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NOTE PURCHASE AGREEMENT

Note Purchase Agreement

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Spencer Trask Specialty Group, LLC

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Title: NOTE PURCHASE AGREEMENT
Governing Law: New York     Date: 3/30/2006
Law Firm: Lowenstein Sandler    

NOTE PURCHASE AGREEMENT, Parties: spencer trask specialty group  llc
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                                                                   Exhibit 10.80

                             NOTE PURCHASE AGREEMENT

        NOTE PURCHASE AGREEMENT (this "Agreement"), dated as of February 16,
2006, by and between Vyteris Holdings (Nevada), Inc., a Nevada corporation
("Seller"), and Spencer Trask Specialty Group, LLC, a Delaware limited liability
company ("Buyer").

                              W I T N E S S E T H:
                              - - - - - - - - - -

        WHEREAS, Seller desires to issue to Buyer, and Buyer desires to purchase
from Seller, a convertible subordinated promissory note, substantially in the
form of EXHIBIT A hereto, in the principal amount of $500,000 (the "Note");

        WHEREAS, Seller has agreed to effect the registration of the shares of
Common Stock underlying the Note under the Securities Act of 1933, as amended,
pursuant to a registration statement substantially in the form of EXHIBIT B
hereto (the "Registration Rights Agreement"); and

         WHEREAS, Seller, pursuant to that certain securities purchase agreement
dated as of August 19, 2005, as same may be amended from time to time
("Securities Purchase Agreement") issued a series of senior secured convertible
debentures, including debentures issued after the original issuance date (the
"Debentures") in the aggregate principal amount of $10.5 million (the "Senior
Debt").

        NOW, THEREFORE, in consideration of the mutual covenants and agreements
hereinafter set forth herein and for good and valuable consideration, the
receipt and sufficiency of which are hereby mutually acknowledged, the parties
agree as follows:

        1.       SALE AND PURCHASE OF THE NOTE

        1.1.     SALE AND PURCHASE. Subject to the terms and conditions of this
Agreement, at the Closing (as defined in Section 2.1 hereof), Seller shall issue
to Buyer, and Buyer shall purchase from Seller, for the Purchase Price (as
defined in Section 1.2(a) hereof), the Note.

        1.2.     PURCHASE PRICE AND PAYMENT.

                 (a)      PURCHASE PRICE. The purchase price for the Note shall be
$500,000 (the "Purchase Price").

                (b)      PAYMENT OF PURCHASE PRICE. The Purchase Price shall be
paid to Seller by Buyer on the Closing Date (as defined in Section 2.1 hereof)
via federal funds wire transfer(s) of immediately available funds, in accordance
with written instructions provided to Buyer prior to the date hereof.

        2.       CLOSING.

        2.1.     TIME AND PLACE. The closing of the sale and purchase of the Note
(the "Closing") shall be deemed to take place at the offices of Littman Krooks
LLP, 655 Third

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Avenue, 20th Floor, New York, New York, at 10:00 a.m., local time, on the date
hereof, or at such later time or date as Buyer and Seller may mutually agree in
writing. The date upon which the Closing shall occur is herein called the
"Closing Date".

        2.2.     CLOSING DELIVERIES.

                (a)      SELLER DELIVERIES. At the Closing, Seller shall deliver
or cause to be delivered to Buyer the following:

                        (i)      the duly executed Note;

                        (ii)     the duly executed Registration Rights Agreement;
and

                        (iii)    copies of any consents necessary to effectuate
this Agreement and to consummate the transactions contemplated hereby.

                (b)      BUYER DELIVERY. At the Closing, Buyer shall deliver or
cause to be delivered to Seller the Purchase Price.

        3.       TERMS OF THE NOTE.

        3.1.     AMOUNT. The principal amount of the Note shall be $500,000.

        3.2.     MATURITY. Unless otherwise converted into the Conversion Shares
(as defined in Section 3.4 hereof) in accordance with the provisions hereof, the
Note shall mature on December 1, 2008, unless such date shall be otherwise
extended in writing by Buyer, in its sole discretion (such date, the "Maturity
Date"). On the Maturity Date, unless, and to the extent, converted into
Conversion Shares in accordance with the provisions hereof, all outstanding
principal and any accrued and unpaid interest due and owing under the Note shall
be immediately paid by Seller.

        3.3.     INTEREST; INTEREST RATE; PAYMENT. (a) The Note shall bear
interest (other than interest accruing as a result of a failure by Seller to pay
any amount when due as set forth in clause (b) below) at a rate equal to ten
(10%) percent (the "Interest Rate") per annum on a 360-day year. Interest (other
than interest accruing as a result of a failure by Seller to pay any amount when
due as set forth in subparagraph (b) below) shall be due and payable in cash
semi-annually in arrears following the end of each semi-annual period,
commencing with the semi-annual period ended June 30, 2006, pro rated for
partial periods; PROVIDED, HOWEVER, that any interest accruing on overdue
amounts pursuant to subparagraph (b) of this Section 3.3 shall be payable on
demand.

                (b)      If all or a portion of the principal amount of the Note
or any interest payable thereon shall not be repaid when due whether on the
applicable repayment date, by acceleration or otherwise, such overdue amounts
shall bear interest at a rate per annum that is three percent (3%) above the
Interest Rate (I.E., 13%) from the date of such non-payment until such amount is
paid in full (as well after as before judgment).

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                (c)      All payments to be made by Seller hereunder or pursuant
to the Note shall be made, without setoff or counterclaim, in lawful money of
the United States by check or wire transfer in immediately available funds.

                3.4.     CONVERSION. (a) Subject to Sections 3.4(b) and 3.5
hereof, at any time prior to the Maturity Date, the Seller shall have the option
to convert the entire principal and interest accrued and owing on the Note, or
any portion of the principal and/or interest thereof, into shares (the
"Conversion Shares") of Common Stock at the Conversion Price. For purposes
hereof, "Conversion Price" shall mean $2.40 per share; PROVIDED, that if at any
time on or after the issuance date of the Note, Seller subdivides (by any stock
split, stock dividend, recapitalization, reorganization, reclassification or
otherwise) its shares of Common Stock into a greater number of shares, then
after the date of record for effecting such subdivision, the Conversion Price
shall be proportionately reduced, or if Seller combines (by reverse stock split,
recapitalization, reorganization, reclassification or otherwise) its shares of
Common Stock into a smaller number of shares, the Conversion Price shall be
proportionately increased.

Upon conversion, Buyer shall be entitled to receive the number of Conversion
Shares calculated by dividing the amount being converted by the Conversion
Price. No fractional shares of Conversion Shares shall be issued upon
conversion. In lieu of any fractional shares to which Buyer would otherwise be
entitled, Seller shall pay cash in an amount equal to such fraction multiplied
by the Conversion Price. The Note shall not be subject to automatic conversion
or to any conversion at the option of Seller.

                (b)      Notwithstanding the provision of Section 3.4(a), if an
equity security or other derivative security convertible or exercisable into an
equity security of the Company ("Applicable Security") is sold in connection
with a Qualified Financing (as hereinafter defined) at any time prior to payment
in full of the principal balance of the Note, all of the principal and interest
due thereunder shall automatically become converted into the Applicable Security
with the same rights and privileges granted to investors in the Qualified
Financing. The number of Applicable Securities received upon conversion pursuant
to this Section 3(b) shall be determined by dividing the aggregate principal
amount due under the Note, together with any accrued but unpaid interest to the
date of conversion, by the price per Applicable Security paid in the Qualified
Financing. For the purposes of the Note, a "Qualified Financing" shall mean the
Company's next private financing of Applicable Securities to investors (i)
yielding aggregate gross proceeds (exclusive of conversion of the Note) to the
Company of at least $500,000 and (ii) which does not invoke or trigger the
provisions of Section 4(b) of the Debentures or Section 6(c) of the Warrants (as
such term is defined in the Securities Purchase Agreement.
 
                3.5.     CONVERSION PROCEDURES. In order to exercise the
conversion rights set forth in Section 3.4(a) hereof, Buyer shall surrender the
Note, appropriately endorsed, to Seller at Seller's principal office,
accompanied by written notice to Seller setting forth the amount of principal
and interest to be converted, the name or names (with address(es)) in which the
Conversion Shares issuable upon such conversion shall be issued and registered
on the books of Seller. For purposes hereof, the "Conversion Date" shall be
deemed to be the date the Note and notice is received by Seller for conversion.
Within five (5) business days after the Conversion Date, Seller shall deliver to
Buyer (i) a stock certificate for the Conversion Shares or (ii) a notice
certified by Seller's Secretary that the Conversion Shares due on such
conversion have been

                                        3
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issued to and registered on the books of Seller in the name or names specified
by Buyer. In the case of conversion of less than the entire principal of and
interest under the Note, Seller shall cancel said Note and shall execute and
deliver a new Note of like tenor for the unconverted amount of the Note dated
the date of execution by Seller upon initial issuance of the Note
notwithstanding any subsequent substitution.

                3.6.     SUBORDINATION. The Note is expressly and fully
subordinated, as to payment and liquidation, to the payment in full of the
Debentures and the Obligations (as such term is defined in the Securities
Purchase Agreement) and the holder of the Note acknowledges and agrees that the
Seller is expressly restricted from pre-paying any amounts in respect of the
principal of the Note (upon acceleration or otherwise) until payment in full of
the Debentures. The holder of this Note shall not commence any judicial or other
collection efforts or exercise any other remedies prior to the date that is
ninety-one (91) days following the payment in full of the Debentures. The Note
is, and is intended to be, "Subordinated Debt" as such term is defined in the
Securities Purchase Agreement.

                3.7.     PREPAYMENT RIGHTS UPON MERGER, CONSOLIDATION, ETC. (a)
If, prior to the Conversion Date, but subject to the provisions of Section 3.6
above, Seller proposes to consolidate with, or merge into, another corporation
or entity, or to effect any sale or conveyance to another corporation or entity
of all or substantially all of the assets of Seller, or effect any other
corporate reorganization, in which the stockholders of the Seller immediately
prior to such consolidation, merger or reorganization own capital stock of the
entity surviving such merger, consolidation or reorganization representing less
than fifty (50%) percent of the combined voting power of the outstanding
securities of such entity immediately after such consolidation, merger or
reorganization (collectively, a "Liquidation Event"), then Seller shall provide
Buyer with at least ten (10) days' prior written notice of any such proposed
action, and Buyer will, at its option, have the right to demand immediate
prepayment of all amounts due and owing under the Note. Buyer will give Seller
written notice of such demand within five (5) days after receiving notice of the
Liquidation Event. All amounts (including all accrued and unpaid interest) due
and owing under the Note shall be paid by Seller to Buyer within five (5) days
from the date of such written notice via federal funds wire transfer(s) of
immediately available funds, in accordance with written instructions to be
provided to Seller by Buyer within at least two (2) business days after giving
Seller such written notice. The provisions of this Section 3.7(a) shall
similarly apply to successive consolidations or mergers.

                (b)      Except as set forth in Sections 3.6, 3.7(a) and 9
hereof, Seller shall not prepay prior to the Maturity Date all or part of this
Note without the express written consent of Buyer.

                3.8      INTENTIONALLY DELETED

                3.9      ASSURANCES WITH RESPECT OF CONVERSION RIGHTS. Seller
shall not, by amendment of its Certificate of Incorporation or By-laws or
through any reorganization, transfer of assets, consolidation, merger,
dissolution, issue or sale of securities or any other voluntary action, avoid or
seek to avoid the observance or performance of any of the terms to be observed
or performed hereunder by Seller but shall at all times in good faith assist in
the carrying out of all the provisions of this Agreement and in taking of all
such actions as may be necessary or appropriate in order to protect the
conversion rights of Buyer against impairment.

                                        4
<PAGE>

                4.       REPRESENTATIONS AND WARRANTIES OF SELLER. Seller hereby
represents and warrants to Buyer as follows:

                4.1      DUE ORGANIZATION AND QUALIFICATION. Seller is a
corporation duly organized, validly existing and in good standing under the laws
of the State of Nevada. Seller has all requisite power and authority to own,
lease and operate its assets and properties and to carry on its business as
presently conducted and as presently contemplated. Seller is duly qualified to
transact business and is in good standing in each jurisdiction in which the
nature of its business or the locations of its property requires such
qualification, except where the failure to do so would not have a material
adverse effect on Seller's business, operations, assets or condition (financial
or otherwise).

                4.2      POWER AND AUTHORITY. Seller has the requisite corporate
power and authority to execute and deliver this Agreement and all other
agreements contemplated by this Agreement (including, without limitation, the
Note and the Registration Rights Agreement) and to perform its obligations
hereunder and thereunder. The execution, delivery and performance of this
Agreement and all other agreements contemplated by this Agreement have been duly
authorized by all necessary corporate action on the part of Seller. This
Agreement has been duly executed and delivered by Seller and is the valid and
binding obligation of Seller, enforceable against Seller in accordance with its
terms, except as such enforceability may be limited by applicable bankruptcy,
moratorium, insolvency, reorganization or other similar laws now or hereafter in
effect generally affecting the enforcement of creditors' rights, specific
performance, injunctive or other equitable remedies. When executed and delivered
by Seller at the Closing, each of the Note and the Registration Rights Agreement
will be the valid and binding obligation of Seller, enforceable against Seller
in accordance with its terms, except as such enforceability may be limited by
bankruptcy, moratorium, insolvency, reorganization or other similar laws now or
hereafter in effect generally affecting the enforcement of creditors' rights,
specific performance, injunctive or other equitable remedies.

                4.3.     CAPITALIZATION. The capitalization of the Seller as of
the date of this Agreement, including its authorized capital stock, the number
of shares issued and outstanding, the number of shares issuable and reserved for
issuance pursuant to the Seller's stock option plans and agreements, the number
of shares issuable and reserved for issuance pursuant to securities (other than
the Note) exercisable for, or convertible into or exchangeable for any shares of
Common Stock and the number of shares initially to be reserved for issuance upon
conversion of the Note is set forth on Schedule 4.3 hereto. All issued and
outstanding shares of capital stock of the Seller have been validly issued,
fully paid and non-assessable. Except as disclosed on Schedule 4.3 hereto, the
Seller owns all of the capital stock of each subsidiary, which capital stock is
validly issued, fully paid and non-assessable, and no shares of the capital
stock of the Seller or any of the subsidiaries are subject to preemptive rights
or any other similar rights of the shareholders of the Seller or any such
subsidiary or any liens created by or through the Seller or any such subsidiary.
Except as disclosed on Schedule 4.3 or as contemplated herein, there are no
outstanding options, warrants, scrip, rights to subscribe to, calls or
commitments of any character whatsoever relating to, or securities or rights
convertible in


 
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