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RELEASE AGREEMENT

Release Agreement

RELEASE AGREEMENT | Document Parties: EPIX PHARMACEUTICALS, INC. | DR. OREN BECKER You are currently viewing:
This Release Agreement involves

EPIX PHARMACEUTICALS, INC. | DR. OREN BECKER

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Title: RELEASE AGREEMENT
Date: 4/6/2007
Industry: Biotechnology and Drugs     Sector: Healthcare

RELEASE AGREEMENT, Parties: epix pharmaceuticals  inc. , dr. oren becker
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<PAGE>
                                                                    Exhibit 10.1

                                RELEASE AGREEMENT

                        Dated this 5th day of April, 2007

Between:           DR. OREN BECKER   Identity no. 056528177
                  Residing at 12 Motza Haktana Street, Mevaseret Zion, Israel
                  ("Oren Becker ")

                                                              of the first part
And between:       EPIX PHARMACEUTICALS LTD. Identity no. 512864307
                  Located at S.A.P. Building, 3 Hayetzira St., Ramat-Gan, Israel
                  ("EPIX Pharmaceuticals Ltd. / THE COMPANY")
                                                              of the second part


Whereas Oren Becker was employed by EPIX Pharmaceutical Ltd.(formerly known as
Predix Pharmaceuticals, Ltd.) as of November 1st, 2000 following an employment
agreement dated October 31st, 2000(the "EMPLOYMENT AGREEMENT"); and

Whereas, the parties have reached an agreement regarding the termination of Oren
Becker employment with the Company according to the terms and conditions
expressly provided herein, in this release agreement (the "RELEASE Agreement");
and

Whereas, the parties agree that such Release Agreement shall constitute a final
settlement between the parties in regards to Oren Becker employment and/or
termination of employment with EPIX Pharmaceuticals Ltd. thereof;

NOW, THEREFORE, it is hereby declared, covenanted and agreed between the parties
as follows:

1.        The preamble to this Release Agreement constitutes an integral part
         hereof.

2.        As of April 19th, 2007 (the "TERMINATION DATE") - Oren Becker's
         employment with the Company shall cease, and the employee-employer
         relationships and Employment Agreement with the Company shall be
         terminated.

3.        Notice period: The period commencing on February 18, 2007 and until
         Termination Date - shall be considered as a prior notice period for
         termination (the: "PRIOR NOTICE PERIOD"). During the Prior Notice
         Period the Company shall pay Oren Becker his regular salary and all
         other social benefits as prescribed under the Employment Agreement.
         Oren Becker shall not be required to report to any Company facility or
         otherwise perform services on behalf of the Company, unless otherwise
         instructed by the Company. Oren Becker agrees that during the Prior
         Notice Period, he will notify Yifat Bar at least twenty-four (24) hours
         in advance if he needs to


<PAGE>

         visit any Company facility or perform any services on behalf of the
         Company.

4.        Options:

         4.1.      Until Termination Date, and within 90 (Ninety) days after
                   Termination Date, Oren Becker shall be entitled to exercise
                  all of his vested options to purchase Common Stock of EPIX
                  Pharmaceuticals, Inc. which were granted to Oren Becker in
                  accordance with any and all option agreements entered into
                  between Oren Becker and the Company during Oren Becker's
                  employment with the Company (the "Options"). Options, which
                  shall vest during the period as of the date of this Release
                  Agreement and until Termination Date, may be exercised by Oren
                  Becker within 90 (Ninety) days after Termination Date. For the
                  avoidance of doubt, after such period - unexercised Options
                   will immediately expire and terminate, and thereafter, Oren
                  Becker shall no longer have any right to exercise such
                  remaining unexercised Options.

         4.2.      The following summarizes all granted Options pursuant to the
                  Predix 2003 Stock Incentive Plan and the EPIX 1992 Stock
                  Incentive Plan to purchase Common Stock of EPIX
                  Pharmaceuticals, Inc. held by Oren Becker that have not been
                   exercised as of the date of this Release Agreement and that
                  shall vest as of the Termination Date.

<TABLE>
<CAPTION>
--------------------------------------------------------------------------------
GRANT DATE       GRANTED       PRICE      CURRENTLY     CURRENTLY      VESTED AS OF
                                         VESTED      UNVESTED     TERMINATION DATE
--------------------------------------------------------------------------------
<S>              <C>           <C>        <C>            <C>          <C>
8/11/2003         10,527       $2.18         7,895         2,632           7,895
--------------------------------------------------------------------------------
8/11/2003          5,045       $2.18         5,045             0           5,045
--------------------------------------------------------------------------------
4/29/2004          1,836       $2.18         1,262           574           1,262
--------------------------------------------------------------------------------
9/23/2004         95,698       $0.98        95,698             0          95,698
--------------------------------------------------------------------------------
9/23/2004         22,456       $0.98        22,456             0          22,456
--------------------------------------------------------------------------------
1/18/2005         69,549       $0.98        36,223        33,326          39,121
--------------------------------------------------------------------------------
4/28/2005         10,948       $1.74         4,334         6,614            4,790
--------------------------------------------------------------------------------
9/19/2006         35,000       $5.31         2,188        32,812           4,375
--------------------------------------------------------------------------------
</TABLE>

                  The exercise of any Options shall be subject to the terms of
                  Sections 4.1 and 5 of this Release Agreement.


<PAGE>

         4.3.      Except specified in this Section 4 of this Release Agreement,
                   the terms and conditions of any and all other stock option
                  agreements entered into between Oren Becker and the Company
                  during Oren Becker's employment with the Company are not
                  modified in any way and remain subject to the terms of the
                  Predix 2003 Stock Incentive Plan or the Amended and Restated
                  1992 Equity Incentive Plan, respectively, or any applicable
                  predecessor or successor plans. For the avoidance of doubt,
                  the vesting of all Options granted under the Amended and
                  Restated 1992 Equity Incentive Plan shall not be accelerated
                  hereunder and shall terminate on the Termination Date, and all
                   such unvested Options on the Termination Date shall be
                  forfeited pursuant to their terms.

5.        Acknowledgement of Prior Agreement. Oren Becker hereby acknowledges and
         declares that on or about October 31, 2000, Oren Becker and the Company
         entered into an Employment Agreement, as amended, a copy of which is
         attached as Exhibit A. Oren Becker further acknowledge and declares
         that certain obligations set forth in that Employment Agreement will
         survive the termination of his employment with the Company, including
         but not limited to the obligations set forth in Section 8 (Proprietary
         Rights and Information), Section 9 (Secrecy and Nondisclosure) and
         Section 10 (Non-Competition). Continued Compliances by Oren Becker with
         the foregoing obligations shall be a condition to the exercise of any
         Options pursuant to Section 4 above and the receipt of any payments
         pursuant to Section 6.4 below.

6.        Final accounting: Upon termination Date, the parties will prepare a
         final accounting, pursuant to which the Company shall:

         6.1.      Convey to Oren Becker a letter, addressed to Kali Insurance,
                  the insurance company, instructing that all sums accrued in
                  the managers insurance policy as a result of the Company's and
                  Oren Becker's contributions towards severance pay and
                  compensatory payments - shall be released to Oren Becker;

         6.2.      Convey to Oren Becker a letter, addressed


 
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