AMENDMENT TO LICENSE AGREEMENT

Exhibit 10.47

***  Text Omitted and Filed Separately

with the Securities and Exchange Commission.

Confidential Treatment Requested

under 17 C.F.R. Sections 200.800(b)(4)

and 240.24b-2.

Amendment to License Agreement

This Amendment made this 20th day of February 2006 (the “Effective Date”) is by and between AnGes MG, Inc., a corporation with its principal executive offices located at 7-7-15, Saito-Asagi, Ibaraki, Osaka, 567-0085, Japan (“Anges”), and VICAL Incorporated, a Delaware corporation having its principal place of business at 10390 Pacific Center Court, San Diego, California 92121, USA (“VICAL”).

WHEREAS, VICAL and Anges entered into a License Agreement (“Agreement”) dated May 24,