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EX-10.7 UNPROTECTED LEASE AGREEMENT

Office Lease Agreement

EX-10.7 UNPROTECTED LEASE AGREEMENT | Document Parties: PREDIX PHARMACEUTICALS HO | You are currently viewing:
This Office Lease Agreement involves

PREDIX PHARMACEUTICALS HO | "EMED" REAL ESTATE DEVELOPMENT AND INVESTMENTS COMPANY LTD.

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Title: EX-10.7 UNPROTECTED LEASE AGREEMENT
Date: 8/3/2005

EX-10.7 UNPROTECTED LEASE AGREEMENT, Parties: predix pharmaceuticals ho ,
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                                                                    Exhibit 10.7

 

                           UNPROTECTED LEASE AGREEMENT

 

        THAT WAS DRAWN UP AND EXECUTED IN TEL AVIV ON SEPTEMBER 26, 2004

 

                                      BETWEEN

 

           "EMED" REAL ESTATE DEVELOPMENT AND INVESTMENTS COMPANY LTD.

                         Public Company No. 52-002359-9

                        Of 3 Hayetzira Street, Ramat Gan

                                                   (hereinafter: the "LANDLORD")

                                                                 ON THE ONE HAND

 

                                       AND

 

                           PREDIX PHARMACEUTICALS LTD.

                             COMPANY NO. 51-2864307

                         OF 3 HAYETZIRA STREET, RAMAT GAN

                                                     (hereinafter: the "TENANT")

                                                               ON THE OTHER HAND

 

In this Lease the following terms shall have the meanings set forth next to

them:

 

"THE STRUCTURE" OR "THE BUILDING"        - a building intended for offices for

                                        commerce and for parking on Bezalel

                                        Street, corner Hayetzira Street, in

                                        Ramat Gan, which is also known by the

                                        nickname "Sh. A. P. House".

 

"THE DEMISED PREMISES" OR "THE UNIT"     - 19th floor, north east.

 

"INDEX"                                   - The Consumer Price Index (including

                                        fruits and vegetables) that is published

                                        by the Central Statistics Office (the

                                        "OFFICE").

 

"THE BASIC INDEX"                        - The Index that was published on

                                        September 15, 2004 for the month of

                                        August 2004.

 

"LINKED" "LINKAGE DIFFERENTIAL"          Multiplying the relevant amount by the

"LINKED VALUES" AND ANY SIMILAR TERM:    relevant value between the last Index

                                        published before the time of the

                                        calculation and/or the payment relevant

                                        to the matter (hereinafter: the "NEW

                                        INDEX") and the Basic Index, or in the

                                        ratio between any other indices if it is

                                         so stated specifically in this Lease.

 

"THE REPRESENTATIVE RATE"                The representative rate of the Dollar as

                                        it is published by the Bank of Israel

                                         for the date

 

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                                        relevant for the carrying out of the

                                        calculation and/or the payment.

 

"THE DEMISED PREMISES FOR PURPOSES       600 square meters. This area is agreed

OF THE PAYMENT OF RENT"                  upon and is not given to inspection

                                        and/or taking exception and/or appeal on

                                        the part of any of the parties.

 

WHEREAS-                                  the Landlord is the sole possessor of

                                        the Demised Premises and the owner of

                                        the rights to register as the sole owner

                                         of the Demised Premises, and it

                                        represents that it is entitled to lease

                                        the Demised Premises, and there is no

                                        impediment to entering into a

                                        contractual relationship by means of

                                        this Lease; and

 

WHEREAS -                                the Tenant approached the Landlord and

                                         proposed to it that it lease the Demised

                                        Premises from it, all pursuant to the

                                        terms and for the consideration detailed

                                        below in this Lease; and

 

WHEREAS -                                the Landlord agreed to lease the Demised

                                        Premises to the Tenant, all pursuant to

                                        the terms and for the consideration

                                         detailed below in this Lease and in the

                                        exhibits annexed to it; and

 

WHEREAS -                                the parties desire to define and arrange

                                         their legal relationship as detailed in

                                        this Lease Agreement as follows:

 

              THEREFORE, IT IS REPRESENTED, AGREED AND CONDITIONED

                         BETWEEN THE PARTIES AS FOLLOWS:

 

The Preamble to this Lease and the exhibits thereto constitute an integral part

thereof. In the event that any exhibit is not annexed to this Lease at the time

of its signing, that exhibit shall be annexed at the time of its preparation,

and it shall be deemed to be an integral part of the Lease.

 

1.     THE TRANSACTION

 

      The Landlord obligates itself to lease to the Tenant, and the Tenant

      obligates itself to lease from the Landlord, the Demised Premises pursuant

      to the terms and at the price detailed in the Lease, including its

      exhibits.

 

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2.     THE TENANT'S REPRESENTATIONS

 

      The Tenant represents that it inspected the Building and its surroundings,

      as well as the Demised Premises, and found them appropriate for its needs

       and that, subject to the delivery of the Demised Premises to the Tenant at

      the appointed delivery time in its current condition, the Tenant shall not

      have any claim of inappropriateness of any nature whatsoever, subject only

      to the terms of this Lease.

 

3.     THE PURPOSE OF THE LEASE

 

      3.1    The Tenant is leasing the Demised Premises in order to operate /

            manage offices therein (hereinafter: the "LEASE PURPOSE"), and for

            no other purpose.

 

      3.2    Any substantive change or broadening of the Lease Purpose requires

            the prior written approval of the Landlord.

 

      3.3    The Tenant represents and warrants that it will not object to the

            fact that the other businesses and offices or some of them will

            conduct their businesses at the times and the hours that they deem

            fit and that it will not have any complaint whatsoever with regard

            thereto.

 

      3.4    The Tenant represents and warrants that it is aware that other

            businesses and offices will operate in the Building, and it

            represents and warrants that it will not have any complaint

            whatsoever against the Landlord with regard thereto, including with

            regard to their hours of operation, the entry and exit arrangements

            they have, the noise interference, the oppression of smells, or any

            other nuisance whatsoever resulting from their activities.

 

      3.5    In order to avoid doubt, it is agreed and clarified hereby that the

            Tenant itself shall be responsible for obtaining all permits

            required by law to open and operate its business in the Demised

            Premises.

 

            The Tenant commits to fulfill all the terms required for the purpose

            of obtaining all the permits, as aforesaid, to manage its business

            pursuant to their terms, and to maintain them in effect throughout

            the entire lease term.

 

4.     THE TERM OF THE LEASE

 

      4.1    The lease term pursuant to this Lease shall commence on October 15,

            2004 (hereinafter: the "DELIVERY DATE"). The entry upon the Demised

            Premises shall be permitted already on October 3, 2004, and from

            that date onward the Tenant shall bear the costs of Arnona

            [municipal real estate taxes], electricity, water, maintenance, and

            the like, other than rental payments.

 

      4.2    The rental term shall terminate at the end of 24 months from its

            commencement, as stated in Section 4.1 above, that is, on October

            14, 2006 (the period between October 15, 2004 and October 14, 2006

            shall be referred to below as: the "LEASE TERM").

 

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            The Landlord hereby gives the Tenant its consent to extend this

            Lease after the Lease Term, for four (4) additional option terms of

            one year each, according to the absolute discretion of the Tenant.

            During the first option period, should the Tenant elect to exercise

            it, the same terms as are detailed in this Lease shall apply.

            Thereafter, should the Tenant elect to make use of the second option

            period, the rental payments (as defined in Section 5.1) shall be

            increased by 5% (the "MONTHLY RENTAL PAYMENTS"). The Monthly Rental

            Payments shall be in effect for the second option period and for the

            two periods thereafter, should the Tenant elect to exercise them,

             and the balance of the terms detailed in this Lease shall apply.

 

            Despite what is stated above, the Tenant shall be entitled at any

            time to bring a replacement tenant in its stead, who shall assume

            all the obligations pursuant to this Lease, provided that the

            Landlord approves the replacement tenant, as aforesaid. The Landlord

            shall be allowed to object to the replacement tenant only for

            reasonable reasons.

 

      4.3    INTERNAL WORK / IMPROVEMENTS / INSTALLATION OF AIR CONDITIONER

 

            4.3.1 The entry of the Tenant onto the Demised Premises shall be

                  conditioned on the delivery of the securities as detailed in

                  Section 14 below.

 

             4.3.2 The Landlord hereby gives its consent for internal work within

                  the Demised Premises, including improvements for the purpose

                  of making it compatible to the needs of the Tenant. This

                  consent is conditioned upon the delivery of a drawing of the

                  improvements which shall be approved by the Landlord.

 

            4.3.3 The Tenant shall solely be liable for the carrying out of the

                  internal work and it covenants that the works will be carried

                  out according to all laws related to their undertaking,

                  including safety instructions, and in coordination with the

                  management company.

 

            4.3.4 The Tenant shall be responsible for any damage that shall be

                  caused during the course of the internal work or as a result

                  thereof to those carrying out the work, to the Landlord and

                  its employees if they entered upon the Demised Premises in

                  coordination with the Tenant, to third parties, as well as to

                  the Demised Premises, to adjacent units, and to the project.

 

            4.3.5 The Landlord hereby gives its consent to the Tenant to install

                  two mini central air conditioners having a volume of six horse

                  power each, on the service floor of Sh. A. P. House, which

                  will serve to cool the service room in the Demised Premises

                   Building.

 

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5.     RENTAL PAYMENTS

 

      The Tenant shall pay the Landlord rent throughout each Lease Term, as

      detailed in the provisions of Section 4 above, in accordance with the

      provisions below:

 

      5.1    The Tenant shall pay the Landlord rent for the Demised Premises in

            the New Israeli Shekel equivalent of $14.50 (fourteen and one half

            U. S. Dollars) per square meter per month, in addition to Value

            Added Tax.

 

      5.2    The rent for the Demised Premises and throughout all the Lease Terms

            shall be paid by the Tenant each six (6) months in advance

            (hereinafter: the "RENT").

 

      5.3    Value Added Tax on the Rent, or any tax that comes in its stead, or

            any tax which, according to the law that imposes it, applies it to

            the Tenant, at the rate that shall apply from time to time according

            to the law, shall be the obligation of the Tenant and shall be paid

            by it by post-dated check dated the date of the payment of the VAT

            to the tax authorities with each payment on account of the rent in

            return for a tax receipt as provided by law. Any tax and/or impost

            which, according to the law that imposes it, applies it to the

            Landlord and/or on the owner of the Demised Premises, shall be paid

            by the Landlord and shall not influence the level of the Rent and

            its manner of payment.

 

      5.4    The Tenant covenants to pay the Rent to the Landlord and the

            management fees to the management company during the entire Lease

            Term, without any condition, and subject to the other terms of this

            Lease, including the provisions of the latter part of Section 4.2,

            whether it made use of the Demised Premises or not, for whatever

            reason. It is emphasized that any claim that the Tenant may have

            against the management company, including regarding setting off

             management fees, shall apply as well to the obligation that appears

            in this section regarding the management fees.

 

6.     ADDITIONAL PAYMENTS

 

      6.1    Throughout the entire Lease Term the Tenant shall pay, in addition

            to the Rent, all the municipal and/or governmental or other

            payments, imposts, arnonas, taxes and obligatory payments of any

            sort whatsoever, including fees, registration and license fees of

            any sort whatsoever relating to the Demised Premises and/or its

            operation and/or its maintenance which apply to whoever rents the

            Demised Premises. Taxes and imposts relating to the Demised

            Premises, its operation, its maintenance, or with regard to the Rent

            that will be imposed in the future and that are not in existence at

            the time of the execution of this Lease Agreement, shall be imposed

            upon the Tenant if it is determined therein that they apply to the

            Tenant. It should be emphasized that all that is stated above shall

            apply only and exclusively regarding payments relating to the use of

            the Demised Premises by the Tenant.

 

            The Landlord shall bear the payment of the property tax and other

            taxes if they are imposed in the future for the rights of ownership

            of the Demised Premises, as

 

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            well as income taxes for the Rent. The Landlord shall bear any tax

            and/or impost and/or other payment in which it is provided that it

            applies to the owner of the Demised Premises or on the party leasing

            out the property, including one-time imposts and fees, such as road

            imposts, sewage (that is not included as a regular monthly payment

            in the arnona payment), etc.

 

      6.2    Without derogating from the generality of the foregoing, the Tenant

            shall bear throughout the Lease Term all payments for the supply of

            water, electricity, telephone, arnona, business tax, sign tax, or

            any other expenditure relating to the use and operation of the

            Demised Premises. The Landlord represents that on those items there

            are no existing debts that were generated prior to the Lease Term

            and that are likely to prevent the use thereof by the Tenant.

 

      6.3    The Tenant shall bear, throughout the entire Lease Term, payments

            due for maintenance and management of the Building in accordance

            with the provisions of the Management Agreement to which it is a

            party and in accordance with the law.

 

      6.4    The Tenant covenants to notify in writing the City of Ramat Gan, the

            Electric Company, and other interested parties regarding the lease

            of the Demised Premises.

 

            Shortly after the time of the commencement of the lease the Tenant

            covenants, should the Landlord so direct him, to transfer the water

            and/or telephone and/or electricity and/or municipal and/or any

            other account that relates to a payment and/or tax that is the

            responsibility of the Demised Premises and generally is paid by the

            Tenant, to the name of the Tenant.

 

7.     MANAGEMENT OF THE BUILDING

 

      7.1    The Tenant will sign with the management company of the Building the

            Management Contract annexed hereto as Exhibit A. the Tenant shall

            pay the management company the management fees as demanded by the

            management company, in accordance with the Management Contract with

            it and in accordance with law.

 

      7.2    The signature of the Tenant on this Lease Agreement and on the

            Management Contract as an exhibit thereto constitutes a direct

            obligation toward the management company, as well as an obligation

            of the Tenant toward the Landlord to fulfill all of its obligations

            toward the management company, whether they are detailed in this

            Lease and whether as they are detailed in the Management Contract

            described above, subject to what is stated in Section 5.4 above.

 

8.     GARAGE AND PARKING SPACES

 

      Within the framework of the Building there were built an underground

      parking garage and an above ground parking garage (collectively: the

      "GARAGES"). The Tenant affirms that it is aware that the Garages are

      operated as garages for commercial purposes by an

 

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      external operator (hereinafter: the "OPERATOR"). It is agreed that the

      Landlord and the external Operator shall be entitled to determine, inter

      alia, a different price for a specific parking space than for an

      unreserved parking space, to collect parking fees from various users on

      the basis of parking by the hour, by the day, or any other period and

      similar commercial considerations upon which the Landlord and the Operator

      shall decide in their discretion.

 

9.     LIABILITY, INDEMNIFICATION AND INSURANCE

 

      The Tenant, and it alone, shall be liable for all bodily and/or property

      damages that shall be caused, as well as for any tort that shall occur in

      the Demised Premises - all in connection with the possession of the

      Demised Premises and/or the use that shall be made thereof, all on

      condition that the damage was not caused willfully and/or intentionally by

      the Landlord and/or the management company and/or by someone acting on

      their behalf or as a result of their failure to act.

 

      The Tenant absolves the Landlord from any liability for damage to property

      found on the Demised Premises (its own property or that of others), as

      well as for all indirect or consequential damages (loss of profits, loss

      of goodwill, etc.) should any of these occur during the Lease Term -

      regardless of what was the cause that brought them on, and all on

      condition that the damage was not caused by a willful or intentional act

      by the Landlord and/or the management company and/or by someone acting on

      their behalf or as a result of their failure to act.

 

      The Landlord shall not bear any liability for bodily injury to the Tenant

      itself, to the employees of the Tenant, to its customers, visitors,

      invitees, or to any other person who arrived at the Building at the

      direction of the Tenant or for any purpose whatsoever connected with the

      Tenant, to the business and/or in the Demised Premises, and which shall be

      caused in the Demised Premises, during the Lease Term, except in those

      cases where the Landlord willfully and/or intentionally caused the damage.

      The liability of the Tenant to the Landlord and/or anyone acting on its

      behalf who is located on the Demised Premises shall not apply if their

      presence is unlawful.

 

      It should be emphasized that the liability of the Tenant pursuant to this

      section is solely and exclusively with regard to the net area of the

      Demised Premises, and shall not apply to the public areas included within

      the framework of this Lease (including bathrooms, stairs, elevators,

      Garage, lobby and the like), and in any event are not intended to derogate

      from the Landlord's liability under law.

 

      The Tenant shall indemnify the Landlord for any damage and/or claim and/or

      debt that the Landlord shall be required to pay in connection with damages

      the source of which is an act of negligence on the part of the Tenant that

      shall have occurred in the Demised Premises and/or in connection with

      and/or related to the possession of the Demised Premises and/or in

      connection with the use made thereof and for which the Tenant is liable

      therefore, as noted above, all immediately upon receipt of the first

      demand in writing from the Landlord, and on condition that a notice of

      damage and/or claim and/or

 

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      debt as aforesaid is delivered to the Tenant immediately upon its receipt,

      and that the Tenant shall have the opportunity to defend against the same.

 

      Without derogating from the provisions of this Section 9, the provisions

      of the liability insurance and the indemnification are included in EXHIBIT

      C annexed hereto, and which constitute an integral part of this Lease.

 

10.    MAINTENANCE OF THE DEMISED PREMISES AND ITS MANAGEMENT

 

      10.1   The Tenant shall be responsible for obtaining the required licenses

            pursuant to any law for the use of the Demised Premises according to

            its purpose and to maintain them in force. The Landlord represents

            that all the licenses and permits in order to occupy the Demised

            Premises and to make general use thereof were received and lawfully

            are in effect.

 

      10.2   The Tenant shall conduct its business in accordance with all laws

            relating thereto, and without causing any interference including,

            but not limited to, noise, smell, pollution, etc., and also not to

            interfere with the other businesses and offices and the environment,

            and also not to interfere with their quiet enjoyment, except for

            reasonable activities, such as repairs, moving equipment, and the

             like.

 

      10.3   The Tenant shall conduct its business in the Demised Premises while

            paying close attention to the regulations and the instruction of the

            management company as a result of its authority, as set forth in

             Section 7 above and its subsections.

 

      10.4   Subject to the liability of the Landlord as the developer who

            established the Building to repair defects that are discovered in

            the Demised Premises and that flow from defective construction, use

            of defective materials, and the like, the Tenant covenants to

            maintain the Demised Premises during the entire Lease Term in a good

            and orderly condition, and will repair without delay and at its own

             expense, any spoilage, damage or defect that is revealed therein

            that is a result of its use, except reasonable wear and tear. Should

            the Tenant not have done so within a reasonable amount of time from

            when it was requested to do so, then the Landlord shall be entitled

            to enter upon the Demised Premises to do so in its stead and at its

            expense, and that without derogating from the right of the Landlord

            for any other relief.

 

             The Tenant will relinquish the possession of the Demised Premises to

            the Landlord at the end of the Lease Term or sooner if this Lease is

            terminated, in the same condition in which it received it, subject

            to reasonable wear and tear. Prior to the vacation of the Demised

            Premises, the Tenant shall remove from the Demised Premises at its

            own expense each object and each addition or fixed device that was

            installed by it and shall restore the situation to its prior

            condition unless the Landlord expressly and in writing agreed to

            leave some of them in the Demised Premises, in which case the same

            shall become its property without any payment therefor. The

            provisions of this section shall not apply to the results of the

            improvements that will be carried out by the Tenant, as stated in

            Section 4.3

 

<PAGE>

 

            above, and which shall be acceptable to the Landlord after approval

            of the drawing of the improvement by the Landlord, as stated above.

 

      10.5   The Landlord shall be entitled, should it so desire, to enter the

            Demised Premises from time to time at reasonable times and with

             prior coordination in order to inspect the fulfillment of the terms

            of this Lease Agreement and/or in order to carry out works and

            repairs.

 

      10.6   The Tenant shall not be entitled to make changes and/or additions to

            the Demised Premises without the prior written consent of the

            Landlord, and in accordance with the terms of the consent, if it is

            given, all according to the absolute discretion of the Landlord,

            provided that the consent not be withheld other than for reasonable

            and relevant grounds.

 

      10.7   The Tenant shall not affix signs or notices on the external walls of

            the Demised Premises or the Building without the prior written

             consent of the payment of the sign tax according to the law. It is

            agreed that the Tenant is entitled to affix and/or to install signs

            on the entrance door to the office, in the lobby of the floor, and

            in the lobby at the entrance to the Building -- at a place set aside

            for it on behalf of the Building management.

 

      10.8   The Tenant will not permit the activities of outside contractors in

            the Demised Premises or in the surroundings without the written

            consent of the Landlord, and in any case the Tenant shall be

            required to verify that the contractor will operate in coordination

            with the Landlord and/or the management company and/or their

            representatives and will follow all the directives given by them.

            The aforesaid shall not apply to repairs or minor works that are not

            likely to affect the Demised Premises and its devices.

 

      10.9   If, and to the extent that, within the framework of the Demised

            Premises a shelter is included, the Tenant shall have the right to

            use the protected area, subject to the Tenant's obligation to permit

            all the tenants of the floor and/or the Building to use the

            protected area where the same is required, in accordance with the

            directions of the civil defense forces and any other appropriate

            authority.

 

            The Tenant obligates itself not to make use of the protected area,

            not to install therein devices, and not to make changes and/or

            additions to it other than as permitted or required pursuant to the

            instructions of the appropriate authorities as they shall be

            installed and/or be amended from time to time.

 

            Should the Tenant not act in accordance with the directives of the

            civil defense authorities and/or any other appropriate authority,

            then the Landlord shall be entitled to enter upon the protected area

            and act therein on its own in accordance with the directives of the

            appropriate authorities, but only after it requested that the Tenant

            do so and it did not do so within a reasonable period of time from

            the time that it was requested so to do.

 

<PAGE>

 

11.    ASSIGNMENT OF RIGHTS

 

      11.1   The Tenant shall not lease the Demised Premises or any part thereof

            in a sublease, shall not assign it or any part thereof to another

             and shall not permit anyone else to make use of it or any part

            thereof, for or without consideration, and likewise it will not

            place a charge or mortgage on any of its rights under this Lease

            Agreement unless it received the express prior written consent of

            the Landlord.

 

      11.2   The Landlord shall be entitled to transfer and/or to assign and/or

            to charge, in part or in whole, its rights in the Building and/or to

            the Demised Premises and/or its rights pursuant to this Lease, in

            whole or in part, provided that the rights of the Tenant not be

            affected. The Tenant obligates itself to cooperate and to sign any

            document that is required or that it shall be requested by the

            Landlord to approve and/or to carry out the foregoing.

 

12.    RELIEF AND REMEDIES

 

      12.1   If any party to this Lease Agreement breaches one of its terms, the

            injured party shall be entitled to all the remedies provided in the

            Contracts Law (Remedies for Breach of Contract), 5731-1970, and that

            without derogating from the provisions of this Lease or the

            provisions of any law, and that also in case a specific relief is

            provided is determined for any breach within the framework of this

            Lease.

 

      12.2   Without derogating from its rights to greater compensation or to any

            other relief, it the case of a fundamental breach of this Lease

            Agreement by the Tenant, or any other breach which is not cured

            within 30 days of the written demand of the Landlord, then the

            Landlord shall be entitled to receive liquidated damages estimated

            in advance to be $3,000 per month (or the pro rata portion thereof)

            linked to the Index as specified, and until the actual date of

            payment, and that whether it opts to enforce the lease or opts to

            terminate it, and the parties represent that they view the above

            amount as fair compensation for the damage that the parties view as

            the aggregate outcome of the fundamental breach of this Lease

            Agreement.

 

      12.3   Any breach of any of the provisions of the Lease set forth below

            shall be deemed to be a fundamental breach thereof:

 

            12.3.1 Any breach of the provisions of Subsections 3.1, 7.1, 10.4,

                   10.6 and Sections 11 and 14 of this Lease that is not cured

                    within 14 days from the time of the giving of notice by the

                   Landlord.

 

            12.3.2 A delay in the making of any payment that the Tenant is

                   obligated to make pursuant to the provisions of Sections 5

                   and 6 (including the subsections thereof) of this Lease, for

                   a period in excess of 14 days and/or any 3 consecutive late

                   payments of a payment that the Tenant must make to the

                   Landlord during the course of a lease year.

 

<PAGE>

 

            12.3.3 Any other breach that is not cured within 30 days from the

                   time that the Landlord demanded that the Tenant cure the

                   aforesaid breach.

 

      12.4   The Landlord shall be entitled to cancel this Lease Agreement and to

            demand that the Tenant immediately vacate the Demised Premises and

            return the possession thereof to it under the terms provided in

            Section 10.4 above in each of the following cases:

 

            12.4.1 The Tenant made a fundamental breach of this Lease Agreement.

 

            12.4.2 The Tenant breached in any manner the provisions of this

                   Lease Agreement and did not cure the breach within 30 days

                   from the date requested.

 

            12.4.3 A motion was submitted to a court having jurisdiction to

                   liquidate the Tenant or to declare it bankrupt, to appoint a

                   trustee, liquidator, temporary liquidator, preliminary

                   liquidator, a receiver for a substantial portion of its

                   assets for it, and a court order is issued in response to the

                   motion, and the order is not set aside within 90 days of its

                   having been issued and/or id the Tenant filed a motion for

                   its liquidation or to have it declared a bankrupt and/or to

                   have an arrangement of creditors.

 

            If a cancellation notice is given, the following provisions shall

            apply:

 

            In the case the Tenant is liquidated, the Landlord shall have the

            right of a lien under law as security for the payment of all the

            damages and the funds that will be due to the Landlord and/or the

            management company from the Tenant in such a situation.

 

            12.4.4 The Tenant will be responsible for the return to the Landlord

                   immediately upon the receipt of a first written demand all

                   reasonable expenses, damages and reasonable losses that will

                   be caused to it as a result of the breach of the Lease by the

                   Tenant, and according to law.

 

            12.4.5 The Tenant shall not have the right to object by any means

                   and/or to attempt to delay or to prevent the Landlord from

                   entering into a contractual relationship with any other

                   tenant and/or to attempt to prevent or to delay the carrying

                   out the renting of the Demised Premises to any replacement

                   tenant whatsoever. All the foregoing shall apply both to the

                   relationship between the Landlord and the Tenant and between

                   the Tenant and the replacement tenant and shall be deemed to

                   be, inter alia, a contractual provision for the benefit of a

                   third party.

 

      12.5   Any delay in the making of a payment by any party shall bear default

            interest at the rate customary at Bank Hapoalim B.M. for

            extraordinary overdrafts at that time for the period of the delayed

            payment.

 

<PAGE>

 

      12.6   In any case in which the Tenant shall be late at his fault by more

            than 30 days in the transfer of any payment that it is obligated to

            make to the Landlord, then the Landlord shall be entitled, on thirty

            (30) days' written notice to the Tenant, and without derogating from

            its right to any other relief, to immediately cease to supply to the

            Tenant and/or the Demised Premises electricity, water, air

            conditioning or other services whatsoever, at its discretion, and

            the Tenant shall not have any contention or claim with regard

            thereto.

 

      12.7   In any case of failure to vacate the Demised Premises on time by the

            Tenant at the end of the Lease Term or upon the cancellation of this

            Lease Agreement, then the Landlord shall be entitled, without

            derogating from its rights for any other relief, and after having

            given sixty (60) days' written notice thereof:

 

            12.7.1 to immediately cease to supply to the Tenant and/or the

                   Demised Premises electricity, water, air conditioning or

                   other services whatsoever, at its discretion, and the Tenant

                   shall not have any contention or claim with regard thereto.

 

             12.7.2 to enter the Demised Premises itself and/or by means of

                   others, and in order to do so to use reasonable force, and to

                   remove all possessions and tangible items that are found

                   there from the Demised Premises, as well as to the change the

                   locks and to prevent access to it by the Tenant or any one

                   acting on its behalf in any way it deems appropriate.

 

                   In any case of failure to vacate the Demised Premises on

                   time, as aforesaid, by the Tenant, the Tenant or the party

                   acting on its behalf shall be deemed to be a "squatter" upon

                   the Demised Premises, and it shall not have any contention or

                   claim against the Landlord or anyone acting on its behalf for

                   the damages caused to it or its possessions as a result of

                   such an activity.

 

                   The Tenant shall be liable to pay the Landlord for all the

                   expenses caused to the Landlord or to someone acting on its

                   behalf in the foregoing actions.

 

      12.8   The delay in, or failure to use any right on the part of the

            Landlord pursuant to this Lease Agreement shall not be deemed under

            any circumstances or in any case to be a "waiver" or the basis for a

            claim of forbearance against it on the part of the Tenant, subject

            to the law.

 

13.    ABSENCE OF PROTECTED TENANCY RIGHTS

 

      13.1   It is specifically represented that the Demised Premises is located

            in a building that was completed after August 20, 1968, and that

            this tenancy is being made expressly conditioned on the fact that

            the protected tenancy laws do not apply to the tenancy, the Tenant

            represents that it did not and will not pay the Landlord key money

            or any other consideration that is not rent, and that the Tenant and

             any party coming in its place will not be a protected tenant in the

            Demised Premises pursuant to the law, and that it will be prohibited

            from raising any contentions or

 

<PAGE>

 

            claims whatsoever with regard to its being a protected tenant or

            that it has greater rights in the Demised Premises than what is

            specifically stated in this Lease.

 

      13.2   The Tenant represents that all the investments that it shall make in

            the Demised Premises, including equipment and devices, shall be made

            solely for its needs, and it shall be prohibited from raising the

            contention that these investments constitute key money or a

            substitute for key money or a payment pursuant to Section 82 of the

            Protected Tenant's Law (Consolidated Version), 5732-1972, or any

            payment that grants it rights whatsoever in the Demised Premises,

            and likewise, it will be prohibited from demanding a contribution or

            a refund, in whole or in part, from the Landlord for the foresaid

            investments.

 

14.    SECURITY

 

      BANK GUARANTY

 

      14.1   As surety to the fulfillment of all the obligations pursuant to this

            Lease Agreement, the Tenant shall present to the Landlord prior to,

            and as a condition to, entering upon the Demised Premises for the

            purposes of carrying out the internal work as detailed in Section

            4.3 above, an assignable unconditional bank guaranty, made out to

            the benefit of the Landlord, exercisable in installments, stamped as

            required by law, at the expense of the Tenant, in the form annexed

            to this Lease as Exhibit B, to remain in force until 45 days after

            the end of the Lease Term, in the sum of $43,500 (forty three

            thousand five hundred U. S. Dollars).

 

      14.2   The Tenant shall bear all the costs of the bank guaranties,

            including the fees of the guarantor bank.

 

      14.3   The Landlord shall be entitled to exercise the guaranty (or a part

            thereof, as the case may be, and in accordance with the amount of

            the debt) in any case of a fundamental breach of this Lease

            Agreement by the Tenant or in any case in which any funds are due to

            the Landlord from the Tenant, which were not paid when due, provided

            that the Tenant was provided with 14 days' prior written notice

            before the drawing down of the guaranty.

 

      14.4   The foregoing notwithstanding, it is agreed that the Tenant may

            provide the Landlord with a bank guaranty for a shorter period of

            time on condition that the Tenant sees to it that the effectiveness

            of the guaranty is extended from time to time at least fourteen (14)

            days prior to its anticipated expiration date.

 

      14.5   If the Tenant does not present the Landlord with an alternative bank

            guaranty at the aforesaid time, then the Landlord shall be entitled

            to exercise the full bank guaranty in its possession, provided it

            notifies the Tenant thereof in writing 14 days prior to the drawing

            down of the guaranty.

 

<PAGE>

 

15.    ARBITRATION

 

      In any case in which disputes arise and/or differences between the parties

      with anything regarding the execution and/or the effectiveness or breach

      and/or the carrying out and/or the interpretation of this Lease, the

      parties will submit the disputes or the differences for the determination

      of an arbitrator whose identity shall be determined by the agreement of

      the parties, or in the absence thereof, the arbitrator shall be appointed

      within ten (10) days from the date on which no agreement between the

      parties was reached by the Chairman of the Israel Bar Association, at the

      request of one of the parties, after giving three days' prior written

      notice to the other party (hereinafter: the "ARBITRATOR").

 

      15.1   The Arbitrator shall act as the sole arbitrator and his

            determination shall be final.

 

      15.2   The provisions of this Section 15 shall be deemed to be an

            arbitration agreement between the parties, and the provisions of the

            Addendum to the Arbitration Law, 5728-1968, shall apply to the

            arbitration that is the subject of this Lease, as well as to the

            Arbitrator.

 

      15.3   It is agreed that the authority of the Arbitrator shall be

            specifically subject to the provisions of this Lease, including its

            exhibits, and that the Arbitrator shall be empowered to issue

            temporary orders and other temporary relief, and he shall be subject

             to the substantive law but not to the laws of evidence and

            procedures.

 

      15.4   A referral to the Arbitrator or the engaging in arbitral proceedings

            shall not give rise to the delay and/or postponement and/or

            exemption of the Tenant any of its obligations as set forth in this

            Lease, including its obligations to make any payments as long as the

            Lease Term is in effect.

 

      15.5   Anything contained in this Section 15 notwithstanding, the Landlord

            has the right to sue the Tenant in the appropriate court in Tel Aviv

            - Jaffa for the eviction or removal of the Tenant from the Demised

            Premises at the end of the Lease Term and/or upon the cancellation

             of this Lease, on condition that no approach has been made to

            appoint an Arbitrator.

 

16.    MISCELLANEOUS

 

      16.1   The Landlord shall be entitled at any time, without the need for any

            consent on the part of the Tenant, to make any change or addition to

            the Building that will not have a substantial detrimental affect on

            the Tenant, its work environment, or its approach thereto, according

            to its absolute discretion, both prior to and after the commencement

            of the Lease Term, including, but not limited to, the addition or

            diminution of area, to add floors, areas or wings to the Building,

            the conversion of closed or open public areas to areas in the

             exclusive use of various users, changes in the entrances, passage

            ways, extra area of any kind, and any other change in construction

            or in the Building plans.

 

            Likewise, the Tenant is aware that the Landlord intends to add

            construction area beyond what is currently permitted according to

            the zoning regulations and the

 

<PAGE>

 

            Tenant agrees to any additional construction that may be made,

            subject to the foregoing.

 

             The Landlord obligates itself that the aforesaid changes and

            additions, if they are undertaken, will be made subject to building

            permits if required, and that they will be made in a manner such

            that the interference to be caused to the Tenant shall be the

            minimum amount possible, in a reasonable manner, and that the

            completeness of the Demised Premises will not be affected.

 

      16.2   This Lease reflects the entirety of all the understandings between

            the parties and it replaces and voids any negotiations, heads of

            agreement, representation or document that preceded its execution,

            any change in the provisions of this Lease shall be effective and

            binding only if in writing and lawfully signed by both parties.

 

      16.3   The debts that the parties to this Lease owe to each other are

            subject to set off only upon prior written agreement.

 

      16.4   Any change and/or waiver and/or variance from the provisions of this

            Lease shall not be binding unless done in writing and signed by the

            parties to the Lease.

 

      16.5   The addresses of the parties for the purposes of giving notices

            shall be as set forth at the head of the Lease. Any notice that

            shall be sent by registered mail shall be deemed to be received by,

            and brought to the attention of, the recipient party within five

            days of its dispatch, and in the case of hand delivery, within 12

            hours of its delivery.

 

            IN WITNESS WHEREOF, THE PARTIES HAVE EXECUTED THIS LEASE:

 

          /s/ ILAN SCHEFFLER                       /s/ SILVIA NOIMAN

-------------------------------------      -------------------------------------

"EMED" REAL ESTATE DEVELOPMENT             PREDIX PHARMACEUTICALS LTD.

   AND INVESTMENTS COMPANY LTD.

           (the Landlord)                             (The Tenant)

By Mr. Ilan Scheffler, Vice President      By Dr. Silvia Noiman, General Manager

 

<PAGE>

 

                               INSURANCE ADDENDUM

 

                                    EXHIBIT C

 

        TO AN UNPROTECTED LEASE AGREEMENT THAT WAS DRAWN UP AND EXECUTED

                        IN TEL AVIV ON SEPTEMBER 26, 2004

 

BETWEEN:      "EMED" REAL ESTATE DEVELOPMENT AND INVESTMENTS COMPANY LTD.

             Public Company No. 52-002359-9

             3 Hayetzira Street

             ShAP House, Ramat Gan

             (hereinafter: the "LANDLORD")

                                                                  ON THE ONE HAND

 

AND BETWEEN: PREDIX PHARMACEUTICALS LTD.

             Company No. 51-2864307

             3 Hayetzira Street

             ShAP House, Ramat Gan

             (hereinafter: the "TENANT")

                                                                ON THE OTHER HAND

 

1.     Without derogating from the liability of the Tenant pursuant to this Lease

      or in accordance with any law, prior to the time of commencement of the

      business of the Tenant in the Demised Premises, or prior to the time of

      the bringing in of any property into the Demised Premises - the earlier of

      the two, the Tenant commits to arrange and keep for the duration of the

      term of this Lease the insurances detailed in the continuation of this

      section (which shall hereinafter be called: the "DEMISED PREMISES

      INSURANCES") with a lawfully authorized and reputable insurance company.

 

      1.1    Insurance of the contents of the Demised Premises, equipment that

             serves the Demised Premises owned and/or under the responsibility of

            the Tenant that is located outside the Demised Premises within the

            Building, as well as any repair, change, improvement, enhancement

            and addition to the Demised Premises that is made and/or will be

            made by the Tenant and/or for it, as well as furniture, equipment

            and


 
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