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<PAGE>
Exhibit 10.14
AMENDMENT No. 1
to
THE DEVELOPMENT AND MANUFACTURING
SERVICES AGREEMENT
Dated 12 AUGUST 2003
Between
LONZA BIOLOGICS ***
and
TRUBION PHARMACEUTICALS, INC. (formerly known as GENECRAFT
INC.)
Schedule 2 - Services
New
Stages
Stage 2 - ***
Stage 3 - ***
Schedule 3 - Price and Payment
Price and Payment for Stage 2
Price and Payment for Stage 3
Clause 1 - "Customer"
Clause 1- "Services"
Clause 6.4 - LB Warranties and Indemnity
Clause 11.1 - Notices to the Customer
Clause 12.5 - Clarification of "Specification"
<PAGE>
THIS FIRST AMENDMENT ("First Amendment") is made the 7th day of
November, 2003
BETWEEN
LONZA BIOLOGICS *** (hereinafter referred to as "LB"),and
TRUBION PHARMACEUTICALS, INC., (formerly known as GENECRAFT, INC.)
of 2401 4th
Avenue, Suite 1050, Seattle, WA 98121, USA (herein after referred
to as the
"Customer")
WHEREAS
A. LB and the
Customer entered into a development and manufacturing services
agreement dated 12 August 2003 pursuant to which LB agreed to
provide
Services to the Customer ("the Agreement"), and,
B The
Customer now wishes LB to perform additional services under the
Agreement; and,
C. LB is willing
to perform such additional services on the terms set out in
the
Agreement, and
D. The parties
wish to amend the Agreement in accordance with Clause 12.5
thereto.
NOW THEREFORE IT IS HEREBY AGREED as follows:
1. A NEW STAGE, STAGE
2, SHALL BE ADDED TO SCHEDULE 2 OF THE AGREEMENT TO
READ AS FOLLOWS:
Stage 2 - ***
2.1 OBJECTIVES
***
2.2 ACTIVITIES
***
2.3 TIMESCALE
Stage 2 shall commence upon signature of the First Amendment to
the
Services Agreement to which this Schedule 2 is attached and shall
be complete
upon issue of the report of activities for Stage 2.
It is estimated that Stage 2 will take *** to complete depending
on
the degree of successful adaptation. This timescale includes ***
for generation
of
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