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EXHIBIT 10.26
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Text Omitted and Filed Separately with the
Securities and Exchange Commission. Confidential Treatment
Requested
under 17 C.F.R. Sections 200.80(b)(4) and 240.246-2.
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LICENSE AND RESEARCH
AGREEMENT
T HIS L ICENSE AND R
ESEARCH A GREEMENT (the "Agreement" ) is entered into as of
December 31, 2006 (the "Effective Date" ) by and
between S YNGENTA P ARTICIPATIONS AG , a corporation organized under the laws of
Switzerland ( "Syngenta" ), and D IVERSA C ORPORATION , a Delaware
corporation ( "Diversa" ). In this Agreement, Syngenta and
Diversa are each referred to individually as a "Party" and
collectively as the "Parties."
R ECITALS
W HEREAS , Diversa and
Syngenta entered into the Amended and Restated Research
Collaboration Agreement, dated as of January 3, 2003, as
amended (the "Research Collaboration Agreement"
);
W HEREAS , Diversa
and Syngenta wish to redefine the scope and terms of the licenses,
research projects and other rights provided in the Research
Collaboration Agreement as set forth in this Agreement;
and
W HEREAS , Diversa
and Syngenta desire to enter into this Agreement to supersede and
replace in its entirety the Research Collaboration Agreement and to
provide for research and development on research projects in the
Biofuel Field and the Animal Feed Field which would be good
candidates for both Transgenic Expression and production by
Fermentation as to which in general, Syngenta would have exclusive
rights in the Syngenta Exclusive Field with respect to Transgenic
Expression and Diversa would have rights for Fermentation
production (as such terms are defined in this
Agreement).
A GREEMENT
N OW , T HEREFORE , in consideration of the
foregoing premises and the mutual covenants herein contained, and
for other good and valuable consideration, the Parties hereby agree
as follows:
1. D EFINITIONS
Unless specifically set forth to the contrary herein, the
following terms, whether used in the singular or plural, shall have
the respective meanings set forth below.
1.1 "Affiliate" means any corporation, firm, limited
liability company, partnership or other entity that directly or
indirectly controls or is controlled by or is under common control
with a Party to this Agreement. As used in this definition, control
means ownership, directly or through one or more Affiliates, of
more than fifty percent (50%) of the shares of stock entitled
to vote for the election of directors, in the case of a
corporation, or more than fifty percent (50%) of the equity
interests in the case of any other type of legal entity, status as
a general partner in any partnership, or any other arrangement
whereby a Party has the right to designate a majority of the Board
of Directors or equivalent governing body of a corporation or other
entity or otherwise has the right to control management of such
corporation or other entity, or if such level of ownership or
control is prohibited in any country, any entity owning or
controlling at the maximum control or ownership right permitted in
the country where such entity exists.
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1.2 "Animal Feed Field" means the use
of Biomolecules in feed applications to alter, modify or improve
feed conversion and/or animal nutrition, which Biomolecules may be
produced or expressed through any means including without
limitation through Fermentation or Transgenic Expression, but
excluding all vaccines and therapeutic applications.
1.3 "Biofuel Field" means the hydrolytic conversion of
Biomass to fermentable sugars and/or other chemicals for use in
fuel production. For the avoidance of doubt, the "Biofuel Field"
shall not include the pre-treatment of Biomass to make it suitable
for hydrolysis or the development and use of organisms designed to
ferment the products of hydrolysis to fuels and/or other
chemicals.
1.4 "Biomass" means material that originates from Plants
which can be or is intended to be used as a feedstock in the
research, development and/or production of biofuels and
bioproducts, including without limitation bioethanol, biodiesel,
other fuels for energy applications and chemicals for any purpose,
including without limitation agricultural, food and non-food crops
and their residues and wastes (e.g. normally non-food material from
crops such as stalks, leaves, husks, seed fiber, hulls), forestry
residues and wastes (e.g. wood chips, sawdust, cardboard,
pressboard, dead trees, tree branches), municipal solid waste (e.g.
household garbage and paper products), food processing and other
industrial wastes, energy crops (e.g. fast growing trees and
grasses grown for this purpose), including, but not limited to,
corn stover, switchgrass, and sugar cane bagasse, as well as trees;
Biomass is often significantly composed of cellulose, hemi
cellulose and lignin structures and may also include oil crops and
starch components of crops.
1.5 "Biomolecule" means any Gene, RNA, and protein or
chemical entity the synthesis of which is directed by such Gene or
Gene pathway, which protein or chemical entity was produced by an
organism.
1.6 "Change in Control" means any of the following
transactions: (a) a merger, reorganization, restructuring, or
consolidation of Diversa which results in the holders of the voting
securities of Diversa outstanding immediately prior thereto ceasing
to hold at least fifty percent (50%) of the combined voting
power of the surviving entity or its parent immediately after such
merger, reorganization, or consolidation; (b) the sale or
transfer which is effectively a sale of all or substantially all of
the assets of Diversa; or (c) any one (1) person (other
than Diversa, any trustee or other fiduciary holding securities
under an employee benefit plan of Diversa, or any corporation owned
directly or indirectly by the stockholders of Diversa, in
substantially the same proportion as their ownership of stock of
Diversa), together with any such person’s "affiliates" or
"associates", as such terms are used in the Securities Exchange Act
of 1934, as amended, becoming the beneficial owner of fifty percent
(50%) or more of the combined voting power of the outstanding
securities of Diversa or by contract or otherwise having the right
to control the Board of Directors or equivalent governing body of
Diversa or the ability to cause the direction of management of
Diversa.
1.7 "Claim" shall have the meaning provided in
Section 11.1.
1.8 "Confidential Information" shall have the meaning
provided in Section 10.1.
1.9 "Control," "Controls," or "Controlled" means
possession of the ability to grant the licenses or sublicenses as
provided for herein (other than by virtue of any license granted
pursuant to this Agreement or the License Agreement) without
violating the terms of any agreement or other arrangement with any
Third Party.
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1.10 "Crop" means any cultivated
Plant.
1.11 " […***…] " shall have the
meaning provided in Section 6.7(ii).
1.12 "Disclosing Party" means the Party providing the
Materials or otherwise disclosing the Confidential Information to
the other Party pursuant to Section 3.12 and/or 10 (as
applicable).
1.13 "Diversa Indemnitee" shall have the meaning provided
in Section 11.1.
1.14 "Diversa Materials" means all Materials Controlled
by Diversa or any of its Affiliates which Diversa or any of its
Affiliates makes available for use in the Research Program or made
available for use in the research program conducted under the
Research Collaboration Agreement.
1.15 "Diversa Platform Technology" shall have the meaning
provided in Section 8.1.
1.16 "Diversa Product" means any product sold or
licensed, or being developed for sale or license, by Diversa or its
Affiliates or Sublicensees as contemplated by this Agreement.
1.17 "Diversa Program Technology" means Research Results
and Program Materials generated in or derived from any Diversa
Project, and Patent Rights and Know-How claiming, disclosing or
covering such Research Results or Program Materials, but excluding
either Party’s proprietary technology and improvements and
intellectual property rights therein which are retained by such
Party under Section 8.1.
1.18 "Diversa Projects" means any project which Diversa
undertakes (alone or with any Affiliate or Third Party) in the
Biofuel Field and/or the Animal Feed Field, in each case involving
Biomolecules produced through Fermentation and undertaken, or
initially undertaken, as set forth in Section 3.
1.19 " […***…] " shall have the
meaning set forth in Section 5.4.
1.20 "Existing Biomolecules" means all Biomolecules
discovered or identified under the research program conducted under
the Research Collaboration Agreement prior to the Effective
Date.
1.21 "Existing Project" means the existing starch
conversion research project under the Research Collaboration
Agreement as of the Effective Date, which is described further in
Exhibit A . The Existing Project excludes any Other Existing
Research.
1.22 "Fermentation" means a microbial fermentation
process, including, without limitation, bacterial-, fungal- and
yeast-based fermentation.
1.23 " Former Syngenta Exclusive Field" means:
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(c) any Biomolecule for admixture to the product
of any physical or chemical processing of Crops or derivatives of
Crops provided that the product contains Plant material unique to
Plants;
(d) any Biomolecule for any industrial application involving
Crops or the close derivatives of Crops, but excluding inert or
minor ingredients from or derived from a Plant source which do not
materially add value to an end product of an industrial
manufacturing process;
(e) any Biomolecule useful for Syngenta’s actual or
potential customers in the agriculture, food and/or natural fibers
markets involving the use of Crops, or the use of close derivatives
of Crops (including all uses of corn, wheat, barley, rice, cotton
and soy, and other oil Crops and their close derivatives), but
excluding inert or minor ingredients from or derived from a Plant
source which do not materially add value to an end product of an
industrial manufacturing process;
(f) any Biomolecule with commercial value, alone or in
combination with other Biomolecules, for use in the Animal Feed
Field;
(g) any Project included in the Other Existing Research and/or
the Existing Project.
1.24 "FTE" means a full time scientist who is an employee
or consultant of Diversa (or in the case of less than a full-time
dedicated scientist, a full-time, equivalent scientist year),
dedicated to research under the Research Program consisting of an
average of […***…] person-hours per year and who is
educated to Ph.D., MS or BS/BA level (or otherwise appropriately
trained) in an appropriate discipline.
1.25 "FTE Funding" shall have the meaning provided in
Section 3.8(c).
1.26 "FTE Requirements" shall have the meaning provided
in Section 3.8(c)(i).
1.27 "GAAP" means generally accepted accounting
principles, as applied in the United States.
1.28 "Gene" means a polynucleotide sequence which can be
transcribed into RNA and generally encodes a protein, optionally
together with its regulatory sequences.
1.29 " […***…] " shall have the
meaning provided in Section 6.7(ii).
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1.30 " […***…] " shall
have the meaning provided in Section 6.7(iv).
1.31 "Indemnitee" shall have the meaning provided in
Section 11.3.
1.32 "Indemnitor" shall have the meaning provided in
Section 11.3.
1.33 "Infringement" shall have the meaning provided in
Section 8.7(a).
1.34 "Inventions" shall have the meaning provided in
Section 8.2(a).
1.35 "JBP Program Technology" has the meaning set forth
in Section 8.2(b).
1.36 "Joint Bagasse Project" shall have the meaning
provided in Section 3.1(d).
1.37 "Know-How" means all proprietary ideas, inventions,
data, instructions, processes, trade secrets, devices, methods,
formulae, Materials, protocols and marketing and other information,
including improvements thereon, whether or not patentable,
including, without limitation, biological, chemical, toxicological,
physical and analytical, safety, manufacturing and quality control
data and information, which are (a) not publicly available and
not covered by Patent Rights, but which (i) are necessary or
useful for the commercial exploitation of the Patent Rights or the
conduct of the Projects or (ii) otherwise relate to
Biomolecules or Products, and (b) Controlled by a Party or its
Affiliate as of the Effective Date (including those based on or
derived from information or inventions generated in the course of
the research program conducted under the Research Collaboration
Agreement) or after the Effective Date if based on or derived from
information or inventions generated in the course of the Research
Program.
1.38 " […***…] Project" shall have the
meaning set forth in Section 8.2(f).
1.39 "License Agreement" means that certain Intellectual
Property Rights License Agreement, dated as of January 3,
2003, between Diversa and Syngenta, as may be amended in accordance
with its terms.
1.40 "Materials" means any chemical or biological substances,
including, without limitation, any: (i) organic or inorganic
chemical element or compound; (ii) Gene or genetic material,
including any genetic control element (e.g., promoters);
(iii) Biomolecule; (iv) vector or construct, plasmid,
phage or virus; (v) host organism, including bacteria and
Plant cells; (vi) eukaryotic or prokaryotic cell line or
expression system; (vii) protein, including any peptide or
amino acid sequence, enzyme, antibody or protein conferring
targeting properties and any fragment of a protein or peptide or
enzyme; or (viii) assay or reagent.
1.41 "Milestones" shall have the meaning provided in
Section 6.1(c).
1.42 "Mixed Delivery Product" means a Syngenta Product
which for technical or commercial reasons requires a combination of
at least one Biomolecule produced through Transgenic Expression and
at least one Biomolecule produced through Fermentation.
1.43 "Net Revenue" means Revenue, less the following
amounts with respect to the applicable Product, to the extent not
previously deducted: trade and quantity discounts and returns and
[…***…] actually granted to purchasers or licensees,
and less taxes withheld (excluding income tax), customs and freight
charges, and calculated using the applicable Party’s standard
accounting procedures in accordance with GAAP, as consistently
applied by such Party.
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1.44 "New Syngenta Project" means
(i) each project designed for application in the Syngenta
Exclusive Field and requested by Syngenta pursuant to
Section 3.1(b) and/or (ii) each project requested by
Syngenta pursuant to Section 3.3, in each case that is
undertaken, or initially undertaken, in the Research Program
(which, for the avoidance of doubt, in the case of clauses
(i) and (ii), excludes the Diversa Projects, the Joint Bagasse
Project, the Existing Project and the Other Existing
Research).
1.45 "Other Existing Research" means the research
projects and research and development activities under the research
program conducted under the Research Collaboration Agreement
existing as of the Effective Date, relating to the
[…***…] Project and the […***…] project,
each of which is described further in Exhibit B.
1.46 "Overlapping Biomolecules" shall have the meaning
provided in Section 6.1(d).
1.47 " […***…] " shall have the
meaning set forth in Section 6.7(v).
1.48 "Patent Activities" shall have the meaning set forth
in Section 8.6(a).
1.49 "Patent Rights" means any United States or foreign
patent or patent application, and any division, continuation,
continuation-in-part, reissue, reexamination, extension or other
governmental action that extends the subject matter of such patent
or patent application, substitution, confirmation, registration or
revalidation of the foregoing, in each case, that claims a
Biomolecule or a Product or a method or process for the manufacture
or use thereof and that is Controlled by Syngenta or Diversa or
their respective Affiliates, or jointly by Syngenta and Diversa as
of the Effective Date (including those inventions made in the
course of the research program conducted under the Research
Collaboration Agreement) or after the Effective Date for inventions
made in the course of the Research Program.
1.50 "Plant" means a monocotyledonous or dicotyledonous
plant, or an angiosperm, a gymnosperm or a pteridophyte.
1.51 "Plant Gene" means a Gene which is native to a
Plant.
1.52 "Previously Paid Milestone" shall have the meaning
set forth in Section 6.1(d).
1.53 "Product" means a Diversa Product or a Syngenta
Product, as applicable.
1.54 "Program Materials" means all Materials which are
developed or made, or the utility of which is determined or
discovered, pursuant to the Research Program or the research
program conducted under the Research Collaboration Agreement,
excluding Diversa Materials and Syngenta Materials.
1.55 "Program Technology" means all Diversa Program
Technology, JBP Program Technology and Syngenta Program
Technology.
1.56 "Project" or "Projects" means the Syngenta
Projects, the Diversa Projects and the Joint Bagasse Project.
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1.57 "Project Plans" shall have the
meaning set forth in Section 3.5(b)(i).
1.58 " […***…] " shall have the
meaning set forth in Section 6.7.
1.59 "Receiving Party" means the Party to whom the
Disclosing Party provides the Materials or otherwise discloses the
Confidential Information pursuant to Section 3.12 and/or 10
(as applicable).
1.60 "Research" means research and development activities
conducted pursuant to the Research Program.
1.61 "Research Collaboration Agreement" shall have the
meaning provided in the Recitals above.
1.62 "Research Committee" shall have the meaning set
forth in Section 4.2.
1.63 "Research Program" means the research and
development program to be conducted pursuant to Section 3. For
the avoidance of doubt "research program conducted under the
Research Collaboration Agreement" means the research and
development activities under the Research Collaboration Agreement
and the research and development activities under the Zymetrics
Agreements.
1.64 "Research Results" means all data and results
arising out of the Research Program and/or which arose out of the
research program conducted under the Research Collaboration
Agreement.
1.65 "Research Term" shall have the meaning set forth in
Section 12.1.
1.66 "Responsible Party" shall have the meaning set forth
in Section 8.6(c).
1.67 "Revenue" means all gross sales invoiced, or other
consideration or value and payments received, by a Party and its
Affiliates, in each case, for the use or sale of any Syngenta
Product or Diversa Product as the case may be, including, without
limitation, […***…] Syngenta Products or Diversa
Products, as applicable. Revenue shall be calculated using the
Party’s standard accounting procedures in accordance with
GAAP, as consistently applied by the Party. All sales or licenses
of Products between a Party and any of its Affiliates shall be
[…***…]; provided that if such […***…] the
following shall apply: If the Affiliate […***…], and
[…***…], then the gross sales invoiced, or other
consideration or value and payments received, […***…]
shall be used to determine Revenue, and all […***…]. If
the Affiliate […***…], and […***…], then
[…***…] which shall be used as the […***…],
and the […***…]; provided that if the
[…***…], then the […***…] and all
[…***…]. The calculation of Revenue shall be subject to
the provisions of Sections 6.4 and 6.5.
1.68 "Sublicensee" means (i) with respect to
Syngenta, a Third Party which receives from Syngenta or its
Affiliate a license or sublicense, and (ii) with respect to
Diversa, a Third Party which receives from Diversa or its Affiliate
a license or sublicense.
1.69 "Subsequent Biomolecules" shall have the meaning
provided in Section 5.4.
1.70 "Syngenta Exclusive Field" means the use of
Biomolecules produced through Transgenic Expression in the Biofuel
Field and/or the Animal Feed Field. For the avoidance of
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doubt, the Syngenta Exclusive Field does not
include the use of Biomolecules produced through Fermentation in
the Biofuel Field and/or the Animal Feed Field or the use of
Biomolecules produced through any method, including Transgenic
Expression and Fermentation, in any field outside the Biofuel Field
and the Animal Feed Field.
1.71 "Syngenta Indemnitee" shall have the meaning
provided in Section 11.2.
1.72 "Syngenta Materials" means all Materials Controlled
by Syngenta or its Affiliates which Syngenta or any of its
Affiliates provides to Diversa for use in the Research Program or
provided to Diversa for use in the research program conducted under
the Research Collaboration Agreement; for clarification, Syngenta
Materials shall exclude all Materials, if any, included in the
Purchased Assets under the Transaction Agreement.
1.73 "Syngenta Product" means any product sold or
licensed, or being developed for sale or license, by Syngenta or
its Affiliates or Sublicensees, which consists of, incorporates, or
is made through the use of a Biomolecule that is discovered,
identified or developed, or the utility of which is discovered or
identified, in the course of the Research Program or the research
program conducted under the Research Collaboration Agreement or
using Program Technology. Syngenta Products do not include any
product that is discovered, identified or developed, or the utility
of which is discovered or identified, using Syngenta Proprietary
Technology outside the course of the Research Program and the
research program conducted under the Research Collaboration
Agreement, without the use of any Program Technology. A Syngenta
Product may be a Transgenic Product and/or a Mixed Delivery
Product.
1.74 "Syngenta Program Technology" means Research Results
and Program Materials generated in or derived from any Syngenta
Project and/or the research program conducted under the Research
Collaboration Agreement (including, without limitation,
(a) the animal feed projects […***…], and
(b) the project for conversion of sugar cane Biomass so that
any Research Results and Program Materials generated in or derived
from such project in this clause (b) are included in this
definition and not in JBP Program Technology), and Patent Rights
and Know-How claiming, disclosing or covering such Research Results
or Program Materials, but excluding either Party’s
proprietary technology and improvements and intellectual property
rights therein which are retained by such Party under
Section 8.1.
1.75 "Syngenta Projects" means (a) the Existing
Project, (b) the Other Existing Research, and/or (c) any
New Syngenta Project.
1.76 "Syngenta Proprietary Technology" means all
technology Controlled by Syngenta or its Affiliates immediately
after the effective date of the Research Collaboration Agreement,
or thereafter independently of the research program conducted under
the Research Collaboration Agreement and the Research Program, and
which Syngenta uses or makes available for the conduct of the
Research Program or the design, development, testing, use,
manufacture or sale of Syngenta Products, including all such United
States and foreign patents and patent applications (including,
without limitation, all reissues, extensions, substitutions,
confirmations, registrations, revalidations, additions,
continuations, continuations-in-part, and divisions thereof) and
other proprietary information, data and know-how. Syngenta
Proprietary Technology excludes all TMRI Intellectual Property
Rights (as defined in the License Agreement) which are licensed to
Diversa by Syngenta under the License Agreement, including without
limitation the TMRI Platform Technology licensed thereunder, and
the TMRI Platform Technology Improvements.
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1.77 "Third Party" means any party
other than Syngenta, Diversa or an Affiliate of either of
them.
1.78 "TMRI Platform Technology" means all tools,
technologies and methods relating to proteomics, metabolomics, RNA
dynamics and bioinformatics and methods to analyze and link these
components of genomics, which are both (i) not publicly
available and are proprietary to or Controlled by Syngenta or its
Affiliates immediately prior to the closing of the transactions
under the Transaction Agreement, and (ii) claimed or disclosed
within the patent applications and patents listed on an exhibit to
the License Agreement or are within the scope of the material trade
secrets related thereto, a written description of such material
trade secrets having been previously provided by Syngenta to
Diversa prior to signing of the Transaction Agreement.
1.79 "TMRI Platform Technology Improvement" means any
enhancement or improvement to the TMRI Platform Technology, whether
or not patentable, made, conceived or reduced to practice solely by
any employee or consultant of Syngenta, solely by any employee or
consultant of Diversa or jointly by any employee or consultant of
Syngenta and any employee or consultant of Diversa at any time
after the effective date of the Research Collaboration Agreement,
and all Patent Rights and Know-How that claim, disclose or cover
such enhancement or improvement.
1.80 "Transaction Agreement" means that certain
Transaction Agreement, dated January 3, 2003, among Torrey
Mesa Research Institute, Diversa and Syngenta, as may be amended in
accordance with its terms.
1.81 "Transgenic Biomass Conversion" shall have the
meaning provided in Section 5.1(a).
1.82 "Transgenic Expression" means expression or
production of Biomolecules in Plants or using Plant Genes.
1.83 "Transgenic Product" means a Syngenta Product
produced through Transgenic Expression.
1.84 "2004 RCA Amendment" shall have the meaning provided
in Section 6.7.
1.85 "Year" means any calendar year.
1.86 "Zymetrics Agreements" means the Joint Venture
Agreement dated and effective as of December 1, 1999 between
Diversa and Syngenta Crop Protection AG (as successor to Novartis
Seeds AG) and the Research and Development Agreement dated and
effective as of December 1, 1999 between Diversa and
Zymetrics, Inc.
2. P URPOSE
2.1 Replacement of Research Collaboration Agreement. The Parties
hereby agree that this Agreement shall replace and supersede the
Research Collaboration Agreement in its entirety as of the
Effective Date, as provided in Section 14.10.
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2.2 Satisfaction of Obligations under Research
Collaboration Agreement. Diversa acknowledges that Syngenta
has satisfied all of its payment obligations to Diversa under the
Research Collaboration Agreement, and Syngenta acknowledges that
Diversa has satisfied all of its obligations to provide research
and development services (including FTEs and management of Third
Party regulatory and development contracts) for which it received
payments from Syngenta under the Research Collaboration Agreement.
The Parties agree that […***…] of the
[…***…] is made in recognition of […***…]
under the Research Collaboration Agreement. For avoidance of doubt,
no additional milestones are payable for any work done under the
Research Collaboration Agreement; provided, however, that Diversa
is eligible under this Agreement to receive the milestones for the
[…***…] project as provided in the Project Plan for
such project. The Parties agree to provide for the assignment to
and assumption by Syngenta of […***…] entered into by
Diversa in accordance with the 2004 RCA Amendment (as defined in
Section 6.7).
3. R ESEARCH P ROGRAM
3.1 Overview of Research Program.
(a) Collaborative Efforts on Research Program. Diversa
and Syngenta have unique and complementary areas of expertise which
they believe will help them confront the significant technical
challenges in the Biofuel Field and the Animal Feed Field. The
Parties agree to collaborate and cooperate with respect to their
respective research and development programs in the Biofuel Field
and the Animal Feed Field during the Research Term, with the goal
of identifying new Biomolecules which, with then current
technology, are likely to be good candidates for both Transgenic
Expression and Fermentation production. The aim of such
collaboration and cooperation is to develop Syngenta Products
utilizing Transgenic Expression (including Mixed Delivery
Products), and Diversa Products produced by Fermentation, based on
common Biomolecule(s).
(b) Syngenta Projects. During the Research Term, Diversa
agrees, at Syngenta’s request and expense as set forth
herein, to undertake Syngenta Projects for Syngenta, which will be
subject to the exclusivity obligations of Section 5. The Other
Existing Research is expected to be completed by
[…***…]. Such Syngenta Projects requested pursuant to
this Section 3.1(b) shall be under the direction of Syngenta,
and shall be paid for by FTE Funding to Diversa by Syngenta, as
provided for in Section 3.8.
(c) Diversa Projects. Diversa will have sole
responsibility, in its sole discretion, for Diversa Projects, which
it may conduct alone or together with any Third Party, subject to
Syngenta’s rights to use Biomolecules discovered in such
Diversa Projects as provided in this Agreement. Syngenta shall have
no obligation to pay for the conduct of the Diversa Projects.
Diversa confirms to Syngenta that, as of the Effective Date,
Diversa’s primary business strategy is to focus on
alternative fuels and expects to devote a significant portion of
its resources to pursue this strategy. Diversa will cooperate and
consult in good faith with Syngenta with respect to decisions
regarding the choice and direction of Diversa Projects; provided,
however, that Diversa Projects conducted with any Third Party are
addressed separately in Section 3.5(a).
(d) Joint Bagasse Project. The Parties recognize and
agree that sugar cane Bagasse is an excellent candidate for the
Biofuel Field and the Parties would like to focus their initial
efforts under the Research Program on further collaborative
activities in this area. The
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Parties have conducted the existing research
program for conversion of sugar cane Biomass under the Research
Collaboration Agreement and agree from and after the Effective Date
to conduct the project for conversion of sugar cane Biomass in the
Biofuel Field, utilizing Transgenic Expression and Fermentation,
under the Research Program through a joint project in this area as
described in detail in Section 3.2 (the "Joint Bagasse
Project" ). In addition, the Parties agree to screen
Biomolecules identified or developed pursuant to the Joint Bagasse
Project for activity on other Biomass substrates as agreed by the
Parties.
(e) Discussion of Other Projects. The Parties may, in
their discretion, discuss working together on research and
development projects regarding Biomolecules produced through
Transgenic Expression for use outside the Biofuel Field and the
Animal Feed Field in related applications that Syngenta may wish to
pursue, subject to mutually acceptable terms.
3.2 Joint Bagasse Project.
(a) The Parties will conduct the Joint Bagasse Project for a
period of two years following the Effective Date. At the end of
such period, unless extended by written agreement of the Parties,
(i) Syngenta may independently proceed with research,
development and commercialization activities as though the Joint
Bagasse Project had been a Syngenta Project during such period, and
(ii) Diversa may independently proceed with research,
development and commercialization activities as though the Joint
Bagasse Project had been a Diversa Project during such period, in
each case, subject to the terms and conditions of this
Agreement.
(b) The Parties intend to conduct the Joint Bagasse
Project in a collaborative manner, seeking Biomolecule candidates
suitable for production through both Fermentation and Transgenic
Expression in the Biofuel Field with a goal of joint
decision-making. During the two-year period following the Effective
Date, the Joint Bagasse Project will be subject to management and
decision-making under Section 4 as if it were a Syngenta
Project. If the Joint Bagasse Project is extended by mutual written
agreement beyond such two-year period, the Joint Bagasse Project
will be subject to management and decision-making under
Section 4; provided that, with regard to any dispute that the
Management Steering Committee is unable to resolve after thirty
(30) days pursuant to Section 4.4, such dispute shall be
decided by Diversa in its discretion provided that such decision
does not conflict with or result in an amendment or modification to
this Agreement.
(c) A summary description of the Joint Bagasse Project as
of the Effective Date is set forth in Exhibit C. Promptly following
the Effective Date (with a goal of 90 days after the Effective
Date), the Parties will collaboratively prepare a Project Plan for
the Joint Bagasse Project, including the applicable milestones, as
such Project Plan may be modified from time to time by written
agreement of the Parties. During the two-year period following the
Effective Date, the Parties will conduct the Joint Bagasse Project
under such Project Plan in accordance with the principles of
Section 3.5 as if references therein to Diversa applied to
both Parties, to the extent applicable, and as if the Joint Bagasse
Project were a Syngenta Project.
(d) During the two-year period following the Effective
Date, each of Syngenta and Diversa agree to provide resources for
the Joint Bagasse Project as follows: (i) Syngenta agrees to
pay Diversa […***…] for funding of FTEs at
[…***…] per FTE (approximately […***…]
FTEs) in 2007 and […***…] for funding of FTEs at
[…***…] per FTE
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(approximately […***…] FTEs) in 2008
for the Joint Bagasse Project, payable each year in equal quarterly
installments in advance; and (ii) Diversa agrees to commit
[…***…] additional FTEs in each of 2007 and 2008, at
its expense, to work on the Joint Bagasse Project.
3.3 Certain Projects Involving Biomolecules Produced by
Fermentation.
(a) During the Research Term, Diversa agrees to
undertake, where requested by Syngenta and subject to
Section 3.8, Syngenta Projects in the Biofuel Field and/or the
Animal Feed Field using Fermentation and, during the period
provided in Section 3.2, the Joint Bagasse Project, on a
non-exclusive basis with respect to Syngenta, where the applicable
Project Plan includes proof of concept, development and/or
commercialization of Biomolecules intended for use in (i) a
Transgenic Product, or (ii) a Mixed Delivery Product. The
Project Plan for each such Syngenta Project and for the Joint
Bagasse Project will identify the Mixed Delivery Product and, to
the extent practicable, the Biomolecule(s) produced using
Fermentation that are intended to be included in such Mixed
Delivery Product (or the characteristics of such Biomolecule(s) if
identification of specific Biomolecule(s) is not practicable).
(b) At Syngenta’s request and expense, Diversa will
supply Syngenta, at Diversa’s cost, with sufficient
quantities of such Biomolecule(s) and/or related Product produced
by Fermentation to carry out such research, development, and
precommercialization activities. If Syngenta commercializes the
Mixed Delivery Product described in (ii) above, then with
respect to the Biomolecule(s) within the Mixed Delivery Product
(described in (ii)) produced by Fermentation, at Syngenta’s
request, Diversa agrees to supply such Biomolecules(s) and/or
related Product to Syngenta on reasonable commercial terms to be
negotiated in good faith by the Parties.
(c) If Syngenta requests that Diversa do so, Diversa will
provide Syngenta with its estimated cost for supply of
Biomolecule(s) under Section 3.3(b) in the quantities
requested by Syngenta (including in such estimate the cost for raw
materials, fermentation, scale up and recovery and formulation
activities, packaging and delivery). Diversa’s estimate of
cost as of the Effective Date is […***…] per gram
depending on purity; […***…] per kilogram of purified
Biomolecule for more than one kilogram; […***…] for 10
kilograms of purified Biomolecule; and […***…] for 50
kilograms of purified Biomolecule. If Diversa supplies
Biomolecule(s) to Syngenta under Section 3.3(b), Syngenta
shall have the right to verify Diversa’s cost of goods in
accordance with Section 7 hereof. Syngenta has the right to
source the supply of such Biomolecule(s) and/or related Product
produced by Fermentation from a Third Party. At Syngenta’s
request, Diversa will assist Syngenta in obtaining the lowest cost
source for such Biomolecule(s) and/or related Product produced by
Fermentation and will make available such information as reasonably
necessary to enable Syngenta to obtain a quote from Third Parties.
If Syngenta elects to use a Third Party supplier, Diversa will
provide the following information with regard to the manufacturing
process used by Diversa with regard to such Biomolecule:
(i) for manufacturing processes and/or strains that are not
described in clause (ii), Diversa will provide to the Third Party
supplier, subject to entering into an agreement with such Third
Party Supplier (on commercially reasonable terms consistent with
agreements of that type), all information regarding the process and
protocols necessary for the Third Party supplier to manufacture and
recover the Biomolecule, as well as the gene for the Biomolecule in
an appropriate vector and any safety and regulatory data regarding
manufacture of such Biomolecule; and (ii) for manufacturing
processes and/or strains that are proprietary Third Party processes
that Diversa may not provide to others, Diversa will provide
Syngenta with contact information for the Third Party that owns
such process and/or strain.
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3.4 Rights of Parties to Conduct Own Efforts
and With Third Parties. Subject to Sections 3 and 5 of this
Agreement, Diversa is free to conduct research, development and
commercialization activities, using Fermentation production only,
in the Biofuel Field and/or the Animal Feed Field, alone or with
Third Parties. In addition, Diversa is free to conduct research,
development and commercialization activities outside the Syngenta
Exclusive Field and outside of Transgenic Biomass Conversion, alone
or with Third Parties. Syngenta is free to conduct research,
development and commercialization activities, using Fermentation
and/or Transgenic Expression or any other means of production, in
the Biofuel Field and/or the Animal Feed Field or in any other
field, alone or with Third Parties.
3.5 Conduct of Research Program.
(a) Overall Conduct. During the Research Term, Diversa
will diligently conduct research and development activities on
Syngenta Projects and, during the period specified in
Section 3.2, on the Joint Bagasse Project pursuant to the
applicable Project Plans and shall use commercially reasonable
efforts to meet the time schedules contemplated in the applicable
Project Plan. Diversa shall conduct the Research Program in a
professional manner. Except as otherwise set forth in this
Section 3.5, Diversa will provide full transparency and
disclosure to Syngenta on a current basis with respect to the
activities in the Research Program and Diversa’s research,
development and commercialization activities which have potential
application in the Biofuel Field and/or the Animal Field, which
shall include without limitation:
(i) frequent communication between Diversa scientists and
Syngenta scientists, including regular site visits;
(ii) Diversa providing Syngenta with access to Diversa’s
books and records pertaining to the Research Program and/or the
research program conducted under the Research Collaboration
Agreement;
(iii) Diversa advising Syngenta regularly of up to date progress
and results;
(iv) Diversa promptly providing Syngenta with reasonable
quantities of the Biomolecules discovered, identified or developed
under the Research Program and under the research program conducted
under the Research Collaboration Agreement and other Materials
Syngenta may reasonably request to enable Syngenta to effectively
and promptly pursue its research and product development activities
as contemplated by this Agreement, subject to Syngenta paying the
reasonable costs of quantities of such Biomolecules provided by
Diversa; provided that, for Syngenta Projects and the Joint Bagasse
Project, a reasonable research quantity of such Biomolecules and
Materials is intended to be covered by the FTE Funding, and with
regard to additional quantities of such Biomolecules and Materials,
the Parties shall share the cost of such additional quantities on
the basis of Syngenta bearing […***…] of such costs and
Diversa bearing […***…] of such costs; and
(v) Diversa promptly providing Syngenta with such other
information as Syngenta may reasonably request to enable Syngenta
to effectively and promptly pursue its research and product
development activities as contemplated by this Agreement.
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With regard to Diversa Projects and other Diversa
research, development and commercialization activities conducted
with or for any Third Party, Diversa will provide information
described in this Section 3.5 to the extent that it is able to
do so under its agreement with such Third Party; provided that such
information shall include at least the following with respect to
Biomolecules that have potential application in the Biofuel Field
and/or the Animal Feed Field (and Diversa shall ensure that such
information is not subject to confidentiality obligations to such
Third Party that would prevent its disclosure to Syngenta):
(a) type of Biomolecule; and, (b) in each case in clause
(b), as available, (i) Biomolecule characterization and
sequence information for such Biomolecule, (ii) activities of
such Biomolecule at various pH and temperature levels, and
(iii) if known, the species name of the source organism and/or
the biodiversity sample the Biomolecule was derived from (e.g.,
acidic water sample from hot springs). With regard to Diversa
license agreements with Third Parties for the in-license of
pre-treatment or Fermentation technologies or processes, Diversa
will provide information described in this Section 3.5 to the
extent that it is able to do so under its agreement with such Third
Party.
Diversa agrees not to enter into any agreement with a Third
Party with respect to any Diversa Projects that are conducted with
or for a Third Party which would prevent or restrict
Diversa’s ability to comply with the foregoing
provisions.
In addition, the activities conducted in connection with the
Research Program will be overseen and administered by the
Management Steering Committee and the Research Committee as
provided in Sections 3 and 4. Notwithstanding anything herein
to the contrary, neither Party shall, without such Party’s
consent, be obligated to conduct Projects in the Research Program
outside the Syngenta Exclusive Field, other than the Existing
Project, the Other Existing Research and the Joint Bagasse Project
as set forth herein.
(b) Project Plans.
(i) Preparation of Project Plans. Diversa, in
consultation with Syngenta, shall be responsible for the
development of project plans for Diversa Projects (excluding all
Diversa Projects conducted with or for any Third Party), which
plans shall be furnished to Syngenta and will set forth detail
reasonably comparable to that specified for Syngenta’s
Project Plan. Syngenta, in consultation with Diversa, shall be
responsible for the development of project plans for Syngenta
Projects, which plan shall be furnished to Diversa and cover the
objectives (including a definition of Product or Product concept),
targets (including, if applicable, the target percentage of
conversion of the applicable Biomass (or pre-treated Biomass) to
the applicable fermentable sugar(s)), the estimated resources
including estimated FTEs, overall timetable, the Milestones
applicable to the Project (as defined in Section 6.1) and
other applicable criteria related to achievement of Milestones in
accordance with Section 6.1, and other matters as may be
determined by the Research Committee, as may be amended in
accordance with the terms of this Agreement (the "Syngenta Project
Plan", and together with the project plans for Diversa Projects
specified in the first sentence of this Section 3.5(b)(i),
collectively the "Project Plans").
(ii) Review and Modification of Project Plans. Each
Party’s scientific personnel will review each Party’s
Project Plans and confer on and discuss the progress and results of
the Syngenta Projects and the Diversa Projects (excluding all
Diversa Projects conducted with or for any Third Party) on an
ongoing basis in accordance with this Section 3.5. The
Research Committee will conduct a comprehensive review of the
Projects (excluding all
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Diversa Projects conducted with or for any Third
Party) and technical opportunities for Syngenta Projects in the
Biofuel Field and Animal Feed Field on a quarterly basis. Diversa
shall make all decisions to add, terminate, modify, reorder the
priority or substitute Diversa Projects and any research activities
included in the Diversa Projects, and the allocation of resources
with respect thereto, subject to the terms of this Agreement.
Syngenta shall make all decisions to add, terminate, modify,
reorder the priority or substitute Syngenta Projects and any
research activities included in the Syngenta Projects, and the
allocation of resources with respect thereto, subject to the terms
of this Agreement; provided that any New Syngenta Project or
modification to a Syngenta Project shall be within the scope of the
Syngenta Exclusive Field (except as provided under
Section 3.3) or, in the case of the Existing Project or the
Other Existing Research, in the Syngenta Exclusive Field or its
current applicable field, unless otherwise agreed by the Parties in
writing.
(iii) Provision of Information. At such time as a Project
is proposed to be conducted under the Research Program, each of the
Parties shall inform the other, to the extent it is able to do so
without breaching any confidentiality obligations, of any
information of which it is aware with respect to Third Party patent
applications or patents which may relate to the Project; provided
that neither Party shall have any obligation to provide the other
Party with any document or other information which would result in
a breach of the attorney/client privilege with respect thereto. If
Diversa is conducting or is to conduct a Syngenta Project, Diversa
will, to the extent it is able to do so without breaching any
confidentiality obligations, promptly inform Syngenta if it is then
conducting or at any time thereafter conducts any research,
development or commercialization activities with a Third Party
which would involve the same Crop as such Syngenta Project or any
resulting Syngenta Product involves.
3.6 Syngenta Activities. By February 15 each Year,
subject to confidentiality obligations to Third Parties, in order
to provide Diversa with the opportunity to assess the potential
financial impact for Diversa in such Year and in other subsequent
Years for which Diversa provides financial guidance to its
investors, Syngenta shall provide Diversa with written information
regarding Syngenta’s current plans for commercialization of
Syngenta Products that have not yet been commercialized, as well as
currently available sales projections or forecasts for Syngenta
Products on which royalties are payable to Diversa hereunder, that
have been commercialized, in each case as estimated by Syngenta in
good faith and such information to be provided taking into account
the proprietary and competitively sensitive nature of such
information; provided, however, that such information shall
constitute confidential information of Syngenta hereunder and
Syngenta shall incur no liability hereunder for
(i) Syngenta’s failure to, or delay in, for any reason
whatsoever, commercializing, or continuing to commercialize, any
such applicable Syngenta Products at all, or in accordance with
such plans, or (ii) actual sales, if any, of such applicable
Syngenta Products failing to meet or exceed such projections or
forecasts. Syngenta shall have no obligation to generate or to
create new information or documents for Diversa to comply with the
preceding sentence and may utilize its pre-existing information and
documents.
3.7 Syngenta Decisions. Syngenta shall have the sole
discretion whether or not to progress a Syngenta Project and/or to
develop and/or commercialize a Syngenta Product, including a Mixed
Delivery Product. If Syngenta decides to progress a Syngenta
Project and to develop and commercialize a Syngenta Product from
any Project, it shall have the sole discretion as to how it is
developed, manufactured and/or commercialized and on what terms,
subject to
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any applicable terms of this Agreement
(including, without limitation, the terms regarding the costs
associated with Biomolecules and/or related Products produced via
fermentation by Diversa that are associated with Mixed Delivery
Products).
3.8 Research Funding for Syngenta Projects.
(a) Determination of Funding. Syngenta is responsible for
FTE funding and expenses related thereto only as provided in
Section 3.2(d), 3.5(a)(iv) and 3.8 and Syngenta shall have no
other payment obligation to Diversa for FTE funding or any other
costs or expenses for research for Diversa Projects, Syngenta
Projects or the Joint Bagasse Project.
(b) Existing Project and Other Existing Research. In
addition to the payments contemplated under Section 6,
Syngenta agrees to pay Diversa for FTEs for Research for the
Existing Project and Other Existing Research as follows:
(i) […***…] FTEs at the rate of
[…***…], for a total of […***…], in 2007;
and (ii) […***…] FTEs at the rate of
[…***…], for a total of […***…], in 2008,
payable each year in equal quarterly installments in advance;
provided, however, that Syngenta may cause […***…] of
such FTEs for 2008 to be deployed on any New Syngenta Project(s)
(including, without limitation, an animal feed project
[…***…]).
(c) New Syngenta Projects. In addition to the payments
contemplated under Section 6, Syngenta agrees to pay Diversa
for FTEs for Research for New Syngenta Projects (the "FTE
Funding" ) as follows:
(i) For any Year of the Research Term, Syngenta shall
give Diversa written notice of its FTE requirements for Research
for such New Syngenta Projects (the "FTE Requirements" ) for
the six (6) month period from July 1 through
December 31 of a given Year by no later than January 1 of
that Year and for the six (6) month period from January 1
through June 30 of a given Year by no later than July 1
of the immediately preceding Year. For the first six
(6) months in which Syngenta notifies Diversa that it has FTE
Requirements, Syngenta’s FTE Requirements may not be more
than […***…] FTEs (equivalent to […***…]
people working full time for a six (6) month period) unless
the Parties agree in writing to a higher number. For each six
(6) month period thereafter, Syngenta’s FTE Requirements
may not be more than one-hundred and fifty percent (150%) (or
[…***…] FTEs, if greater) or less than fifty percent
(50%) of the FTE Requirements for the immediately preceding
six (6) month period, and in no event may Syngenta’s FTE
Requirements exceed […***…] FTEs for any six
(6) month period (equivalent to […***…] people
working full time for a six (6) month period), in each case
unless otherwise agreed to by the Parties in writing.
Notwithstanding the preceding sentence, if, for any six
(6) month period, the FTE Requirement is less than or equal to
[…***…] FTEs (equivalent to […***…] people
working full time for a six (6) month period), Syngenta may
reduce the FTE Requirements to […***…] for the next six
(6) month period, and if, for any six (6) month period,
the FTE Requirement is […***…], Syngenta may increase
the FTE Requirements to up to […***…] FTEs (equivalent
to […***…] people working full time for a six
(6) month period) for the next six (6) month period in
which has FTE Requirements. Diversa will provide the number of FTEs
specified in the written notice from Syngenta of Syngenta’s
FTE Requirements in accordance with this Section 3.8(c)(i) for
a given six (6) month period for such New Syngenta Projects
during such six (6) month period, which FTEs shall perform
research in any New Syngenta Project undertaken in the Research
Program as provided under this Agreement.
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(ii) The cost of the Research to be
funded by Syngenta for New Syngenta Projects in any such six
(6) month period during the Research Term shall be calculated
based on the number of FTEs allocated to the Research at the
following rates for the applicable Year subject to the last
sentence of this subsection:
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Notwithstanding the foregoing, if an FTE does not
have at least a BS or BA degree, then the Parties will mutually
agree on the appropriate FTE rate for such FTE.
(d) Payment of Funding. FTE Funding payments required to
be made by Syngenta to Diversa for a given six (6) month
period shall be made in equal installments in advance of each
quarter within such six (6) month period during the Research
Term (provided that the first and last installments during the
Research Term may be adjusted as appropriate for the FTE Funding
due). In the event the number of FTEs actually used on any New
Syngenta Projects subject to FTE Funding as provided herein for any
quarter is less than the number of FTEs expected to be used on such
New Syngenta Projects based on FTE Funding provided by Syngenta for
the applicable six (6) month period, the difference shall be
promptly refunded to Syngenta; provided that no such refund shall
be required if fewer than the expected number of FTEs is actually
used due to Syngenta’s termination of any New Syngenta
Project during the applicable six (6) month period (other than
upon termination of this Agreement by Syngenta under
Section 12).
3.9 Responsibility for Research Expenses. Except as
expressly set forth in Sections Section 3.2(d), 3.5(a)(iv) and
3.8, and except with respect to the […***…] Project,
for which Syngenta shall be solely responsible as to all expenses
incurred under such project (other than for Diversa FTEs for which
payment has been made by Syngenta at the applicable FTE rate as set
forth herein, which, together with the funding provided for the
applicable materials as set forth in the attached Project Plan for
the […***…] Project, includes the development and
delivery of […***…] , as set forth in the attached
Project Plan for the […***…] Project), Diversa shall be
responsible for the expense of the conduct of its obligations under
the Research Program (and the research program conducted under the
Research Collaboration Agreement), including without limitation the
expense of personnel, equipment, materials and supplies required to
carry out the Research Program, and expenses for the research
(except as provided in Section 3.8), development and
commercialization of Diversa Projects and Diversa Products and any
other products (except Syngenta Products as otherwise expressly
provided herein) sold or licensed, or developed for sale or
license, by Diversa or its Affiliates or Sublicensees which
incorporate or are made through use of Program Technology. Syngenta
shall be responsible for the expenses set forth in Section 3.8
required to carry out New Syngenta Projects under the Research
Program and all expenses related to development and
commercialization of Syngenta Products except as otherwise provided
in this Agreement with regard to Diversa’s obligations under
the Research Program. For the avoidance of doubt, where Syngenta is
responsible for FTE Funding for New Syngenta Projects, such FTE
Funding will be in full satisfaction of the expenses of Diversa
activities under the Research Program including the following (but
will not limit Syngenta’s obligations under
Section 6):
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(i) all reasonable quantities of
laboratory and office consumables;
(ii) equipment including without limitation clean
cabinets, constant environment cabinets, and incubators;
(iii) costs of contract services as needed such as
culture identification/storage, and protein sequencing (if not more
than 10% over Diversa’s capacity);
(iv) development of new methods as needed to support new
laboratory assays;
(v) media preparation, maintaining lab supplies,
reasonable gene synthesis and reasonable gene sequencing services
back up support and assistance, subject to Syngenta paying the
reasonable costs of gene synthesis and gene sequence services with
respect to Biomolecules other than those Biomolecules discovered in
the course of a Syngenta Project; and
(vi) expenses of Diversa’s staff such as scientific
meeting attendance and travel.
3.10 Responsibility for Third Party Payments. Except as
expressly set forth in this Agreement or in the License Agreement,
Diversa shall be responsible for all payments due to Third Parties
for the acquisition and maintenance of licenses to intellectual
property necessary for the practice of the TMRI Platform Technology
in the Research Program (and the research program conducted under
the Research Collaboration Agreement), the acquisition and
maintenance of licenses to intellectual property for commercially
available software, arrays, chips and other materials necessary for
its conduct of the Research Program (and the research program
conducted under the Research Collaboration Agreement), and any
other technology and Diversa Materials that it provides in the
Research Program (or provided in the research program conducted
under the Research Collaboration Agreement) or Diversa otherwise
incorporates into the Biomolecules, including Biomolecules
incorporated into the Syngenta Products, and the costs of
negotiating and preparing such licenses; provided, however, that,
except in the case of Biomolecules, Diversa shall not be
responsible for any of the foregoing payments or costs after the
Effective Date if Diversa does not use any such licenses or
technologies for the practice of Diversa’s proprietary
technology; provided further that all such expenses which Diversa
believes are for Syngenta’s account and not Diversa’s
expense must be approved by Syngenta in advance. For the avoidance
of doubt, if Diversa maintains a license with a Third Party in its
overall operations, no part of the cost of the license fee shall be
allocated to or payable by Syngenta; provided that if a unique or
custom array or chip is needed under such license and available
only for a separate fee, then the separate fee may be charged to
Syngenta if Syngenta has approved such expense in advance. Except
as expressly set forth in this Agreement, Syngenta shall be
responsible for all payments due to Third Parties for the
acquisition and maintenance of licenses to intellectual property
necessary for any technology and Syngenta Materials that it
provides in the Research Program (or provided in the research
program conducted under the Research Collaboration Agreement), and
the costs of negotiating and preparing such licenses.
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3.11 Records of FTEs. Diversa shall
keep records of all FTEs used in connection with Syngenta Projects
and the Joint Bagasse Project within the Research Program including
the number of FTEs who do not have at least a BS/BA degree, and
within […***…] during the Research Term shall provide
Syngenta with a report describing by Project for
[…***…] the number of FTEs utilized in Research for
such Syngenta Projects and the Joint Bagasse Project, the number of
such FTEs who do not have at least a BS/BA degree, the number of
hours each FTE worked, and the research activities conducted by
each FTE. Such records shall be kept reasonably accessible during
the applicable Research and for […***…] following the
end of the Research to which they pertain. Syngenta shall have the
right during such applicable period to have an independent
representative or agent of Syngenta, reasonably acceptable to
Diversa, which approval shall not be unreasonably withheld, audit
such records during ordinary business hours, at reasonable times
mutually agreed by Syngenta and Diversa, to verify the FTEs used in
the Research for Syngenta Projects. Such audits may be made no more
than once each calendar year. Syngenta’s representative or
agent will be obliged to execute a confidentiality agreement
acceptable to Diversa in its reasonable judgment prior to
commencing any such audit and may only disclose to Syngenta the
amount of any variance or error. Syngenta shall bear the expense of
such audit unless the results of the audit show that the amount
actually due to Diversa for the Research for Syngenta Projects and
the Joint Bagasse Project for the applicable period is less than
ninety-five percent (95%) of the amount charged by Diversa or
paid by Syngenta for the applicable Research for that period, in
which case Diversa shall reimburse Syngenta for the audit expenses.
If the audit determines that there has been an overpayment or
overfunding by Syngenta, the amount thereof shall be remitted to
Syngenta within […***…] in accordance with
Section 7.2. If the audit determines that there has been an
underpayment or underfunding by Syngenta, the amount thereof shall
be remitted to Diversa within […***…]. The foregoing
provisions shall also apply to use of FTEs by Diversa pursuant to
the Research Collaboration Agreement.
3.12 Use of Materials and Syngenta Proprietary
Technology.
(a) Limitations on Use. The Disclosing Party has provided
Materials to the Receiving Party pursuant to the Research
Collaboration Agreement and may provide Materials to the other
Party, in its discretion, for use in the Research Program. Subject
to the terms of this Agreement, all rights to the Materials shall
be retained by the Disclosing Party. Except as expressly permitted
by this Agreement or the License Agreement (including, without
limitation, the licenses granted herein and therein and with
respect to research conducted under the Research Collaboration
Agreement), a Receiving Party shall use any Materials provided to
it by the Disclosing Party, and any data or information derived
therefrom, solely for research activities under the Research
Program or the activities under the Research Collaboration
Agreement which are or have been approved in advance by the
Research Committee and not for any other purpose without the
express prior written consent of the Disclosing Party. Except as
expressly permitted by this Agreement or the License Agreement
(including, without limitation, the licenses granted herein and
therein and research conducted under the Research Collaboration
Agreement), the Receiving Party shall not transfer any Materials
provided to it by the Disclosing Party to any Third Party without
the prior written consent of the Disclosing Party. Notwithstanding
the foregoing, the Receiving Party shall be permitted to transfer
such Materials to a potential or actual Third Party manufacturer of
any of its Products; provided that such Third Party manufacturer
agrees to be bound by the terms and conditions set forth in this
Agreement
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regarding the use and disclosure of such
Materials. Without the express written consent of the Disclosing
Party, the Receiving Party shall not reverse engineer, reconstruct,
synthesize or otherwise modify or copy any Materials provided by
the Disclosing Party, or attempt the same.
(b) Limitations on Disclosure. Except for use in
connection with the Research Program or as expressly permitted
under this Agreement or under the License Agreement (including,
without limitation, the licenses granted herein and therein and for
use in connection with research conducted under the Research
Collaboration Agreement), neither Party shall have any right to use
or to disclose to any Third Party any proprietary technology,
Patent Rights, Know-How, Research Results or Materials of the other
Party.
4. M ANAGEMENT S TEERING C
OMMITTEE ; R
ESEARCH C OMMITTEE
4.1 Management Steering Committee. At least once per Year
during the Research Term, a "Management Steering Committee" shall
meet to review the productivity of the activities conducted under
this Agreement and the overall progress of the Projects and the
Research Program (provided that, with respect to Diversa Projects
conducted with or for any Third Party, disclosures shall be subject
to the provisions of Section 3.4), and to consider potential
opportunities for future collaboration to develop and commercialize
Products in the Biofuel Field and the Animal Feed Field and for any
other collaborative projects. The Management Steering Committee
will include senior executive(s) from each of the Parties and other
scientific and management personnel as desired and needed.
4.2 Establishment of Research Committee; Representatives.
Syngenta and Diversa shall each appoint an equal number (not
exceeding four) representatives of each Party to a research
committee (the "Research Committee" ). The chair of the
Research Committee shall rotate annually between the Parties. A
Party may change its appointments to the Research Committee at any
time with written notice to the other Party.
4.3 Responsibilities. In general, in furtherance of
Section 3.1(a), the Research Committee will thoroughly review
on an ongoing basis the Projects (provided that, with respect to
Diversa Projects conducted with or for any Third Party, disclosures
shall be subject to the provisions of Section 3.4) and
technical opportunities for new Projects in the Biofuel Field and
the Animal Feed Field that have promise for the development of
Products produced by both Transgenic Expression and by
Fermentation, and at least once a calendar quarter, representatives
of the Research Committee shall meet in person to discuss the
foregoing. In addition, the Research Committee will oversee,
review, direct and supervise all operational and scientific aspects
of the Syngenta Projects. In connection with each Syngenta Project,
the Research Committee shall discuss and must agree on
(i) staffing levels, duration, technical feasibility, research
activities and goals, and successful outcomes, and
(ii) recommendations to Syngenta as to whether the Milestones
as set forth in Section 6 have been achieved. In addition,
subject to Section 3, the Research Committee shall be
responsible with respect to Syngenta Projects for:
(a) monitoring and reporting research progress and in
furtherance of Section 3.5(a), ensuring open and frequent
exchange between the Parties with respect to Syngenta Project
activities;
(b) approving allocations of tasks and resources required to
carry out the goals of the Syngenta Projects;
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(c) approving all plans and annual budgets for
the Syngenta Projects within the Research Program;
(d) redirecting the activities to be conducted with respect to
the Syngenta Projects in the Research Program, and reallocating the
FTEs in support of such activities;
(e) discussing patent matters relating to the Syngenta Projects;
and
(f) performing such other functions as appropriate to further
the purposes of this Agreement, as determined by the Parties.
4.4 Decision Making by Research Committee. Except as
otherwise provided in this Agreement, all decisions of the Research
Committee with respect to the Syngenta Projects will be made by
unanimous approval, with Diversa representatives collectively
having one (1) vote and the Syngenta representatives
collectively having one (1) vote, and recorded in writing. If
the Research Committee is unable to resolve, after thirty
(30) days, a dispute regarding any issue presented to it or
arising in it with respect to a Syngenta Project, such dispute
shall be referred to the Management Steering Committee. If the
Management Steering Committee is unable to resolve such dispute
after thirty (30) days, such dispute shall be decided by
[…***…] provided that such decision does not conflict
with or result in an amendment or modification to this Agreement,
and the Management Steering Committee shall advise the Research
Committee and the executives referred to in Section 13.2 of
the disputed issue and the resolution thereof.
4.5 Meetings.
(a) Full Disclosure; Efficiency. The Parties intend that the
meetings of the Research Committee be conducted pragmatically and
efficiently in accordance with the terms of this Agreement,
including the collaborative spirit of Sections 3.1(a) and
3.5(a).
(b) Timing and Attendance. The Research Committee will
meet on a quarterly basis alternating between the locations of
Diversa and Syngenta and its Affiliates, or at such other sites as
the Research Committee may agree, and will otherwise communicate
regularly by telephone, electronic mail, facsimile and/or video
conference. Attendance at meetings shall be at the respective
expense of the participating Parties. If personal attendance is not
possible, voting by proxy is permissible. Either Party may include
other full-time employees of such Party or its Affiliates from time
to time at Research Committee meetings as non-voting participants.
Each Party may invite consultants of a Party or its Affiliates,
with the prior approval of the other Party, to attend, but not vote
at, Research Committee meetings.
(c) Minutes. The Research Committee shall keep accurate
minutes of its meetings that record all decisions and all actions
recommended or taken. The Party hosting the meeting shall be
responsible for the preparation and circulation of the draft
minutes. Draft minutes shall be delivered to the Research Committee
within twenty (20) days after each meeting. Draft minutes
shall be edited by each Party’s Research Committee
representatives within twenty (20) days of receipt thereof and
shall be adopted in final form at the next meeting of the Research
Committee with their approval and evidenced by the signature on the
minutes of all members present at the meeting described therein.
Diversa shall provide to Syngenta’s and its Affiliates’
employees nominated by Syngenta, […***…]. Minutes of
the Research Committee meetings shall be treated as Confidential
Information of each Party in accordance with the provisions of
Section 10 hereof. The foregoing provisions of this
Section 4.5(c) shall also apply to all minutes of meetings
conducted under the Research Collaboration Agreement.
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4.6 Records and Reports.
(a) Research Records. Diversa shall maintain records that will
properly reflect all work done and results achieved in the
performance of the Research Program (including all data in the form
required under any applicable governmental regulations and, with
respect to Syngenta Projects, as directed by the Research
Committee), including laboratory records sufficient to establish
the dates of first conception and reduction to practice of any
inventions within the Research Program. Diversa shall provide
Syngenta and its Affiliates with access to or copies of such
records relevant to the Research Program (excluding all Diversa
Projects conducted with or for any Third Party; however, access to
or copies of Research Results from Diversa Projects conducted with
or for any Third Party shall be provided to the extent set forth in
Section 3.5) (provided that Diversa shall have no obligation
to provide access to or copies of records to the extent related to
Diversa’s proprietary nucleic acid libraries (except with
respect to Subsequent Biomolecules as provided herein), discovery
and evolution technologies, and improvements thereto, and all its
screening assays, robotic devices and software related thereto), as
Syngenta may reasonably request, including copies of relevant pages
of laboratory notebooks, raw data and reports on Research Results.
Diversa shall maintain such records for the term of this Agreement.
If Diversa wishes to destroy such records with regard to any
Syngenta Project thereafter, it will give Syngenta at least
[…***…] prior written notice thereof, and Syngenta
shall have the right to have transferred to it the records which
Diversa wishes to destroy at Syngenta’s expense provided that
it gives Diversa notice thereof within such […***…] and
Diversa shall be entitled to delete or destroy any Confidential
Information of Diversa included therein. The foregoing provisions
shall also apply to records of work conducted by Diversa pursuant
to the Research Collaboration Agreement.
(b) Reports to the Research Committee. During the
Research Term, Diversa shall periodically, and not less often than
quarterly, provide to the Research Committee written reports
summarizing the progress of the research performed on Syngenta
Projects pursuant to the Research Plan during the preceding
quarter. Diversa shall also periodically, and not less than
quarterly, provide a written report (which may be provided as part
of the report described in the preceding sentence) summarizing
Program Technology necessary or useful for the discovery,
development, testing use, manufacture or sale of Syngenta Products
or otherwise useful in the Syngenta Exclusive Field or the Syngenta
Projects, which are made or developed by Diversa under this
Agreement during the Research Term or under the Research
Collaboration Agreement, with significant discoveries or advances
being communicated as soon as practical after such information is
obtained or its significance is appreciated.
(c) Syngenta Information. Syngenta may, in
Syngenta’s discretion, provide Diversa with access to or
copies of books and records, laboratory notebooks and other written
or electronic materials and/or software owned or otherwise
Controlled by Syngenta or its Affiliates for use by Diversa in the
conduct of the Research Program and may provide Diversa with such
access as may be required by Diversa in connection with the
licenses granted to Diversa under this Agreement or in the License
Agreement, with respect to which Syngenta and its Affiliates shall
retain all ownership rights. Diversa shall maintain the foregoing
and any such information previously provided pursuant to the
Research Collaboration Agreement in confidence as
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Syngenta Confidential Information and at
Syngenta’s request shall give Syngenta access thereto at
anytime during Diversa’s normal business hours and shall, at
Syngenta’s request, promptly return such books and records,
notebooks, software, and other information and materials, and all
copies thereof.
4.7 Market Development Team. In the case of any Syngenta
Product being developed in the Biofuel Field, at or before the time
of achievement of the milestone referenced in
Section 6.1(b)(ii) with respect to such Syngenta Product, a
"Market Development Team" for such Syngenta Product s
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