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Lease Agreement

LEASE | Document Parties: Alexandria Real Estate | ARE-MA Region No 20, LLC | ARE-QRS Corp | ARQULE, INC | CHICAGO TITLE INSURANCE COMPANY | TITLE COMPANY You are currently viewing:
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Alexandria Real Estate | ARE-MA Region No 20, LLC | ARE-QRS Corp | ARQULE, INC | CHICAGO TITLE INSURANCE COMPANY | TITLE COMPANY

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Title: LEASE
Governing Law: Massachusetts     Date: 5/6/2005
Law Firm: Wilmer Cutler;Arnold Porter    

LEASE, Parties: alexandria real estate , are-ma region no 20  llc , are-qrs corp , arqule  inc , chicago title insurance company , title company
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Exhibit 10.2

LEASE

by and between

ARE-MA Region No. 20, LLC

Landlord

and

ARQULE, INC.

Tenant

Dated: May __, 2005

Premises at 19 Presidential Way, Woburn, Massachusetts

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TABLE OF CONTENTS

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Page

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TABLE OF CONTENTS.............................................................. i

ARTICLE I Reference Data................................................. 1

1.1. Incorporated References........................................ 1

1.2. Exhibits....................................................... 3

ARTICLE II Lease Grant; Extended Terms.................................... 4

2.1. Term........................................................... 4

2.2. Option to Extend Term.......................................... 4

2.3. Annual Fixed Rent During the Original Term..................... 4

2.4. Annual Fixed Rent During Extended Terms........................ 4

ARTICLE III Rent........................................................... 6

3.1. Annual Fixed Rent.............................................. 6

3.2. Additional Rent................................................ 6

3.3. Real Estate Taxes.............................................. 6

3.4. Insurance...................................................... 8

3.5. Certain Provisions Applicable to Insurance Policies............ 9

3.6. Waiver of Subrogation.......................................... 10

3.7. Utilities...................................................... 10

3.8. Net Lease; Nonterminability by Tenant.......................... 10

ARTICLE IV Additional Covenants........................................... 11

4.1. Tenant's Affirmative Covenants................................. 11

4.2. Landlord's Repair and Maintenance Obligations.................. 13

4.3. Tenant's Work.................................................. 13

4.4. Tenant's Indemnity............................................. 14

4.5. Landlord's Indemnity........................................... 14

4.6. Landlord's Right to Enter...................................... 14

4.7. Personal Property at Tenant's Risk............................. 15

4.8. Payment of Cost of Enforcement................................. 15

4.9. Yield-Up....................................................... 15

4.10. Estoppel Certificates.......................................... 17

4.11. Park Restrictions.............................................. 17

4.12. Holding Over................................................... 17

4.13. Assignment and Subletting...................................... 18

4.14. Waste; Nuisance................................................ 19

4.15. Installations, Alterations or Additions........................ 20

4.16. Signage........................................................ 21

4.17. Parking........................................................ 21

4.18. Landlord's Additional Covenants................................ 21

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ARTICLE V Casualty or Taking............................................. 22

5.1. Casualty....................................................... 22

5.2. Taking......................................................... 23

5.3. Restoration.................................................... 24

5.4. Award.......................................................... 24

ARTICLE VI Defaults....................................................... 25

6.1. Events of Default.............................................. 25

6.2. Remedies....................................................... 25

6.3. Remedies Cumulative............................................ 26

6.4. Landlord's Rights to Cure Defaults............................. 26

6.5. Effect of Waivers of Default................................... 26

6.6. No Accord and Satisfaction..................................... 27

6.7. Interest on Overdue Sums....................................... 27

ARTICLE VII Mortgages...................................................... 27

7.1. Rights of Mortgage Holders..................................... 27

7.2. Superiority of Lease: Option to Subordinate.................... 28

ARTICLE VIII Miscellaneous Provisions....................................... 28

8.1. Notices from One Party to the Other............................ 28

8.2. Quiet Enjoyment................................................ 29

8.3. Recordation of Lease........................................... 29

8.4. Bind and Inure: Limitation of Landlord's Liability............ 29

8.5. Acts of God.................................................... 29

8.6. Landlord's Default; Tenant's Right of Self-Help................ 30

8.7. Brokerage...................................................... 30

8.8. Applicable Law and Construction................................ 30

8.9. Submission Not an Offer........................................ 31

8.10. Security Deposit............................................... 31

8.11. Parties Responsible for Costs of Own Obligations............... 32

8.12. Limitation on Damages.......................................... 32

ARTICLE IX First Opportunity; Right of First Refusal...................... 32

9.1. Tenant's Right of First Opportunity to Purchase................ 32

9.2. Tenant's Right of First Refusal................................ 33

ARTICLE X Development of Expansion Lot................................... 33

10.1. Tenant's Approval Right During Term............................ 33

10.2. Activities on Expansion Lot.................................... 34

10.3. Construction Activities of Landlord on Expansion Lot........... 34

10.4. Expansion Right................................................ 34

ARTICLE XI Landlord's Representations And Warranties...................... 36

11.1. Representations and Warranties of Landlord..................... 36

</TABLE>

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EXHIBIT A DESCRIPTION OF PRIMARY LOT

EXHIBIT B DESCRIPTION OF EXPANSION LOT

EXHIBIT C FIXTURES, FURNISHINGS AND EQUIPMENT OF TENANT TO BE

REMOVED FROM PREMISES

EXHIBIT D NOTICE OF LEASE

EXHIBIT E FORM OF PURCHASE AGREEMENT

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<PAGE>

LEASE AGREEMENT

ARE-MA Region No. 20, LLC, a Delaware limited liability company (the

"Landlord"), hereby leases and demises to ARQULE, INC., a Delaware corporation

(the "Tenant") and Tenant hereby leases from Landlord, the Premises (as

described in Section 1.1 of this Lease) on the terms and provisions of this

Lease.

ARTICLE I

REFERENCE DATA

1.1. Incorporated References. Each reference in this Lease to any of the

following subjects shall be construed to incorporate the data stated for that

subject in this Section 1.1.

Primary Lot: The parcel of land described in Exhibit A

attached hereto.

Expansion Lot: The parcel of land described in Exhibit B

attached hereto.

Cross-Easements: Those rights and easements appurtenant to

the Primary Lot for drainage facilities,

water and sewer and other utility lines,

granted pursuant to recorded instruments,

including the Easement and Agreement made

as of December 7, 2000, and recorded in

the Middlesex South Registry District of

the Land Court as Document No. 1158395

(the "Easement and Agreement" and together

with the Declaration of Protective

Covenants (hereinafter defined) and other

appurtenant easements, the "Cross

Easements"). Landlord shall not amend or

modify any Cross Easements without the

prior consent of Tenant, which may be

withheld by Tenant in its reasonable

discretion.

Premises: The Primary Lot, the Building and the

Cross-Easements.

Building: The building located on the Primary Lot.

Rentable Area of Building: 128,325 square feet on three levels. The

19,473 square feet of mechanical space in

the Building is excluded from the Rentable

Area of Building and the calculation of

Annual Fixed Rent.

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<PAGE>

Original Address of Landlord: ARE-MA Region No. 20, LLC

c/o Alexandria Real Estate Equities,

Inc.

135 North Robles Avenue, Suite 250

Pasadena, CA 91101

Attention: Corporate Secretary

Original Address of Tenant: 19 Presidential Way

Woburn, MA 01801

Landlord's Representative: Thomas Andrews

Tenant's Representative: Steven M. Lacerte

Security Deposit: $1,604,063 (equal to six (6) months' of

Annual Fixed Rent during Original Term in

the form of a Letter of Credit)

Term Commencement Date: May __, 2005

Original Term: If the Term Commencement Date is the first

day of a calendar month, the period

beginning on the Term Commencement Date

and ending on the day before the tenth

(10th) anniversary of the Term

Commencement Date. If the Term

Commencement Date is a day other than the

first day of a calendar month, the period

beginning on the Term Commencement Date

and ending on the last day of the month in

which the tenth (10th) anniversary of the

Term Commencement Date occurs (whichever

of the foregoing expiration dates is

applicable, the "Original Term Expiration

Date").

Extended Terms: Two (2) five (5) year periods, subject to

the provisions of Section 2.2.

Intended Uses: General office, manufacturing, research

and development (including RDNA, genetic,

biomedical and combinational chemistry,

and animal testing), testing laboratory,

other accessory general office and

manufacturing uses, and other uses

ancillary and/or related thereto,

including but not limited to parking.

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Other Charges: Amounts payable by the owner of the

Primary Lot under that certain Declaration

of Protective Covenants dated May 27,

1988, and recorded with the Middlesex

South Registry District of the Land Court

as Document No. 777192, as amended by

Amendment to Declaration of Covenants

dated October 12, 1989, and recorded with

the Middlesex South Registry District of

the Land Court as Document Number 809254

(collectively, the "Declaration of

Protective Covenants") and the Easement

and Agreement.

Lease Year: (a) If the Term Commencement Date is the

first day of a calendar month, each one

year period beginning on the Term

Commencement Date and each anniversary

thereof and ending on the day before the

next succeeding such anniversary and (b)

If the Term Commencement Date is a day

other than the first day of a calendar

month, each one year period beginning on

the first day of the calendar month

immediately after the month in which the

Term Commencement Date occurs, and each

anniversary of such day, and ending on the

day before the next succeeding such

anniversary. Appropriate pro-rations shall

be made for any partial months or other

periods prior to the commencement of the

first Lease Year.

Broker(s): CBRE Lynch Murphy Walsh Advisors

Public Liability Insurance Limits Comprehensive General Liability Limit of

(per occurrence):: $5,000,000

Annual Fixed Rent: Determined under Sections 2.3 and 2.4 of

this Lease.

1.2. Exhibits. The Exhibits listed below in this Section are incorporated

in this Lease by reference and are to be construed as a part of this Lease:

EXHIBIT A: Description of Primary Lot.

EXHIBIT B: Description of Expansion Lot.

EXHIBIT C: Fixtures, Furnishings and Equipment of

Tenant to be removed from Premises

EXHIBIT D: Form of Notice of Lease

EXHIBIT E: Form of Purchase Agreement

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ARTICLE II

LEASE GRANT; EXTENDED TERMS

2.1. Term. Landlord leases the Premises to Tenant and Tenant leases the

Premises from Landlord, for the Term.

2.2. Option to Extend Term. Tenant shall have two (2) separate options to

extend the then term of this Lease, in each case for an additional five (5) year

period (i.e., for a total, if any of such options is exercised as provided

herein, of ten (10) successive years beyond the Original Term) (each five (5)

year period being referred to herein as an "Extended Term"), provided (i) to

exercise any such option, Tenant shall give notice in writing to Landlord of its

exercise not less than twelve (12) months prior to expiration of the Original

Term or the first Extended Term, as applicable (the "Exercise Date"), and (ii)

no default continuing beyond any applicable notice, grace or cure period in the

obligations of Tenant under this Lease shall exist at the time each such notice

is given. All of the terms and provisions of this Lease shall be applicable

during each such Extended Term except that (i) Tenant shall have no option to

extend the Term of this Lease beyond the second Extended Term and (ii) the

Annual Fixed Rent for each Extended Term shall be adjusted in accordance with

Section 2.4 hereof. The word "Term" or "term" as used herein shall mean the

Original Term, plus any of the Extended Terms as to which Tenant shall have

exercised its option under this Section 2.2.

2.3. Annual Fixed Rent During the Original Term. For the Original Term of

this Lease the Annual Fixed Rent for the Building shall be as set forth below:

<TABLE>

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Annual Fixed Rent Annual Fixed Annual Fixed

Lease Year per square foot Rent Rent per month

--------------------------------- ----------------- ------------- --------------

<S> <C> <C> <C>

Commencement Date through

May 31, 2006 $23.1200 $2,966,874.00 $247,239.50

June 1, 2006 through May 31, 2007 $23.8136 $3,055,880.22 $254,656.69

June 1, 2007 through May 31, 2008 $24.5280 $3,147,556.63 $262,296.39

June 1, 2008 through May 31, 2009 $25.2638 $3,241,983.33 $270,165.28

June 1, 2009 through May 31, 2010 $26.0218 $3,339,242.83 $278,270.24

June 1, 2010 through May 31, 2011 $26.8024 $3,439,420.11 $286,618.34

June 1, 2011 through May 31, 2012 $27.6065 $3,542,602.71 $295,216.89

June 1, 2012 through May 31, 2013 $28.4347 $3,648,880.79 $304,073.40

June 1, 2013 through May 31, 2014 $29.2877 $3,758,347.22 $313,195.60

June 1, 2014 through May 31, 2015 $30.1664 $3,871,097.64 $322,591.47

</TABLE>

2.4. Annual Fixed Rent During Extended Terms.

(a) If Tenant shall exercise its option(s) to extend the Term

pursuant to Section 2.2, the Annual Fixed Rent shall be adjusted, effective as

of the first day of each Extended Term (each an "Adjustment Date"), to equal

ninety-five (95%) of the Market Rent (as hereinafter determined and defined) as

of the applicable Adjustment Date. "Market Rent" shall be computed as of each

Adjustment Date at the fair market rental rate (per square foot of Rentable

Area) that would be agreed upon between a landlord and a tenant entering into a

new

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lease for "as is" space in a comparable building, taking into account and giving

effect to (i) the estimated savings to Landlord of costs and expenses associated

with leasing the Premises to Tenant rather than to a third party, including

without limitation leasing commissions and lost rent due to vacancy periods and

(ii) in determining comparability, considerations such as size, configuration,

location (i.e., suburbs of Boston, excluding Cambridge, MA and Boston city

limits), quality, age and condition of premises and lease term, assuming the

landlord and tenant are informed and well-advised and each is acting in what it

considers its own best interests. Market Rent shall include the provision by

Landlord to Tenant of a tenant improvement allowance, free rent and/or other

special concessions ("Fair Market Concessions") in amounts that would be agreed

upon between a landlord and a tenant entering into a new lease for comparable

space as to location (i.e., suburbs of Boston, excluding Cambridge, MA and

Boston city limits), configuration, size and use, in a comparable building as to

location, quality, reputation and age, with a comparable build-out, and a

comparable term, assuming the landlord and tenant are informed and well-advised

and each is acting in what it considers its own best interests. Notwithstanding

anything to the contrary in this Section 2.4(a), the determination of Market

Rent pursuant to Section 2.4(b) shall exclude the value of Tenant's Property and

any installations, alterations or additions to the Premises made after the date

of this Lease. In determining the Market Rent, the net present value approach

shall be utilized (with an appropriate discount rate) to reflect the fact that

Landlord will realize the savings set forth in clause (i) above immediately upon

the commencement of the applicable Extended Term.

(b) Landlord and Tenant shall negotiate in good faith to determine

the Annual Fixed Rent (including Fair Market Concessions) for the applicable

Extension Period, for a period of thirty (30) days after the date on which

Landlord receives Tenant's written notice of Tenant's election to exercise the

extension option provided for under this Section. In the event Landlord and

Tenant are unable to agree upon the Annual Fixed Rent for any Extension Period

within said thirty (30)-day period, the Market Rent for the Premises shall be

determined by two (2) licensed real estate brokers, one of whom shall be named

by the Landlord and one of whom shall be named by Tenant. Each real estate

broker so selected shall be licensed in the jurisdiction in which the Building

is located as a real estate broker specializing in the field of

laboratory/biotech leasing in the suburban Boston, Massachusetts area, having no

less than ten (10) years' experience in such field, and recognized as ethical

and reputable within the field. Landlord and Tenant agree to make their

appointments promptly within ten (10) days after the expiration of the thirty

(30)-day period, or sooner if mutually agreed upon. Each broker, within fifteen

(15) days after both brokers have been selected, shall submit his or her

determination of the Market Rent and the Fair Market Concessions. If the higher

determination of Market Rent is not more than ten percent (10%) of the lower

determination (based on net present values using an annual discount rate of five

percent (5%)), then the Market Rent shall be the average of the two (2) rental

rate and concession determinations. If the higher determination of Market Rent

is greater than 10% of the lower determination of Market Rent, then the two (2)

brokers selected by Landlord and Tenant shall promptly select a third broker

within ten (10) days after they have delivered their determinations. The third

broker shall meet all the qualifications required above for the first two (2)

brokers and shall make its determination of the Market Rent within ten (10) days

after he or she has been appointed. In such event, the Market Rent shall be the

determination of the three brokers (on a net present value basis as described

above) that is not the highest or the lowest determination, provided, that, if

any two brokers have an identical determination of Market Rent, such

determination shall be the Market Rent hereunder for the

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applicable Extension Term. Subject to Section 2.4(c), Landlord and Tenant shall

each pay the fee of the broker selected by it, and they shall equally share the

payment of the fee of the third broker.

(c) If the Market Rent is determined by brokers pursuant to Section

2.4(b), Tenant shall have the right, within ten (10) days after such

determination, to revoke its notice to extend the term of this Lease, in which

event Tenant shall be obligated to pay the fees of all of the brokers engaged to

determine Market Rent, and the Term of this Lease shall expire at the end of the

then current Term. If Tenant does not revoke its notice to extend the Term of

this Lease pursuant to the immediately preceding sentence, then, within thirty

(30) days after the Market Rent is determined, whether by agreement of Landlord

and Tenant or by brokers, as aforesaid, the parties shall promptly execute a

supplement to this Lease confirming the same.

ARTICLE III

RENT

3.1. Annual Fixed Rent. Tenant covenants and agrees to pay rent ("Annual

Fixed Rent") to Landlord at the original Address of Landlord or at such other

place or to such other person or entity as Landlord may by written notice to

Tenant from time to time direct, at the Annual Fixed Rent set forth in, or

determined by the provisions of, Article II, in equal installments equal to

1/12th of the Annual Fixed Rent in advance on the first day of each calendar

month during the Term; and for any portion of a calendar month at the beginning

of the Term, prorated for such portion.

3.2. Additional Rent. Tenant covenants and agrees to pay as Additional

Rent to Landlord an administrative management fee in the amount of Fifteen

Thousand Dollars ($15,000) per year, which amount shall be due and payable on

the first anniversary of the Commencement Date and on each anniversary of the

Commencement Date during the Original Term. In addition, Tenant shall pay the

amounts provided for in Section 3.3 and Section 3.4 as Additional Rent.

3.3. Real Estate Taxes.

(a) Each year during the Term, Landlord shall submit to Tenant a

statement of all invoices for Real Estate Taxes (hereinafter defined) payable by

Tenant pursuant to this Section 3.3, and Tenant shall pay the same to Landlord

not later than ten (10) days prior to the date on which the same may be paid

without interest or penalty. For purposes of this Lease, the term "Real Estate

Taxes" shall mean: (i) all taxes, assessments (special or otherwise), levies,

fees, water and sewer rents and charges and all other governmental levies and

charges, general and special, ordinary and extraordinary foreseen and

unforeseen, to the extent allocable to the Term hereof, imposed with respect to

the ownership or operation of the Primary Lot or the Building; and (ii) all

charges for utilities furnished to the Premises which may become a lien on the

Building or the Primary Lot (collectively "taxes and assessments" or if singular

"tax or assessment"). "Real Estate Taxes" shall not include any income, sales,

gross receipts, value added, estate, transfer, capital gains, inheritance,

succession, gift, franchise, capital stock tax, any income taxes arising out of

or related to the ownership and operation of the Primary Lot or the Building or

any taxes relating to the Expansion Lot. Tenant shall have the right to apply to

the

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appropriate governmental authority or agency to have taxes and assessments

assessed directly to Tenant, and Landlord shall cooperate with Tenant completing

such application and documentation necessary to effect such direct assessment.

In the case of any such taxes and assessments assessed directly to Tenant,

Tenant shall cause the same to be paid on or prior to the date on which the same

may be paid without interest or penalty.

(b) With respect to any taxes and assessments assessed directly to

Landlord, Landlord shall pay all taxes and assessments to the applicable

government authorities before or on the dates due, and shall promptly provide to

Tenant evidence of such payment.

(c) With respect to taxes and assessments which may lawfully be paid

in installments, for the purpose of this Section 3.3, taxes and assessments in

any period shall include only such portion of the same which is required to be

paid within such period and any interest payable thereon computed (whether or

not such is the case) as if Landlord had elected to pay the same over the

longest period permitted by law.

(d) If, at any time during the Term, the present system of ad

valorem taxation of real property shall be changed so that in lieu of the whole

or any part of the ad valorem tax on real property, there shall be assessed on

Landlord a capital levy or other tax on the gross rents received with respect to

the Primary Lot and Building, or both, or a federal, state, county, municipal,

or other local income, franchise, excise or similar tax, assessment, levy or

charge (distinct from any now in effect) measured by or based, in whole or in

part, upon gross rents, then any and all of such taxes, assessments, levies or

charges, to the extent so measured or based ("Substitute Taxes"), shall be

payable by Tenant without duplication; provided, however, Tenant's obligation

with respect to the aforesaid Substitute Taxes shall be limited to the amount

thereof as computed at the rates that would be payable if the Premises were the

only property of Landlord. Landlord shall furnish to Tenant a copy of any notice

of any public, special or betterment assessment received by Landlord concerning

the Premises and charged to Tenant hereunder promptly upon Landlord's receipt

thereof.

(e) If Landlord shall obtain any abatement or refund on account of

any real estate taxes as to which Tenant shall have paid payments hereunder,

then, within thirty (30) days after receiving the same, Landlord shall refund to

Tenant Tenant's portion of any such abatement or refund, after deducting

therefrom the reasonable costs and expenses incurred by Landlord in obtaining

such abatement or refund.

(f) For so long as taxes are assessed directly against Landlord, if

at least twenty (20) days prior to the last day for filing an application for

abatement of taxes or assessments for any tax year, Tenant shall give notice to

Landlord that it desires to file an application for abatement of such taxes and

assessments or to otherwise contest the assessed valuation of the Primary Lot

and Building for such tax year, and if within ten (10) days after the receipt of

such notice, Landlord does not give notice back to Tenant that Landlord shall

itself file such application or commence such contest, then Tenant shall have

the right either in its own name or in the name of Landlord but at its own cost

and expense to file such application or commence such contest. If within ten

(10) days after receipt by Landlord of such notice from Tenant, Landlord shall

give Tenant notice that Landlord shall itself file such application or commence

such contest, then Landlord shall do so prior to the expiration of the time for

the

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filing of the same at its own cost and expense. In any event, if any abatement

by whomever prosecuted shall be obtained, the cost and expense of obtaining the

same shall be the first charge upon such abatement and shall be reimbursed to

the party expending the same from the proceeds thereof, prior to any other

distribution. If Tenant shall file an application for abatement or commence such

contest pursuant to the provisions of this paragraph, Tenant shall prosecute the

same to final determination with reasonable diligence and shall not, without

Landlord's consent (which shall not be unreasonably withheld, conditioned or

delayed), settle, compromise or discontinue the same except that Tenant may

discontinue the prosecution of the same at any time after giving Landlord notice

thereof and a reasonable opportunity to assume prosecution of the same. If

Landlord shall file an application for abatement or commence such contest,

Landlord shall prosecute the same to final determination with reasonable

diligence and shall not without Tenant's consent (which shall not be

unreasonably withheld, conditioned or delayed), settle, compromise, or

discontinue the same except that Landlord may discontinue the prosecution of the

same at any time after giving Tenant notice thereof and a reasonable opportunity

to assume prosecution of the same. If either party shall file an application for

an abatement or commence such contest, the other will cooperate and furnish any

pertinent information in its files reasonably required by the prosecuting party.

In every case, any abatement, refund, rebate or credit received shall be paid

first to the party which prosecuted such abatement in the amount of the costs

and expenses expended by it in such connection, and the balance to each party

(within thirty (30) days after receipt) in the proportion that it paid the tax

or assessment being abated, refunded, rebated or credited. Landlord shall pay

any sums due to Tenant from any abatement within thirty (30) days after receipt

of the same even if this Lease shall have expired. Tenant shall timely pay all

sums payable under this Lease in respect of taxes and assessments

notwithstanding the pendency of an abatement proceeding or any such contest.

(g) Real Estate Taxes assessed for a real estate tax fiscal year

which extends after the Term or earlier termination of this Lease shall be

apportioned between Landlord and Tenant at the expiration of the Term.

3.4. Insurance. Throughout the Term, subject to Section 3.5(b), Landlord

shall obtain and maintain the insurance listed in Sections 3.4(b) and 3.4(c), at

Tenant's sole cost and expense, which shall be payable by Tenant as Additional

Rent, and Tenant shall obtain and maintain the insurance listed in Section

3.4(a) at Tenant's sole cost and expense:

(a) Commercial general liability insurance indemnifying Landlord and

Tenant, and if Landlord shall elect, Landlord's mortgagees, against all claims

and demands for any injury to person or property which may be claimed to have

occurred on the Premises or on the sidewalk or ways immediately adjoining the

Premises (including, without limitation the main access driveway), in amounts

which shall, at the beginning of the Term, be at least equal to the limits set

forth in Section 1.1, and, from time to time during the Term, shall be for such

higher limits, if any, as are reasonably required by Landlord; provided,

however, that such increases shall not be required more than biannually, shall

not be required if comparable landlords of comparable buildings do not require

such increases, and shall not exceed those amounts then customarily carried on

properties similar to the Premises in the greater Boston area;

(b) Direct risk of physical loss (all risk) insurance which shall in

no event be less than 100% replacement value of the Premises (in the Yield-Up

Condition), together with

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rental loss coverage in an amount equal to one year's Annual Fixed Rent and

estimated additional rent, insuring the Building and its rental value with a

replacement cost coverage endorsement and agreed value endorsement, together

with deductibles not to exceed $250,000; and

(c) Insurance against loss or damage from sprinklers and from

leakage or explosions or cracking of boilers, pipes carrying steam or water, or

both, pressure vessels or similar apparatus (to the extent that any of the

foregoing are present in the Premises), in the so-called "broad form", in such

amounts and with such deductibles as Landlord may reasonably determine, and

insurance against such other hazards and in such amounts as may from time to

time be required by a bank, insurance company or other lending institution

holding a mortgage on the Building and/or the Primary Lot.

3.5. Certain Provisions Applicable to Insurance Policies.

(a) Policies for insurance provided for under the provisions of

Sections 3.4(b) and 3.4(c) shall have a deductible not in excess of $250,000,

and shall, in case of loss, be first payable to the holders of any mortgages on

the fee simple interest in the Building and/or the Primary Lot under a standard

mortgagee's clause, and shall be deposited with the holder of any mortgage or

with Landlord, as Landlord may elect. Landlord, Alexandria Real Estate Equities,

Inc. (so long as it is an indirect owner of the Landlord) and, if required,

Landlord's mortgagee, shall be named as an additional insured for general

liability in all such policies issued therefor. All policies for insurance

required under the provisions of Section 3.4 shall be obtained from responsible

companies qualified to do business in the Commonwealth of Massachusetts and in

good standing therein, having a Best's Insurance Rating of at least "A minus"

and a financial size category of at least "VIII". All policies for insurance

required hereunder shall also state that any loss will be payable in accordance

with such policy, notwithstanding any act or omission of either Landlord or

Tenant. Each of Landlord and Tenant agrees to furnish the other party with

copies of certificates on ACORD form 27 of all such insurance which such party

is obligated to obtain pursuant to Section 3.4 prior to the beginning of the

Term hereof and during each Extension Term. Each such policy shall be

noncancelable with respect to the interest of Tenant without at least thirty

(30) days, prior written notice thereto. In the event of a claim under any

insurance policies, Landlord and Tenant shall cooperate with one another and

provide the other party with copies of such insurance policies upon request.

(b) Tenant shall pay the costs of insurance obtained by Landlord

pursuant to Section 3.4 (including general coverages, such as earthquake,

fidelity, etc typically maintained by Landlord or its affiliates for similar

properties, provided, that, at such time as the Premises is no longer owned by

an organization that, together with its affiliates, owns more than ten

properties similar to the Premises, the foregoing shall include only coverages

typically maintained by owners of properties similar to the Premises in the

greater Boston metropolitan area) as Additional Rent within thirty (30) days

after delivery of an invoice therefor by Landlord, together with reasonable

supporting documentation of such costs. In the event that Landlord obtains any

such insurance pursuant to a blanket insurance policy, Tenant shall be obligated

to pay only those insurance costs allocable to the Premises on an equitable

basis. Upon request from time to time by Tenant, Landlord shall provide

reasonable supporting documentation of how it allocates insurance costs under

its blanket insurance policy to the Premises.

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3.6. Waiver of Subrogation. Landlord and Tenant shall each procure an

appropriate clause in or endorsement to any property insurance covering the

Premises, the Building and personal property, fixtures and equipment located

therein, wherein the insurance companies shall waive subrogation or consent to a

waiver of right of recovery, and Landlord and Tenant agree not to make any claim

against, or seek to recover from, the other for any loss or damage to its

property or the property of others resulting from fire or other hazards to the

extent covered by such property insurance; provided, however, that the release,

discharge, exoneration and covenant not to sue contained herein shall be limited

by and coextensive with the terms and provisions of the waiver of subrogation or

waiver of right of recovery. If either party shall be unable to obtain the

inclusion of such clause even with the payment of an additional premium, then

such party shall attempt to name the other party as a loss payee under the

policy. If it shall not be possible to have the other party named as a loss

payee, even with the payment of an additional premium, then the first party

shall not be required to obtain such waiver of subrogation or consent to waiver

provision and such party shall so notify the first party and the first party's

agreement to name the other party as an additional insured shall be satisfied.

Tenant acknowledges that Landlord shall not carry insurance on, and shall not be

responsible for, (i) Tenant's Property, and (ii) any loss suffered by Tenant due

to interruption of Tenant's business.

3.7. Utilities. Tenant shall pay directly to the proper authorities

charged with the collection thereof all charges for water, sewer, gas,

electricity, telephone and other utilities or services used or consumed on the

Premises, whether designated as a charge, tax, assessment fee or otherwise,

including, without limitation, water and sewer use charges and taxes, if any,

all such charges to be paid as the same from time to time become due. If Tenant

is not charged directly by the respective utility for any of such utilities or

services, Tenant shall from time to time, within ten (10) days of receipt of

Landlord's reasonably documented invoice therefor, pay to Landlord such charges.

Landlord shall not be liable for any interruption or failure in the supply of

any such utilities to the Premises; provided, however, that such failure or

interruption does not arise out of any willful act of Landlord or any of

Landlord's employees, servants, licensees, invitees, contractors, affiliates,

agents, or consultants (together, the "Landlord's Parties"). Notwithstanding the

foregoing, Tenant shall have the right to terminate this Lease upon notice to

Landlord if any interruption or failure in the supply of any utilities to the

Premises shall continue for more than one hundred eighty (180) consecutive days.

If Landlord receives any proceeds from a loss of rents insurance policy due to

the interruption or failure to provide utilities to the Premises, Landlord shall

abate the Annual Fixed Rent to the extent of the insurance proceeds received by

Landlord. In addition, Landlord shall use its best efforts to restore any

interrupted utility service affecting Tenant's use of the Premises.

3.8. Net Lease; Nonterminability by Tenant.

(a) The Annual Fixed Rent, the Additional Rent and all other amounts

payable hereunder to Landlord shall be paid without notice or demand and without

setoff, abatement, suspension, deferment, reduction or deduction except as

otherwise provided in this Lease or by operation of law, and Landlord shall have

no obligations in respect of the Premises or Tenant, except as otherwise

expressly provided herein.

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(b) This Lease shall not terminate, nor shall Tenant have any right

to terminate this Lease, nor shall the obligations and liabilities of Tenant set

forth herein be otherwise affected, except as otherwise expressly provided in

this Lease or by operation of law or by final decree or final judgment of any

court having jurisdiction.

ARTICLE IV

ADDITIONAL COVENANTS

4.1. Tenant's Affirmative Covenants. Tenant covenants at its expense at

all times during the Term and for such further time as Tenant occupies the

Premises or any part thereof:

(a) Perform Obligations. To perform promptly all of the obligations

of Tenant set forth in this Lease; and to pay when due the Annual Fixed Rent and

Additional Rent and all charges, rates and other sums which by the terms of this

Lease are to be paid by Tenant.

(b) Use. To use the Premises only for the Intended Uses, and from

time to time to procure all licenses and permits necessary therefor at Tenant's

sole expense and to provide copies thereof to Landlord.

(c) Repair and Maintenance. To keep and maintain the Premises in

good condition and repair, including the plumbing, electrical, lighting, roof

membrane, interior mechanical systems, and all doors, door frames, and door

openers, and all windows, frames and plate glass located on and serving the

Premises, except for (a) reasonable use and wear, (b) damage resulting from

Casualty or Taking (which shall instead be governed by Article V), (c) portions

of the Premises that Landlord is obligated to repair and maintain in accordance

with Section 4.2, and (d) damage resulting from the negligent or other acts or

omissions of Landlord or Landlord's Parties ("Landlord's Negligence") (Landlord

hereby agreeing, subject to the waiver of subrogation provisions of Section 3.7

and in the case of a Casualty or Taking subject to the provisions of Article V,

to perform at Landlord's sole expense any repair or maintenance to the Premises

made necessary by Landlord's Negligence); to keep in a safe, secure and sanitary

condition all trash and rubbish temporarily stored at the Premises; to arrange

for and be responsible for all of the costs of a trash and rubbish removal

service in connection with Tenant's use of the Premises; and to make all

interior repairs and replacements (which shall not include replacements of the

Structural Components or foundation of the Building), which are required to keep

the Premises in good order, condition and repair as required hereunder, and to

do all other work necessary for the foregoing purposes whether the same may be

ordinary or extraordinary, foreseen or unforeseen.

(d) Compliance with Law and Insurance Requirements. To make all

repairs, alterations, additions or replacements to the Premises required by any

law or ordinance or any order or regulation of any public authority other than

to the Structural Components and foundation of the Building; to keep the

Premises equipped with all safety appliances so required; to pay all municipal,

county, or state taxes assessed against the leasehold interest hereunder, or

against personal property of any kind on or about the Premises; not to dump,

flush, or in any way introduce any hazardous substances or any other toxic

substances into the septic, sewage or other waste disposal system serving the

Premises except in compliance with a valid sewer use permit;

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not to generate, store or dispose of hazardous substances in or on the Premises

or dispose of hazardous substances from the Premises (including any discharge to

the sewer system serving the Premises) except for use, storage, generation and

off-site disposal of hazardous substances normally attendant to Building

operations and Tenant's manufacturing, research and development processes in

compliance with the Resource Conservation and Recovery Act of 1976, as amended,

42 U.S.C. Section 6901 et seq., the Massachusetts Hazardous Waste Management

Act, M.G.L. c. 21 C, as amended, the Massachusetts Oil and Hazardous Material

Release Prevention and Response Act, M.G.L. c. 2lE, as amended, and all other

applicable codes, regulations, ordinances and laws; to notify Landlord of any

incident which would require the filing of a notice under applicable law; to

provide Landlord, from time to time upon Landlord's reasonable request, a list

of hazardous substances which Tenant uses or stores on the Premises, subject to

such confidentiality, proprietary information and trade secret assurances as

Tenant may reasonably impose on Landlord, and without further disclosure of such

records and information to third parties; and to comply with the orders and

regulations of all governmental authorities with respect to zoning, building,

fire, health and other codes, regulations, ordinances or laws applicable to

Tenant's specific use of the Premises, except that Tenant may defer compliance

so long as the validity of any such law, ordinance, order or regulation shall be

contested by Tenant in good faith and by appropriate legal proceedings, if

Tenant first gives Landlord appropriate assurance against any loss, cost or

expense on account thereof. The term "hazardous substances" as used in this

paragraph shall mean "hazardous substances" as defined in the Comprehensive

Environmental Response Compensation and Liability Act of 1980, as amended, 42

U.S.C. Section 9601 and regulations adopted pursuant to said Act.

Landlord acknowledges that the Primary Lot and the Expansion Lot are

located adjacent to the Industri-plex Superfund site. Tenant acknowledges that

Tenant's Intended Uses will include the generation and storage of hazardous

substances on the Premises. Without limitation of any of Tenant's obligations

under this Lease in respect of the Premises or Landlord, Tenant agrees to

indemnify, defend with counsel acceptable to Landlord and hold harmless

Landlord, all of Landlord's mortgagees and their respective officers, directors,

principals, agents and employees from and against all loss, cost or damage that

any of them may incur or be liable for in connection with any condition on the

Premises or arising on the Premises relating to the release or threat of release

of hazardous substances in respect of the Premises and directly attributable to

the act, omission or neglect of Tenant or any of Tenant's employees, agents,

independent contractors or invitees including, without limitation, any condition

not in conformity with the requirements of applicable law.

Within fifteen (15) days thereafter, Tenant shall provide copies to

Landlord of any notice that Tenant may receive, from or give to any governmental

authority or any other party in respect of any release or threat of release of

hazardous substances in respect of the Premises. Landlord and Landlord's

environmental consultants shall have the right from time to time, upon not less

than 24 hours' advance notice to Tenant and accompanied by a representative of

Tenant, to enter the Premises, subject to Tenant's rights and Landlord's

obligations under Section 4.6, to undertake at Landlord's sole cost an

assessment thereof to determine whether any release or threat of release of

hazardous substances has occurred, and Tenant shall cooperate with Landlord

(which cooperation shall not include Tenant's expenditure of money to third

parties) in undertaking such assessment, including, without limitation,

providing copies of such reports and such other information as Landlord or its

consultant may reasonably request, but subject to such

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confidentiality, proprietary information and trade secret assurances as Tenant

may reasonably impose on Landlord, and without further disclosure of such

records and information to third parties; provided, however, Tenant may elect to

undertake such assessment using its own consultants if satisfactory to Landlord

and the holders of mortgages on the Premises and said consultants shall provide

to Landlord and such holders such assessment and a reliance letter from such

consultants regarding the aforesaid without additional charges beyond those

which Landlord would have incurred if Landlord's consultant had undertaken said

assessment. Tenant shall promptly correct any such condition if (a) such

condition does not comply with the requirements of applicable law or permits or

approvals, (b) such condition was caused by the act, omission, or neglect of

Tenant or any of Tenant's employees, agents, independent contractors or

invitees, and (c) Landlord gives written notice of such condition to Tenant

(with Tenant recognizing that Landlord shall have no duty to Tenant to conduct

such assessment or to give such notice to Tenant) in accordance with the

Massachusetts Contingency Plan and the requirements of any other applicable law.

If such assessment discloses any such release that exceeds reportable quantities

under applicable law and was caused by the act or omission of Tenant or any of

its employees, agents, contractors, or invitees, Tenant shall promptly reimburse

Landlord for all costs and expense Landlord may incur in undertaking such

assessment as Additional Rent.

4.2. Landlord's Repair and Maintenance Obligations. Subject to the

provisions of Article V of this Lease, Landlord covenants, at its sole expense

at all times during the Term to keep in good order, condition and repair the

structural components, structural components of the roof, exterior walls,

foundation and the parking areas and driveways located on the Premises and/or

serving the Building (collectively, "Structural Components"). Without limitation

of the foregoing, Landlord shall be responsible, at its sole expense, for all

capital replacements of the Structural Components and for causing such

Structural Components to be in compliance with all applicable laws and

regulations during the entire Term. Landlord shall not be responsible for damage

to the Premises resulting from the negligence or other acts or omissions of

Tenant or Tenant's employees, servants, agents, contractors licensees,

affiliates, consultants or invitees ("Tenant's Negligence"), Tenant hereby

agreeing to perform at Tenant's expense any repair or maintenance to the

Premises made necessary by Tenant's Negligence; provided, however, that if such

damage to the Premises results from a Casualty (as defined in Section 5.1)

caused by Tenant's Negligence, Landlord shall repair, maintain or restore the

Premises or portion thereof in accordance with and to the extent required by

Article V.

4.3. Tenant's Work. Tenant shall procure at Tenant's sole expense all

necessary permits and licenses before undertaking any work on the Premises; to

do all such work in a good and workmanlike manner employing materials of good

quality and so as to conform with all applicable zoning, building, fire, health

and other codes, regulations, ordinances and laws; to keep the Premises at all

times free of liens for labor and materials, and to discharge or bond over such

liens forthwith after notice thereof from Landlord; to employ for such work only

contractors approved by Landlord which approval shall not be unreasonably

withheld, delayed or conditioned; to require all contractors employed by Tenant

to carry worker's compensation insurance in accordance with statutory

requirements and commercial general liability insurance covering such

contractors on or about the Premises in amounts that at least equal the limits

set forth in Section 1.1; and to save Landlord harmless and indemnified from all

injury, loss, claims or damage to any person or property due to such work

(provided, however, that Tenant shall not

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be required to indemnify and save Landlord harmless from Landlord's negligent or

intentional acts or omissions to act) and, upon Landlord's request, to furnish

to Landlord statements from all contractors and subcontractors certifying

payment in full of any obligation owed to them in respect of work undertaken on

the Premises.

4.4. Tenant's Indemnity. Tenant hereby agrees to defend, with counsel

reasonably acceptable to Landlord (which approval shall not be unreasonably

withheld, delayed or conditioned), all actions against Landlord, any partner,

trustee, stockholder, officer, director, employee, beneficiary or member or

manager of Landlord, holders of mortgages secured by the Building and/or the

Primary Lot and any other party having an interest in the Premises ("Indemnified

Parties") with respect to, and to pay, protect, indemnify and save harmless, to

the extent permitted by law, all Indemnified Parties from and against, any and

all liabilities, losses, damages, costs, expenses (including reasonable

attorneys' fees), causes of action, suits, claims, demands or judgments of any

nature arising from (i) injury to or death of any person, or damage to or loss

of property, on or about the Premises, or connected with the use, condition or

occupancy thereof except to the extent caused by the negligent or intentional

act or omission to act of Landlord, (ii) violation of this Lease by Tenant, or

(iii) any wrongful act, fault, wrongful omission, or other misconduct of Tenant

or its agents, contractors, licensees, sublessees or invitees. Nothing in this

Section 4.4, however, shall derogate from the effectiveness of insurance

required to be maintained by Tenant under this Lease naming Landlord as an

insured. This Section 4.4 is further subject to the waiver of subrogation

provisions in Section 3.7.

4.5. Landlord's Indemnity. Landlord hereby agrees to defend, with counsel

reasonably acceptable to Tenant (which approval shall not be unreasonably

withheld, delayed or conditioned), all actions against Tenant, any partner,

trustee, stockholder, officer, director, employee, beneficiary or member or

manager of Tenant ("Tenant Indemnified Parties") with respect to, and to pay,

protect, indemnify and save harmless, to the extent permitted by law, all Tenant

Indemnified Parties from and against, any and all liabilities, losses, damages,

costs, expenses (including reasonable attorneys' fees), causes of action, suits,

claims, demands or judgments of any nature arising from (i) injury to or death

of any person, or damage to or loss of property, on or about the Premises, or

connected with the use, condition or occupancy thereof to the extent caused by

the negligent or intentional act or omission to act of Landlord, (ii) violation

of this Lease by Landlord, or (iii) any wrongful act, fault, wrongful omission,

or other misconduct of Landlord or its agents, contractors, licensees,

sublessees or invitees. Nothing in this Section 4.5, however, shall derogate

from the effectiveness of insurance required to be maintained by Tenant under

this Lease naming Landlord as an insured. This Section 4.5 is further subject to

the waiver of subrogation provisions in Section 3.7. Landlord further agrees to

indemnify, defend with counsel acceptable to Tenant and hold harmless Tenant and

its officers, directors, principals, agents and employees from and against all

loss, cost or damage that any of them may incur or be liable for in connection

with any condition on the Premises or arising on the Premises relating to the

release or threat of release of hazardous substances in respect of the Premises

and directly attributable to the act, omission or neglect of Landlord or any of

Landlord's employees, agents, independent contractors or invitees including,

without limitation, any condition not in conformity with the requirements of

applicable law.

4.6. Landlord's Right to Enter. Landlord and its agents shall be permitted

to enter into the Premises at reasonable times and upon reasonable advance

notice to examine the Premises, make

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such repairs and replacements as Landlord may be entitled to make under this

Lease, without, however, any obligation to do so except as provided in this

Lease, to view the Premises for Tenant's compliance with Tenant's obligations

under this Lease, and show the Premises to prospective purchasers and lenders,

and, during the last twelve (12) months of the Term or earlier if Tenant shall

be in default under this Lease beyond applicable notice, grace and cure periods,

to show the Premises to prospective tenants and to keep affixed in suitable

places notices of availability of the Premises. Landlord's exercise of its right

of access to the Premises as provided in this Lease shall be subject to the

following: (a) Landlord shall not unreasonably interfere with Tenant's business

activities, (b) Landlord shall indemnify and hold harmless Tenant from and

against all loss, cost and expense resulting from the negligent or intentional

act or omission to act of Landlord in the course of exercise of such right, (c)

Landlord shall, except in the case of an emergency, enter the Premises only when

accompanied by a representative of Tenant during normal business hours and upon

not less than 24 hours' notice, in order to ensure the continued confidentiality

of Tenant's business materials, and (d) Landlord shall at all times adhere to

such safety, security, confidentiality, proprietary information and trade secret

rules and guidelines as Tenant may reasonably impose.

4.7. Personal Property at Tenant's Risk. All of the furnishings, fixtures,

equipment, effects and property of every kind, nature and description of Tenant

and of all persons claiming by, through or under Tenant which, during the

continuance of this Lease or any occupancy of the Premises by Tenant or anyone

claiming under Tenant, may be on the Premises, shall, as between the parties, be

at the sole risk and hazard of Tenant and if the whole or any part thereof shall

be destroyed or damaged by fire, water or otherwise, or by the leakage or

bursting of water pipes, steam pipes, or other pipes, by theft or from any other

cause, no part of said loss or damage is to be charged to or to be borne by

Landlord, except that Landlord shall in no event be indemnified or held harmless

or exonerated from any liability to Tenant or to any other person, for any

injury, loss, damage or liability resulting from Landlord's Negligence. Tenant

shall insure Tenant's personal property.

4.8. Payment of Cost of Enforcement. Tenant shall pay on demand Landlord's

expenses, including reasonable attorney's fees, incurred in successfully

enforcing any obligation of Tenant under this Lease continuing beyond applicable

notice, grace and cure periods or in curing any default by Tenant under this

Lease as provided in Section 6.4.

4.9. Yield-Up.

(a) At the expiration of the Term or earlier termination of this

Lease, Tenant shall surrender all keys to the Premises and shall remove the

furnishings, fixtures and equipment set forth in Exhibit C attached hereto, as

defined below. Tenant shall have the right, but not the obligation, to remove

any installments, alterations or improvements made by Tenant during the Term.

Tenant shall repair all damage caused by such removal and to yield-up the

Premises in broom-clean condition and in the same good order and repair in which

Tenant is obliged to keep and maintain the Premises by the provisions of this

Lease (except for reasonable wear and tear, damage by Casualty and Taking and

damage resulting from Landlord's Negligence).

(b) Upon surrender of the Premises in accordance with this Section

4.9, the Premises shall be free of Hazardous Materials brought upon, kept, used,

stored, handled, treated,

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generated in, or released or disposed of from, the Premises by any person other

than a Landlord Party (collectively, "TENANT HAZMAT OPERATIONS") and released of

all Hazardous Materials Clearances. At least three (3) months prior to the

surrender of the Premises at the end of the Term, Tenant shall deliver to

Landlord a narrative description of the actions proposed to be taken by Tenant

(the "SURRENDER PLAN") in order to surrender the Premises free of Hazardous

Materials and in a manner that results in the release of all Hazardous Materials

Clearances at the expiration or earlier termination of the Term. Such Surrender

Plan shall be accompanied by a current listing of (i) all Hazardous Materials

licenses and permits held by or on behalf of any Tenant Party with respect to

the Premises, and (ii) all Hazardous Materials used, stored, handled, treated,

generated, released or disposed of from the Premises, and shall be subject to

the reasonable review and approval of an environmental consultant selected by

Landlord and reasonably acceptable to Tenant to ensure that the Surrender Plan

is likely to result in the surrender of the Premises free of all Hazardous

Materials and in a manner that results in the release of all Hazardous Materials

Clearances. In connection with the review and approval of the Surrender Plan,

upon the request of Landlord, Tenant shall deliver to Landlord or its consultant

such additional non-proprietary information concerning Tenant HazMat Operations

as Landlord shall reasonably request. On or before such surrender, Tenant shall

deliver to Landlord evidence that the approved Surrender Plan shall have been

completed, and Landlord shall have the right, at Landlord's sole cost and

expense, to cause Landlord's environmental consultant to inspect the Premises

and perform such additional procedures as may be deemed reasonably necessary to

confirm that the Premises will be surrendered free of all Hazardous Materials

and that all Hazardous Materials Clearances have or will be issued as of the

effective date of such surrender or early termination of the Lease. Tenant shall

reimburse Landlord, as Additional Rent, for the actual out-of pocket expense

incurred by Landlord for Landlord's environmental consultant to review and

approve the Surrender Plan and to visit the Premises and verify satisfactory

completion of the same, which cost shall not exceed $5,000. Landlord shall have

the unrestricted right to deliver such Surrender Plan and any report by

Landlord's environmental consultant with respect to the surrender of the

Premises to third parties with a need to access to the information contained in

the Surrender Plan. The term "HAZARDOUS MATERIALS" means any substances,

materials or wastes currently or in the future deemed or defined in any

applicable law as "hazardous substances", "toxic substances", "contaminants",

"pollutants" or words of similar import, but shall expressly exclude any such

substances or materials contained in the Premises and/or used in connection with

the electrical, HVAC and other systems serving the Premises (such as hydraulic

oil used for the elevators and water treatment in the boilers) to the extent the

presence of such substances or materials is required for the proper operation of

the Premises and such systems and is in compliance with all applicable laws and

regulations.

(c) If Tenant shall fail to prepare or submit a Surrender Plan

approved by Landlord, or if Tenant shall fail to complete the approved Surrender

Plan, or if such Surrender Plan, whether or not approved by Landlord, shall fail

to result in the surrender of the Premises free of Hazardous Materials and in

the issuance of all Hazardous Materials Clearances, then Landlord shall have the

right, from and after the expiration of the Term or the earlier termination of

this Lease, and continuing through and including the date that is 180 days

thereafter, to take such actions as Landlord may deem reasonably appropriate to

assure that all Hazardous Materials are removed from the Premises and all

Hazardous Materials Clearances are issued, the reasonable costs of which actions

shall be reimbursed by Tenant as Additional Rent.

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(d) The yield-up of the Premises in accordance with the foregoing

provisions of this Section 4.9 shall be referred to as the "Yield-Up Condition."

Landlord and Tenant shall conduct an inspection of the Premises prior to the end

of the Term to facilitate Landlord's identification of the items to be removed

under this Section 4.9. Any property not so removed that remains on or at the

Premises shall be deemed abandoned and may be removed and disposed of by

Landlord in such manner as Landlord shall determine, provided, that, Tenant

shall have no obligation to pay Landlord any expense incurred by it is effecting

such removal and disposition and in making any incidental repairs and

replacements to the Premises and for use and occupancy during the period after

the expiration of the Term and prior to Tenant's performance of its obligations

under this Section 4.9.

4.10. Estoppel Certificates.

(a) Upon not less than ten (10) business days' prior notice from

Landlord, Tenant shall execute and deliver to Landlord a statement in writing

certifying that this Lease is unmodified and in full force and effect and that

except as stated therein Tenant has no knowledge of any defenses, offsets or

counterclaims against its obligations to pay the Annual Fixed Rent and to

perform its other covenants under this Lease (or, if there have been any

modifications that the same is in full force and effect as modified and stating

the modifications and, if there are any defenses, offsets or counterclaims,

setting them forth in reasonable detail), the dates to which the Annual Fixed

Rent have been paid and a statement that Landlord is not in default hereunder

beyond applicable notice, grace and cure periods (or if in default beyond

applicable notice, grace and cure periods, the nature of such default, in

reasonable detail). Any such statement delivered pursuant to this Section 4.10

may be relied upon by any prospective purchaser or mortgage of the Premises, or

any prospective assignee of any such mortgage.

(b) Upon not less than ten (10) business days' prior notice from

Tenant, Landlord shall execute and deliver to Tenant a statement in writing

certifying that this Lease is unmodified and in full force and effect and that

except as stated therein Landlord has no knowledge of any defenses, offsets or

counterclaims against its obligations to perform its covenants under this Lease,

(or, if there have been any modifications that the same is in full force and

effect as modified and stating the modifications and, if there are any defenses,

offsets or counterclaims, setting them forth in reasonable detail), the dates to

which the Annual Fixed Rent has been paid and a statement that Tenant is not in

default hereunder beyond applicable notice, grace and cure periods (or if in

default beyond applicable notice, grace and cure periods, the nature of such

default, in reasonable detail). Any such statement delivered pursuant to this

Section 4.10 may be relied upon by any prospective lender, subtenant or assignee

of Tenant.

4.11. Park Restrictions. Each of Landlord and Tenant shall comply with the

restrictions and covenants set forth in Declaration of Protective Covenants.

4.12. Holding Over. Tenant covenants that it will vacate the Premises

immediately upon the expiration or sooner termination of this Lease. If Tenant

retains possession of the Premises or any part thereof after the termination of

the Term without Landlord's express consent, Tenant shall be treated as a tenant

at sufferance and shall pay to Landlord the following percentages of Annual

Fixed Rent payable during the last Lease Year preceding expiration or

termination of the term: 110% for the first month of such holdover, 125% for the

second and

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third months of such holdover and 150% thereafter. Landlord's acceptance of such

rent shall not in any manner adversely affect Landlord's rights to evict Tenant

from the Premises; provided, however, that such rent shall constitute liquidated

damages and Tenant shall have no obligation to pay separate or additional

damages incurred by Landlord. Landlord may elect to refuse payment of holdover

rent pursuant to this Section 4.12 and in such event Landlord shall have the

right to remove Tenant through summary proceedings for holding over beyond the

expiration of the Term of this Lease.

4.13. Assignment and Subletting.

(a) Except as otherwise expressly provided herein, Tenant shall not

assign this Lease or sublet all or any portion of the Premises without

Landlord's prior written consent, which consent shall not be unreasonably

withheld, delayed or conditioned. Within twenty (20) days after delivery by

Tenant of any request for Landlord's consent to a sublease or assignment,

Landlord shall deliver notice to Tenant indicating whether it consents or does

not consent to such proposed sublease or assignment. If Landlord withholds its

consent, such notice shall contain a detailed explanation of the factors

considered and conclusions arrived at by Landlord in withholding its consent. If

Landlord fails to deliver such notice to Tenant within such twenty (20) day

period, Landlord shall be deemed to have consented to the proposed assignment or

sublease. The sole factors that Landlord may consider in determining whether to

consent or not to consent to a sublease or assignment are (a) whether the

proposed subtenant or assignee has sufficient net worth and working capital to

perform the obligations under the proposed this Lease or the proposed sublease,

as the case may be and (b) whether the use and occupancy of the Premises by the

proposed subtenant or assignee would result in additional material financial

risks to Landlord. Landlord acknowledges that Tenant may, from time to time,

desire to grant Tenant's lender(s) a security interest in the equipment and

furnishings that Tenant may install or maintain in the Premises and that Tenant

shall have the right to grant such security interests without the consent of

Landlord, provided that no such security interest shall encumber any fixture

that Tenant is not entitled under the terms of this Lease to remove at the

expiration of the Term. Any attempted assignment of this Lease without the prior

written approval of Landlord shall be void. No assignment approved or permitted

to be made without Landlord's consent under the next following paragraph of this

Section 4.13, and no indulgence granted by Landlord to any assignee or

sublessee, shall in any way impair the continuing primary liability (which after

an assignment shall be joint and several with the assignee) of Tenant hereunder,

and no approval in a particular instance shall be deemed to be a waiver of the

obligation to obtain Landlord's approval in any other case.

(b) Notwithstanding the terms of Section 4.13(a), Landlord agrees

that Tenant shall have the right, without Landlord's consent, to assign this

Lease or sublease all or a portion of the Premises, as applicable as follows:

(i) Tenant shall have the right to assign this Lease to a

Credit Entity (hereinafter defined). As used herein, a "Credit Entity" shall

mean any person that immediately following such assignment and having given

effect thereto will have a publicly traded unsecured senior debt rating of

"Baa2" or better from Moody's Investor's Services, Inc. or a rating of "BBB" or

better from Standard & Poor's Corporation (or comparable ratings from successor

- 18 -

<PAGE>

rating agencies) (or, if such Person does not then have rated debt, a

determination that by either of such rating agencies its unsecured senior debt

would be so rated by such agency);

(ii) Tenant shall have the right to sublease all or a portion

of the Premises to a Credit Entity; or

(iii) Tenant shall have the right to assign this Lease or

sublet all or any portion of the Premises to any corporation, person or entity

directly or indirectly controlling or controlled by, or under common control

with, Tenant (an "Affiliate of Tenant") or to any successor by merger,

consolidation or acquisition of all or substantially all of the assets of

Tenant, provided that, in the case of an assignment to an Affiliate of Tenant or

to a successor by merger, consolidation or acquisition of all or substantially

all of the assets of Tenant, such assignee shall have a net worth and working

capital sufficient to enable such assignee to meet Tenant's financial

obligations hereunder.

(c) In connection with any assignment of the Lease permitted without

the consent of Landlord pursuant to Section 4.13(b), effective on the date of

the assignment, Tenant shall be released from all obligations under this Lease

arising prior to such effective date.

(d) If Landlord's consent is required with respect to any assignment

of this Lease or any sublease of the Premises or any part thereof, and Landlord

shall grant such consent, Tenant shall, in consideration therefor, pay to

Landlord, as Additional Rent, an amount equal to one-half of:

(i) in the case of an assignment, one-half (1/2) of all sums

and other consideration paid to Tenant by the assignee for, or by reason of,

such assignment to the extent such sums are in excess of the obligations assumed

by the assignee to pay Annual Fixed Rent, Additional Rent and other sums under

this Lease; and

(ii) in the case of a sublease, one-half (1/2) of any rents,

additional charges, or other consideration payable under the sublease by the

subtenant to Tenant that are in excess of the Annual Fixed Rent and Additional

Rent accruing during the term of the sublease in respect of the subleased space

(at the rate per square foot payable by Tenant hereunder) pursuant to the terms

hereof;

after deducting in both such cases all of Tenant's reasonable out-of-pocket

expenses actually and directly incurred in connection with such sublease or

assignment including, without limitation, reasonable legal fees, brokerage

commissions, marketing costs, alterations to the space, rent concessions, tenant

improvements or allowance, or any rent-free period, such expenses to be

amortized over the term of the sublease (in the case of a sublease) or over the

remaining term of this Lease (in the case of an assignment where the

consideration is not paid in a lump sum on the date of such assignment).

The sums payable under this Section 4.13(d) shall be paid to Landlord as

and when payable by the subtenant or assignee to Tenant.

4.14. Waste; Nuisance. Tenant shall not commit any nuisance or allow or

suffer any waste to the Premises.

- 19 -

<PAGE>

4.15. Installations, Alterations or Additions.

(a) Tenant shall not make any installations, alterations or

additions in, to or on the Premises which would have a material adverse effect

on the structural or external architectural integrity of the Premises, or the

cost of which would exceed $250,000 with respect to a single project, without

obtaining the prior written consent of Landlord, which consent shall not be

unreasonably withheld, delayed or conditioned. In all cases where plans are

prepared for any work to be done by Tenant having a cost of more than $250,000

or involving structural modifications, Tenant shall furnish copies of the same

to Landlord no less than fifteen (15) days prior to the date on which Tenant

shall commence work in the Premises and in all such cases, Tenant shall provide

to Landlord as-built plans in respect of such work promptly after Tenant

completes the same.

(b) Installations, alterations or improvements performed by Tenant

in or at the Building shall not require Landlord's prior consent if such

installations, alterations or improvements would not have a material adverse

effect on the structural or architectural integrity of the Premises. Landlord

shall not have the right to require Tenant to remove at the end of the Term

Tenant's Property or any installations, alterations or additions made during the

Term. Notwithstanding the foregoing, nothing in this Section 4.15 shall require

Tenant to obtain Landlord's consent to the installation, removal or substitution

of Tenant's Property (hereinafter defined) in connection with the operation of

Tenant's business so long as such installation, removal or substitution does not

adversely affect in any material respect any structural component of the

Building. "Tenant's Property" shall mean all of the following located in or used

by Tenant in connection with the Premises (which shall be the sole property of

Tenant): all personal property of any type whatsoever, all trade fixtures,

machinery, office equipment, manufacturing equipment and used in connection with

Tenant's business, production equipment, laboratory equipment, office equipment,

furniture, together with all additions thereto, substitutions therefor and

replacements thereof.

(c) The following procedures shall apply with respect to any

installations, alterations or additions in, to or on the Premises that require

Landlord's prior consent pursuant to Section 4.15(a): Tenant shall submit to

Landlord for review and comment construction plans, specifications and drawings

for the Proposed Alterations ("Construction Drawings"). Landlord shall deliver

its written comments on the Construction Drawings to Tenant not later than ten

(10) business days after Landlord's receipt of the same. If Landlord does not

respond within ten (10) business days to any request by Tenant for consent to

the Construction Drawings, then Landlord's consent shall be deemed given. Such

process shall continue until the Construction Drawings are approved or deemed

approved by Landlord. Any disputes in connection with such comments shall be

resolved in accordance with Section 4.15(d) hereof.

(d) In the event of any dispute regarding the design of the Proposed

Alterations, which is not settled within ten (10) business days after notice of

such dispute is delivered by one party to the other, Tenant shall make the final

decision regarding the design of the Tenant Improvements, provided (i) Tenant

acts reasonably and such final decision is either consistent with or a

compromise between Landlord's and Tenant's positions with respect to such

dispute, and (ii) such dispute does not involve a proposed modification or

alteration of the exterior shell of the Building.

- 20 -

<PAGE>

(e) Landlord and Tenant hereby agree that disputes over Proposed

Alterations that are not resolved pursuant to Section 4.15(c), (each, an

"ARBITRATION MATTER") which cannot be resolved between Landlord and Tenant will

be submitted to binding arbitration. If either party delivers to the other a

demand for arbitration of an Arbitration Matter, then Landlord and Tenant shall

meet (which meeting may take place by telephone conference) within three (3)

business days after delivery of the demand for arbitration and make a good faith

attempt to mutually appoint a single Arbitrator (as defined below) to determine

the Arbitration Matter. If Landlord and Tenant are unable to agree upon a single

Arbitrator, then each shall, by written notice delivered to the other within

five (5) business days after the meeting, select an Arbitrator. If either party

fails to timely give notice of its selection for an Arbitrator, the other

party's Arbitrator shall be the sole Arbitrator. If each party selects an

Arbitrator, then the two Arbitrators so appointed shall, within five (5)

business days after their appointment, appoint a third Arbitrator, who shall be

the sole Arbitrator. If the two Arbitrators so selected cannot agree on the

selection of the third Arbitrator within the time above specified, then either

party, on behalf of both parties, may request such appointment of such third

Arbitrator by application to any state court of general jurisdiction in the

jurisdiction in which the Premises are located, upon 5 business days prior

written notice to the other party of such intent. The Arbitrator shall hold an

arbitration proceeding, to be attended by Landlord and Tenant, within ten (10)

business days of the Arbitrator's appointment. The decision of the Arbitrator

shall be made within two (2) days after the arbitration proceeding. Each party

shall pay the fees and expenses of the Arbitrator appointed by or on behalf of

such party. The fees and expenses of any single Arbitrator or the third

Arbitrator shall be borne equally by both parties. The parties hereby waive any

right to appeal the decision of the Arbitrator. An "ARBITRATOR" for purposes of

this Section only shall be any person appointed by or on behalf of either party

pursuant to the provisions hereof and shall be a retired judge of the Superior

Court or Land Court of Middlesex County, Massachusetts or an individual

otherwise mutually agreed to by Landlord and Tenant.

(f) Landlord shall not charge any fees for such approvals or in

connection with the construction of any such alterations.

4.16. Signage. Tenant shall have the right, without the consent of

Landlord, to display Tenant identification signage on the exterior and interior

of the Building, in the parking areas serving the Building and on the Primary

Lot. The size, design and placement of said signage shall be in compliance with

applicable laws. Tenant shall have no obligation to remove any signage upon the

expiration or earlier termination of this Lease.

4.17. Parking. Tenant shall have the exclusive right to use and occupy the

parking areas located on the Land.

4.18. Landlord's Additional Covenants. Except for mortgages granted with

respect to the Premises to secure a financing, Landlord shall not encumber the

Premises or permit any other person to use or occupy the Premises without the

prior consent of Tenant. Without the prior written consent of Tenant, Landlord

shall not construct any installations, alterations or additions on, to or under

the Premises, except to the extent necessary to perform its obligations under

this Lease.

- 21 -

<PAGE>

ARTICLE V

CASUALTY OR TAKING

5.1. Casualty.

(a) If, at any time during the Term, the Building or the Premises

are damaged or destroyed by a fire or other insured casualty, Landlord shall

notify Tenant within 30 days after discovery of such damage (a "Restoration

Notice") as to the amount of time Landlord reasonably estimates it will take to

restore the Premises, as applicable (the "Restoration Period"). If the

Restoration Period is estimated to exceed fifteen (15) months (the "Maximum

Restoration Period"), Landlord may, in such notice, elect to terminate this

Lease as of the date that is seventy-five (75) days after the date of discovery

of such damage or destruction; provided, however, that notwithstanding

Landlord's election to restore, Tenant may elect to terminate this Lease by

written notice to Landlord delivered within forty-five (45) days of receipt of a

notice from Landlord estimating a Restoration Period for the Premises longer

than the Maximum Restoration Period. Unless either Landlord or Tenant so elects

to terminate this Lease pursuant to this Section 5.1, Landlord shall promptly

restore the Premises (including all tenant improvements that were part of the

Premises as of the date of this Lease), as needed to obtain any license,

clearance or other authorization of any kind required to enter into and restore

the Premises issued by any Governmental Authority having jurisdiction over the

use, storage, handling, treatment, generation, release, disposal, removal or

remediation of Hazardous Materials (hereinafter defined) in, on or about the

Premises (collectively referred to herein as "HAZARDOUS MATERIALS CLEARANCES");

provided, however, that if repair or restoration of the Premises is not

substantially complete as of the end of the Maximum Restoration Period, Landlord

shall cease all work, and Tenant may by written notice to Landlord delivered

within five (5) business days of the expiration of Maximum Restoration Period,

elect to terminate this Lease. If Tenant elects to terminate this Lease,

Landlord shall be relieved of its obligation to make repairs or restoration, and

this Lease shall terminate as of the date of discovery of such damage or

destruction. Landlord shall retain any Rent paid and the right to any Rent

payable by Tenant and applicable to the date of termination. If Tenant does not

timely elect to terminate, this Lease shall remain in full force and effect, and

Landlord shall complete all repairs and restoration as soon as reasonably

practicable.

(b) Notwithstanding anything to the contrary contained in Section

5.1(a), (i) if there is Material Damage (as hereinafter defined) and the date

set forth in the Restoration Notice is more than twelve (12) months from the

date of such damage, then Tenant shall have the right to terminate this Lease by

giving notice to Landlord (a "TENANT TERMINATION NOTICE"), not later than thirty

(30) days following Tenant's receipt of the Restoration Notice. If this Lease is

terminated by Landlord p


 
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