<Page>
Exhibit 10.19
MASTER LEASE AGREEMENT
(QUASI)
DATED AS OF NOVEMBER 10, 2004 ("AGREEMENT")
THIS AGREEMENT is between General Electric
Capital Corporation (together with
its successors and assigns, if any,
"Lessor") and Synta Pharmaceuticals Corp.
("Lessee"). Lessor has an office at 83
WOOSTER HEIGHTS ROAD, DANBURY, CT 06810.
Lessee is a corporation organized and
existing under the laws of state of
Delaware. Lessee's mailing address and
chief place of business is 45 HARTWELL
AVENUE, LEXINGTON, MA 02421. This Agreement
contains the general terms that
apply to the leasing of Equipment from
Lessor to Lessee. Additional terms that
apply the Equipment (term, rent, options,
etc.) shall be contained on a schedule
("Schedule").
1. LEASING:
(a) Lessor agrees to lease to Lessee,
and Lessee agrees to lease from Lessor,
the equipment and other property
("EQUIPMENT") described in any Schedule signed
by both parties.
(b) Lessor shall purchase Equipment
from the manufacturer or supplier
("SUPPLIER") and lease it to Lessee if on
or before the Last Delivery Date
(specified in the Schedule) Lessor receives
(i) a Schedule for the Equipment,
(ii) evidence of insurance which complies
with the requirements of Section 8,
and (iii) such other documents as Lessor
may reasonably request. Each of the
documents required above must be in form
and substance satisfactory to Lessor.
Lessor hereby appoints Lessee its agent for
inspection and acceptance of the
Equipment from the Supplier. Once the
Schedule is signed, the Lessee may not
cancel the Schedule.
2. TERM, RENT AND PAYMENT:
(a) The rent payable for the Equipment
and Lessee's right to use the Equipment
shall begin on the earlier of (i) the date
when the Lessee signs the Schedule
and accepts the Equipment or (ii) when
Lessee has accepted the Equipment under a
Certificate of Acceptance ("LEASE
COMMENCEMENT DATE"). The term of this
Agreement shall be the period specified in
the applicable Schedule. The word
"term" shall include all basic and any
renewal terms.
(b) Lessee shall pay rent to Lessor at
its address stated above, except as
otherwise directed by Lessor. Rent payments
shall be in the amount set forth in,
and due as stated in the applicable
Schedule. If any Advance Rent (as stated in
the Schedule) is payable, it shall be due
when the Lessee signs the Schedule.
Advance Rent shall be applied to the first
rent payment. In no event shall any
Advance Rent or any other rent payments be
refunded to Lessee. If rent is not
paid within ten (10) days of its due date,
Lessee agrees to pay a late charge of
five cents ($.05) per dollar on, and in
addition to, the amount of such rent but
not exceeding the lawful maximum, if
any.
3. TAXES:
(a) If permitted by law, Lessee shall
report and pay promptly all taxes, fees
and assessments due, imposed, assessed or
levied against Lessor or Lessee on
account of any Equipment (or purchase,
ownership, delivery, leasing, possession,
use or operation thereof) by any
<Page>
governmental entity or taxing authority
during or related to the term of this
Agreement, including, without limitation,
all license and registration fees, and
all sales, use, personal property, excise,
franchise, stamp or other taxes,
imposts, duties and charges, together with
any penalties, fines or interest
thereon(collectively "TAXES"). Lessee shall
have no liability for Taxes imposed
by the United States of America or any
State or political subdivision thereof or
any foreign jurisdiction which are on or
measured by the net income of Lessor,
and any such Taxes are excluded from
"Taxes" as such term is used throughout
this Agreement. Lessee shall promptly
reimburse Lessor (on an after tax basis)
for any Taxes charged to or assessed
against Lessor. Lessee shall send Lessor a
copy of each report or return and evidence
of Lessees payment of Taxes upon
request.
(b) Lessee's obligations, and Lessor's
rights and privileges, contained in this
Section 3 shall survive the expiration or
other termination of this Agreement.
4. REPORTS:
(a) If any tax or other lien shall
attach to any Equipment, Lessee will notify
Lessor in writing, within ten (10) days
after Lessee becomes aware of the tax or
lien. The notice shall include the full
particulars of the tax or lien and the
location of such Equipment on the date of
the notice.
(b) Lessee will deliver to Lessor
financial statements as follows: If Lessee is
a privately held company, then Lessee
agrees to provide quarterly financial
statements, certified by Lessee's president
or chief financial officer including
a balance sheet, statement of operations
and cash flow statement within 30 days
of each quarter end and its complete
audited annual financial statements,
certified by a reorganized firm of
certified public accountants, within 120 days
of fiscal year end or at such time as
Lessee's Board of Directors receives the
audit. If Lessee is a publicly held
company, then Lessee agrees to provide
quarterly unaudited statements and annual
audited statements, certified by a
recognized firm of certified public
accountants, within 10 days after the
statements are provided to the Securities
and Exchange Commission ("SEC") or
make such statements available on its
website. All such statements are to be
prepared using generally accepted
accounting principles ("GAAP") and, if Lessee
is a publicly held company, are to be in
compliance with SEC requirements.
(c) Lessor may inspect any Equipment
during normal business hours after giving
Lessee reasonable prior notice.
(d) Lessee will keep the Equipment at
the Equipment Location (specified in the
applicable Schedule) and will give Lessor
prior written notice of any relocation
of Equipment. If Lessor requests, Lessee
will promptly notify Lessor in writing
of the location of any Equipment.
(e) If any Equipment is lost or
damaged (where the estimated repair costs would
exceed the greater of ten percent (10%) of
the original Equipment cost or ten
thousand and 00/100 dollars ($10,000), or
is otherwise involved in an accident
causing personal injury or property damage,
Lessee will promptly and fully
report the event to Lessor in writing.
(f) If Lessor requests, Lessee will
furnish a certificate of an authorized
officer of Lessee stating that he has
reviewed the activities of Lessees and
that, to the best of his knowledge,
there
2
<Page>
exists no default or event which with
notice or lapse of time (or both) would
become such a default within thirty (30)
days after any request by Lessor.
(g) Lessee will promptly notify Lessor
of any change in Lessee's state of
incorporation or organization.
5. DELIVERY, USE AND
OPERATION:
(a) All Equipment shall be shipped
directly from the Supplier to Lessee.
(b) Lessee agrees that the Equipment
will be used by Lessee solely in the
conduct of its business and in a manner
complying with all applicable laws,
regulations and insurance policies.
(c) Lessee will not move any equipment
from its leased or owned locations
("LOCATION"), except for purposes of
repair, refurbishment or maintenance, and
Lessee will not move any piece of Equipment
with an original equipment value of
$25,000 or more from one Location to
another Location without written
notification to Lessor.
(d) Lessee will keep the Equipment
free and clear of all liens and encumbrances
other than those which result from acts of
Lessor.
(e) Lessor shall not disturb Lessees
quiet enjoyment of the Equipment during
the term of the Agreement unless a default
has occurred and is continuing under
this Agreement.
6. MAINTENANCE:
(a) Lessee will, at its sole expense,
maintain each unit of Equipment in good
operating order and repair, normal wear and
tear excepted. The Lessee shall also
maintain the Equipment in accordance with
manufacturers recommendations. Lessee
shall make all alterations or modifications
required to comply with any
applicable law, rule or regulation during
the term of this Agreement. If Lessor
requests, Lessee shall affix plates, tags
or other identifying labels showing
ownership thereof by Lessee and Lessor's
security interest therein. The tags or
labels shall be placed in a prominent
position on each unit of Equipment.
(b) Lessee will not attach or install
anything on the Equipment that will
impair the originally intended function or
use of such Equipment without the
prior written consent of Lessor, which
consent may not be withheld, conditioned
or delayed unreasonably. All additions,
parts, supplies, accessories, and
equipment ("ADDITIONS") furnished or
attached to any Equipment that are not
readily removable shall become subject to
the lien or Lessor. All Additions
shall be made only in compliance with
applicable law. Lessee will not attach or
install any Equipment to or in any other
personal or real property without the
prior written consent of Lessor, which
consent may not be withheld, conditioned
or delayed unreasonably.
7. STIPULATED LOSS VALUE: If
for any reason any unit of Equipment becomes
lost, stolen, destroyed, irreparably
damages or unusable ("CASUALTY
OCCURRENCES") Lessee shall promptly and
fully notify Lessor in writing. Lessee
shall pay Lessor the sum of (i) the
Stipulated Loss Value (see Schedule) of the
affected unit determined as of the rent
payment date prior to the casualty
Occurrence; and (ii) all rent and other
amounts which are then due under this
3
<Page>
Agreement on the Payment Date (defined
below) for the affected unit. The Payment
Date shall be the next rent payment after
the Casualty Occurrence. Upon payment
of all sums due hereunder, the term of this
lease as to such unit shall
terminate.
8. INSURANCE:
(a) Lessee shall bear the entire risk
of any loss, theft, damage to, or
destruction of, any unit of Equipment from
any cause whatsoever from the time
the Equipment is delivered to Lessee and
installed (if applicable).
(b) Lessee agrees, at its own expense,
to keep all Equipment insured for such
amounts and against such hazards as Lessor
may reasonably require. All such
policies shall be with companies, and on
terms, reasonably satisfactory to
Lessor. The insurance shall include
coverage for damage to or loss of Equipment,
liability for personal injuries, death or
property damage. Lessor shall be named
as additional insured with a loss payable
clause in favor of Lessor, as its
interest may appear, irrespective of any
breach of warranty or other act or
omission of Lessee. The insurance shall
provide for liability coverage in any
amount equal to at least ONE MILLION U.S.
DOLLARS ($1,000,000.00) total
liability per occurrence, unless otherwise
stated in any Schedule. The
casualty/property damage coverage shall be
in an amount equal to the higher of
the Stipulated Loss Value or the full
replacement cost of the Equipment. No
insurance shall be subject to any
co-insurance clause. The insurance policies
shall provide that the insurance may not be
altered or canceled by the insurer
until after thirty (30) days written notice
to Lessor. Lessee agrees to deliver
to Lessor evidence of insurance reasonable
satisfactory to Lessor.
(c) Lessee hereby appoints to Lessor
as Lessee's attorney-in-fact to make proof
of loss and claim for insurance, and to
make adjustments with insurers and to
receive payment of an execute or endorse
all documents, checks or drafts in
connection with insurance payments. Lessor
shall not act a Lessees
attorney-in-fact unless Lessee is in
default. Lessee shall pay any reasonable
expenses if Lessor in adjusting or
collecting insurance. Lessee will not make
adjustments with insurers except with
respect to claims for damage to any unit
of Equipment where the repair costs are
less than the lesser of ten percent
(10%) of the original Equipment cost or ten
thousand and 00/100 dollars
($10,000). Lessor may, at its option, apply
proceeds of insurance, in whole or
in part, to (i) repair or replace Equipment
or any portion thereof, or (ii)
satisfy any obligation of Lessee to Lessor
under this Agreement.
9. RETURN OF EQUIPMENT:
(a) At the expiration or termination
of this Agreement or any Schedule, Lessee
shall perform any testing and repairs
required to place the units of Equipment
in the same condition and appearance as
when received by Lessee (reasonable wear
and tear excepted) and in good working
order for the original intended purpose
of the Equipment. If required the units of
Equipment shall be deinstalled,
disassembled and crated by an authorized
manufacturer's representative or such
other service person as is reasonably
satisfactory to Lessor. Lessee shall
remove installed markings that are not
necessary for the operation, maintenance
or repair of the Equipment. All Equipment
will be cleaned, cosmetically
acceptable, and in such condition as to be
immediately installed into use in a
similar environment for which the Equipment
was
4
<Page>
originally intended to be used. All waste
material and fluid must be removed
from the Equipment and disposed of in
accordance with then current waste
disposal laws. Lessee shall return the
units of Equipment to a location within
the continental United States as Lessor
shall direct. Lessee shall obtain and
pay for a policy of transit insurance for
the redelivery period in an amount
equal to the replacement value of the
Equipment. The transit insurance must name
Lessor as the loss payee. The Lessee shall
pay for all costs to comply with this
section (a).
(b) Until Lessee has fully complied
with the requirements of Section 9(a)
above, Lessee's rent payment obligation and
all other obligations under this
Agreement shall continue from month to
month notwithstanding any expiration or
termination of the lease term. Lessor may
not terminate the Lessee's right to
use Equipment, unless Lessee is in
default.
(c) Lessee shall provide to Lessor a
detailed inventory of all components of
the Equipment including model and serial
numbers. Lessee shall also provide an
up-to-date copy of all other documentation
pertaining to the Equipment. All
service manuals, blueprints, process flow
diagrams, operating manuals, inventory
and maintenance records shall be given to
Lessor at least ninety (90) days and
not more than one hundred twenty (120) days
prior to lease termination.
(d) Lessee shall make the Equipment
available for on-site operational
inspections by potential purchasers at
least one hundred twenty (120) days prior
to and continuing up to lease termination.
Lessor shall provide Lessee with
reasonable notice prior to any inspection.
Lessee shall provide personnel, power
and other requirements necessary to
demonstrate electrical, hydraulic and
mechanical systems for each item of
Equipment.
10. DEFAULT AND REMEDIES:
(a) Lessor may in writing declare this
Agreement in default if: (i) Lessee
breaches its obligation to pay rent or any
other sum when due and fails to cure
the breach within ten (10) days; (ii)
Lessee breaches any of its insurance
obligations under Section 9; (iii) Lessee
breaches any of its other obligations
and fails to cure that breach within thirty
(30) days after written notice from
Lessor; (iv) any representation or warranty
made by Lessee in connection with
this Agreement shall be false or misleading
in any material respect; (v) Lessee
or any guarantor or other obligor for the
Lessee's obligations hereunder
("GUARANTOR") becomes insolvent or ceases
to do business as a going concern;
(vi) any Equipment is illegally used; (vii)
if Lessee or any Guarantor is a
natural person, any death or incompetency
of Lessee or such Guarantor; (viii) a
petition is filed by or against Lessee or
any Guarantor under any bankruptcy or
insolvency laws and in the event of an
involuntary petition, the petition is not
dismissed, within forty-five (45) days of
the filing date; (ix) Lessee default
under any other material obligation for (A)
borrowed money, (B) the deferred
purchase price of property, or (C) payments
due under the lease agreement; (x)
there is any dissolution, termination or
existence, merger, consolidation or
change in controlling ownership or Lessee
or any Guarantor, but not to include
an initial public offering, or any other
stock offering, preferred to common, in
which the primary purpose is to raise cash
equity; or (xi) there is a material
adverse change in the Lessee's financial
condition. The default declaration
shall apply to all Schedules unless
specifically excepted by Lessor.
(b) After a default, at the request of
Lessor, Lessee shall comply with the
provisions of Section 9(a) and the
following provisions shall apply also. Lessee
hereby authorizes Lessor to
5
<Page>
peacefully enter any premises where any
Equipment may be and take possession of
the Equipment. Lessee shall immediately pay
to Lessor without further demand as
liquidated damages for loss of a bargain
and not as a penalty, the Stipulated
Loss Value of the Equipment (calculated as
of the rent payment date prior to the
declaration of default), and all rents and
other sums then due under this
Agreement and all Schedules. Lessor may
terminate this Agreement as to any or
all of the Equipment. A termination shall
occur only upon written notice by
Lessor to Lessee and only as to the units
of Equipment specified in any such
notice. Lessor may, but shall not be
required to, sell Equipment at private or
public sale, in bulk or in parcels, with or
without notice, and without having
the Equipment present at the place of sale.
Lessor may also, but shall not be
required to, lease, otherwise dispose of or
keep idle all or part of the
Equipment. Lessor may use Lessee's premises
for a reasonable period of time for
any or all of the purposes stated above
without liability for rent, costs,
damages or otherwise. The proceeds of sale,
lease or other disposition, if any,
shall be applied in the following order of
priorities: (i) to pay all of
Lessor's costs, charges and expenses
incurred in taking, removing, holding,
repairing and selling, leasing or otherwise
disposing of Equipment; then (ii) to
the extent not previously paid by Lessee,
to pay Lessor all sums due from Lessee
under this Agreement; then (iii) to
reimburse to Lessee any sums previously paid
by Lessee as liquidated damages; and then
(iv) to Lessee, if there exists any
surplus. Lessee shall immediately pay any
deficiency in (i) and (ii) above.
(c) The foregoing remedies are
cumulative, and any or all thereof may be
exercised instead of or in addition to each
other or any remedies at law, in
equity, or under statute. Lessee waives
notice of sale or other disposition (and
the time and place thereof), and the manner
and place of any advertising. Lessee
shall pay Lessor's actual attorney's fees
incurred in connection with the
enforcement, assertion, defense or
preservation of Lessor's rights and remedies
under this Agreement, or if prohibited by
law, such lesser sum as may be
permitted. Waiver of any default shall not
be a waiver of any other or
subsequent default.
(d) Any default under the terms of
this or any other agreement between Lessor
and Lessee may be declared by Lessor a
default under this and any such other
agreement.
11. ASSIGNMENT: LESSEE SHALL NOT SELL,
TRANSFER, ASSIGN, ENCUMBER OR SUBLET ANY
EQUIPMENT OR THE INTEREST OF LESSEE IN THE
EQUIPMENT WITHOUT THE PRIOR WRITTEN
CONSENT OF LESSOR. Lessor may, without the
consent of Lessee, assign this
Agreement, any Schedule or the right to
enter into a Schedule. Lessee agrees
that is Lessee receives written notice of
an assignment from Lessor, Lessee will
pay all rent and all other amounts payable
under any assigned Schedule to such
assignee or as instructed by Lessor. Lessee
also agrees to confirm in writing
receipt of the notice of assignment as may
be reasonably requested by assignee.
Lessee hereby waives and agrees not to
assert against any such assignee any
defense, set-off, recoupment claim or
counterclaim which Lessee has or may at
any time have against Lessor for any reason
whatsoever.
12. NET LEASE: Lessee is
unconditionally obligated to pay all rent and other
amounts due for the entire lease term no
matter what happens, even if the
Equipment is damaged or destroyed, if it is
defective or if Lessee no longer can
use it. Lessee is not entitled to reduce or
set-off against rent or other
amounts due to Lessor or to anyone to whom
Lessor assigns this Agreement or any
Schedule whether Lessees claim arises out
of this Agreement, any Schedule, any
6
<Page>
statement by Lessor, Lessor's liability of
any manufacturers liability, strict
liability, negligence or otherwise.
13. INDEMNIFICATION:
(a) Lessee hereby agrees to indemnify
Lessor, its agents, employees, successors
and assigns (on an after tax basis) from
and against any and all losses,
damages, penalties, injuries, claims,
actions and suits, including legal
expenses, of whatsoever kind and nature
arising out of or relating to the
Equipment or this Agreement, except to the
extent the losses, damages,
penalties, injuries, claims, actions, suits
or expenses result from Lessor's
gross negligence or willful misconduct
("CLAIMS"). This indemnity shall include,
but is not limited to, Lessor's strict
liability in tort and Cla