AMENDMENT NO. 1 TO TERMINATION AGREEMENT

Lease Termination Agreement

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This Lease Termination Agreement involves

60 WESTVIEW, LLC | CRITICAL THERAPEUTICS, INC | GP HOLDINGS QRS CORP | Microbia Precision Engineering, Inc

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Title: AMENDMENT NO. 1 TO TERMINATION AGREEMENT
Date: 5/12/2008
Industry: Biotechnology and Drugs Sector: Healthcare

Exhibit 10.2

AMENDMENT NO. 1 TO TERMINATION AGREEMENT

THIS AMENDMENT NO. 1 TO TERMINATION AGREEMENT (this “Amendment”) is made as of March 31, 2008, by and between ARE — 60 WESTVIEW, LLC, a Delaware limited liability company ( “Landlord” ), and CRITICAL THERAPEUTICS, INC., a Delaware corporation ( “Tenant” ).

RECITALS :

A. Landlord and Tenant entered into that certain Agreement For Termination of Lease And Voluntary Surrender of Premises dated as of January 16, 2008 (the “ Termination Agreement ”), pursuant to which Landlord and Tenant agreed to terminate the Lease (as defined therein) for the premises commonly known as 60 Westview Street, Lexington, Massachusetts (the “ Premises ”).

B. As provided in the Termination Agreement, the Lease would terminate as of 11:59 PM on the date that is the day before the “Commencement Date

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