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Exhibit 10.62
AGREEMENT
THIS AGREEMENT (this "Agreement") is made and is effective as
of
October 20, 2003, (the "Effective Date")
between Dr. Robert L. Hunter ("Hunter")
and CytRx Corporation, a Delaware
corporation ("CytRx") with reference to the
following facts:
A.
CytRx has developed CytRx Know-How (as hereinafter defined)
and has CytRx Patent Rights (as hereinafter
defined) in the fields of:
(i) The
composition and use of surface-active copolymers
exemplified by poloxamer 188 to treat
ischemic tissue, myocardial damage,
stroke, pathological hydrophobic
interactions in biological fluids, tissue
damaged by reperfusion injury, sickle cell
disease, and in performing
angioplasty procedures (with the CytRx
Know-How and CytRx Patent Rights in this
field referred to collectively as the
"FLOCOR Intellectual Property");
(ii)
the composition and use of surface active copolymers
(exemplified by poloxamers, reverse
poloxamers and diether fatty acid conjugates
of poloxyethylene) to treat infections
caused by microorganisms, including
bacteria, fungi, and viruses and to treat
tumors (with the CytRx Know-How and
CytRx Patent Rights in this field referred
to collectively as the
"Anti-Infectives Intellectual Property");
and
(iii)
conventional vaccine adjuvants exemplified by
poloxamer P1005 (with the CytRx Know-How
and CytRx Patent Rights in this field
referred to collectively as the "OptiVax
Intellectual Property").
B.
CytRx has exclusively licensed to Merck & Co. ("Merck), Ivy
Animal Health, Inc. ("Ivy Animal Health"),
TiterMax USA, Inc. ("TiterMax"), and
Vical Inc. ("Vical"), and has granted an
option to acquire an exclusive license
to Progenics Pharmaceuticals, Inc.
("Progenics"), CytRx Know-How and CytRx
Patent Rights in certain fields under
agreements collectively referred to as the
CytRx Licenses, copies of which are
attached hereto as SCHEDULE A.
C.
Hunter has previously participated in the development of most
of the poloxamer technology that is the
subject of the Licensed Intellectual
Property (as hereinafter defined) and has
developed Hunter Know-How (as
hereinafter defined).
D.
CytRx and Hunter wish to continue the development and
subsequent commercialization of the FLOCOR
Intellectual Property, the
Anti-Infectives Intellectual Property and
the Opti-Vax Intellectual Property
(collectively referred to as the "Licensed
Intellectual Property") and other
potential technologies in the field of
FLOCOR, Opti-Vax and Anti-Infectives (as
such terms are hereinafter defined) through
a jointly owned new corporation to
be formed by them and named SynthRx Inc.
("SynthRx").
E.
CytRx and Hunter wish to provide for the formation and
operation of SynthRx, for Hunter to provide
the initial capital for SynthRx, for
SynthRx to obtain an exclusive license
under the Licensed Intellectual Property
from CytRx and for both CytRx and Hunter to
provide know how to SynthRx upon the
terms and conditions set forth herein.
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NOW, THEREFORE, in consideration of the foregoing premises and
the
mutual covenants herein contained, the
parties hereby agree as follows:
ARTICLE I.
DEFINITIONS
Unless specifically set forth to the contrary herein, the
following
terms, whether used in the singular or
plural, shall have the respective
meanings set forth below:
1.1 The term
"Affiliate" shall mean (i) any corporation or
business entity of which 50% or more of the
securities or other ownership
interests representing the equity, the
voting stock or general partnership
interest are owned, controlled or held,
directly or indirectly, by SynthRx,
Hunter or CytRx; or (ii) any corporation or
business entity which, directly or
indirectly, owns, controls or holds 50% or
more of the securities or other
ownership interests representing the equity
or the voting stock of SynthRx or
CytRx.
1.2 The term
"Anti-Infectives" shall mean
polyoxypropylene/polyoxyethylene copolymers
and other polyoxyethylene conjugates
having therapeutic activity or having the
ability to enhance the therapeutic
activity of other agents against infective
organisms, including bacteria,
viruses and fungi.
1.3 The term
"CytRx Know-How" shall mean contracts, information
and materials, including but not limited
to, discoveries, Improvements,
processes, formulas, data, know-how and
trade secrets, patentable or otherwise,
which (i) are in CytRx's possession or
control at the Effective Date or are
developed by CytRx during the term of this
Agreement, if any, (ii) are not
generally known, (iii) are valuable to
SynthRx in connection with the research,
development, marketing, use or sale of
Licensed Products in the Field in the
Territory, and (iv) CytRx has the right to
provide to SynthRx.
1.4 The term
"CytRx Licenses" shall mean the previously entered
into exclusive license agreements between
CytRx and Merck, Ivy Animal Health,
Titermax and Vical and the exclusive
license agreement to be entered into
between CytRx and Progenics upon Progenics
exercising the option previously
granted to it by CytRx for certain CytRx
Know-How and CytRx Patent Rights for
certain fields as defined in each license
agreement listed in SCHEDULE A.
1.5 The term
"CytRx Patent Rights" shall mean (i) all United
States or foreign patents or patent
applications, and patents to be issued
pursuant thereto, owned by or licensed to
CytRx, related to Flocor, Opti-vax or
the Anti-Infectives, excluding the use in
certain fields that are covered in the
CytRx Licenses listed in SCHEDULE A hereto;
or (ii) are divisions,
continuations, reissues, renewals,
extensions, supplementary protection
certificates, utility models and the like
of any such United States patents and
patent applications and foreign equivalents
thereof. Hunter and CytRx
acknowledge that the patent rights licensed
from Rush-Presbyterian-St. Luke's
Medical Center have reverted to Rush, that
they are no longer part of CytRx
Patent Rights and that SynthRx must
negotiate directly with Rush if it is to
obtain rights to these parts of the
Anti-Infectives Intellectual Property.
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1.6 The term
"Field" shall mean the use of Licensed Intellectual
Property in all fields for FLOCOR,
Anti-Infectives and Opti-Vax, set forth in
recital A to this Agreement except for
those fields of use that are or will be
licensed under the CytRx Licenses.
1.7 The term
"FLOCOR" shall mean surface-active copolymers of an
ethylene oxide-propylene oxide condensation
product that have cytoprotective,
rheologic and antithrombotic activities
exemplified by poloxamer 188.
1.8 The term
"Opti-Vax" shall mean novel
polyoxyethylene/polyoxypropylene copolymers
that are high molecular weight
molecules and are useful as vaccine
adjuvants.
1.9 The term
"Hunter Know-How" shall mean information and
materials, including but not limited to,
discoveries, improvements, processes,
formulas, dates, know-how and trade
secrets, patentable or otherwise, which are
in Hunter's possession or control at the
Effective Date or are developed by
Hunter alone or with others during the term
of this Agreement, if any, (i) are
not generally known, (ii) are valuable to
SynthRx in connection with the
research, development, marketing, use or
sale of the Licensed Products in the
Field in the Territory, and (iii) which
Hunter has the right to provide to
SynthRx. Hunter's rights are subject to an
employment agreement with the
University of Texas-Houston.
1.10
The term "Hunter Patent Rights" shall mean in the fields of
Flocor, the antiinfectives and OptiVax (i)
all United States or foreign patents
or patent applications and patents to be
issued pursuant thereto, owned by or
licensed to Hunter, including but not
limited to those listed in SCHEDULE B
hereto; or (ii) are divisions,
continuations, reissues, renewals, extensions,
supplementary protection certificates,
utility models and the like of any such
United States patents and patent
applications and foreign equivalents thereof.
1.11
The term "License Agreement" shall mean the License Agreement
between CytRx and SynthRx in the form set
forth in SCHEDULE C hereto.
1.12
The term "Licensed Product" shall mean a Product for use in
the Field, which in the absence of this
Agreement would infringe one or more
claims of the CytRx Patent Rights, or a
Product that is made using a process or
method covered by one or more claims of the
CytRx Patent Rights.
1.13
The term "Proprietary Information" shall mean all SynthRx
Know-How, Hunter Know-How and CytRx
Know-How, and all other scientific,
clinical, regulatory, marketing, financial
and commercial information or data,
whether communicated in writing or orally
or by sensory detection, which is
provided by one party to the other party in
connection with this Agreement.
1.14
The term "Product" shall mean any prescription or
over-the-counter prophylactic, diagnostic
or therapeutic product, vaccine or
device for use in the Field in the
Territory.
1.15
The term "Territory" shall mean all of the countries in the
world.
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ARTICLE II.
FORMATION AND OPERATION OF SYNTHRX
2.1 Formation and Initial
Capitalization of SynthRx. Within 20
business days following the Effective Date
(the "Closing Date"), Hunter and
CytRx shall form SynthRx and provide it
with the CytRx Know How and Hunter Know
How components of their capital
contributions (which shall be returned to them
by SynthRx in the event Hunter or CytRx
fails to make the balance of his or its
capital contribution as set forth in this
Section 2.1). Within 20 business days
following Hunter's completion of the sale
of his CytRx shares (described below),
Hunter and CytRx shall provide the
additional contributions of capital for
SynthRx described in this Section 2.1, with
each of these contributions to be
conditioned upon the other and with the
date on which such contributions are
made being referred to herein as the
"Second Closing Date." The initial capital
to be provided by Hunter pursuant to this
Section 2.1 (the "Hunter Capital
Contribution") shall be in the form of the
foregoing Hunter Know-How and a cash
contribution to SynthRx in an amount equal
to 85% of the net proceeds (after
brokerage commissions) from sale of 497,000
shares of CytRx common stock (the
"Hunter Shares") to a third party, which
sale shall be effected by Hunter not
later than the 90th business day following
the Effective Date. Hunter hereby
represents that, subject to applicable
community property laws, he is the sole
owner of the Hunter Shares, free and clear
of all liens, claims and
encumbrances, and has the right to sell and
transfer all of the Hunter Shares
without the consent of any third party in a
Rule 144(k) transaction under the
Securities Act of 1933. CytRx shall provide
reasonable assistance to Hunter in
identifying and completing the sale of the
Hunter Shares to a third party but
makes no representation or warranty as to
the price per share that will be
received by Hunter or the amount of federal
or state taxes that will be payable
by Hunter in connection with his sale of
the Hunter Shares. CytRx will make its
capital contribution, which will be in the
form of the foregoing CytRx Know-How
and a transfer of property in the form of
the grant of the license described in
Section 2.2 hereof (the "CytRx Capital
Contribution") with the license grant to
be made concurrently with Hunter making the
cash portion of the Hunter Capital
Contribution. In consideration of the
Hunter Capital Contribution and CytRx
Capital Contribution, SynthRx shall issue
Hunter a number of shares of its
common stock equal to 80.1% of the total
outstanding capital stock of SynthRx on
the Closing Date and shall issue CytRx a
number of shares of its common stock
equal to 19.9% of the total outstanding
capital stock of SynthRx on the Closing
Date.
2.2 Transfer
of License for Stock and Cash Payment. On the Second
Closing Date, SynthRx shall, in
consideration of the grant of the license to the
Licensed Intellectual Property set forth in
Section 3.1 hereof, (i) issue CytRx
all of the shares of common stock described
in Section 2.1 hereof and (ii) make
a cash payment to CytRx equal in amount to
the Hunter Capital Contribution, less
$500,000 that will be retained by SynthRx
for its initial working capital (the
"CytRx Cash License Payment"). The common
shares issued to Hunter and CytRx
pursuant to Section 2.1 hereof shall be the
only capital shares of SynthRx that
will be initially issued, and SynthRx shall
as of the Closing and the Second
Closing Date have no other obligation to
issue any of its securities or have any
other debt or financial obligations to
Hunter other than reimbursement of actual
direct expenditures for the establishment
of SynthRx, CytRx or any third party
(except for other obligations set forth in
this Agreement).
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2.3 CytRx Data
Transfer. CytRx will transfer to SynthRx all
regulatory filings (including, without
limitation, all INDs), tangible materials
(including finished drug, work-in-progress,
drug substance and drug product) and
records, notes, data and other information
or know how pertaining to FLOCOR,
OptiVax and its Anti-Infectives patent
portfolio. SynthRx acknowledges that
CytRx has agreed to permit TransForm
Pharmaceuticals, Inc. ("TransForm") access
to and the right to reference certain
existing FLOCOR data under an agreement
that has been provided to SynthRx (the
"TransForm Agreement"). SynthRx agrees to
comply with the terms of the TransForm
Agreement, and CytRx will be entitled to
retain any amounts payable by TransForm to
CytRx under the terms of that
agreement. CytRx shall have the right to
sublicense the rights to use Poloxamer
188 to TransForm Pharmaceuticals as an
"excepient" in animal drug products and
with written permission from SynthRx for
human drug products, and CytRx shall be
entitled to retain all license fees,
royalties or other compensation generated
by such sublease. CytRx agrees to reimburse
any SynthRx expenses associated with
the TransForm Agreement, including employee
time.
2.4 CytRx
Materials Transfer. CytRx will transfer all product and
data related to the product being stored
and transferred pursuant to this
Section 2.4 covered by this Agreement to
SynthRx on the Second Closing Date.
SynthRx will be assigned ownership by CytRx
of all existing FLOCOR product
currently in storage and any existing
polymer products related to any of the
licensed technologies, which will be held
at their current storage sites at
SynthRx's expense or at SynthRx's election
will be transferred to alternative
locations at SynthRx's expense. This
includes FLOCOR at Hanson Cold Storage, an
undetermined amount in storage at Quintiles
that has been put into vials with a
buffer for clinical trial use, a small
amount at HITEX in France, data and
samples in storage at Covance, and samples
that are in the freezer at CytRx's
Atlanta office. The material at Hanson and
Quintiles will have to be retested by
SynthRx before use. SynthRx will reserve up
to 2 kg of purified FLOCOR material
and will make that available at no charge
to CytRx. CytRx makes no
representation or warranty as to the
physical condition or usability in any
future clinical trials of any of these drug
products or materials.
2.5 Hunter
Know-How Transfer. Hunter will transfer to SynthRx all
information and materials related to
Flocor, OptiVax and the Anti-Infectives,
including but not limited to, discoveries,
improvements, processes, formulas,
dates, know-how and trade secrets,
patentable or otherwise, which are in
Hunter's possession or control at the
Effective Date or are developed by Hunter
alone or with others during the term of
this Agreement, if any, that (i) are not
generally known, (ii) are necessary to
SynthRx in connection with the research,
development, manufacture, marketing, use or
sale of the Licensed Products in the
Field in the Territory, and (iii) which
Hunter has the right to provide to
SynthRx.
2.6 Management
of SynthRx. SynthRx shall have a Board of Directors
consisting of five members, who shall be
Hunter, three additional directors
designated by Hunter and a fifth director
designated by CytRx. At CytRx's sole
discretion, CytRx may, in lieu of
designating a director to SynthRx Board of
Directors, designate an observer who shall
be entitled to attend all SynthRx
Board of Director meetings. The Chief
Executive Officer of SynthRx shall be
Hunter or an individual designated by
Hunter or the SynthRx Board of Directors.
2.7 Additional
Financings. CytRx shall have the right with respect
to any subsequent issuance of securities by
SynthRx to maintain its then
percentage interest (19.9% on a fully
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diluted basis) in SynthRx's capital stock
by purchasing up to its pro rata share
of the securities proposed to be issued so
as to maintain CytRx's percentage
interest in SynthRx, upon the same
financial terms as which SynthRx proposes to
issue these securities to any third party.
CytRx shall be required to exercise
this pre-emptive right not later than 30
days following written notice from
SynthRx of the proposed issuance, and this
pre-emptive right shall not apply to
any issuance of (i) securities offered to
the public pursuant to an IPO by
SynthRx or (ii) securities issued or to be
issued to officers, directors,
employees or consultants pursuant to a
stock option plan, employee stock
purchase plan or other similar plan that is
approved by SynthRx's Board of
Directors. SynthRx shall not initiate any
action (such as the repurchase of
outstanding shares of its common stock)
that would cause CytRx's ownership
percentage of SynthRx to increase to in
excess of 19.9% if such increase, in the
opinion of CytRx's independent public
accountants would require CytRx to
consolidate SynthRx's operating results
with those of CytRx or have any other
materially adverse accounting impact on
CytRx.
2.8 Right of
First Refusal. In the event Hunter or his Affiliates
propose to sell or transfer any of their
SynthRx securities to a third party in
a transaction not covered by Section 2.10,
CytRx shall have a right of first
refusal to purchase all or any portion of
those securities (the "Hunter Transfer
Shares") upon the same financial terms as
proposed to be paid by the third
party. CytRx shall have 30 days from
receipt of a written notice from Hunter or
his Affiliate identifying the proposed
purchaser, the financial terms of the
proposed sale or transfer and all other
material terms and conditions of the
proposed transaction in which to exercise
this right of first refusal and to pay
for the Hunter Transfer Shares that it
elects to purchase. Hunter or his
Affiliate thereafter will have 90 days to
complete the sale or transfer of the
Hunter Transfer Shares not purchased by
CytRx on financial and other terms no
less favorable to Hunter or his Affiliate
than those set forth in the foregoing
notice.
2.9
Registration Rights. CytRx will have customary piggyback
registration rights with respect to all of
its SynthRx securities. In addition,
CytRx shall have the right at any time
commencing on or after 9 months from an
Initial Public Offering to require SynthRx
to register on the appropriate SEC
form of registration statement any or all
of CytRx's SynthRx securities for
resale or in connection with the
distribution by CytRx of these securities to
its shareholders. SynthRx shall bear all of
the expenses of any registration of
CytRx's SynthRx securities under this
Section 2.9.
2.10
Strategic Transactions. In the event of a merger,
consolidation or sale of assets by SynthRx
in which SynthRx's shareholders are
to receive any payments for or with respect
to their SynthRx shares, CytRx shall
have the right to require its payment
options be no less favorable than any
other shareholder. In the event SynthRx
seeks to enter into any strategic
alliance, joint venture, merger or
acquisition, financing, any in-licensing or
out-licensing of a technology or other
similar transaction (a "Strategic
Transaction"), it may request the
assistance of CytRx in structuring and
completing such Strategic Transaction. If
CytRx provides this assistance,
SynthRx shall pay CytRx for this assistance
an amount equal to 10% of all
consideration received or paid (including
debt assumed) by SynthRx throughout
the term of the Strategic Transaction,
including without limitation license
payments, milestone payments, or royalties,
with any such payment to be deemed
to be an additional payment for the license
granted to SynthRx under Article III
hereof. In the case of payments to CytRx
for this assistance in connection with
any sublicensee of the license granted to
SynthRx under Article III hereof, the
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total amount to be paid to CytRx under this
Section 2.10 and under the license
shall not exceed 25% of the license fee,
milestone payments and royalties paid
by the sublicensee to SynthRx.
ARTICLE III.
LICENSE
3.1 SynthRx
License Grant. Subject to the payment set forth in
Section 2.2 hereof, CytRx shall grant to
SynthRx effective as of the Second
Closing Date an exclusive license in the
Territory, with the right to
sublicense, the Licensed Intellectual
Property to research, develop, use,
manufacture, have manufactured, sell, offer
to sell or have sold (i) Licensed
Products; and (ii) Opti-Vax as it relates
to use in the Field. The license shall
be in the form of the License Agreement
attached hereto as SCHEDULE C, which
shall be executed by SynthRx and CytRx
effective as of the Closing Date.
3.2 Assignment
of Hunter Intellectual Property. Hunter shall
assign to SynthRx without any further
payment by SynthRx all of Hunter's rights,
title and interest in and to the Hunter
Know-How effective as of the Closing
Date. Within 60 days of the Closing Date,
Hunter shall make available to SynthRx
in English and in writing for its use,
Hunter Know-How in Hunter's possession as
of the Closing Date, including but not
limited to the embodiments of such Hunter
Know-How as set forth on the attached
SCHEDULE D. Hunter also warrants that he
has no pending patent applications. During
the term of this Agreement Hunter
shall promptly disclose to SynthRx in
writing on an ongoing basis all Hunter
Know-How not previously disclosed.
ARTICLE IV.
CONFIDENTIALITY AND PUBLICATION
4.1
Nondisclosure Obligation. All Proprietary Information
disclosed by a disclosing party to a
receiving party hereunder shall be
maintained in confidence by the receiving
party and shall not be disclosed to a
non-party or used for any purpose except as
set forth herein without the prior
written consent of the disclosing party,
except to the extent that such
Proprietary Information:
(a) is known
by recipient at the time of its receipt, and
not through a prior disclosure by the
disclosing party, as documented by
business records;
(b) is
properly in the public domain;
(c) is
subsequently disclosed to the receiving party by a
third party who may lawfully do so and is
not under an obligation of
confidentiality to the disclosing
party;
(d) is
developed by the receiving party independently of
Proprietary Information received from the
disclosing party as documented by
business records;
(e) is
disclosed to governmental or other regulatory
agencies in order to obtain patents or to
gain approval to conduct clinical
trials or to market Licensed Product, but
such disclosure may be only to the
extent reasonably necessary to obtain
patents or authorizations upon prior
review and consent of the disclosing
party;
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(f) is deemed
necessary by SynthRx to be disclosed to
sublicensees, agents, consultants,
Affiliates, distributors and/or other third
parties for the research and development,
manufacture, use sale or offer for
sale of Licensed Products (or for such
parties to determine their interest in
performing such activities) in accordance
with this Agreement on the condition
that such third parties agree to be bound
by the confidentiality obligations
contained in this Agreement, provided the
term of confidentiality for such third
parties shall be no less than ten (10)
years; or
(g) is
required to be disclosed by law or court order,
provided that notice is promptly delivered
to the other party in order to
provide an opportunity to challenge or
limit the disclosure obligations.
ARTICLE V.
TERM AND TERMINATION
5.1 Term and
Expiration. This Agreement shall continue in effect
until the later of ten years from the
Effective Date or expiration of all
royalty obligations under the License
Agreement.
5.2
Termination for Cause. Either CytRx or Hunter may terminate
this Agreement by written notice to the
other party prior to the Second Closing
Date in the event the other party fails to
cure a breach of its obligations
under this Agreement within 10 days after
receiving written notice of such
breach. After the Second Closing Date,
either CytRx or SynthRx may terminate
this Agreement by written notice to the
other party in the event the other party
fails to cure a breach of its obligations
under this Agreement within 30 days
after receiving written notice of such
breach. In addition to terminating this
Agreement and any other remedies that may
be available to CytRx as a result of
any uncured breach by Hunter or SynthRx
under this Agreement, CytRx shall be
entitled to terminate the license granted
under the License Agreement.
ARTICLE VI.
MISCELLANEOUS
6.1
Assignment. This Agreement may not be assigned by Hunter or
CytRx prior to the Closing Date. After the
Closing Date, CytRx or SynthRx may
assign this Agreement without the other
party's consent in connection with a
merger into, a consolidation with, or a
transfer of all or substantially all of
its corporate assets or the transfer of all
or substantially all of the assets
related to the product line to which this
Agreement pertains as an entirety or
to any corporation, partnership or other
person or entity, so long as the
successor surviving person or entity in any
such merger, consolidation,
partnership or other person or entity
transfer or reorganization assumes in
writing the obligations of this Agreement.
Such merger, consolidation, transfer
or reorganization shall not in any way be a
breach of this Section 6.1, nor be a
default under this Agreement. Any permitted
assignee shall assume all
obligations of its assignor under the
Agreement.
6.2
Severability. In the event any one or more of the provisions
contained in this Agreement should be held
invalid, illegal or unenforceable in
any respect, the validity, legality
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and enforceability of the remaining
provisions contained herein shall not in any
way be affected or impaired thereby, unless
the absence of the invalidated
provision(s) adversely affect the
substantive rights of the parties. The parties
shall in such an instance use their best
efforts to replace the invalid, illegal
or unenforceable provision(s) with valid,
legal and enforceable provision(s)
which, insofar as practical, implement the
purposes of this Agreement.
6.3 Notices.
All notices or other communications which are
required or permitted hereunder shall be in
writing and sufficient if delivered
personally, sent by telecopier (and
promptly confirmed by personal delivery,
registered or certified mail or overnight
courier), sent by
internationally-recognized overnight or
second day courier or sent by registered
or certified mail, postage prepaid, return
receipt requested, addressed as
follows:
if to CytRx, to:
CytRx Corporation
11726 San Vicente Boulevard
Suite 650
Los Angeles, California 90049
Attention: President & CEO
Facsimile No. (310) 826-5529
if to Hunter, to:
Robert L. Hunter
4606
Willow
Bellaire, TX 77401
Facsimile No.: (713) 500 - 0732
if to SynthRx, to:
To be provided when SynthRx becomes
operational________________________
___________________________________
Facsimile No.:
(_____)____________
or to such other address as the party to
whom notice is to be given may have
furnished to the other party in writing in
accordance herewith. Any such
communication shall be deemed to have been
given when delivered if personally
delivered or sent by telecopier on a
business day, on the business day after
dispatch if sent by nationally-recognized
overnight courier and on the third
business day following the date of mailing
if sent by mail.
6.4 Applicable
Law. The Agreement shall be governed by and
construed in accordance with the laws of
the State of Texas and the United
States without reference to any rules of
conflict of laws.
6.5 Dispute
Resolution. The parties shall negotiate in good faith
and use reasonable efforts to settle any
dispute, controversy or claim arising
from or related to this Agreement or the
breach thereof. If the parties do not
fully settle, and a party wishes to pursue
the matter, each such dispute,
controversy or claim that is not an
"Excluded Claim" shall be finally resolved
by binding arbitration in Las Vegas, Nevada
in accordance with the Commercial
Arbitration Rules and Supplementary
Procedures for Large Complex Disputes of the
American Arbitration Association ("AAA"),
and judgment on the arbitration award
may be entered in any court having
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jurisdiction thereof. A panel of three
persons experienced in the pharmaceutical
business shall conduct the arbitration.
Within 30 days after initiation of
arbitration, each party shall select one
person to act as arbitrator and the two
party-selected arbitrators shall select a
third arbitrator within 30 days of
their appointment. If the arbitrators
selected by the parties are unable or fail
to agree upon the third arbitrator, the AAA
shall appoint the third arbitrator.
Any party may apply to the arbitrators for
interim injunctive relief until the
arbitration award is rendered or the
controversy is otherwise resolved. Any
party also may, without waiving any remedy
under this Agreement, seek from any
court having jurisdiction any injunctive or
provisional relief necessary to
protect the rights or property of that
party pending the arbitration award. The
arbitrators shall have no authority to
award punitive or any other type of
damages not measured by a party's
compensatory damages. Each party shall bear
its own costs and expenses and attorneys'
fees and an equal share of the
arbitrators' and any administrative fees of
arbitration. Except to the extent
necessary to confirm an award or as may be
required by law, neither a party nor
an arbitrator may disclose the existence,
content, or results of an arbitration
without the prior written consent of both
parties. In no event shall an
arbitration be initiated after the date
when commencement of a legal or
equitable proceeding based on the dispute,
controversy or claim would be barred
by the applicable Texas statute of
limitations. As used in this Section, the
term "Excluded Claim" shall mean a dispute,
controversy or claim that concerns
(a) the validity or infringement of a
patent, trademark or copyright; or (b) any
antitrust, anti-monopoly or competition law
or regulation, whether or not
statutory.
6.6 Entire
Agreement. This Agreement contains the entire
understanding of the parties with respect
to the subject matter hereof. All
express or implied agreements and
understandings, either oral or written,
heretofore made are expressly merged in and
made a part of the Agreement. The
Agreement may be amended, or any term
hereof modified, only by a written
instrument duly executed by each of the
parties hereto.
6.7 Headings.
The captions to the several Articles and Sections
hereof are not a part of the Agreement, but
are merely guides or labels to
assist in locating and reading the several
Articles and Sections hereof.
6.8
Independent Contractors. It is expressly agreed that the
parties shall be independent contractors
and that the relationship between the
parties shall not constitute a partnership,
joint venture or agency. No party
shall have the authority to make any
statements, representations or commitments
of any kind, or to take any action, which
shall be binding on any other party,
without the prior consent of the other
party.
6.9 Waiver.
The waiver by either party hereto of any right
hereunder or the failure to perform or of a
breach by the other party shall not
be deemed a waiver of any other right
hereunder or of any other breach or
failure by said other party whether of a
similar nature or otherwise.
6.10
Counterparts. The Agreement may be executed in two or more
counterparts, each of which shall be deemed
an original, but all of which
together shall constitute one and the same
instrument.
10
<PAGE>
6.11
Waiver of Rule of Construction. Each party has had the
opportunity to consult with counsel in
connection with the review, drafting and
negotiation of this Agreement. Accordingly,
the parties agree that the rule of
construction that any ambiguity in this
Agreement shall be construed against the
drafting party shall not apply.
IN WITNESS WHEREOF, the parties have executed this Agreement as of
the
date first set forth above.
/s/ ROBERT L. HUNTER
--------------------------------
Dr. Robert L. Hunter
Date: October 21, 2003
--------------------------
CYTRX CORPORATION
By: /s/ STEVEN A. KRIEGSMAN
---------------------------
Title:
------------------------
Date:
-------------------------
11
<PAGE>
SCHEDULE A
PATENTS & LICENSES
U.S. PATENT
5,554,372 (subject to U.S. government
regulations)
5,990,241
6,086,899
RE 36,665
5,567,859
5,696,298
5,824,322
Pending application 90/104,088
RELATED FOREIGN PATENTS
WO96/04932
U.S. PATENT
5,234,683
5,114,708
5,824,322
RELATED FOREIGN PATENTS
596,986
Australia
556
Spain
1,279,822
Canada
228,448
France
36,564
Chile
228,448
United Kingdom
96,104,742
China
176,179
Mexico
228,448
Germany
228,448
Netherlands
228,448
EPO
864,556
South Africa
A - 1
<PAGE>
LICENSE AGREEMENTS
<TABLE>
<CAPTION>
AGREEMENT
DATE
---------
----
<S>
<C>
TiterMax, USA, Inc.
June 15, 2000
Merck & Co.
November 1, 2000
Ivy Animal Health
February 16, 2001
Vical Incorporated
December 7, 2001
PSMA Development Co., LLC
December 23, 2002
(option agreement)
TransForm Pharmaceuticals, Inc.
April 22, 2003
</TABLE>
A-2
<PAGE>
SCHEDULE B
HUNTER PATENT RIGHTS
None
B - 1
<PAGE>
SCHEDULE C
LICENSE AGREEMENT
THIS LICENSE AGREEMENT (this "Agreement") is made and is effective
as
of ______ ___, 2003, (the "Effective Date")
between SynthRx, Inc. a Texas
corporation ("SynthRx") and CytRx
Corporation, a Delaware corporation ("CytRx")
with reference to the following facts:
A.
CytRx has developed CytRx Know-How (as hereinafter defined)
and has CytRx Patent Rights (as hereinafter
defined) in the fields of:
(i) the
composition and use of surface-active copolymers
exemplified by poloxamer 188 to treat
ischemic or damaged tissue, myocardial
damage, stroke, pathological hydrophobic
interactions in biological fluids,
tissue damaged by reperfusion injury,
sickle cell disease, cancer and in
performing angioplasty procedures (with the
CytRx Know-How and CytRx Patent
Rights in this field referred to
collectively as the "FLOCOR Intellectual
Property");
(ii) the composition and
use of surface active copolymers
(exemplified by poloxamers, reverse
poloxamers and diether, diester or diamide
fatty acid conjugates of poloxyethylene) to
treat infections caused by
microorganisms, including bacteria, fungi,
and viruses and to treat tumors (with
the CytRx Know-How and CytRx Patent Rights
in this field referred to
collectively as the "Anti-Infectives
Intellectual Property"); and
(iii)
conventional vaccine adjuvants exemplified by
poloxamer P1005 (with the CytRx Kn