AMENDMENT NO. 1 TO THE LICENSE AGREEMENT CONTROL NO. 2007-04-0173 BETWEEN SENOMYX INC. AND THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

EXHIBIT 10.2

***Text Omitted and Filed Separately

with the Securities and Exchange Commission.

Confidential Treatment Requested

Under 17 C.F.R. Sections 200.80(b)(4) and 240.24b-2.

AMENDMENT NO. 1 TO THE

LICENSE AGREEMENT CONTROL NO. 2007-04-0173

BETWEEN SENOMYX INC. AND

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

The parties to the License Agreement with an effective date of October 11, 2006 (“Agreement”) cited above wish to amend such Agreement, effective as of February 7, 2007 (“Amendment Effective Date”) as set forth below to incorporate additional intellectual property.

Now, therefore, it is hereby agreed as follows:

1.  The cover page is amended by the addition of the case “2004-B00.”

2.  The UCSD Disclosure Dockets listed in the first RECITAL are amended by the addition of the case listed below:

“2004-B00   2004-100   [ …***… ]

3.  Exhib