Manufacturing and Supply Agreement

Requirements Supplier Agreement

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This Requirements Supplier Agreement involves

CORNERSTONE THERAPEUTICS INC | Jagotec AG | SkyePharma PLC

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Title: Manufacturing and Supply Agreement
Date: 6/18/2009
Industry: Biotechnology and Drugs Sector: Healthcare

Exhibit 10.1

JAGOTEC AG

12 June 2009

Cornerstone Therapeutics Inc.
1255 Crescent Green Drive, Suite 250
Cary, NC 27518
USA

Dear Sirs

Manufacturing and Supply Agreement dated 20 August 2007 between Cornerstone Therapeutics Inc. (“Cornerstone,” formerly known as Critical Therapeutics, Inc.) and Jagotec AG (“Jagotec”) and (for the purposes of Clause 20 only) SkyePharma PLC (“MSA”)

We write in connection with Clause 9.1 and Schedule 1 of the MSA.

The parties have agreed that:-

1.		The Price for all Product delivered in the Years 2009 (whether before or after the date of this letter) and 2010 shall be US$[*] per [] tablets of Product. As a result of the increase, Jagotec shall issue to Cornerstone a further invoice for any additional amounts due for Product invoiced prior to the date of this letter and Cornerstone shall pay such additional amounts within [**] days of receipt of such further invoice;

2.		The Price for Product delivered in the Year 2011 and each Year thereafter shall be increased as follows:

		By [*] 2010 and by [*] in each Year thereafter

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