AMENDMENT NO. 1 TO THE DEVELOPMENT AND MANUFACTURING SERVICES AGREEMENT

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                                                                   Exhibit 10.17

                                                                    (LONZA LOGO)

                                 AMENDMENT NO. 1

                                        TO

              THE DEVELOPMENT AND MANUFACTURING SERVICES AGREEMENT

                              dated 08 January 2004

                                     between

                               LONZA BIOLOGICS ***

                                        and

                          TRUBION PHARMACEUTICALS, INC.

Re:

Schedule 2 -- Services

New Stage

     Add Stage 15 ***

Schedule 3 -- Price and Payment
   Price and Payment for Stage 15

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                                                                     (LONZA LOGO)

THIS AMENDMENT is made the 4th day of June 2004

BETWEEN

1.    LONZA BIOLOGICS ***, the registered office of which is at *** ("LB") and

2.    TRUBION PHARMACEUTICALS, INC., of 2401 4th Avenue, Suite 1050, Seattle, WA
      98121, USA (herein after referred to as the "Customer").

WHEREAS

A.    Customer and LB entered into a development and manufacturing services
     agreement dated 08 January 2004 ("the Agreement'), under which LB is
     required to perform Services relating to the Cell Line and the Product, as
     further described in the Agreement, and

B.    Customer would like LB to perform additional services under the Agreement,
     and

C.    LB is prepared to perform the additional services, and the parties wish to
     amend the Agreement accordingly.

NOW THEREFORE it is agreed hereby as follows:

1.    Schedule 2 of the Agreement shall be amended to include the following
     additional stage, Stage 15 (De