means the Common Stock, par value $.01 per share, of
      the Company.

             "COMPANY" means Vanda Pharmaceuticals Inc., a Delaware corporation,
      and any successor thereto, whether by merger or otherwise.

            "EDB SECURITYHOLDER" means BioMedical Sciences Investment Fund Pte
      Ltd.

            "ENCUMBRANCE" means any lien, security interest, pledge, claim,
      option, right of first refusal, marital right or other encumbrance with
      respect to any Share.

            "IPO" means the initial Public Offering of Shares after the date
      hereof.

             "LAW" means any federal, state, local or foreign statute, law,
      ordinance, regulation, rule, code, order, other requirement or rule of
      law.

            "MEDI GROUP" shall mean (i) MEDI Ventures, (ii) MedImmune, and (iii)
      any successors or permitted assignees of any of the foregoing.

            "MEDI VENTURES" shall mean MedImmune Ventures, Inc., a Delaware
      corporation, including any successor thereto or any permitted assignee of
      the interest, in whole or in part, of MEDI Ventures under this Agreement.

            "MEDIMMUNE" shall mean MedImmune, Inc., a Delaware corporation,
      including any of its successors or permitted assigns.

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            "MEP" means the Management Equity Plan of the Company, as amended,
      from time to time.

            "1933 ACT" means the Securities Act of 1933, as amended, and the
      rules and regulations thereunder.

            "1934 ACT" means the Securities Exchange Act of 1934, as amended,
      and the rules and regulations thereunder.

            "OUTSTANDING," with respect to any Shares, means, as of any date of
      determination, all Shares that have been issued on or prior to such date,
      other than Shares repurchased or otherwise reacquired by the Company, or
      any controlled Affiliate thereof, on or prior to such date.

            "PARTICIPANT" has the meaning assigned in the MEP.

            "PERMITTED TRANSFEREE" means: (a) any Securityholder's Affiliate
       (including, without limitation, in the case of MEDI Ventures, any member
      of the MEDI Group); (b) in the case of any Securityholder who is a natural
      person, (i) the spouse, parents and lineal descendants (in each case,
      whether natural or adopted) of such Securityholder, (ii) a Person to whom
      Shares are transferred by such Securityholder by will or the laws of
      descent and distribution, or (iii) a trust administered and controlled by
      such Securityholder that is established for the exclusive benefit of such
      Securityholder or his or her Permitted Transferees; (c) the Company or any
      subsidiary thereof; (d) in the case of any Securityholder which is a
      grantor trust, its grantor; or (e) any Person with respect to which the
      Board of Directors shall have adopted a resolution by a vote of 66-2/3% of
      its members stating that the Board of Directors has no objection if a Sale
      of Shares is made to such Person.

            "PERSON" means an individual, a partnership, a joint venture, a
      corporation, an association, a trust, an individual retirement account or
      any other entity or organization, including a government or any department
      or agency thereof.

            "PREFERRED SECURITYHOLDER" means each Securityholder that owns
      shares of Preferred Stock.

            "PREFERRED SECURITYHOLDER RESTRICTED PERSON" means any Preferred
      Securityholder or any Affiliate thereof, or the general partner, managing
      partner, managing member or investment manager of any thereof, or any
      officer, director or private equity professional thereof.

            "PREFERRED SHARE" means any share of Preferred Stock.

            "PREFERRED STOCK" means any of the Company's Series A Preferred
      Stock or Series B Preferred Stock.

            "PUBLIC COMPANY" means a company as to which the aggregate number of
      Common Shares that have been sold in Public Offerings shall equal not less
      than 25% of the Common Shares then outstanding.

            "PUBLIC OFFERING" means an underwritten public offering of equity
      securities of the Company pursuant to an effective registration statement
      under the 1933 Act.

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            "REGISTRABLE SHARES" means (a) Common Shares issued pursuant to the
      Care Capital Securityholder and the EDB Securityholder pursuant to the
      2003 Stock Subscription Agreements; (b) Common Shares issued upon the
      conversion of Preferred Shares; (c) any other Common Shares issued to a
      Securityholder after the date hereof, whether or not upon conversion of
      any Preferred Share, so long as the Board of Directors shall have
      determined prior to such issuance that such Common Shares shall be
      "Registrable Shares"; and (d) any Shares issued or issuable in respect of
      Shares referred to in clauses (a), (b) or (c) above by way of a stock
      dividend or a stock split or in connection with a combination or
      subdivision of shares, reclassification, recapitalization, merger,
      consolidation or other reorganization of the Company. As to any particular
      Registrable Shares that have been issued, such securities shall cease to
      be Registrable Shares when (i) a registration statement with respect to
      the sale of such securities shall have become effective under the 1933 Act
      and such securities shall have been disposed of under such registration
      statement, (ii) they shall have been distributed to the public pursuant to
      Rule 144, (iii) they shall have been otherwise transferred or disposed of,
      and new certificates, in the case of certificated shares, therefor not
      bearing a legend to the effect set forth in the first paragraph of the
       form of legend required by Section 4.2(a) restricting further transfer
      shall have been delivered by the Company, and subsequent transfer or
      disposition of them shall not require their registration or qualification
      under the 1933 Act or any similar state law then in force or (iv) they
      shall have ceased to be outstanding.

            "REGISTRATION EXPENSES" means all out-of-pocket expenses incident to
      the Company's performance of or compliance with Section 5, including,
       without limitation, all registration and filing fees (including filing
      fees with respect to the National Association of Securities Dealers,
      Inc.), all fees and expenses of complying with state securities or "blue
      sky" laws (including reasonable fees and disbursements of underwriters'
      counsel in connection with any "blue sky" memorandum or survey), all
      printing expenses, all listing fees, all registrars' and transfer agents'
      fees, all "road show" expenses of the Company and the underwriters, the
      fees and disbursements of counsel for the Company and of its independent
      public accountants, including the expenses of any special audits and/or
      "cold comfort" letters required by or incident to such performance and
      compliance, the reasonable fees and disbursements of one outside counsel
      retained by the holders of Registrable Shares being registered (which
      counsel shall be satisfactory to the holders of a majority of the shares
      of Registrable Shares being registered), but excluding underwriting
      discounts and commissions and applicable transfer taxes, if any, which
      shall be borne by the sellers of the Registrable Shares being registered
      in all cases.

            "RESTRICTED SHARES" means all Shares other than (a) Shares that have
      been registered under a registration statement pursuant to the 1933 Act,
      (b) Shares with respect to which a Sale has been made in reliance on and
      in accordance with Rule 144 or other applicable exemption from
      registration under the 1933 Act or (c) Shares with respect to which the
      holder thereof shall have delivered to the Company either (i) an opinion,
      in form and substance satisfactory to the Company, of counsel, who shall
      be satisfactory to the Company, or (ii) a "no action" letter from the
      Commission, to the effect that subsequent transfers of such Shares may be
      effected without registration under the 1933 Act.

            "RESTRICTED TRANSFEREE" means any Person described in the most
      recent list, if any, of Persons (which list will be entitled "LIST OF
      RESTRICTED TRANSFEREES") that shall have been approved by the Board of
      Directors and delivered by the Company to a Prospective Seller (as defined
      for purposes of Section 4.4) not later than ten Business Days after
      receipt by each Other Stockholder (as therein defined) and the Company of
      an Offer Notice (as therein defined).

            "RULE 144" means Rule 144 (or any successor provision) under the
      1933 Act.

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            "SALE" means (including with correlative meanings, the terms "SELL"
      or "SOLD") any sale, assignment, transfer, distribution (whether by a
      partnership to any of its partners or otherwise) or other disposition of
      Shares or of a participation therein.

            "SECURITYHOLDER" means each Person (other than the Company) holding
      Shares that is a party to this Agreement, so long as such Person shall
      beneficially own any Shares (whether or not any such Person owns any
      Shares on the date hereof).

            "SERIES A PREFERRED STOCK" means Series A Preferred Stock, par value
      $.01 per share, of the Company.

            "SERIES B PREFERRED STOCK" means Series B Preferred Stock, par value
      $.01 per share, of the Company.

            "SERIES B PREFERRED DIRECTOR" means the three members of the Board
      of Directors designated by holders of the outstanding shares of Series B
      Preferred Stock, voting together as a class and to the exclusion of all
      other classes of capital stock of the Company.

            "SHARE" means any share of Common Stock or Preferred Stock.

            "THIRD PARTY" means, with respect to any Securityholder, any other
      Person, other than the Company and its subsidiaries or any Affiliate of
      such Securityholder.

SECTION 2. CERTAIN GOVERNANCE MATTERS

            2.1    Board of Directors Meetings; Director Compensation. The
Company agrees to use its best efforts to ensure that each committee of the
Board of Directors shall include at least one designee of the Series B Preferred
Directors. The Company agrees that the Board of Directors shall meet at least
quarterly, unless otherwise agreed by the Board of Directors. In the event that
any non-employee director receives any compensation for serving on the Board of
Directors, all non-employee directors shall be entitled to receive compensation
therefor at the same rate and on the same terms. The Company shall reimburse the
non-employee directors for their customary and reasonable expenses incurred in
attending meetings of the Board of Directors (or meetings of committees thereof)
in accordance with the Company's policy on reimbursement of such expenses.

            2.2    Insurance. The Company shall maintain a directors' and
officers' liability insurance policy upon such terms as may be determined by the
Board of Directors.

            2.3 Employee Stock Options. With respect to any Shares issued or
options or rights granted to employees and consultants after the date hereof,
unless otherwise approved by the Board of Directors, the Company shall cause
each employee and consultant of the Company to enter into an agreement providing
for vesting of such Shares or options or rights in accordance with the MEP, as
in effect on the date hereof. No Shares or options or rights shall vest in the
12 months following the date of commencement of the employee's or consultant's
services in the case of new hires, or the date of issuance or grant in the case
of subsequent stock or option grants. Immediately after the Initial Closing (as
such term is defined in the Purchase Agreement), the Company shall reserve an
additional 3,337,114 Shares for issuance under the MEP.

            2.4    Qualified Small Business Stock. The Company agrees to use its
Best Efforts (as defined below) to cause its capital stock to be characterized
as "qualified small business stock" as defined in Section 1202(c) of the Code
("QUALIFIED SMALL BUSINESS STOCK"), unless the Board of Directors

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determines that such a characterization is not in the best interests of the
Company. "Best efforts" shall mean only that the Company: (i) complies with any
applicable filing or reporting requirements imposed by the Code on issuers of
Qualified Small Business Stock; (ii) executes and delivers to each
Securityholder, from time to time, such forms, documents, schedules and other
instruments as may be reasonably requested thereby to cause the Securityholder's
Shares of the Company to be characterized as Qualified Small Business Stock; and
(iii) submits to the Securityholders and to the Internal Revenue Service any
reports that may be required under Section 1202(d)(l)(C) of the Code and any
related Treasury Regulations. The Company further agrees that, within 10 days
after any Securityholder has delivered to the Company a written request
therefor, the Company shall deliver to such Securityholder a written statement
informing the Securityholder whether, in the Company's good-faith judgment after
a reasonable investigation, such Securityholder's interest in the Company
constitutes "qualified small business stock" as defined in Section 1202(c) of
the Code, or would constitute "qualified small business stock," if determination
of whether stock constitutes "qualified small business stock" were made by
taking into account the modifications set forth in Section 1045(b)(4) of the
Code. The Company's obligation to furnish a written statement pursuant to this
Section 2.4 shall continue notwithstanding the fact that a class of the
Company's stock may be traded on an established securities market.

            2.5    Financial Statements and Reports to Stockholders; Budget. The
Company agrees to deliver to each Preferred Securityholder:

            (a)    as soon as practicable after the end of each month, and in any
event within 30 days (45 days in the case of the month ending each fiscal
quarter) thereafter, consolidated balance sheets of the Company and its
subsidiaries as of the end of each such month and consolidated statements of
income and cash flow for such month and for the current fiscal year to date and
which shall show an analysis of variances from the budget and the prior month
(with the exception that no notes need be attached to such statements and
year-end audit adjustments may not have been made);

            (b)    as soon as practicable after the end of each fiscal quarter of
the Company, and in any event within 45 days thereafter, unaudited financial
statements of the Company on a quarterly basis prepared in accordance with
generally accepted accounting principles and fairly reflecting the fiscal
affairs of the Company for such quarterly period and analyzing variances from
the budget and the prior fiscal quarter (with the exception that no notes need
be attached to such statements and year-end audit adjustments may not have been
made);

            (c)    as soon as practicable after the end of each fiscal year of
the Company, and in any event within 120 days thereafter, an audited
consolidated balance sheet of the Company as of the end of such year and audited
consolidated statements of income, stockholders' equity and cash flows for such
year, which year-end financial reports shall be (i) in reasonable detail, (ii)
prepared in accordance with generally accepted accounting principles, and (iii)
accompanied by the opinion of independent public accountants of recognized
standing selected by the Company; and

            (d)    within 30 days prior to the end of each fiscal year, an
operating budget and plan respecting the next fiscal year that will be subject
to the approval of the Board of Directors.

            2.6    Right of First Refusal, Co-Sale and Drag-Along Provisions.
Following the Initial Closing, the Company shall require all purchasers (other
than purchasers under the 2004 Purchase Agreement) from the Company of shares of
Common Stock who, following such purchase, shall hold greater than 1 % of Common
Stock (calculated on a fully-diluted basis), to agree to the terms and
conditions set forth in the attached Exhibit 2.6.

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            2.7    Inspection. The Company shall permit each Preferred
Securityholder, at such Securityholder's expense, to visit and inspect the
Company's properties, to examine its books of account and records and to discuss
the Company's affairs, finances and accounts with its officers, all at such
reasonable times as may be requested by each such Securityholder; provided,
however, that the Company shall not be obligated to provide access (i) to a
competitor of the Company, any information which it reasonably considers to be a
trade secret or confidential information; or (ii) to MEDI Ventures, any trade
secret or confidential information if the Board of Directors determines in good
faith that it would be contrary the Company's best interests to share such
information with MEDI Ventures. The rights of a Preferred Securityholder under
this Section 2.7 may not be assigned as part of such Securityholder's sale of
any of the Registrable Securities except with the consent of the Company, which
consent shall not be unreasonably withheld; provided, however, that
notwithstanding the foregoing, (i) MEDI Ventures may assign these rights to any
member of the MEDI Group and (ii) any Securityholder which is a grantor trust
may transfer its rights to its grantor.

            2.8    Employee Confidentiality Agreement. The Company shall require
that each employee and consultant hired or engaged by the Company following the
date hereof signs an employee confidentiality agreement, substantially in the
form attached hereto as Exhibit 2.8 (unless such agreement shall be modified by
the Company upon the approval of the Board of Directors (including a majority of
the Series B Directors)). Further, within 15 days of the Initial Closing, the
Company shall require that each of its current employees and consultants signs
such an employee confidentiality agreement, substantially in the form attached
hereto as Exhibit 2.8.

            2.9 Securityholder Matters.

            (a)    This Agreement shall not impose any fiduciary duty on any
Securityholder or its Affiliates in any such Securityholder's capacity as a
Securityholder. To the maximum extent permitted by Law, each Securityholder
hereby waives all fiduciary duties that, absent such waiver, may be implied by
Law, and, in doing so, recognizes, acknowledges and agrees that its duties and
obligations to each other Securityholder and to the Company are only as
expressly set forth herein.

            (b)    Each Securityholder acknowledges that the other
Securityholders and their Affiliates may own interests in and/or manage other
businesses, including businesses that may compete with the Company or the other
Securityholders. Each Securityholder and its Affiliates, and their respective
officers, directors, Securityholders, partners, members, agents and employees,
and each member of the Board of Directors (or observer thereon) designated by
such Securityholder (collectively, a "CORPORATE OPPORTUNITIES GROUP"), shall not
be prohibited or restricted from engaging or investing in, independently or with
others, any business opportunity of any type or description, including, without
limitation, those business opportunities that might be the same or similar to
the Company's business. None of the Company, any Securityholder or such
Securityholder's Corporate Opportunities Group shall have any right in or to
such other business opportunities of any other Securityholder or such other
Securityholder's Corporate Opportunities Group or to the income or proceeds
derived therefrom. No Securityholder or its Corporate Opportunities Group shall
be obligated to present any business opportunity to the Company or any other
Securityholder or such other Securityholder's Corporate Opportunities Group,
even if the opportunity is of the character that, if presented to the Company,
could be undertaken by the Company or, if presented to any other Securityholder
or other Securityholder Corporate Opportunities Group, could be undertaken by
such Persons. Each Securityholder and its Corporate Opportunities Group shall
have the right to hold any such business opportunity for its own account or to
recommend such opportunity to Persons other than the Company, any other
Securityholder or any Person in such other Securityholder's Corporate
Opportunities Group.

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            (c)    Notwithstanding the foregoing, nothing in this Section 2.9
shall relieve, limit, alter or otherwise change the fiduciary duty owed to the
Company by any officer, director or stockholder who is not a Securityholder.

SECTION 3. PREEMPTIVE RIGHTS

            3.1    Offer to Sell. Except in the case of Excluded Securities, the
Company shall not issue, sell or exchange, or agree to issue, sell or exchange
(i) any Common Shares, (ii) any Preferred Shares of the Company that by their
terms are convertible into or exchangeable for Common Shares, or (iii) any
option, warrant or other right to subscribe for, purchase or otherwise acquire
any equity security of the Company specified in the foregoing clause (i) or
(ii), in each such case for the purpose of financing the business of the Company
(an "EQUITY FINANCING"), unless in each case the Company shall have first
offered to sell to the Securityholders (for purposes of this Section 3, each an
"OFFEREE" and, together, the "OFFEREES") such Offeree's Section 3 Proportionate
Percentage of such securities (for purposes of this Section 3, the "OFFERED
SECURITIES"), at a price and on such other material terms and conditions as are
generally applicable to such Equity Financing and which shall have been
specified by the Company in writing and delivered to each Offeree (for purposes
of this Section 3, the "OFFER"). The Offer shall by its terms remain open and
irrevocable for a period of 20 Business Days from the date it is delivered by
the Company to the Offerees. For purposes of this Section 3, the "SECTION 3
PROPORTIONATE PERCENTAGE" means, as of any date of determination, the percentage
figure equal to the ratio between the number of Common Shares beneficially owned
by an Offeree of the Company and the aggregate number of Common Shares
outstanding (and issuable upon the exercise of all convertible securities
outstanding).

            3.2    Acceptance of Offer. Each Offeree shall have the right and
option, for a period of 20 Business Days after delivery by the Company of the
Offer, to accept any or all its Offered Securities on the terms stated in the
Offer. Acceptance shall be made by delivering, within the 20 Business Day period
of the Offer, a written notice (for purposes of this Section 3, a "NOTICE OF
ACCEPTANCE") to the Company, which notice shall set forth the portion of the
Offered Securities that such Offeree elects to purchase. Such Offer, or any
portion thereof, may be irrevocably rejected at any time within such 20 Business
Day period by written notice to the Company by the Offeror.

            3.3    Overallotment Securities. If any Offeree fails to properly
accept all of its Offered Securities, then such unaccepted Offered Securities
shall become the "OVERALLOTMENT SECURITIES." Each Offeree that properly accepts
all of its Offered Securities (a "FULLY-EXERCISING OFFEREE") shall have the
right, at the time it accepts and for a period of 10 days thereafter
(collectively, the "OVERALLOTMENT PERIODS"), to purchase a portion of the
Overallotment Securities on a pro rata basis according to such Fully-Exercising
Offeree's Section 3 Proportionate Percentage.

            3.4    Remaining Securities. Upon expiration of the Overallotment
Periods, the Company shall have 90 days to sell all or any part of the remaining
Overallotment Securities (the "REMAINING SECURITIES") to any other Person or
Persons, upon terms and conditions in all material respects, including, without
limitation, price, which are not materially more favorable, in the aggregate, to
such other Person or Persons and not materially less favorable to the Company
than those set forth in the Offer. Upon the closing of the sale to such other
Person or Persons of all the Remaining Securities, which closing shall include
full payment to the Company, (i) the Offerees shall purchase from the Company,
and the Company shall sell to the Offerees, the Offered Securities with respect
to which Notices of Acceptance were delivered to the Company by the Offerees for
the price and at the terms specified in the Offer, and (ii) the Fully-Exercising
Offerees shall purchase from the Company, and the Company shall sell to the
Fully-Exercising Offerees, the Overallotment Securities.

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            3.5    Excluded Securities. The rights of the Offerees under this
Section 3 shall not apply to the following securities (the "EXCLUDED
SECURITIES"):

            (a)    securities issued in connection with a Public Offering or
securities issued in a Rule 144A offering;

            (b)    Common Shares issued, or stock options granted, or Common
Shares issuable upon exercise of stock options granted, pursuant to the MEP;

            (c)    securities issued as a stock dividend or upon any stock split
or other subdivision or combination of Shares;

            (d)    the issuance of any Common Shares upon the exercise,
conversion or exchange of any option, warrant, convertible or exchangeable
security or other right to subscribe for, purchase or otherwise acquire any
security of the Company;

            (e)    securities issued (i) in connection with any acquisition of
the stock, assets or business of a Person, or (ii) in respect of the initiation
of a joint venture or strategic alliance with another Person, in each case,
which has been approved by the Board of Directors; and

            (f)    any securities offered or sold after an IPO.

            3.4    Board of Directors Determination. The Board of Directors shall
be entitled to make any determination required or permitted to be made under
this Section 3, including any determination of compliance with the provisions
hereof by any Person, and any such determination shall be final and binding on
the Company and all stockholders.

SECTION 4. RESTRICTIONS ON TRANSFER.

            4.1    General Restriction. Each Securityholder agrees that it will
not, directly or indirectly, offer, sell, assign, transfer, grant or sell a
participation in, pledge or otherwise dispose of any Shares (or solicit any
offers to buy or otherwise acquire, or take a pledge of, any Shares) in any
manner that would conflict with or violate the 1933 Act or this Agreement.

            4.2    Legends.

            (a)    To the extent required by, or advisable to comply with, the
1933 Act or other applicable law, the Company shall affix to each certificate
evidencing outstanding Shares that is issued to any Securityholder a legend in
substantially the following form:

            "THE SECURITIES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN
      REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. NO REGISTRATION
      OF TRANSFER OF SUCH SECURITIES WILL BE MADE ON THE BOOKS OF THE ISSUER
      UNLESS SUCH TRANSFER IS MADE IN CONNECTION WITH AN EFFECTIVE REGISTRATION
      STATEMENT UNDER SUCH ACT OR PURSUANT TO AN EXEMPTION FROM THE REGISTRATION
       REQUIREMENTS OF SUCH ACT OR SUCH ACT DOES NOT APPLY.

            THE SECURITIES EVIDENCED BY THIS CERTIFICATE ARE SUBJECT TO CERTAIN
      RESTRICTIONS ON TRANSFER AS SET FORTH IN A SECURITYHOLDER AGREEMENT DATED
      AS OF SEPTEMBER 28, 2004, A COPY OF WHICH IS ON FILE AT

                                       9

<PAGE>

      THE PRINCIPAL EXECUTIVE OFFICES OF THE ISSUER. NO REGISTRATION OF TRANSFER
      OF SUCH SECURITIES WILL BE MADE ON THE BOOKS OF THE ISSUER UNLESS AND
      UNTIL SUCH RESTRICTIONS SHALL HAVE BEEN COMPLIED WITH."

            (b) In the event that any Shares shall cease to be Restricted
Shares, the Company shall, upon the written request of the holder thereof, issue
to such holder a new certificate evidencing such Shares without the first
paragraph of the legend required by Section 4.2(a) endorsed thereon. In the
event that any Shares shall cease to be subject to the restrictions on transfer
set forth in this Agreement, the Company shall, upon the written request of the
holder thereof, issue to such holder a new certificate evidencing such Shares
without the second paragraph of the legend required by Section 4.2(a).

            4.3    Certain Restrictions on Transfer. Each Securityholder agrees
that it will not, directly or indirectly, make any Sale or create, incur or
assume any consensual Encumbrance with respect to any Shares held by such
Securityholder, other than: (a) any Sale that is made in compliance with the
procedures, and subject to the limitations, set forth in Section 4.4; (b) any
Sale that is made in compliance with the procedures, and subject to the
limitations, set forth in Section 4.5; (c) any Sale pursuant to a Public
Offering in accordance with Section 5; or (d) any Sale to a Permitted
Transferee. Notwithstanding the foregoing, except as otherwise expressly
provided herein, all Sales permitted by the foregoing clauses (a) through (d)
shall be subject to, and shall not be made other than in compliance with, the
provisions of Sections 4.1, 4.2, 4.6 and 4.7.

             4.4    Right of First Refusal.

            (a)    If any Securityholder receives from or otherwise negotiates
with a Third Party a bona fide financed offer to purchase (for purposes of
Sections 4.4 and 4.5, an "OFFER") any of the Shares owned or held by such
Securityholder, and such Securityholder intends to pursue a sale of such Shares
to such Third Party, such Securityholder (for purposes of Sections 4.4 and 4.5,
the "PROSPECTIVE SELLER") shall provide the Company and each Securityholder that
owns Shares (for purposes of Sections 4.4 and 4.5, the "OTHER SECURITYHOLDERS")
written notice of such Offer (for purposes of Sections 4.4 and 4.5, an "OFFER
NOTICE"). The Offer Notice shall identify the Third Party making the Offer, the
number of Shares with respect to which the Prospective Seller has such an Offer
(for purposes of Sections 4.4 and 4.5, the "OFFERED SHARES"), the price per
Share at which a sale is proposed to be made (for purposes of Sections 4.4 and
4.5, the "OFFER PRICE"), the form of consideration to be paid and all the other
material terms and conditions of the Offer.

            (b)    The receipt of an Offer Notice by each Other Securityholder
and the Company from a Prospective Seller shall constitute an offer by such
Prospective Seller to sell to each Other Securityholder (other than the
Prospective Seller and its Affiliates) and the Company the Offered Shares at the
Offer Price in cash (in an amount equal to the cash consideration specified in
such Offer Notice or, if such consideration is not cash, an amount equal to the
fair market value of such noncash consideration as determined in good faith by
the Board of Directors). Such offer shall be irrevocable for 20 Business Days
after receipt of such Offer Notice (for purposes of Sections 4.4 and 4.5, the
"NOTICE PERIOD") by each such Other Securityholder and the Company. During the
Notice Period, each such Other Securityholder and the Company shall, subject to
the priorities set forth in the next succeeding paragraph, have the right to
accept such offer as to all or a portion of the Offered Shares by giving a
written notice of acceptance (for purposes of this Section 4.4, the "NOTICE OF
ACCEPTANCE") to the Prospective Seller prior to the expiration of the Notice
Period (for the purposes of this Section 4.4, any such Other Securityholder or
the Company so accepting such offer, an "ACCEPTING PARTY"). In the event that
within five Business Days prior to the expiration of the Notice Period, the
Prospective Seller shall not have received Notices of Acceptance for all the
Offered Shares, the Prospective Seller shall notify each such Other
Securityholder

                                       10

<PAGE>

of such fact and shall provide each thereof an opportunity to submit an
additional Notice of Acceptance of any such Offered Shares.

            Each such Other Securityholder and the Company shall be entitled to
accept such offer from the Prospective Seller in the following order of
priority: First, the Company shall be entitled to accept such offer for any or
all of the Offered Shares; second, if the Company shall not have accepted such
offer for all the Offered Shares, each such Other Securityholder shall be
entitled to accept such offer for not more than the portion of the remaining
Offered Shares determined on a pro rata basis based on the ratio of the number
of Common Shares then beneficially owned by such Other Securityholder to the
number of Common Shares then beneficially owned by all such Other
Securityholders; and third, if one or more such Other Securityholders and the
Company have not accepted such offer for all the Offered Shares, each such Other
Securityholder shall then be entitled to accept such offer for not more than the
portion of the remaining Offered Shares determined on a pro rata basis based on
the ratio of (i) the number of Offered Shares specified in such Other
Securityholder's Notice of Acceptance in respect of which such Other
Securityholder shall not be entitled to accept the Prospective Seller's offer as
a result of the application of clause second above to (ii) the number of Offered
Shares specified in all such Other Securityholders' Notices of Acceptance in
respect of which such Other Securityholders shall not be entitled to accept the
Prospective Seller's offer as a result of the application of clause second above
(it being understood that each such Other Securityholder shall be entitled to
indicate its interest in accepting more than its pro rata share of the remaining
Offered Shares and to accept the Prospective Seller's offer with respect to such
additional Offered Shares if all the Offered Shares are not otherwise accepted
pursuant to clause first, second and third). If the Company or any such Other
Securityholder so accepts the Prospective Seller's offer, such Person will
purchase for cash from the Prospective Seller, and the Prospective Seller will
sell to such Accepting Party, such number of Offered Shares as to which such
Accepting Party shall have accepted the Prospective Seller's offer. The price
per Share to be paid by such Accepting Party shall be the Offer Price specified
in the Offer Notice. The Notice of Acceptance shall specify (i) such Accepting
Party's acceptance of the Prospective Seller's offer and (ii) the number of
Offered Shares to be purchased by such Accepting Party.

            (c)    The consummation of any such purchase by and sale to any
Accepting Party shall take place on such date, not later than 30 Business Days
after receipt of the Notice of Acceptance from such Accepting Party by the
Prospective Seller, as such Accepting Party and the Prospective Seller shall
select. Upon the consummation of such purchase and sale, the Prospective Seller
shall (i) deliver to the Accepting Party certificates (in the case of
certificated shares) evidencing the Offered Shares purchased and sold duly
endorsed in blank or accompanied by written instruments of transfer in form
satisfactory to such Accepting Party duly executed by the Prospective Seller, or
an instruction (in the case of uncertificated shares) to register such Offered
Shares purchased and sold in a manner satisfactory to the Accepting Party, and
(ii) shall assign all its rights under this Agreement with respect to the
Offered Shares purchased and sold pursuant to an instrument of assignment
reasonably satisfactory to such Accepting Party.

            (d)    In the event that (i) each such Other Securityholder and the
Company shall have received an Offer Notice from a Prospective Seller but the
Prospective Seller shall not have received from the Company and one or more
Other Securityholders Notices of Acceptance as to all the Offered Shares prior
to the expiration of the Notice Period or (ii) an Accepting Party shall have
given a Notice of Acceptance to the Prospective Seller but shall have failed to
consummate, other than as a result of the fault of the Prospective Seller, a
purchase of the Offered Shares with respect to which such Notice of Acceptance
was given within 45 days after receipt of the Notice of Acceptance by the
Prospective Seller, such Prospective Seller shall have the right to reject any
or all Notices of Acceptance theretofore received from the Other Securityholders
and the Company, and nothing in this Section 4.4 shall limit the right of the
Prospective Seller to make a sale of the Offered Shares so long as all the
Offered Shares that are sold

                                       11

<PAGE>

or otherwise disposed of by the Prospective Seller (which number of Offered
Shares shall be not less than the number of Offered Shares specified in such
Offer Notice) are sold for the consideration specified in such Offer Notice (A)
within 60 days after the date of receipt of such Offer Notice by each such Other
Securityholder and the Company, (B) at an amount not less than the Offer Price
included in such Offer Notice and (C) to the Third Party making the Offer (so
long as none of such Third Parties is a Restricted Transferee).

            (e)    In the event that each such Other Securityholder and the
Company shall have received an Offer Notice from a Prospective Seller but shall
not have given a Notice of Acceptance for all the Offered Shares to the
Prospective Seller prior to the expiration of the Notice Period following
receipt of such Offer Notice and such Prospective Seller shall not have sold the
remaining Offered Shares before the expiration of the 60 day period in
accordance with paragraph (d) above, then such Prospective Seller shall not give
another Offer Notice for a period of 90 days from the last day of such 60 day
period.

            (f)    Anything in this Section 4.4 or in Section 4.3 to the contrary
notwithstanding, the provisions of this Section 4.4 will not be applicable to
any Sale or Encumbrance described in clauses (b) through (e) of Section 4.3.

            4.5    Right to Participate in Certain Dispositions.

            (a)    So long as any Securityholder (and its Affiliates) shall
beneficially own, in the aggregate, at least 10% of the Common Shares
outstanding or issuable upon the exercise or conversion of any outstanding
options or other rights to acquire Common Shares, no such Securityholder shall
in any transaction or series of related transactions, directly or indirectly,
sell or otherwise dispose of for value any Shares held by it to any Third Party
or Parties, unless the terms and conditions of such sale or other disposition
shall include an offer to include, at the option of each of the Other
Securityholders, in such sale or other disposition to the Third Party or Third
Parties, such Other Securityholder's Pro Rata Portion (as hereinafter defined)
of the Offered Shares on the terms set forth in this Section 4.5.

            (b)    If, so long as any Securityholder (and its Affiliates) shall
beneficially own, in the aggregate, at least 10% of the Common Shares
outstanding or issuable upon the exercise or conversion of any outstanding
options to acquire Common Share, any such Securityholder receives from a Third
Party or Parties an Offer to acquire the Offered Shares, thus becoming a
Prospective Seller in accordance with the definition of Section 4.4, and such
Prospective Seller intends to pursue a sale of such Shares to such Third Party
or Parties, the Prospective Seller shall send the Offer Notice to each of the
Other Securityholders not later than the 20th   Business Day prior to the
consummation of the sale or other disposition contemplated by the Offer. The
Offer Notice shall identify the Offered Shares, the price offered for such
Offered Shares, all other material terms and conditions of the Offer and, in the
case of an Offer in which the consideration payable for Shares consists in whole
or in part of consideration other than cash, such information relating to such
other consideration as the Company may reasonably determine. During the Notice
Period, each Other Securityholder shall have the right and option to notify the
Prospective Seller of such Other Securityholder's interest in selling or
otherwise disposing of up to its Pro Rata Portion of the Offered Shares pursuant
to the Offer. Each Other Securityholder desiring to exercise such option shall,
prior to the expiration of the Notice Period, provide the Prospective Seller
with a written notice specifying the number of Shares as to which such Other
Securityholder has an interest in selling or otherwise disposing of pursuant to
the Offer (for purposes of this Section 4.5, a "NOTICE OF INTEREST"), and shall
deliver to the Prospective Seller (A) the certificate or certificates (in the
case of certificated shares) evidencing the Shares to be sold or otherwise
disposed of pursuant to such Offer by such Other Securityholder duly endorsed in
blank or accompanied by written instruments of transfer in form satisfactory to
the Prospective Seller executed by such Other Securityholder, or an instruction
(in the case of uncertificated shares) to register the transfer of the Shares or
be sold or otherwise disposed of

                                       12

<PAGE>

pursuant to such Offer by such Other Securityholders in a form satisfactory to
the Prospective Seller executed by such Other Securityholder, (B) an instrument
of assignment reasonably satisfactory to the Prospective Seller assigning, as of
the consummation of the sale or other disposition to the Third Party or Parties,
all such Other Securityholder's rights hereunder with respect to the Shares to
be sold or otherwise disposed of, and (C) a special irrevocable
power-of-attorney authorizing the Prospective Seller to sell or otherwise
dispose of such Shares pursuant to the terms of the Offer and to take all such
actions as shall be necessary or appropriate in order to consummate such sale or
other disposition. Delivery of such certificate or certificates evidencing the
Shares to be sold (or such instruction), the instrument of assignment and the
special irrevocable power-of-attorney authorizing the Prospective Seller to sell
or otherwise dispose of such Shares shall constitute an irrevocable election by
such Other Securityholder to authorize and permit the Prospective Seller to sell
such Shares pursuant to the Offer.

            (c)    Promptly after the consummation of the sale or other
disposition of the Shares of the Prospective Seller and the Other
Securityholders to the Third Party or Parties pursuant to the Offer, the
Prospective Seller shall remit to each of the Other Securityholders the total
sales price of the Shares of such Other Securityholders sold or otherwise
disposed of pursuant thereto.

            (d)    If at the end of the Notice Period, any Other Securityholder
shall not have given a Notice of Interest (and delivered all other required
documents) with respect to some or all of its Pro Rata Portion of the Offered
Shares,


 
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