Exhibit 10.30
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CoTherix,
Inc.
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Schering
AG
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Mr. Donald
Santel
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CEO
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5000 Shoreline
Court
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Suite
101
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E:
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South San
Francisco, California 94080
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U.S.A.
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T:+49.30.468- 15431
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+49.30.468-
11 11
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F:+49.30.468- 14086
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Your
Ref.
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Your letter dated
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Our Ref. (please indicate when replying)
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Date
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RA/UK/ha (6v1301_1)
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2006-05-07
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Amendment #3 to Development and
License Agreement and
Amendment #2 to Manufacturing and Supply
Agreement
Dear Don,
We refer to the Development and
License Agreement by and between CoTherix, Inc., Belmont,
California (hereinafter „CoTherix” - formerly called,
Exhale Therapeutics, Inc.’) and Schering dated
October 2, 2003 as amended by amendment agreements of
November 4/ 22, 2004 and December 14/ 29, 2004
(hereinafter the „License Agreement”), and the
Manufacturing and Supply Agreement by and between CoTherix and
Schering dated May 12/17, 2004 as amended by amendment
agreement of November 4/ 22, 2004 (hereinafter the
„MSA”).
As Schering and CoTherix have agreed
that, as of January 1, 2006, the ampoules for Commercial
Product shall be changed from 2 ml ampoules to 1 ml ampoules
whereas the prices for 1 ml ampoules of Commercial Product shall
stay the same as they used to be for 2 ml ampoules of Commercial
Product, it is hereby confirmed that, as of January 1, 2006,
Commercial Product shall be filled in 1 ml ampoules, and prices for
this Commercial Product filled in 1 ml ampoules and packed in
30-ampoules boxes, shall be set forth in Section 6.2 of the
License Agreement and Section 7.2 of the MSA as follows (as
before):
“The Ex Works price for paper,
one-color labeld ampoules, packed in a 30-ampoule box of Commercial
Product per ampoule shall be as follows:
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Firm Orders of
[* * *] to [* * *] million ampoules per Contract
Year:&nb
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