AMENDMENT TO LICENSE AGREEMENT

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OREXIGEN THERAPEUTICS, INC. | Oregon Health & Science University

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Title: AMENDMENT TO LICENSE AGREEMENT
Date: 12/19/2006

AMENDMENT TO LICENSE AGREEMENT

, Parties: orexigen therapeutics inc. , oregon health & science university

EXHIBIT 10.8

CERTAIN MATERIAL (INDICATED BY AN ASTERISK) HAS BEEN OMITTED FROM THIS DOCUMENT PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION.

AMENDMENT TO LICENSE AGREEMENT

Effective as of Nov. 1, 2003, Oregon Health & Science University (hereinafter “OHSU”), having offices AT 2525 SW 1 ^st Ave, Suite 120, Portland, OR 97201, and Orexigen Therapeutics, Inc. (hereinafter “LICENSEE”), a Delaware corporation having offices at 28202 Cabot Road, Suite 200, Laguna Niguel, CA 92577 agree to amend the Agreement in the following ways:

Section 6.05 (page 10), will be changed to the following:

6.05

LICENSEE agrees to issue to OHSU one hundred thousand (100,000) shares of LICENSEE common stock (the “Shares”).

The following section will be added as Section 6.05.3

6.05.03

LICENSEE agrees to issue to OHSU addition

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