First Addendum to Roche/CBMX Research and Development Agreement

Research and Development Agreement

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ACACIA RESEARCH CORP | Combimatrix Corporation

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Title: First Addendum to Roche/CBMX Research and Development Agreement
Date: 3/16/2006
Industry: SEMICO

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EXHIBIT 10.17

cbmx

COMBIMATRIX

CORPORATION

6500 Harbour Heights Pkwy

Muklteo, WA 98275

Tel 425.493.2000

Fax 425.493.2010

www.combimatrix.com

Via Overnight Courier

25 March 2003

Stefan Willemsen

Roche Diagnostics GmbH

Nonenwald 2

82377 Penzberg

Germany

First Addendum to Roche/CBMX Research and Development Agreement

Dear Stefan:

As we discussed, we need to update Annex I in the current R&D Agreement to update the project milestones and priorities of the Committee and to add in completed milestones for the sake of completeness.

Please sign both copies of this letter with a revised Annex I to substitute in the revised Annex I.

Sincerely,

Combimatrix