SECOND AMENDMENT TO LEASE AGREEMENT

                     SECOND AMENDMENT TO LEASE

      AGREEMENT (this "Agreement") made as of the 5th day of November,
2007 by and between REP A10 LLC, a Delaware limited liability company having
its principal office at 225 Broadhollow Road, Melville, New York 11747
(hereinafter called "Landlord"), and SCIENTIFIC INDUSTRIES, INC., a Delaware
corporation having an office at 70 Orville Drive, Bohemia, New York 11788
(hereinafter called "Tenant").

                               RECITALS

      WHEREAS, AIP Associates, predecessor-in-interest to Landlord and Tenant
entered into an Agreement of Lease dated as of October __, 1989 (the "Original
Lease") for the lease of 25,000 square feet of space (the "demise Premises" or
"Premises") in the building located at 70 Orville Drive, Bohemia, New York (the
"Building");

      WHEREAS, Tenant, by written notice to Landlord dated as of December
16, 1998, exercised its option pursuant to Article 38 of the Lease, to extend
the term of the Lease to and including December 31, 2004;

      WHEREAS, Landlord and Tenant have entered into a First Amendment of
Lease dated as of September 1, 2004 (the "First Amendment"), whereby, among
other things, the term of the Lease was extended to and including January 31,
2010;

      WHEREAS, Tenant, by written notice to Landlord dated as of October 26,
2007, has exercised its option pursuant to Article 38 of the Lease (as replaced
pursuant to Section 2.7 of the First Amendment (, to extend the term of the
Lease to and including January 31, 2015 (the "Extended Expiration Date"); and

      WHEREAS, Landlord and Tenant desire to confirm Tenant's exercise of its
renewal option by entering into this Agreement.

      NOW, THEREFORE, in consideration of the mutual promises contained
herein and for other good and valuable consideration, the receipt and
sufficiency of which being hereby acknowledged, the parties agree as follows:

                                ARTICLE I
                               Definitions

1.1    The recitals are specifically incorporated into the body of this
Agreement and shall be binding upon the parties hereto.
1.2    Unless expressly set forth to the contrary and except as modified by
this Agreement, all capitalized or defined terms shall have the meanings
ascribed to them in the Lease.
1.3    The term "Lease", as used herein, shall mean and refer to the Original
Lease, as modified and amended by the First Amendment.

                             ARTICLE II
                        Lease Modifications

Effective as of the date hereof, the Lease is and shall be modified and
amended as follows:

2.1    Term.   Article I of the Lease, as previously modified and amended by
Section 2.1 of the First Amendment, is hereby further modified and
amended to provide that the term of the Lease is extended to and including
the Extended Expiration Date, unless sooner terminated pursuant to any of
the provisions of the Lease.   All references made in the Lease to the
"Expiration Date" or otherwise to the date upon which the term of the Lease
expires shall mean and refer to the Extended Expiration Date.
2.2    Rent.   Article 3 of the Lease, as previously modified and amended by
Section 2.2 of the First Amendment, is hereby further modified and
amended as follows:

2.2.1 From the date hereof to and including January 31, 2010, Rent sha