Exhibit 10.2
Execution Version
PATENT LICENSE
AGREEMENT
PATENT LICENSE AGREEMENT (“
Agreement ”), dated January 20, 2009 (the “
Effective Date ”), by and between PANACOS
PHARMACEUTICALS, INC., a Delaware corporation (“
Panacos ”), and MYRIAD PHARMACEUTICALS, INC., a
Delaware corporation (“ Myriad ”). Panacos and
Myriad are referred to collectively herein as the
“Parties” and each, individually as a
“Party.”
WHEREAS, pursuant to an Asset
Purchase Agreement dated as of January 20, 2009, by and
between Panacos and Myriad (“ Purchase Agreement
”), Myriad acquired certain assets from Panacos used or which
Myriad intends to use in connection with the development
(preclinical and clinical), manufacture and commercialization of
3-O-(3’,3’-dimethylsuccinyl) betulinic acid and salts
and solvates thereof, and polymorphs thereof (“
Bevirimat ”);
WHEREAS, the assets acquired by
Myriad under the Purchase Agreement include all of Panacos’s
interest in and to the Bevirimat Patents (as hereinafter defined),
and the assets retained by Panacos under the Purchase Agreement
include the Panacos Patents (as hereinafter defined);
WHEREAS, Myriad has agreed to grant
certain licenses to Panacos and its Affiliates under the Bevirimat
Patents; and
WHEREAS, Panacos has agreed to grant
certain licenses to Myriad and its Affiliates under the Panacos
Patents.
NOW, THEREFORE, in consideration of
the premises and the mutual covenants and agreements set forth
herein, the receipt and sufficiency of which are hereby
acknowledged, the Parties hereto agree as follows:
Section 1.
DEFINITIONS
1.1 The following terms, when used
in this Agreement, shall have the respective meanings ascribed to
them below:
(a) “ Affiliate ”
means any corporation, firm, partnership, or other entity that,
directly or indirectly, controls, is controlled by, or is under
common control with a Party. For purposes of this definition,
“control” shall mean the ownership of at least fifty
percent (50%) of the voting share capital of such entity or
any comparable equity or ownership interest.
(b) “ Bevirimat Patents
” shall mean the patents and patent applications identified
on Exhibit A hereto.
(c) “ Panacos Patents
” shall mean the patents and patent applications identified
on Exhibit B hereto.
(d) “ Person ”
means an individual, a corporation, a limited liability company, a
partnership, an association, a trust or other entity or
organization, including a federal, state, local or foreign
government or regulatory entity or political subdivision or an
agency or instrumentality thereof.
(e) “ Product
Operations ” means the development (preclinical and
clinical), manufacture, marketing, distribution, sale, or any other
exploitation of or activity with respect to, Bevirimat.
1.2 Unless otherwise defined in
Section 1.1 or herein, each capitalized term used in this
Agreement that is defined in the Purchase Agreement shall have the
meaning specified for such term in the Purchase
Agreement.
Section 2.
LICENSES
2.1 License to Myriad Under the
Panacos Patents . Panacos hereby grants to Myriad and its
Affiliates an exclusive, perpetual worldwide, royalty-free,
transferable (subject to Section 9.4) license, with the right
to grant sublicenses to others under the Panacos Patents to
develop, manufacture, make and have made, offer to sell, sell,
import, distribute, promote and use Bevirimat.
2.2 Sublicensees of Myriad .
Any sublicensee of Myriad or its Affiliates permitted under
Section 2.1 shall be bound by the terms of this Agreement, and
any such sublicense shall not relieve Myriad or its Affiliates of
their obligations or liabilities under this Agreement.
2.3 License to Panacos Under the
Bevirimat Patents . Myriad hereby grants to Panacos and its
Affiliates a non-exclusive, perpetual, worldwide, royalty-free,
transferable (subject to Section 9.4) license, with the right
to grant sublicenses to others in support of or ancillary to the
business of Panacos or its Affiliates (i) under the Bevirimat
Patents to manufacture, make and have made, and use Bevirimat
solely as an intermediate in the synthesis of maturation inhibitors
other than Bevirimat, and (ii) under all claims set forth in
United States Patent Number 5,679,828 and its foreign equivalents
relating to compounds other than Bevirimat to develop, manufacture,
make and have made, offer to sell, sell, import, distribute,
promote and use all maturation inhibitors other than
Bevirimat.
2.4 Sublicensees of Panacos .
Any sublicensee of Panacos or its Affiliates permitted under
Section 2.3 shall be bound by the terms of this Agreement, and
any such sublicense shall not relieve Panacos or its Affiliates of
their obligations or liabilities under this Agreement.
2.5 Duration of Licenses .
Unless this Agreement is earlier terminated pursuant to the terms
of Section 8.2 of this Agreement, the license granted under
any Panacos Patent pursuant to Section 2.1 or any Bevirimat
Patent pursuant to Section 2.3 shall extend for the life of
the particular patent involved. Any sublicense granted to any
Panacos Patent pursuant to Section 2.1 or any Bevirimat Patent
pursuant to Section 2.3 shall terminate in accordance with the
termination of the applicable license under Section 2.1 or
2.3, as the case may be.
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2.6 Preservation of Rights .
Any sale, assignment, license, sublicense, disposition, grant of a
lien or other security interest in, or transaction (i) by
Panacos or any of its Affiliates affecting the Panacos Patents, or
(ii) by Myriad or any of its Affiliates affecting the
Bevirimat Patents, shall not affect and shall at all times be
subject to the rights of the other Party and its Affiliates under
this Agreement. In addition, to the extent permitted by applicable
law, in the event that a Party becomes insolvent, files a petition
in bankruptcy, has such a petition filed against it, determines to
file a petition in bankruptcy, or receives notice of a third
party’s intention to file an involuntary petition in
bankruptcy (a “Filing Party”), such Filing Party shall
immediately notify the other Party in writing, and the other Party
shall have the right but not the obligation, if the Filing Party
remains insolvent or any such petition is not resolved within three
(3) months after the date it is filed, to (i) immediately
terminate this Agreement, in whole or in part as the other Party
may determine, upon written notice to the Filing Party; or
(ii) assume responsibilities for the prosecution or
maintenance of any patents or patent applications licensed to it by
the Filing Party.
2.7 Affiliates . With respect
to the grant of any license to or the exercise of any right by an
Affiliate of a Party, the Party shall: (i) cause the Affiliate
to be bound by the terms and conditions of this Agreement; and
(ii) be responsible for the performance by the Affiliate of
the obligations under this Agreement.
Section 3.
CONSIDERATION
3.1 The licenses granted under this
Agreement are on a royalty free basis without compensation from a
Party to any other Party.
Section 4. OWNERSHIP
RIGHTS
4.1 All property rights in or
related to the patents and patent applications licensed hereunder
are and will remain the exclusive property of the applicable owner,
and, as between the Parties shall not be subject to challenge with
respect to such ownership.
Section 5. PROSECUTION AND
MAINTENANCE OF PATENT RIGHTS
5.1 Responsibility . Subject
at all times to Section 5.2, Panacos shall be solely
responsible for the prosecution, maintenance and renewal of the
Panacos Patents, including the payment of all fees and expenses in
connection therewith, and Myriad shall be solely responsible for
the prosecution, maintenance and renewal of the Bevirimat Patents,
including the payment of all fees and expenses in connection
therewith. Panacos will provide Myriad with copies of all documents
exchanged with the relevant patent offices concerning the Panacos
Patents, and Myriad will provide Panacos with copies of all
documents exchanged with the relevant patent offices concerning the
Bevirimat Patents.
5.2 Abandonment of Patents .
Panacos shall have the right to unilaterally abandon any Panacos
Patent, and Myriad shall have the right to unilaterally abandon any
Bevirimat Patents, provided at least ninety (90) days prior to
the renewal date or other date for loss or abandonment of any such
patent or patent application that a Party wishes to abandon, the
owning Party gives notice to the other Party of its intent to
abandon. If the other Party does not want such patent or patent
application to become abandoned, the other Party
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shall have the option to acquire the rights in
said patent or patent application by: (i) giving written
notice to the Party desiring to abandon the patent or patent
application within sixty (60) days following the delivery of
the original notice; and (ii) paying the renewal or
maintenance fees that are then due or taking such other action as
may be necessary to prevent the loss or abandonment, provided
that , in the case of Panacos, such option shall only apply to
United States Patent Number 5,679,828 and its foreign equivalents.
In connection with the foregoing, the owning Party shall promptly
provide the other Party all information reasonably requested by the
other Party regarding such patent or patent application. If the
other Party does not exercise its option within the sixty
(60) day period, the patent or patent application may be
abandoned by its owner. If the other Party exercises its option,
the owning Party shall promptly execute such documents and take
such other actions as may be reasonably necessary to accomplish the
transfer of ownership. Following the transfer of ownership, the
patent or patent application so transferred shall no longer be
deemed to be included within the scope of this Agreement, and the
former owner shall have no further rights under this Agreement with
respect thereto. Notwithstanding the foregoing, the Party owning a
pending patent application included with the Panacos Patents or the
Bevir