THE DEVELOPMENT AND MANUFACTURING SERVICES AGREEMENT

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                                                                   Exhibit 10.24

                                 AMENDMENT No. 8

                                       to

                        THE DEVELOPMENT AND MANUFACTURING
                                SERVICES AGREEMENT

                              Dated 08 January 2004

                                     Between

                               LONZA BIOLOGICS ***

                                       and

                           TRUBION PHARMACEUTICALS, INC.

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     THIS AMENDMENT No. 8 ("Eighth Amendment") is made the 5th day of October
2005

     BETWEEN

     LONZA BIOLOGICS *** of *** (hereinafter referred to as "LB"), and

     TRUBION PHARMACEUTICALS, INC., of 2401 4th Avenue, Suite 1050, Seattle, WA
98121, USA (herein after referred to as the "Customer")

     WHEREAS

     A.    LB and the Customer entered into a development and manufacturing
          services agreement ("the Agreement") dated 08 January 2004, pursuant
          to which LB agreed to provide Services to the Customer, and,

     B.    The Customer now wishes LB to perform additional services under the
          Agreement, and,

     C.    LB is willing to perform such additional services on the terms set out
          in the Agreement, and

     D.    The parties wish to amend the Agreement in accordance with Clause 13.5
          thereto.

     NOW THEREFORE IT IS HEREBY AGREED as follows:

     1.0 STAGE 26 IN SCHEDULE 2 OF THE AGREEMENT SHALL BE DELETED IN ITS
ENTIRETY AND REPLACED WITH THE FOLLOWING:

     "STAGE 26 ***

     BACKGROUND

     ***

     26.1 OBJECTIVES

     ***

     26.2 ACTIVITIES

     ***

     26.3 DELIVERABLES

          26.3.1 A copy of the sampling plan prepared in activity 26.2.1.

          26.3.2 Samples from the development study as agreed in activity 26.2.1
     and 26.2.14

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