SECOND AMENDMENT TO LEASE AGREEMENT

EXHIBIT 10.1

SECOND AMENDMENT TO LEASE AGREEMENT

THIS SECOND AMENDMENT TO LEASE AGREEMENT (“ this Second Amendment ”) is made as of March 31, 2008, by and between ARE-QRS CORP. , a Maryland corporation, having an address at 385 E. Colorado Blvd., Suite 299, Pasadena, California 91101 (“ Landlord ”), and EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC. , formerly known as Emergent Immunosolutions Inc. and as successor in interest to Antex Biologics, Inc., a Delaware corporation, having an address at Suite 100, 300 Professional Drive, Gaithersburg, Maryland 20879 (“ Tenant ”).

RECITALS

A.       Landlord and Tenant have entered into that certain Lease (“ Original Lease ”) dated as of December 1, 1998, as amended by a First Amendment to Lease dated as of September 30, 2004 (“ First Amendment ”; the Original Lease and the First Amendment are hereinafter collectively referred to as the “ Lease ”), wherein Landlord leased to Tenant certain premises (“ Premises ”) located at 300 Professional Drive, Gaithersburg, Maryland 20879, as more particularly described in the Lease.

B.        The Lease expires on November 30, 2008. Tenant desires to extend the term of the Lease for a period of 1 year so that it will expire on November 30, 2009, and Landlord is willing to extend the term of the Lease on the terms herein set forth.

AGREEMENT

NOW, THEREFORE, the parties hereto agree that the Lease is amended as follows:

1.          Extension of Term . Effective as of the date hereof, the definition of Term Expiration Date in Section 2.1.7(c) of the Lease is hereby amended by deleting that definition in its entirety and replacing it with the following new definition:

2.        Tenant Notices . Effective as of the date hereof, Section 2.1.11 of the Lease is hereby deleted in its entirety and replaced with the following new Section 2.1.11:

3.        Improvement Rent . Effective as of the date hereof, Section 5.3 of the Lease is hereby deleted in its entirety.

4.        Rent Credit . Effective as of the date hereof, Section 5.4 of the Lease is hereby amended by deleting and replacing the reference to “120” therein with “132”. All remaining terms of Section 5.4 shall

remain unchanged.

5.        Extension Right . Effective as of the date hereof, Section 41 the Lease is hereby deleted in its entirety and replaced with the following new Section 41:

41.      Extension Right . Tenant shall have the right (“ Extension Right ”) to extend the term of this Lease for 5 years (“ Extension Term ”) on the same terms and conditions as this Lease (other than Basic Annual Rent). Upon the commencement of the Extension Term, Basic An