FIRST AMENDMENT TO JOINT MARKETING AGREEMENT

<PAGE>
                                                                EXHIBIT 10.21(a)



                  FIRST AMENDMENT TO JOINT MARKETING AGREEMENT

        THIS FIRST AMENDMENT TO JOINT MARKETING AGREEMENT (this "AMENDMENT") is
made as of February 13, 2006 by and between Helix BioMedix, Inc., a Delaware
corporation ("HXBM"), and Body Blue Inc., a Canadian corporation ("BODY BLUE"),
and amends that certain Joint Marketing Agreement between the parties dated
effective November 2, 2004 (the "AGREEMENT"). Capitalized terms not otherwise
defined herein shall have the meanings ascribed to them in the Agreement.

        WHEREAS, the parties entered into the Agreement to provide for the
marketing of HXBM products to certain prospective customers; and

        WHEREAS, the parties wish to memorialize their agreement to share
revenues from certain other transactions which were not specifically
contemplated either by the Agreement or by that certain Referral Fee Agreement
between the parties dated September 12, 2005 (the "REFERRAL FEE AGREEMENT");

        NOW, THEREFORE, in consideration of the premises and the mutual
covenants contained herein and other good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, the parties, intending
to be legally bound, do agree as follows:

1.   Revenue Share. The parties hereby agree to the following revenue share
allocations for the following corresponding transactions; provided, however,
that notwithstanding anything contained in the Agreement or this Amendment to
the contrary, both parties shall retain complete discretion as to whether or not
to engage in any transaction with any third party:

<TABLE>
<CAPTION>

      Description of Transaction                                      Amount
      --------------------------                                      ------
<S>   <C>                                             <C>

1.    Non-manufacturing agreement sourced by           Body Blue to receive ***% of HXBM
      Body Blue by which the licensing                 Net Revenue under any such agreement
      customer either sells products through
      retail channels or directly to
      consumers (e.g., ***)

2.