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LEASE

Lease Agreement

LEASE | Document Parties: ILLUMINA INC | BMR-9885 TOWNE CENTRE DRIVE LLC, You are currently viewing:
This Lease Agreement involves

ILLUMINA INC | BMR-9885 TOWNE CENTRE DRIVE LLC,

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Title: LEASE
Governing Law: California     Date: 5/3/2007
Industry: Scientific and Technical Instr.     Law Firm: Allen Matkins Leck Gamble Mallory & Natsis LLP     Sector: Technology

LEASE, Parties: illumina inc , bmr-9885 towne centre drive llc
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Exhibit 10.42

EXECUTION VERSION

LEASE
(Parcel 3: 9865 Towne Centre Drive, San Diego, California)

by and between

BMR-9885 TOWNE CENTRE DRIVE LLC ,
a Delaware limited liability company

and

ILLUMINA, INC.,
a Delaware corporation

 


 

LEASE
(Parcel 3: 9865 Towne Centre Drive, San Diego, California)

     THIS LEASE (this “ Lease ”) is entered into as of this 26 th day of January, 2007 (the “ Execution Date ”), by and between BMR-9885 Towne Centre Drive LLC, a Delaware limited liability company (“ Landlord ”), and Illumina, Inc., a Delaware corporation (“ Tenant ”).

RECITALS

     A. WHEREAS, Landlord is the owner of three (3) parcels of real property located in the City of San Diego, County of San Diego, State of California, legally described as Parcels 1, 2 and 3 of Parcel Map 18286 filed with the San Diego County Recorder on June 21, 1999 (together with any easements and appurtenances thereto, the “ Initial Illumina Lease Land ”). The Original Illumina Lease Land consists of approximately 10.781 gross acres and is improved with two (2) buildings and an atrium on Parcels 1 and 2 (the “ Existing Parcel 1 and Parcel 2 Buildings ”) and one (1) building on Parcel 3 (the “ Diversified Building ” and, collectively with the Existing Parcel 1 and Parcel 2 Buildings, the “ Original Illumina Lease Buildings ”) consisting of 115,870 square feet of space and commonly known as 9855 through 9885 (and consecutive addresses), Towne Centre Drive, San Diego, California. The Original Illumina Lease Land and the Original Illumina Lease Buildings are shown on the site plan attached hereto as Exhibit A and made a part of this Lease. The Original Illumina Lease Land and the Original Illumina Lease Buildings are collectively referred to as the “ Original Illumina Lease Premises .”

     B. WHEREAS, On July 6, 2000, Landlord (as successor in interest to Tenant) and Diversified Eastgate Pointe, LLC, a California limited liability company (as successor in interest to Matsix Investments, Inc., “ Diversified ”), entered into that certain Eastgate Pointe Building “D” Lease (the “ Diversified Lease ”), pursuant to which Diversified leases approximately 6,600 rentable square feet of space located in the Diversified Building (the “ Diversified Space ”);

     C. WHEREAS, On August 18, 2004, Tenant and Landlord entered into that certain Single Tenant Lease (the “ Original Illumina Lease ”), pursuant to which Landlord leases the Original Illumina Lease Premises to Tenant;

     D. WHEREAS, Concurrently herewith, Landlord and Tenant are amending and restating the Original Illumina Lease (such amended and restated lease, the “ Illumina Lease ”) to, among other things, (i) exclude the Parcel 3 Land (including the Diversified Building) from the “Premises” covered by the Illumina Lease; (ii) eliminate Tenant’s right of first refusal to lease space in the Building (as defined below); (iii) eliminate the development fee; and (iv) extend the term of the Original Illumina Lease to be co-terminous with the term of this Lease;

     E. WHEREAS, Landlord intends to construct an additional building totaling approximately 83,866 rentable square feet on the Property (the “ Expansion Building ” and, together with the Diversified Building, the “ Buildings ”);

     F. WHEREAS, Landlord may subdivide (the “ Subdivision ”) Parcel 3 so that it will consist of two lots that may be legally conveyed in accordance with California’s Subdivision Map Act as follows: (a) the portion of Parcel 3 on which the Expansion Building is located, and to be more particularly defined by Landlord in connection with the Subdivision (the “ Subdivided Property ”), and (b) the portion of Parcel 3 excluding the Subdivided Property. The term “ Property ” shall mean Parcel 3, together with all landscaping, parking facilities and other improvements and appurtenances related thereto, including the Buildings, the Common Areas, the Premises (as defined below) and the Diversified Space; and

     G. WHEREAS, Landlord wishes to lease to Tenant, and Tenant desires to lease from Landlord, the Premises (as defined below) pursuant to the terms and conditions of this Lease, as detailed below.

AGREEMENT

     NOW, THEREFORE, Landlord and Tenant, in consideration of the mutual promises contained herein and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, and intending to be legally bound, agree as follows:

 


 

1. Lease of Premises .

     1.1. Effective on the Execution Date, Landlord hereby leases to Tenant, and Tenant hereby leases from Landlord, (a)approximately 4,400 rentable square feet of space located in the Diversified Building (the “ Diversified Building Premises ”), and (b) upon the satisfaction of the conditions set forth in this Section 1.1 , the interior portion of the Expansion Building described below (the “ Expansion Premises ” and, together with the Diversified Building Premises, the “ Premises ”): (a) from and after the Phase 1 Commencement Date (as defined below), 40,866 rentable square feet located in the Expansion Building (the “ Phase 1 Premises ”), (b) from and after the Phase 2 Commencement Date (as defined below), 21,500 rentable square feet located in the Expansion Building (the “ Phase 2 Premises ”), and (c) from and after the Phase 3 Commencement Date (as defined below), the remainder of the interior space located in the Expansion Building (including all elevator shafts and stairwells) (the “ Phase 3 Premises ”), subject to and with the benefit of the terms, covenants, conditions and provisions of this Lease. The term “ Phase ” shall mean and refer to each of the Phase 1 Premises, the Phase 2 Premises and the Phase 3 Premises. On or before Substantial Completion of the Landlord’s Construction Work (as defined below), Tenant and Landlord shall mutually agree to: (1) the location of the Phase 1 Premises, and shall attach a diagram of its location to this Lease as Exhibit C ; (2) the location of the Phase 2 Premises, and shall attach a diagram of its location to this Lease as Exhibit D ; and (3) the location of the Phase 2 Premises, and shall attach a diagram of its location to this Lease as Exhibit E. In the event the parties are unable to agree on the location of each of the Phase 1 Premises, the Phase 2 Premises and the Phase 3 Premises by the Substantial Completion of the Landlord’s Construction Work, Landlord shall reasonably designate the location of each of the Phase 1 Premises and the Phase 2 Premises, and shall attach: (x) a diagram of the location of the Phase 1 Premises to this Lease as Exhibit C , (y) a diagram of the location of the Phase 2 Premises to this Lease as Exhibit D , and (z) a diagram of the location of the Phase 3 Premises to this Lease as Exhibit E .

     1.2. Tenant shall have, as appurtenant to the Premises, the exclusive right of tenants of the Buildings (including any assignees, sublessee and assigns) to use, and permit its invitees to use in common with Landlord and others, the elevators, walkways, access roads, and driveways necessary for access to the Premises and the parking areas, loading areas, pedestrian sidewalks, landscaped areas, trash enclosures, recreation areas and other areas and facilities, if any, which are located on the Property (the “ Common Areas ”). Tenant’s use of the Common Areas shall at all times be in compliance with all Applicable Laws and shall be consistent with and in connection with Tenant’s Permitted Use as set forth in Section 2.8 . Tenant shall use the Common Areas only in such a manner as will not interfere with the use of, and access to, the Diversified Space and the parking spaces to be provided to the occupants thereof under the Diversified Lease.

     1.3. This Lease and all rights and remedies of Tenant hereunder are subject and subordinate to Section 2(e) (Common Areas), Section 2(j) (Parking), Section 2(k) (Premises), Section 9 (Services and Utilities), Article 30 (Quiet Enjoyment) and Article 32 (Signage & Sign Control) of the Diversified Lease.

2. Basic Lease Provisions . For convenience of the parties, certain basic provisions of this Lease are set forth herein. The provisions set forth herein are subject to the remaining terms and conditions of this Lease and are to be interpreted in light of such remaining terms and conditions.

     2.1. Binding . This Lease shall take effect upon the Execution Date and, except as specifically otherwise provided within this Lease, each of the provisions hereof shall be binding upon and inure to the benefit of Landlord and Tenant from the Execution Date.

     2.2. Rentable Areas of the Premises . The term “ Rentable Area ” of (i) the Diversified Building Premises shall be deemed to be 4,400 square feet; (ii) the Phase 1 Premises shall be deemed to be 40,866 square feet, (iii) the Phase 2 Premises shall be deemed to be 21,500 square feet, (iv) the Phase 3 Premises shall be deemed to be 21,500 square feet, and (v) the Expansion Premises shall be deemed to be 83,866 square feet, even if it is determined upon final measurement of the Diversified Building Premises, such Phase or the Expansion Premises that the Rentable Area of the Diversified Building Premises, such Phase or the Expansion Premises is smaller or larger than the amount set forth in this Section 2.2 .

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     2.3. Basic Annual Rent .

          2.3.1 Diversified Building Premises . Initial monthly and annual installment of Basic Annual Rent for the Diversified Building Premises (the “ Diversified Building Premises Basic Annual Rent ”) as of the Execution Date is set forth on Schedule 1 attached hereto.

          2.3.2 Expansion Premises . Initial monthly and annual installments of Basic Annual Rent for the Expansion Premises (the “ Expansion Premises Basic Annual Rent ” and, together with the Diversified Building Premises Basic Annual Rent, the “ Basic Annual Rent ”) as of the Phase 1 Commencement Date, subject to adjustment in accordance with Section 6.1 , shall be as follows:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Per Rentable

 

 

 

 

 

 

 

 

 

 

 

 

S.F. of

 

 

 

 

 

 

 

 

Rentable S.F. of

 

Phase 1

 

 

 

 

 

Total

 

 

Phase 1 Premises

 

Premises

 

Total Annual

 

Monthly

Phase 1 Premises

 

 

40,866

 

 

$

2.80

 

 

$

1,373,097.60

 

 

$

114,424.80

 

     2.4. Estimated Delivery Dates . The Estimated Delivery Dates for each Phase of the Premises are as follows:

          2.4.1 Phase 1 Estimated Delivery Date . October 1, 2008.

          2.4.2 Phase 2 Estimated Delivery Date . Twelve (12) months after the Phase 1 Commencement Date.

          2.4.3 Phase 3 Estimated Delivery Date . Twelve (12) months after the Phase 2 Commencement Date.

     2.5. Commencement Date : Subject to Section 5.2 , the Commencement Date shall be determined as follows:

          2.5.1 Diversified Building Premises Commencement Date : The Execution Date;

          2.5.2 Phase 1 Commencement Date : Thirty (30) days after the later of: (a) the Phase 1 Estimated Delivery Date, or (b) Substantial Completion of Landlord’s Construction Work and the Tenant Improvements (each as defined below);

          2.5.3 Phase 2 Commencement Date : Thirty (30) days after the earlier of: (a) the Phase 2 Estimated Delivery Date, or (b) the date Tenant actually occupies any portion of the Phase 2 Premises to conduct business therein (including storage); and

          2.5.4 Phase 3 Commencement Date : Thirty (30) days after the earlier of: (a) the Phase 3 Estimated Delivery Date, or (b) the date Tenant actually occupies any portion of the Phase 3 Premises to conduct business therein (including storage).

     2.6. Expiration Date : Fifteen (15) years from the Phase 1 Commencement Date; provided , however , Tenant shall have the option to extend this Lease as provided in Article 42 .

     2.7. Security Deposit : An amount equal to $40,836.75, which amount shall be increased accordingly as occupancy of the Expansion Building by Tenant is increased as provided in Article 10 .

     2.8. Permitted Use : (a) Laboratory research, administration, pharmaceutical, diagnostic, office, manufacturing and related health care and research uses in conformity with Applicable Laws (as defined below); and (b) such other legally permitted uses as are approved by Landlord, which approval shall not be unreasonably withheld or delayed.

     2.9. Address for Rent Payment :

BMR-9885 Towne Centre Drive LLC
Unit E
P.O. Box 51918
Los Angeles, CA 90051-6218

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     2.10. Address for Notices to Landlord :

BMR-9885 Towne Centre Drive LLC
17140 Bernardo Center Drive, Suite 222
San Diego, California 92128
Attn: General Counsel/Real Estate

     2.11. Address for Notices to Tenant :

Illumina, Inc.
9885 Towne Centre Drive
San Diego, CA 92121
Attn: Christian Henry

     2.12. The following Exhibits are attached hereto and incorporated herein by reference:

 

 

 

Exhibit A

 

Original Illumina Lease Premises

Exhibit B

 

Intentionally Omitted

Exhibit C

 

Phase 1 Premises

Exhibit D

 

Phase 2 Premises

Exhibit E

 

Phase 3 Premises

Exhibit F

 

Acknowledgement of Commencement Date and Expiration Date

Exhibit G

 

Tenant’s Personal Property

Exhibit H

 

Rules and Regulations

Exhibit I

 

Form of Estoppel Certificate

Exhibit J

 

Work Letter

Exhibit K

 

Form of Letter of Credit

Exhibit L

 

Reciprocal Easement Agreement

Exhibit M

 

Form of Subordination, Non-Disturbance and Attornment Agreement

 

 

 

Schedule 1

 

Diversified Building Premises Rent Schedule

3. Term . The actual term of this Lease (the “ Term ”) shall be the period from the Execution Date through the Expiration Date, subject to earlier termination of this Lease as provided herein.

4. Landlord’s Construction Work and Tenant Improvements .

     4.1. Shell and Core Construction of Expansion Building .

          4.1.1 Commencement of Landlord’s Construction Work . On or before June 1, 2007, Landlord shall, at Landlord’s sole cost and expense, cause Landlord’s contractor, Reno Contracting or such replacement thereof as Landlord may make from time to time with Tenant’s approval, which approval shall not be unreasonably withheld or delayed (“ Contractor ”), to commence and thereafter diligently prosecute the construction of the shell and core of the Expansion Building to completion pursuant to the Approved CW Plans (as defined in the Work Letter), subject only to CW Permitted Changes (as defined in the Work Letter), (all such construction, collectively, “ Landlord’s Construction Work ”). Landlord’s Construction Work shall be performed in a workmanlike manner, and in compliance with all Applicable Laws. The commencement and completion of Landlord’s Construction Work shall be subject to delays resulting from acts of Tenants, acts of God; acts of terrorism; adverse weather conditions; war; invasion; insurrection; acts of a public enemy; terrorism; riot; mob violence; civil commotion; sabotage; labor disputes; general shortage of labor, materials, facilities, equipment or supplies on the open market; delay in transportation; delays caused by new, or changes to existing, laws, rules, regulations or orders of any Governmental Authority; moratorium or other governmental action; inability to obtain permits or approvals, including, without limitation, city and public utility approvals beyond the time periods that generally prevail for obtaining such permits and approvals; the acts or inaction of the contractor and subcontractors, if any; or any other cause beyond the reasonable control of Landlord, financial ability excepted, whether similar or dissimilar to the foregoing (collectively, “ Force Majeure ”).

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          4.1.2 Completion of Construction . Landlord’s Construction Work shall be deemed “ Substantially Complete ” or there shall be “ Substantial Completion ” if Landlord has (a) completed all of Landlord’s Construction Work identified on the Approved CW Plans (subject only to such incomplete or defective work as will not materially or adversely impact Tenant’s continuous and uninterrupted use of the Expansion Premises for its Permitted Use (collectively, the “ Punchlist Items ”)) and (b) received a temporary or permanent certificate of occupancy from the applicable municipal authority(ies) and a certificate of substantial completion from the architect.

          4.1.3 Warranties . Landlord shall use commercially reasonable efforts (but without any obligation to commence or pursue any litigation) to cause Contractor to complete with reasonable promptness the Punchlist Items and repair with reasonable promptness all defects in the construction of Landlord’s Construction Work in accordance with the Approved CW Plans as to which Tenant notifies Landlord in writing (which notice Tenant shall give within thirty (30) days following the Phase 1 Commencement Date). Notwithstanding the foregoing, Landlord shall cause all Punchlist Items that reasonably can be completed within thirty (30) days after Substantial Completion of the Landlord’s Construction Work to be completed within thirty (30) days after Substantial Completion of the Landlord’s Construction Work. Except for such Punchlist Items and except for latent defects and non-compliance of Landlord’s Construction Work with Applicable Laws, Tenant shall, subject to the terms hereof, be deemed to have accepted the Expansion Premises in the condition delivered to it “As Is,” provided , however , except as to those items that Landlord is required to correct pursuant to this Section, Landlord shall partially assign to Tenant (but without prejudice to any of Landlord’s rights of enforcement) all warranties that it has received under the construction contract, any subcontract, or from any material supplier. Notwithstanding the foregoing, if Tenant notifies Landlord within the period beginning on Substantial Completion of the Landlord’s Construction Work and continuing through the date that is twelve (12) months thereafter (the “ CW Warranty Period ”), of (a) latent defects in the construction of the Landlord’s Construction Work; or (b) non-compliance of Landlord’s Construction Work with Applicable Laws, then as Landlord’s sole and exclusive obligation with respect thereto, Landlord shall cause such latent defect or non-compliance promptly to be remedied. All warranty claims shall be barred and shall lapse unless such claim is made in writing to Landlord, with a description of the claim made, on or before the expiration of the CW Warranty Period.

     4.2. Tenant Improvements .

          4.2.1 Tenant Improvements . Landlord shall cause the Contractor to commence and thereafter diligently prosecute the construction of the tenant improvements in the Expansion Building pursuant to the Work Letter (the “ Tenant Improvements ”). The Tenant Improvements shall be performed in a workmanlike manner and in compliance with all Applicable Laws and substantially in compliance with the Approved TI Plans (as defined in the Work Letter), subject to minor deviations that do not alter the type, scope and quality of the Tenant Improvements depicted on the Approved TI Plans. The portion of the TI Costs for which Landlord is responsible (the “ TI Allowance ”) shall not exceed (subject to the terms hereof) the TI Allowance Amount (as defined below). “TI Costs” means all Tenant Delay Costs (as defined below) and costs of the Tenant Improvements (the “ TI Costs ”), including the costs of (i) construction, (ii) construction management by Landlord (which costs shall be stipulated to equal one and one-half percent (1.5%) of the cost of the Tenant Improvements, including the Excess Cost (as defined below)) (the “ Construction Management Fee ”), (iii) space planning, architect, engineering and other related services, (iv) costs and expenses for labor, material, equipment and fixtures, and (v) building permits and other taxes, fees, charges and levies by governmental and quasi-governmental agencies for permits or for inspections of the Tenant Improvements. Notwithstanding the foregoing, in no event shall the TI Allowance be used for: (w) the purchase of any furniture, personal property or other non-building system equipment, (x) the cost of work that is not authorized by the Approved TI Plans (subject to any TI Change) or otherwise approved in writing by Landlord, (y) costs resulting from any default by Tenant of its obligations under this Lease, or (z) costs that are recoverable or reasonably recoverable by Tenant from a third party (e.g., insurers, warrantors or tortfeasors). The “ TI Allowance Amount ” shall be Forty-Seven and 15/100 Dollars ($47.15) per rentable square foot of the Expansion Building, plus the amount of any Additional Allowance that Tenant elects to use to pay the cost of the Tenant Improvements.

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          4.2.2 In the event the estimated total TI Costs (the “ Estimated TI Costs ”) exceeds the TI Allowance Amount, Tenant shall pay such overage, as reasonably estimated by Landlord from time to time (the “ Excess Cost ”), as the work progresses as follows: on or before the tenth (10 th ) day of each month, Landlord shall deliver to Tenant an application for reimbursement, accompanied by reasonable documentary evidence of the construction costs of such Tenant Improvements incurred since the last application for reimbursement. On or before the tenth (10 th ) day following delivery of such application for reimbursement, Tenant shall pay to Landlord an amount that (when added to any prior reimbursements of Excess Costs by Tenant) will equal (a) a fraction, the numerator of which is the amount of TI Costs incurred prior to the date of the application for reimbursement, and the denominator of which is the Estimated TI Costs, times (b) the Excess Cost (the “ Tenant Reimbursement ”). In the event the TI Allowance and the estimated Excess Cost are not sufficient to cover the actual TI Costs, including all approved change orders, Landlord shall adjust the Excess Cost accordingly.

          4.2.3 Architects and Consultants . The architect, engineering consultants, design team, general contractor and subcontractors responsible for the construction of the Tenant Improvements shall be selected pursuant to the procedures set forth in the Work Letter. Subject to the terms of the Work Letter, Tenant hereby approves of Ferguson Pape Baldwin Architects as Landlord’s architect and Reno Contracting as Landlord’s general contractor.

          4.2.4 Completion of Tenant Improvements . The Tenant Improvements shall be deemed “ Substantially Complete ” or there shall be “Substantial Completion” if (i) Landlord has completed, in compliance with all Applicable Laws, all of the Tenant Improvements identified on and substantially in accordance with the Approved TI Plans (subject only to the Punchlist Items and minor deviations that do not alter the type, scope and quality of the Tenant Improvements depicted on the Approved TI Plans) and Tenant is provided with continuous and uninterrupted use of the applicable portion of the Expansion Premises and the Expansion Building for Tenant’s Permitted Use (including Tenant’s parking), except to the extent reasonably necessary for Landlord’s Contractor to complete the Punchlist Items in accordance with Section 4.1.2 , and (ii) Landlord has obtained a certificate of occupancy or temporary certificate of occupancy (or its equivalent) allowing Tenant to legally occupy the Expansion Premises.

          4.2.5 Warranties . Landlord shall use commercially reasonable efforts (but without obligation to commence or pursue any litigation) to cause Contractor to complete with reasonable promptness the Punchlist Items and repair with reasonable promptness all defects in the construction of the Tenant Improvements in accordance with the Work Letter as to which Tenant notifies Landlord in writing (which notice Tenant shall give within thirty (30) days following the Phase 1 Commencement Date). Notwithstanding the foregoing, Landlord shall cause all Punchlist Items that reasonably can be completed within sixty (60) days after Substantial Completion of the Tenant Improvements to be completed within sixty (60) days after Substantial Completion of the Tenant Improvements. Except for such Punchlist Items and except for latent defects and non-compliance of Tenant Improvements with Applicable Laws, Tenant shall, subject to the terms hereof, be deemed to have accepted the Expansion Premises in the condition delivered to it “As Is,” provided , however , except as to those items that Landlord is required to correct pursuant to this Section, Landlord shall partially assign to Tenant (but without prejudice to any of Landlord’s rights of enforcement) all warranties that it has received under the construction contract, any subcontract, or from any material supplier. Notwithstanding the foregoing, if Tenant notifies Landlord within the period beginning on Substantial Completion of the Tenant Improvements and continuing through the date that is twelve (12) months thereafter (the “ TI Warranty Period ”), of (a) latent defects in the construction of the Tenant Improvements; or (b) non-compliance of Tenant Improvements with Applicable Laws, then as Landlord’s sole and exclusive obligation with respect thereto, Landlord shall cause such latent defects or non-compliance promptly to be remedied. All warranty claims shall be barred and shall lapse unless such claim is made in writing to Landlord, with a description of the claim made, on or before the expiration of the TI Warranty Period.

     4.3. Additional Allowance . Landlord shall, at Tenant’s request, provide an additional tenant improvement allowance not to exceed Thirty-Five Dollars ($35.00) per rentable square foot of the Expansion Premises (the “ Additional Allowance ”), which amount may be used by Tenant to increase the scope of Landlord’s Construction Work or the Tenant Improvements pursuant to the terms and conditions contained in the Work Letter and/or pay for any other costs payable by Tenant pursuant to the Work Letter. In the event Tenant elects to use all or any

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portion of the Additional Allowance, Tenant shall pay to Landlord, as Rent, an amount equal to the Additional Allowance disbursed by Landlord, together with interest thereon at the rate of nine percent (9%) per annum. Tenant shall make payments in respect of the Additional Allowance plus interest thereon in equal monthly installments so that the full amount shall be paid on or before the expiration of the initial Term. Tenant shall pay such amounts with the payment of Basic Annual Rent for each month. If Tenant has not paid the full amount of the Additional Allowance plus interest thereon at the expiration or earlier termination of this Lease, then upon the expiration or termination of this Lease, Tenant shall, within thirty (30) days thereafter, pay the unpaid portion of such amount to Landlord. The payments Tenant is requested to make in respect of the Additional Allowance shall constitute “Additional Rent.”

5. Possession and Commencement Date .

     5.1. Tenant’s Access . So long as Tenant does not (in Landlord’s reasonable judgment) unreasonably or unnecessarily interfere with Landlord’s Construction Work or the Tenant Improvements, upon reasonable prior written notice to Landlord, Tenant may enter upon any Phase prior to the respective Commencement Date for the purpose of, among other things, installing improvements (including cabling) or the placement of personal property; provided , however , that Tenant shall furnish to Landlord evidence satisfactory to Landlord that insurance coverages required of Tenant under the provisions of Article 23 are in effect, and such entry shall be subject to all the terms and conditions of this Lease other than the payment of Rent. Tenant shall reimburse Landlord for all actual documented incremental costs that result from such entry and indemnify, defend and hold harmless Landlord from and against any loss, cost, claim, lawsuit, liability or expense (including reasonable attorneys’ fees and disbursements) arising out of any entry and/or activities upon the Expansion Premises by Tenant or Tenant’s Agents.

     5.2. Possession and Commencement Date .

          5.2.1 Diversified Building Premises . Tenant hereby acknowledges that immediately prior to the Diversified Building Premises Commencement Date, Tenant occupied the Diversified Building Premises and that Tenant is in possession of the Diversified Building Premises, and is familiar with the condition thereof and accepts the Diversified Building Premises in its “as is” condition with all faults, and Landlord makes no representation or warranty of any kind with respect the Diversified Building Premises, and Landlord will have no obligation to improve, alter or repair the Diversified Building Premises, except as specifically set forth herein. Tenant acknowledges that Tenant was the prior owner of the Diversified Building and as such is fully aware of the current conditions of the Diversified Building.

          5.2.2 Phase 1 Premises .

               (a) Landlord shall endeavor to tender possession of the Phase 1 Premises to Tenant on or before the Phase 1 Estimated Delivery Date. If Landlord’s Construction Work or the Tenant Improvements as required pursuant to the terms of the Work Letter are not Substantially Complete on or before the Phase 1 Estimated Delivery Date for any reason whatsoever, then, except as provided below, this Lease shall not be void or voidable, Landlord shall not be liable to Tenant for any loss or damage resulting therefrom and the Phase 1 Commencement Date shall not occur until Substantial Completion of Landlord’s Construction Work and the Tenant Improvements occurs; provided , however , if the satisfaction of the requirements for Substantial Completion of Landlord’s Construction Work or the Tenant Improvements have been actually delayed by any Tenant Delay, then, subject to the terms hereof, Substantial Completion of Landlord’s Construction Work and the Tenant Improvements shall be deemed to occur when (as reasonably determined by Landlord) Substantial Completion of Landlord’s Construction Work and the Tenant Improvements would have occurred if such Tenant Delay had not occurred. Within thirty (30) days after Substantial Completion of Landlord’s Construction Work and the Tenant Improvements, Landlord’s architect shall calculate and certify in writing to Landlord and Tenant the Rentable Area of the Phase 1 Premises in accordance with Article 9 . “ Tenant Delay ” shall mean: (1) delays or failure of Tenant or Tenant’s architect to deliver items in accordance with the Work Letter attached hereto as Exhibit J ; (2) Tenant’s failure to timely fulfill its obligations as set forth in the Work Letter within the time periods set forth therein; (3) delays caused by CW Tenant Change Order Requests (as defined in the Work Letter) or TI Tenant Change Order Requests (as defined in the Work Letter); 4) unavailability of materials, components or finishes for the Tenant Improvements that have an unusually long lead-time for delivery; (5) a willful or negligent act or

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omission of Tenant, Tenant’s Agents that interferes with the progress of the work, (6) any delay that results from Tenant’s use of an architect other than Ferguson Pape Baldwin Architects for purposes of the TI Program and the Schematic TI Plans, or (7) any other event or circumstance described as a Tenant Delay in the Work Letter. Landlord shall not assess any day towards a Tenant Delay for delays caused solely by Landlord’s contractors, Landlord or any third parties or due to Force Majeure. Notwithstanding anything above to the contrary, (i) the first ten (10) days of Tenant Delays (if any) associated with any CW Tenant Change Order Request or TI Tenant Change Order Request shall not be deemed a Tenant Delay, (ii) no delay shall be considered a Tenant Delay unless Landlord provides Tenant written notice of such Tenant Delay, to the extent Landlord and/or management personnel of Landlord’s contractor(s) are aware of such Tenant Delay, and Tenant fails to cure such delay within one (1) business day; provided that no such notice and cure period shall be required if such delay is with respect to interference with the Landlord’s construction activities and Landlord has previously notified Tenant of similar Tenant Delays, (iii) no delay shall be considered a Tenant Delay in the event Substantial Completion of Landlord’s Construction Work and the Tenant Improvements occurs on or before the Phase 1 Estimated Delivery Date. Landlord and Contractor shall take commercially reasonable actions, remedial or otherwise, to complete the Landlord’s Construction Work and the Tenant Improvements by the Phase 1 Estimated Delivery Date notwithstanding any Tenant Delay. All additional cost and expense payable by Landlord, if any, to complete the Landlord’s Construction Work or the Tenant Improvements due to Tenant Delay (“ Tenant Delay Costs ”), shall constitute TI Costs, and to the extent the TI Costs exceed the TI Allowance Amount, Tenant shall pay such actual and documented additional costs and expenses as “Excess Costs” in accordance with Section 4.2.2 of this Lease.

               (b) Landlord and Tenant shall each execute and deliver to the other a factually correct written acknowledgment of the actual Phase 1 Commencement Date and the Expiration Date when such is established in the form of Exhibit F , and shall attach it to this Lease as Exhibit F-1 . Failure to execute and deliver such acknowledgement, however, shall not affect the Phase 1 Commencement Date or Landlord’s or Tenant’s liability hereunder. Failure by Tenant to obtain validation by any medical review board or other similar governmental licensing of the Expansion Premises required for the Permitted Use by Tenant shall not serve to extend the Phase 1 Commencement Date.

          5.2.3 Phase 2 Premises .

               (a) In the event Tenant elects to occupy the Phase 2 Premises before the Phase 2 Estimated Delivery Date, then Tenant shall deliver to Landlord at least five (5) business days before the date Tenant elects to occupy the Phase 2 Premises a written notice setting forth the date Tenant intends to occupy the Phase 2 Premises (collectively, the “ Phase 2 Commencement Date Notice ”).

               (b) Landlord shall tender possession of the Phase 2 Premises to Tenant upon the Phase 2 Commencement Date. On the Phase 2 Commencement Date, Landlord and Tenant shall each execute and deliver to the other a factually correct written acknowledgement of the actual Phase 2 Commencement Date and the Expiration Date when established, in the form Exhibit F , and shall attach it to this Lease as Exhibit F-2 . Failure to execute and deliver such acknowledgement, however, shall not affect the Phase 2 Commencement Date or Tenant’s liability hereunder.

          5.2.4 Phase 3 Premises .

               (a) In the event Tenant elects to occupy the Phase 3 Premises (which shall include all, and not less than all, of the remainder unoccupied portion of the Expansion Building) before the Phase 3 Estimated Delivery Date, Tenant shall deliver to Landlord at least five (5) business days a written notice setting forth the date that Tenant intends to occupy the Phase 3 Premises (collectively, the “ Phase 3 Commencement Date Notice ”).

               (b) Landlord shall tender possession of the Phase 3 Premises to Tenant upon the Phase 3 Commencement Date. On the Phase 3 Commencement Date, Landlord and Tenant shall each execute and deliver to the other factually correct written acknowledgement of the actual Phase 3 Commencement Date and the Expiration Date when established, in the form Exhibit F , and shall attach it to this Lease as Exhibit F-3 . Failure to execute and deliver such

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acknowledgement, however, shall not affect the Phase 3 Commencement Date or Tenant’s liability hereunder.

          5.2.5 Tenant’s Termination and Abatement Rights.

               (a)  First Milestone Termination Right . Notwithstanding the foregoing, in the event Landlord has not commenced the grading of the land where the Expansion Building will be located (“ Grading Work ”) by September 1, 2007, as such date may be equitably extended to reflect any Tenant Delay and any Force Majeure delays (“ Outside Date Termination Date ”), then Tenant shall have the right to terminate this Lease by notice to Landlord given no later than thirty (30) days following such date, at which time neither party shall have any further right or obligation hereunder (except for those terms and provisions which expressly survive the expiration or sooner termination of this Lease).

               (b)  Second Milestone Abatement and Termination Right . Notwithstanding the foregoing, in the event that Substantial Completion of the Tenant Improvements has not occurred by October 1, 2008 , as such date may be equitably extended to reflect any Tenant Delay and any Force Majeure delays (the “ TI Completion Outside Date ”), then Tenant shall be entitled to one (1) day of abatement of Expansion Premises Basic Annual Rent for the Phase 1 Premises for every day past the applicable TI Completion Outside Date that Substantial Completion of the Tenant Improvements has not occurred. In the event that Substantial Completion of the Tenant Improvements has not occurred by October 1, 2009, as such date may be equitably extended to reflect any Tenant Delay and any Force Majeure delays (the “ TI Completion Termination Date ”), then Tenant shall have the right to terminate this Lease by notice to Landlord given no later than thirty (30) days following such date, at which time neither party shall have any further right or obligation hereunder (except for those terms and provisions which expressly survive the expiration or sooner termination of this Lease); provided , however , for purposes of this Section 5.2.5(b) , in no event shall the period of excused delay for Force Majeure exceed ninety (90) days in the aggregate.

6. Rent .

     6.1. Diversified Building Premises . Starting on the Execution Date, Tenant shall pay to Landlord as Basic Annual Rent for the Diversified Building Premises, the rent set forth on the rent schedule attached hereto as Schedule 1 , subject to adjustments in accordance with Article 7 . The Diversified Building Premises Basic Annual Rent shall be paid in equal monthly installments on or before the first day of the applicable month.

     6.2. Expansion Premises . Starting on the Phase 1 Commencement Date, Tenant shall pay to Landlord as Basic Annual Rent for the Expansion Premises, the product of (a) the rate per rentable square feet set forth in Section 2.3 (as adjusted in accordance with Article 7 ), and (b) the rentable square feet of the Phases that are included in the Expansion Premises from time to time, subject to adjustment pursuant to the terms of this Lease, including, without limitation: (i) the Expansion Premises Basic Annual Rent shall increase on the Phase 2 Commencement Date by the product of (1) the number of rentable square feet of the Phase 2 Premises and (2) the same Expansion Premises Basic Annual Rent rate per rentable square foot that applies to the Expansion Premises from time to time; (ii) the Expansion Premises Basic Annual Rent shall increase on the Phase 3 Commencement Date by the product of (1) the number of rentable square feet of the Phase 3 Premises and (2) the same Expansion Premises Basic Annual Rent rate per rentable square foot that applies to the Expansion Premises from time to time; and (iii) the biennial rent adjustments in accordance the provisions of Article 7 hereof. Expansion Premises Basic Annual Rent and the TI Allowance Amount shall be paid in equal monthly installments on or before the first day of the applicable month.

     6.3. In addition to Basic Annual Rent, from and after the Commencement Date, Tenant shall pay to Landlord as additional rent (“ Additional Rent ”) at times hereinafter specified in this Lease (a) amounts related to Insurance Costs, Utility Costs and Taxes (each as defined below) and (b) any other amounts that Tenant agrees to pay under the provisions of this Lease that are owed to Landlord, including, without limitation, any and all other sums that may become due by reason of any default of Tenant or failure on Tenant’s part to comply with the agreements, terms, covenants and conditions of this Lease to be performed by Tenant, after notice and the lapse of any applicable cure periods.

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     6.4. Basic Annual Rent (including the Diversified Building Premises Basic Annual Rent and the Expansion Premises Basic Annual Rent) and Additional Rent shall together be denominated “ Rent .” Rent shall be paid to Landlord, without, except as otherwise provided herein, abatement, deduction or offset, in lawful money of the United States of America at the office of Landlord as set forth in Section 2.10 or to such other person or at such other place as Landlord may from time designate in writing. In the event the Commencement Date for any Phase commences or ends on a day other than the first day of a calendar month, then the Rent for such fraction of a month shall be prorated for such period on the basis of a thirty (30) day month and shall be paid at the then-current rate for such fractional month.

7. Rent Adjustments .

     7.1. Initial Term .

          7.1.1 Diversified Building Premises . The Diversified Building Premises Basic Annual Rent per rentable square foot of the Diversified Building Premises shall be increased in accordance with Schedule 1 attached hereto.

          7.1.2 Expansion Premises . The Expansion Premises Basic Annual Rent per rentable square foot of the Expansion Premises shall be increased on every other anniversary (i.e., the second anniversary, the fourth anniversary, the sixth anniversary, etc.) of the Phase 1 Commencement Date by five percent (5%) of the Expansion Premises Basic Annual Rent per rentable square foot of the Expansion Premises immediately preceding such increase. The monthly installment of Expansion Premises Basic Annual Rent that is due for the month in which each such adjustment occurs (the installment due immediately before such month) shall be the first installment that will be increased to reflect such increase in Expansion Premises Basic Annual Rent.

     7.2. Extended Term .

          7.2.1 Diversified Building Premises . The Diversified Building Premises Basic Annual Rent for the Diversified Building Premises shall be adjusted on the first (1 st ) day of each Extended Term to the amount calculated in accordance with Section 42.1 , and shall be adjusted every twenty-four (24) months thereafter by five percent (5%) of the Diversified Building Premises Basic Annual Rent per rentable square foot of the Diversified Building Premises immediately preceding such increase. The monthly installment of the Diversified Building Premises Basic Annual Rent that is due for the month in which each such adjustment occurs (the installment due immediately before such month) shall be the first installment that will be increased to reflect such increase in the Diversified Building Premises Basic Annual Rent.

          7.2.2 Expansion Premises . The Expansion Premises Basic Annual Rent for the Expansion Premises shall be adjusted on the first (1 st ) day of each Extended Term to the amount calculated in accordance with Section 42.1 , and shall be adjusted every twenty-four (24) months thereafter by five percent (5%) of the Expansion Premises Basic Annual Rent per rentable square foot of the Expansion Premises immediately preceding such increase. The monthly installment of the Expansion Premises Basic Annual Rent that is due for the month in which each such adjustment occurs (the installment due immediately before such month) shall be the first installment that will be increased to reflect such increase in the Expansion Premises Basic Annual Rent.

8. Taxes .

     8.1. Commencing with the Commencement Date and continuing for each calendar year or, at Landlord’s option, tax year (each such “tax year” being a period of twelve (12) consecutive calendar months for which the applicable taxing authority levies or assesses Taxes), for the balance of the Term, Tenant shall pay to Landlord the amount of all Taxes levied and assessed for any such year upon the Property (including the Diversified Space). “ Taxes ” shall mean all government impositions including, without limitation, property tax costs consisting of real and personal property taxes and assessments (including amounts due under any improvement bond upon the Property or any portion thereof, including the Parcel or parcels of real property upon which the Buildings are located or assessments levied in lieu thereof) imposed by any federal, state, regional, local or municipal governmental authority, agency or subdivision (each, a “ Governmental Authority ”) on the Property or improvements thereon, any tax on or

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measured by gross rentals received from the rental of space in the Buildings, or tax based on the square footage of the Premises or the Buildings as well as any parking charges, utilities surcharges, or any other costs levied, assessed or imposed by, or at the direction of, or resulting from statutes or regulations, or interpretations thereof, promulgated by any Governmental Authority in connection with the use or occupancy of the Premises or the parking facilities exclusively serving the Premises; any tax on this transaction or this Lease; provided , however , that “ Taxes ” shall in no event include any franchise or federal or state income tax, excess profit taxes, gift taxes, capital stock taxes, inheritance and succession taxes, estate taxes or any tax based on net rentals received from the rental of space in the Buildings. Any amount paid by Tenant for any partial year of the Term shall be prorated on the basis of the number of days of such partial year. Payment shall be made in the following manner: Tenant shall pay to Landlord the amounts owed under this Article 8 within thirty (30) days after Landlord gives notice to Tenant of the amount of such Taxes payable by Tenant (or not less than fifteen (15) days prior to delinquency, whichever is later). Landlord also shall provide Tenant with a copy of the applicable tax bill or tax statement from the relevant taxing authority. Notwithstanding the foregoing, if Applicable Laws allow any such Taxes to be paid in installments, then Tenant may make such payments to Landlord in installments, provided that each such installment shall be payable to Landlord not less than ten (10) days prior to the date upon which payment of the applicable installment to the taxing authority becomes delinquent. In addition to any other amounts due from Tenant to Landlord, if Tenant fails to pay Taxes to Landlord as herein required, Tenant shall pay to Landlord the amount of any interest, penalties or late charges imposed by any governmental authority for late payment. “ Applicable Laws ” means all federal, state, municipal and local laws, codes, ordinances, rules and regulations of Governmental Authorities, committees, associations, or other regulatory committees, agencies or governing bodies having jurisdiction over the Property, Landlord or Tenant, including both statutory and common law and hazard waste rules and regulations.

          8.1.1 Tenant shall have the right, by appropriate proceedings, to protest or contest in good faith any assessment or reassessment of Taxes, any special assessment, or the validity of any Taxes or of any change in assessment or tax rate; provided , however , that prior to any such challenge Tenant must either (a) pay the Taxes alleged to be due in their entirety and seek a refund from the appropriate authority or (b) post a bond in an amount sufficient to ensure full payment of the Taxes, including any potential interest, late charge and penalties. Upon a final determination with respect to any such contest or protest, Tenant shall promptly pay to the appropriate Governmental Authority all sums found to be due with respect thereto. In any such protest or contest, Tenant may act in its own name, and at the request of Tenant, Landlord shall cooperate with Tenant in any way Tenant may reasonably require in connection with such contest or protest, including signing such documents as Tenant reasonably shall request, provided that such cooperation shall be at no expense to Landlord and shall not require Landlord to attend any appeal or other hearing. Any such contest or protest shall be at Tenant’s sole expense, and if any penalties, interest or late charges become payable with respect to the Taxes as a result of such contest or protest, Tenant shall pay the same.

          8.1.2 If Tenant obtains a refund as the result of Tenant’s protest or contest, and subject to Tenant’s obligation to pay Landlord’s costs (if any) associated therewith, Tenant shall be entitled to such refund to the extent it relates to the Property during the Term.

     8.2. If, at any time during the Term under the laws of any Governmental Authority, a tax or excise on rent or any other tax howsoever described is levied or assessed by any such political body against Landlord on account of rentals payable to Landlord hereunder, such tax or excise shall be considered “ Taxes ” for the purposes of this Article 8 , although any amount assessed against Landlord as state or federal income tax shall not be deemed “ Taxes .”

     8.3. To the extent Landlord is required by a lender, Tenant shall timely pay all tax and insurance impound payments due on the Property.

     8.4. Taxes on Tenant’s Property .

          8.4.1 Tenant shall pay at least twenty (20) days prior to delinquency any and all taxes levied against any personal property or trade fixtures placed by Tenant in or about the Property.

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          8.4.2 If any such taxes on Tenant’s personal property or trade fixtures are levied against Landlord or Landlord’s property or, if the assessed valuation of the Buildings is increased by inclusion therein of a value attributable to Tenant’s personal property or trade fixtures, and if Landlord, after written notice to Tenant, pays the taxes based upon any such increase in the assessed valued of the Buildings, then Tenant shall, upon demand, repay to Landlord the taxes so paid by Landlord.

     8.5. Cut-Off Date . Notwithstanding anything herein to the contrary, Tenant shall not be responsible for Taxes attributable to any calendar year which are first billed to Tenant more than eighteen (18) months after the expiration of the applicable calendar year, except with respect to supplemental Taxes.

9. [Intentionally Omitted] .

10. Security Deposit .

     10.1. Pursuant to the Original Illumina Lease, Tenant has deposited with Landlord an amount equal to $1,911,855 as the security deposit under the Original Illumina Lease (the “ Original Illumina Lease Security Deposit ”), and (a) from and after the Execution Date, Landlord shall continue to hold a portion of the Original Illumina Lease Security Deposit in an amount equal to $40,836.75 (the “ Security Deposit ”), in accordance with the terms and conditions of this Section 10 , (b) from and after the Execution Date, Landlord shall hold a portion of Original Illumina Lease Security Deposit equal to $865,177.50 in accordance with the terms and conditions of Section 8 of the Illumina Lease, and (c) Landlord shall return the remaining portion of the Original Illumina Lease Security Deposit in an amount equal to $1,005,840.75 to Tenant.

     10.2. The Security Deposit shall be held by Landlord as security for the faithful performance by Tenant of all of the terms, covenants and conditions of this Lease to be kept and performed by Tenant during the period commencing on the Execution Date and ending upon the expiration or termination of this Lease. In addition, Tenant shall deposit the following amounts with Landlord and the Security Deposit shall be increased by such amounts: (a) a sum equal to $343,274.40 upon commencement of construction of the Landlord’s Construction Work, (b) a sum equal to $180,600.00 on the Phase 2 Commencement Date, and (c) a sum equal to $189,630.00 on the Phase 3 Commencement Date. If Tenant defaults with respect to any provision of this Lease, including, but not limited to, any provision relating to the payment of Rent, then Landlord may (but shall not be required to) use, apply or retain all or any part of the Security Deposit for the payment of any Rent or any other sum in default, or to compensate Landlord for any other loss or damage that Landlord may suffer by reason of Tenant’s default. If any portion of the Security Deposit is so used or applied, then Tenant shall, within twenty (20) days following demand therefor, deposit cash with Landlord in an amount sufficient to restore the Security Deposit to its original amount, and Tenant’s failure to do so shall be a material breach of this Lease. Landlord shall not be required to keep this Security Deposit separate from its general fund, and Tenant shall not be entitled to interest on the Security Deposit. The provisions of this Article 10 shall survive the expiration or earlier termination of this Lease.

     10.3. In the event Landlord receives documentation from Tenant that demonstrates to Landlord’s reasonable satisfaction that Tenant has achieved a rating of “BBB” or better from Standard & Poor’s Corporation (“ S&P ”), or “Baa” or better from Moody’s Investors Service, Inc. (“ Moody’s ”)(or in each case any successor thereof), and Tenant is not then in Default, Landlord shall return a portion of the Security Deposit so that the remaining Security Deposit equals one (1) month of Basic Annual Rent for the entire Premises to Tenant; provided , however , in the event (a) Tenant subsequently has neither a S&P rating of “BBB” or better nor a Moody’s rating of “Baa” or better, or (b) Tenant assigns its interest in this Lease to another person or entity in accordance with Section 27 hereof, unless such assignee satisfies the requirements set forth in this Section 10.3 , Tenant shall, within fifteen (15) days after written notice thereof, deposit an amount with Landlord sufficient to restore said Security Deposit to the amount set forth in Section 2.7 and Tenant’s failure to do so shall constitute a Default of this Lease.

     10.4. In the event of bankruptcy or other debtor-creditor proceedings against Tenant, the Security Deposit shall be deemed to be applied first to the payment of Rent and other charges due Landlord for all periods prior to the filing of such proceedings.

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     10.5. Landlord may deliver to any purchaser of Landlord’s interest in the Property the funds deposited hereunder by Tenant, and thereupon Landlord shall be discharged from any further liability with respect to such deposit. This provision shall also apply to any subsequent transfers.

     10.6. If Tenant is not then in Default under this Lease nor is any event then occurring which with the giving of notice or the passage of time, or both, would constitute a Default hereunder, then the Security Deposit, or any balance thereof, shall be returned to Tenant (or, at Landlord’s option, to the last assignee of Tenant’s interest hereunder) within thirty (30) days after the expiration or earlier termination of this Lease.

     10.7. The Security Deposit may be in the form of cash, a letter of credit or any other security instrument acceptable to Landlord in its sole discretion. Tenant may at any time, except during Default, deliver a letter of credit (“ L/C Security ”) as the entire Security Deposit, as follows.

          10.7.1 If Tenant elects to deliver L/C Security, then Tenant shall provide Landlord, and maintain in full force and effect throughout the Term, a letter of credit in substantially the form of Exhibit K issued by an issuer reasonably satisfactory to Landlord, in the amount of the Security Deposit, with an initial term of at least one year. If, at the Expiration Date, any Rent remains uncalculated or unpaid, then: (a) Landlord shall with reasonable diligence complete any necessary calculations; (b) Tenant shall extend the expiry date of such L/C Security from time to time as Landlord reasonably requires; and (c) in such extended period, Landlord shall not unreasonably refuse to consent to an appropriate reduction of the L/C Security. Tenant shall reimburse Landlord’s legal costs (as estimated by Landlord’s counsel) in handling Landlord’s acceptance of L/C Security or its replacement or extension

          10.7.2 If Tenant delivers to Landlord satisfactory L/C Security in place of the entire Security Deposit, Landlord shall promptly remit to Tenant any cash Security Deposit Landlord previously held.

          10.7.3 Landlord may draw upon the L/C Security, and hold and apply the proceeds in the same manner and for the same purposes as the Security Deposit, if: (a) an uncured Default exists; (b) as of the date thirty (30) days before any L/C Security expires (even if such scheduled expiry date is after the Expiration Date) Tenant has not delivered to Landlord an amendment or replacement for such L/C Security, reasonably satisfactory to Landlord, extending the expiry date to the earlier of (i) six (6) months after the then-current Expiration Date or (ii) the date one year after the then-current expiry date of the L/C Security; (c) the L/C Security provides for automatic renewals, Landlord asks the issuer to confirm the current L/C Security expiry date, and the issuer fails to do so within ten (10) business days; (d) Tenant fails to pay (when and as Landlord reasonably requires) any bank charges for Landlord’s transfer of the L/C Security; or (e) the issuer of the L/C Security ceases, or announces that it will cease, to maintain an office in the city where Landlord may present drafts under the L/C Security. This Section does not limit any other provisions of this Lease allowing Landlord to draw the L/C Security under specified circumstances.

          10.7.4 Tenant shall not seek to enjoin, prevent, or otherwise interfere with Landlord’s draw under L/C Security, even if it violates this Lease. Tenant acknowledges that the only effect of a wrongful draw would be to substitute a cash Security Deposit for L/C Security, causing Tenant no legally recognizable damage. Landlord shall hold the proceeds of any draw in the same manner and for the same purposes as a cash Security Deposit. In the event of a wrongful draw, the parties shall cooperate to allow Tenant to post replacement L/C Security simultaneously with the return to Tenant of the wrongfully drawn sums, and Landlord shall upon request confirm in writing to the issuer of the L/C Security that Landlord’s draw was erroneous.

          10.7.5 If Landlord transfers its interest in the Property, then Tenant shall at Tenant’s expense, within ten (10) business days after receiving a request from Landlord, deliver (and, if the issuer requires, Landlord shall consent to) an amendment to the L/C Security naming Landlord’s grantee as substitute beneficiary; provided , however , in the event Landlord transfers its interest in the Property more than once in a twelve (12) month period, Landlord shall pay any fee owed to the issuing bank in connection with any such additional transfer. If the required Security changes while L/C Security is in force, then Tenant shall deliver (and, if the issuer requires, Landlord shall consent to) a corresponding amendment to the L/C Security.

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11. Use .

     11.1. Tenant shall use the Premises for the purpose set forth in Section 2.8 , and shall not use the Premises, or permit or suffer the Premises to be used, for any other purpose without Landlord’s prior written consent, which consent Landlord may withhold in its reasonable discretion.

     11.2. Tenant shall not use or occupy the Property in violation of Applicable Laws; zoning ordinances; or the certificate of occupancy issued for the Buildings, and shall, upon five (5) days’ written notice from Landlord, discontinue any use of the Property that is declared or claimed by any Governmental Authority having jurisdiction to be a violation of any of the above, or that Landlord has a reasonable basis to believe that such use violates any of the above and Landlord identifies such basis in its notice to Tenant. Tenant shall comply with any direction of any Governmental Authority having jurisdiction that shall, by reason of the nature of Tenant’s use or occupancy of the Property, impose any duty upon Tenant with respect to the Property or with respect to the use or occupation thereof.

     11.3. Tenant shall not do or permit to be done anything that will invalidate or increase the cost of any fire, environmental, extended coverage or any other insurance policy covering the Property, and shall comply with all rules, orders, regulations and requirements of the insurers of the Property, and Tenant shall promptly, upon demand, reimburse Landlord for any additional premium charged for such policy by reason of Tenant’s failure to comply with the provisions of this Article 11 .

     11.4. Tenant shall, at its sole cost and expense, promptly and properly observe and comply with all present and future orders, regulations, directions, rules, laws, ordinances, and requirements of all Governmental Authorities (including, without limitation, state, municipal, county and federal governments and their departments, bureaus, boards and officials) arising from the use or occupancy of the Property, including, without limitation, the requirements of Americans with Disabilities Act of 1990 (together with regulations promulgated pursuant thereto, the “ ADA ”). Tenant’s obligations under this Section 11.4 shall include any Alterations to the Property (including (a) the Diversified Building and, (b) from and after the Phase 1 Commencement Date, the Expansion Building) that Tenant is required or elects to make pursuant to the terms of this Lease; provided , however , Landlord shall be responsible for ADA compliance of the Landlord’s Construction Work and the Tenant Improvements.

     11.5. Tenant shall keep all doors opening onto public corridors closed, except when in use for ingress and egress.

     11.6. No additional locks or bolts of any kind shall be placed upon any of the doors or windows by Tenant, nor shall any changes be made to existing locks or the mechanisms thereof without Landlord’s prior written consent. Tenant shall, upon termination of this Lease, return to Landlord all keys to offices and restrooms either furnished to or otherwise procured by Tenant. In the event any key so furnished to Tenant is lost, Tenant shall pay to Landlord the cost of replacing the same or of changing the lock or locks opened by such lost key if Landlord shall deem it necessary to make such change

     11.7. No awnings or other projections shall be attached to any outside wall of the Buildings. No curtains, blinds, shades or screens shall be attached to or hung in, or used in connection with, any window or door of the Buildings other than Landlord’s standard window coverings. Neither the interior nor exterior of any windows shall be coated or otherwise sunscreened without Landlord’s prior written consent, nor shall any bottles, parcels or other articles be placed on the windowsills. No equipment, furniture or other items of personal property shall be placed on any exterior balcony without Landlord’s prior written consent.

     11.8. Subject to Diversified’s right to place signs on the Property in accordance with Section 32 of the Diversified Lease, Tenant shall, at Tenant’s sole cost and expense, have the exclusive right to install the maximum amount of any legally permitted signage on the Property (including any building thereon) (“ Signage ”), which Signage shall be subject to Landlord’s prior written consent, which consent shall not be unreasonably withheld, conditioned or delayed. Tenant shall keep the Signage in good condition and repair. The size, design, and other physical aspects of any sign shall be subject to Landlord’s written approval prior to installation, which approval will not unreasonably be withheld, any covenants, conditions, or restrictions

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encumbering the Property and, any Applicable Laws. The cost of the sign(s), including but not limited to the permitting, installation, maintenance and removal thereof shall be at Tenant’s sole cost and expense. If Tenant fails to maintain its sign(s), or if Tenant fails to remove such sign(s) upon termination of this Lease, or fails to repair any damage caused by such removal (including without limitation, painting the damaged portions of the Buildings and any other portions of the Buildings that Landlord reasonably determines in good faith shall be painted so that repainting the damaged portion of the Buildings does not adversely affect the visual appearance of the Buildings, if required by Landlord; provided , however , in no event shall Landlord require Tenant to repaint an entire Building), Landlord may do so at Tenant’s expense. Tenant shall on demand reimburse Landlord for all costs incurred by Landlord to effect such removal, which amounts shall be deemed Additional Rent and shall include without limitation, all sums disbursed, incurred or deposited by Landlord, including Landlord’s costs, expenses and actual attorneys’ fees with interest thereon. Tenant shall indemnify, defend and hold harmless Landlord from and against any loss, cost, claim, lawsuit, liability or expense (including reasonable attorneys’ fees and disbursements) arising directly or indirectly out of Tenant’s failure to perform any of its obligations under this Section 11.8 .

     11.9. Tenant shall only place equipment within the Premises with floor loading consistent with the structural design of the Buildings without Landlord’s prior written approval, and such equipment shall be placed in a location designed to carry the weight of such equipment.

     11.10. Tenant shall not (a) use or allow the Property to be used for any unlawful or reasonably objectionable purposes or (b) cause, maintain or permit any nuisance or waste in, on or about the Property (other than the Diversified Space).

     11.11. Except for Landlord’s Construction Work and Tenant Improvement work, Tenant shall be responsible for all liabilities, costs and expenses arising out of or in connection with the compliance of the Property (other than the Diversified Space) with the ADA, and Tenant shall indemnify, defend and hold harmless Landlord from and against any loss, cost, claim, lawsuit, liability or expense (including reasonable attorneys’ fees and disbursements) arising out of any failure of the Property (other than the Diversified Space) to comply with the ADA. Notwithstanding the foregoing, Landlord represents and warrants that upon Substantial Completion of Landlord’s Construction Work and the Tenant Improvement work, the Expansion Building shall comply with all Applicable Laws, including the ADA and any compliance costs as a result of a breach of this representation and warranty shall be at Landlord’s sole cost and expense and Landlord shall indemnify, defend and hold harmless Tenant from and against any loss, cost, claim, lawsuit, liability or expense (including reasonable attorneys’ fees and disbursements) arising out of any failure of the Landlord’s Construction Work or the Tenant Improvements to comply with the ADA. The provisions of this Section 11.11 shall survive the expiration or earlier termination of this Lease.

12. Diversified Lease and Subdivision .

     12.1. Diversified Lease . From and after the Commencement Date, (a) Tenant shall be responsible for paying all amounts with respect to Taxes, Insurance Costs, Utility Costs and any other costs and expenses Landlord is required to pay in connection with the Diversified Space in accordance with Article 9 of the Diversified Lease, and (b) Landlord assumes, and is responsible for performing, all of the obligations of the landlord under and related to the Diversified Lease (other than the payment of expenses in accordance with Section 12.1(a) above). Notwithstanding the foregoing, (x) Tenant is solely responsible for maintaining the Property (other than the Diversified Space) in accordance with the terms and conditions of this Lease, and (y) Diversified is solely responsible for maintaining the Diversified Space pursuant to Section 11(b) of the Diversified Lease.

     12.2. Estoppel . Tenant certifies that (a) the Diversified Lease is unmodified and in full force and effect and (b) to Tenant’s knowledge, there are not any uncured defaults on the part of landlord or the tenant under the Diversified Lease.

     12.3. Recreation Facilities . Tenant acknowledges that Diversified has certain rights to the Property (excluding the Expansion Building) pursuant to the Diversified Lease, including, without limitation, the right to use: (a) the Diversified Building lobby, utility room, common corridors and hallways, 5 covered reserved parking spaces, uncovered parking areas, stairways & elevators and access to other generally understood public or common areas (“ Diversified

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Building Common Areas ”), and (b) the full court basketball/sports courts, outdoor seating areas, dressing, locker and working rooms, restrooms, and showers located on the Property (collectively, the “ Recreation Facilities ” and, together with the Diversified Building Common Areas, the “ Diversified Areas ”). Diversified shall have the non-exclusive right to use the Diversified Areas 24 hours a day, 7 days a week other than Diversified’s exclusive right to use the 5 covered reserved parking spaces pursuant to the Diversified Lease. Tenant hereby agrees that it shall not regulate, restrict or charge any fees in connection with Diversified’s use of the Diversified Areas.

     12.4. Subdivision . Landlord may subdivide Parcel 3 so that it will consist of two lots that may be legally conveyed in accordance with California’s Subdivision Map Act. At Landlord’s request, Tenant shall execute, acknowledge and deliver such further instruments and do such further acts as may be necessary to modify the subdivision of such property. Tenant shall not oppose or object to any changes or modifications to the subdivision for such property.

13. Brokers .

     13.1. Tenant represents and warrants that it has had no dealings with any real estate broker or agent in connection with the negotiation of this Lease other than Steve Rosetta and Ted Simpson, Cushman & Wakefield (“ Tenant’s Broker ”), and that it knows of no other real estate broker or agent that is or might be entitled to a commission in connection with this Lease. Landlord shall compensate Tenant’s Broker in relation to this Lease pursuant to a separate agreement between Landlord and Landlord’s Broker (the “ Commission Agreement ”).

     13.2. Landlord represents and warrants that it has had no dealings with any real estate broker or agent in connection with the negotiation of this Lease other than Doug Lozier at CB Richard Ellis, Inc. (“ Landlord’s Broker ”), and that it knows of no other real estate broker or agent that is or might be entitled to a commission in connection with this Lease. Landlord shall compensate Landlord’s Broker in relation to this Lease pursuant to the Commission Agreement.

     13.3. Tenant acknowledges and agrees that the employment of brokers by Landlord is for the purpose of solicitation of offers of leases from prospective tenants and that no authority is granted to any broker to furnish any representation (written or oral) or warranty from Landlord unless expressly contained within this Lease. Landlord is executing this Lease in reliance upon Tenant’s representations, warranties and agreements contained within Section 13.1 .

     13.4. Tenant agrees to indemnify, defend and hold Landlord harmless from any and all cost or liability for compensation claimed by any other broker or agent, other than Tenant’s Broker, employed or engaged by it or claiming to have been employed or engaged by Tenant. Landlord agrees to indemnify, defend and hold Tenant harmless from any and all cost or liability for compensation claimed by any other broker or agent, other than Landlord’s Broker, employed or engaged by it or claiming to have been employed or engaged by Landlord.

14. Holding Over .

     14.1. If, with Landlord’s prior written consent, Tenant holds possession of all or any part of the Property after the Term, Tenant shall become a tenant from month to month after the expiration or earlier termination of the Term, and in such case Tenant shall continue to pay (a) the Basic Annual Rent in accordance with Article 6 , as adjusted in accordance with Article 7 , and (b) any amounts for which Tenant would otherwise be liable under this Lease if this Lease were still in effect, including, without limitation, payments for Taxes and insurance. Any such month-to-month tenancy shall be subject to every other term, covenant and agreement contained herein.

     14.2. Notwithstanding the foregoing, if Tenant remains in possession of the Property after the expiration or earlier termination of the Term without Landlord’s prior written consent, Tenant shall become a tenant at sufferance subject to the terms and conditions of this Lease, except that the per diem Basic Annual Rent shall be equal to: (a) for the first three (3) months that Tenant remains in possession of the Property after the expiration or earlier termination of this Lease, one hundred twenty-five percent (125%) of the Basic Annual Rent in effect during the last thirty (30) days of the Term; and (b) for any time thereafter that Tenant remains in possession of the Property after the expiration or earlier termination of this Lease, one hundred

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fifty percent (150%) of the Basic Annual Rent in effect during the last thirty (30) days of the Term.

     14.3. Acceptance by Landlord of Rent after the expiration or earlier termination of the Term shall not result in an extension, renewal or reinstatement of this Lease.

     14.4. The foregoing provisions of this Article 14 are in addition to and do not affect Landlord’s right of reentry or any other rights of Landlord hereunder or as otherwise provided by Applicable Laws.

15. Property Management Fee . Tenant shall pay to Landlord on the first day of each calendar month of the Term, as Additional Rent, the “ Property Management Fee ,” which shall equal one percent (1%) of the Basic Annual Rent due from Tenant.

16. Condition of Premises and the Property . Except as otherwise provided herein, Tenant acknowledges that neither Landlord nor any agent of Landlord has made any representation or warranty with respect to the condition of the Premises, the Property or with respect to the suitability of the Premises for the conduct of Tenant’s business.

17. Regulations and Parking and Recreation Facilities .

     17.1. Tenant shall faithfully observe and comply with the rules and regulations adopted by Landlord and attached hereto as Exhibit H , together with such other reasonable and nondiscriminatory rules and regulations as are hereafter promulgated by Landlord in its reasonable discretion (the “ Rules and Regulations ”).

     17.2. Subject to Diversified’s rights under Section 12.3 , Tenant shall have the right to use, at no additional cost, the parking facilities serving the Premises. As part of Landlord’s Construction Work, the Property shall contain sufficient parking to comply with applicable zoning requirements.

     17.3. Tenant shall, at Tenant’s sole cost and expense, comply with the terms and conditions set forth in, and perform each of the obligations of the Parcel 3 Owner (as defined in the REA) described in, Sections 3 , 4.1 , 4.2 , 4.3 , 4. 4, 4.8 , 7 , 8 , 9 , 11.3 , 11.10 , 11.11 and 11.12 of the Reciprocal Easement Agreement attached hereto as Exhibit L (the “ REA ”), in accordance with the terms of conditions of the REA as if Tenant were the Parcel 3 Owner.

     17.4. Subject to Section 18.5 and provided there is no material adverse impact on Tenant’s Permitted Use and access to the Premises (including the parking facilities), Landlord reserves the right to subdivide the real property; provided , however , that such right shall be exercised in a way that does not materially adversely affect Tenant’s beneficial use and occupancy of the Premises, including Tenant’s Permitted Use and Tenant’s access to the Premises (including the parking facilities).

     17.5. Tenant shall, and shall cause Tenant’s Agents to, faithfully observe and comply with any rules and regulations adopted pursuant to Section 4.7 of the REA (the “ Recreation Facilities Rules and Regulations ”). Landlord has the right to refuse to allow Tenant’s Agents to access the Recreation Facilities if such Tenant’s Agent has not complied with the applicable Recreation Facilities Rules and Regulations after receiving written notice of such failure to comply.

     17.6. Tenant shall have the right to use the Recreation Facilities during the hours reasonably established by Landlord as the operating hours of the Recreation Facilities. Notwithstanding anything to the contrary in this Lease, Landlord shall have no responsibility to Tenant or Tenant’s Agents (as defined below), for any accidents, claims, demands, liabilities, causes of action, judgments, costs, liens, damages, injuries, suits, losses or expenses, including attorneys’ fees, of any nature, kind or description, arising out of, caused by, or resulting from Tenant or Tenant’s Agent’s use of the Recreational Facilities or the negligence of Landlord Parties (as defined in Section 22.3 ) or Tenant’s Agents in connection with the operation and maintenance of such Recreational Facilities.

     17.7. So long as this Lease is in full force and effect, Landlord shall not amend or modify the REA without first obtaining: (a) the prior written consent of the original Tenant hereunder (but not any assignee or subtenant), which consent shall not be unreasonably withheld,

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conditioned or delayed, and (b) solely with respect to amendments or modifications that could reasonably be expected to have a material adverse effect on obligations assumed by any successors and assigns of Tenant under the REA, the prior written consent of any such successors and assigns, which consent shall not be unreasonably withheld, conditioned or delayed. All amendments or modifications which result in an increase of the costs and expenses to be incurred by Tenant under Section 17.3 shall be deemed material and adverse.

18. Utilities and Services .

     18.1. Tenant shall, at Tenant’s sole cost and expense, procure and maintain contracts, with copies furnished promptly to Landlord after execution thereof, in customary form and substance for, and with contractors specializing and experienced in, the maintenance of the following equipment and improvements, if any, if and when installed on the Property: (a) HVAC equipment, (b) boilers and pressure vessels, (c) fire extinguishing systems, including fire alarm and smoke detection devices, (d) landscaping and irrigation systems, (e) roof coverings and drains, (f) clarifiers, (g) basic utility feeds to the perimeter of the Buildings, and (h) any other equipment reasonably required by Landlord. Notwithstanding the foregoing, in the event Tenant fails to maintain the contracts required under this Section 18.1 within one (1) business day after Landlord provides Tenant written notice of such failure, Landlord reserves the right, upon notice to Tenant, to procure and maintain any or all of such contracts, and if Landlord so elects, Tenant shall reimburse Landlord, upon demand, for the actual documented costs thereof .

     18.2. Within sixty (60) days after the Commencement Date, and within sixty (60) days after the beginning of each calendar year during the Term, Landlord shall give Tenant a written estimate for such calendar year of the cost of utilities for the Property (including the Diversified Space), if not separately metered (“ Utility Costs ”), and insurance provided by Landlord for the Property (including the Diversified Space) (“ Insurance Costs ”). Tenant shall pay such estimated amount to Landlord in advance in equal monthly installments. Within ninety (90) days after the end of each calendar year, Landlord shall furnish to Tenant a statement showing in reasonable detail the costs incurred by Landlord for Utility Costs and Insurance Costs for the Property (including the Diversified Space) during such year (the “ Annual Statement ”), and Tenant shall pay to Landlord the costs incurred in excess of the payments previously made by Tenant within thirty (30) days of receipt of the Annual Statement. In the event that the payments previously made by Tenant for Utility Costs and Insurance Costs for the Property (including the Diversified Space) exceed Tenant’s obligation, such excess amount shall be credited by Landlord to the Rent or other charges next due and owing, provided that, if the Term has expired, Landlord shall remit such excess amount to Tenant. In the event Tenant disputes the amounts of any Annual Statement for the particular calendar year delivered by Landlord to Tenant and Tenant is not in Default hereunder, Tenant shall have the right, at Tenant’s cost, after reasonable notice to Landlord, to have Tenant’s authorized employees inspect, at Landlord’s office in San Diego County during normal business hours, Landlord’s books, records and supporting documents concerning the expenses set forth in such Annual Statement; provided , however , Tenant shall have no right to conduct such inspection, have an audit performed by the Accountant as described below, or object to or otherwise dispute the amount of the expenses set forth in any such Annual Statement unless Tenant notifies Landlord of such objection and dispute, completes such inspection, and has the Accountant commence and complete such audit within one hundred and eighty (180) days immediately following Landlord’s delivery of the particular Annual Statement in question (the “ Review Period ”); provided, further, that notwithstanding any such timely objection, dispute, inspection, and/or audit, and as a condition precedent to Tenant’s exercise of its right of objection, dispute, inspection and/or audit as set forth in this Section 18.2 , Tenant shall not be permitted to withhold payment of, and Tenant shall timely pay to Landlord, the full amounts as required by the provisions of this Lease in accordance with such Annual Statement. However, such payment may be made under protest pending the outcome of any audit which may be performed by the Accountant as described below. In connection with any such inspection by Tenant, Landlord and Tenant shall reasonably cooperate with each other so that such inspection can be performed pursuant to a mutually acceptable schedule. If after such inspection and/or request for documentation, Tenant still disputes the amount of the expenses set forth in the Annual Statement, Tenant shall have the right, within the Review Period, to cause an independent certified public accountant selected by Tenant and compensated on a non-contingency fee basis (the “ Accountant ”) to complete an audit of Landlord’s books and records to determine the proper amount of the expenses incurred and amounts payable by Tenant for the calendar year which is the subject of such Annual Statement. Such audit by the Accountant shall be final and binding upon Landlord and Tenant. If such audit reveals that Landlord has

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over-charged Tenant, then within thirty (30) days after the results of such audit are made available to Landlord, Landlord shall reimburse to Tenant the amount of such over-charge. If the audit reveals that the Tenant was under-charged, then within thirty (30) days after the results of such audit are made available to Tenant, Tenant shall reimburse to Landlord the amount of such under-charge. Tenant agrees to pay the cost of such audit unless it is subsequently determined that Landlord’s original Annual Statement which was the subject of such audit overstated expenses by five percent (5%) or more of the actual expenses which were the subject of such audit. The payment by Tenant of any amounts pursuant to this Section 18.2 shall not preclude Tenant from questioning, during the Review Period, the correctness of the particular Annual Statement in question provided by Landlord, but the failure of Tenant to object thereto, conduct and complete its inspection and have the Accountant conduct the audit as described above prior to the expiration of the Review Period for such Annual Statement shall be conclusively deemed Tenant’s approval of the Annual Statement in question and the amount of expenses shown thereon. If following Tenant’s delivery to Landlord of a written request to make Landlord’s books and records regarding the expenses reasonably available to Tenant and/or the Accountant to conduct any such inspection and/or audit described above in this Section 18.2 , Landlord fails to make Landlord’s books reasonably available for such purposes during Landlord’s normal business hours, and such failure continues for five (5) business days after Tenant notifies Landlord thereof, then the Review Period shall be extended one (1) day for each such additional day that Tenant and/or the Accountant, as the case may be, is so prevented from accessing such books and records. In connection with any inspection and/or audit conducted by Tenant pursuant to this Section 18.2 , Tenant agrees to keep, and to cause all of Tenant’s employees and consultants and the Accountant to keep, all of Landlord’s books and records and the audit, and all information pertaining thereto and the results thereof, strictly confidential (except if required by any court to disclose such information or if such information is available from an inspection of public records).

     18.3. Tenant shall make all arrangements for and pay for all water, sewer, gas, heat, light, power, telephone service and any other service or utility Tenant required at the Property (including the Diversified Space). Landlord shall not be liable for, nor shall any eviction of Tenant result from, the failure to furnish any utility or service, whether or not such failure is caused by Force Majeure or Landlord’s inability, despite the exercise of reasonable diligence, to furnish any such utility or service. Except as provided in Section 18.5 , in the event of such failure, Tenant shall not be entitled to termination of this Lease, any abatement or reduction of Rent, or relief from the operation of any covenant or agreement of this Lease. Tenant shall pay for, prior to delinquency of payment therefor, any utilities and services that may be furnished to the Property (including the Diversified Space) during or, if Tenant occupies any portion of the Premises after the expiration or earlier termination of the Term, after the Term.

     18.4. From and after the Commencement Date, Tenant shall be responsible for paying all amounts with respect to Insurance Costs, Utility Costs, Taxes and other amounts for which Tenant is responsible under this Lease (other than Expansion Premises Basic Annual Rent) for the Expansion Premises as if it was part of the Expansion Premises on the Commencement Date.

     18.5. Notwithstanding the foregoing and subject to Sections 17 and 35 , if because of (i) any repair, maintenance, alteration, development or construction performed by Landlord after the Commencement Date, which substantially interferes with Tenant’s use of the Premises and which was not caused by Tenant, (ii) any material interference by Landlord with Tenant’s access to the Premises (including the parking facilities) that is not caused by Tenant, or (iii) the presence of Hazardous Materials in, on or around the Premises in connection with the Landlord’s Construction Work or the Tenant Improvements which (a) is not caused by Tenant, and (b) poses a health risk to occupants of the Premises (each, an “ Adverse Condition ”), Tenant is unable to conduct its business in a reasonable manner in a material portion of the Premises as a direct result of the Adverse Condition and Tenant therefore actually does not occupy or use such portion of the Premises, as the case may be, and such condition persists for more than the “Interruption Period” (as defined below), then following the Interruption Period, Tenant shall be entitled to an abatement of Rent for the portion of the Premises rendered untenantable. However, in the event that the remaining portion of the Premises is not sufficient to allow Tenant to conduct its business therein, and if Tenant does not conduct its business from such remaining portion, then for such time after expiration of the Interruption Period during which Tenant is so prevented from effectively conducting its business therein, the Rent for the entire Premises shall be abated; provided , however , if Tenant continues to occupy any portion of the Premises, or reoccupies and conducts its business from any portion of the Premises, during such period, the

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Rent allocable to such reoccupied portion, based on the proportion that the rentable area of such reoccupied portion of the Premises bears to the total rentable area of the Premises, shall be payable by Tenant from the date such business operations commence. Such abatement shall commence as of the first day after the expiration of the “Interruption Period” and terminate upon the cessation of such Adverse Condition. As used herein, the term “ Interruption Period ” shall mean seven (7) consecutive business days after written notice thereof to Landlord, or such shorter period as applicable under the coverage which is or would be covered by rental abatement insurance required to be carried by Landlord.

19. Alterations .

     19.1. Tenant shall make no alterations, additions or improvements in or to the Property or engage in any construction, demolition, reconstruction, renovation, or other work of any kind in, at, or serving the Premises (“ Alterations ”) without Landlord’s prior written approval, which approval Landlord may withhold in its sole and absolute discretion; provided , however , that Landlord’s approval shall not be unreasonably withheld, conditioned or delayed in connection with any Alteration that does none of the following (i) adversely affects the exterior appearance of a Building or the Premises, (ii) adversely affects the structural aspects of a Building, including, without limitation, the roof, foundation, load bearing walls and structural elements of a Building or the Premises, (iii) adversely affects any base-building system or equipment, including, without limitation, the base building HVAC, mechanical, electrical, plumbing or life safety systems; (iv) creates a foreseeable risk of violating any Applicable Law or increasing insurance premiums; (v) violates any recorded document affecting the Property; (vi) causes a Building to be inconsistent with the quality and scope of a class “A” office buildings in the vicinity of the Buildings; (vii) involves a use of the Premises that is inconsistent with the current use of the Premises; nor (viii) in Landlord’s reasonable judgment, reduces the quality or value of a Building or the Property (each, a “ Design Problem ”). In seeking Landlord’s approval, Tenant shall provide Landlord, at least ten (10) business days in advance of any proposed construction, with plans, specifications, bid proposals, work contracts, requests for laydown areas and such other information concerning the nature and cost of the Alterations as Landlord may reasonably request.

     19.2. Notwithstanding the provisions of Section 19.1 , Tenant may make non-structural Alterations to the Premises (“ Acceptable Changes ”) upon at least ten (10) business days prior written notice to Landlord but without Landlord’s prior consent provided (a) the Acceptable Changes do not involve Design Problems; and (b) the cost of such Acceptable Changes do not exceed Fifty Thousand Dollars ($50,000) per occurrence or an aggregate amount of One Hundred Thousand Dollars ($100,000) in any twelve (12) month period.

     19.3. All Alterations made by Tenant shall be: (a) performed in a good and workmanlike manner and in conformance with any and all Applicable Laws and CC&Rs; and (b) shall be made only by a licensed, bonded contractor and such architects, suppliers and mechanics approved in advance by Landlord (which shall not be unreasonably withheld, conditioned or delayed); provided , however , that such contractor need not be bonded or approved and such architects, suppliers and mechanics need not be approved by Landlord in connection with Acceptable Changes.

     19.4. Tenant shall not construct or permit to be constructed partitions or other obstructions that will interfere with free access to mechanical installation or service facilities of the Buildings, or interfere with the moving of Landlord’s equipment to or from the enclosures containing such installations or facilities.

     19.5. Tenant shall accomplish any work performed on the Property in such a manner as to permit any fire sprinkler system and fire water supply lines to remain fully operable at all times.

     19.6. Tenant covenants and agrees that all work done by Tenant or Tenant’s contractors shall be performed in full compliance with Applicable Laws. Within thirty (30) days after completion of any Alterations, Tenant shall provide Landlord with complete “as-built” drawing print sets and electronic CADD files on disc (or files in such other current format in common use as Landlord reasonably approves or requires) showing any changes in the Property (but only if drawings and plans were required by this Lease or were prepared in connection with any such Alterations).

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     19.7. Before commencing any work, Tenant shall give Landlord at least ten (10) business days’ prior written notice of the proposed commencement of such work.

     19.8. Except for those items listed on Exhibit G , all Alterations, attached equipment, decorations, fixtures, trade fixtures, additions and improvements, subject to Section 19.8 , attached to or built into the Property, made by either of the Parties, including, without limitation, all floor and wall coverings, built-in cabinet work and paneling, sinks and related plumbing fixtures, laboratory benches, exterior venting fume hoods and walk-in freezers and refrigerators, ductwork, conduits, electrical panels and circuits shall (unless, prior to such construction or installation, Landlord elects otherwise) become the property of Landlord upon the expiration or earlier termination of the Term, and shall remain upon and be surrendered with the Property as a part thereof. The Property shall at all times remain the property of Landlord and shall be surrendered to Landlord upon the expiration or earlier termination of this Lease. Except for those items on Exhibit G , all trade fixtures, Tenant Improvements, Alterations and Signage installed by or under Tenant shall be the property of Landlord. Notwithstanding the foregoing, at any time during the Term, subject to Landlord’s prior written approval, which approval shall not be unreasonably withheld, conditioned or delayed, Tenant shall have the right to update Exhibit G .

     19.9. Tenant shall repair any damage to the Property caused by Tenant’s removal of any property from the Property. During any such restoration period, Tenant shall pay Rent to Landlord as provided herein as if the affected portion of the Premises were otherwise occupied by Tenant. The provisions of this Section shall survive the expiration or earlier termination of this Lease.

     19.10. Except as to those items listed on Exhibit G attached hereto, all business and trade fixtures, machinery and equipment, built-in furniture and cabinets, together with all additions and accessories thereto, attached to or built into the Property shall be and remain the property of Landlord and shall not be moved by Tenant at any time during the Term. If Tenant shall fail to remove any of its effects from the Property within ten (10) days after the termination of this Lease, then Landlord may, at its option, remove the same in any manner that Landlord shall choose and store said effects without liability to Tenant for loss thereof or damage thereto, and Tenant shall pay Landlord, upon demand, any actual, documented and reasonable costs and expenses incurred due to such removal and storage or Landlord may, at its sole option and upon notice to Tenant, sell such property or any portion thereof at private sale and without legal process for such price as Landlord may obtain and apply the proceeds of such sale against any (a) amounts due by Tenant to Landlord under this Lease and (b) any actual and documented expenses incident to the removal, storage and sale of said personal property.

     19.11. Notwithstanding any other provision of this Article 19 to the contrary, in no event shall Tenant remove any improvement from the Property as to which Landlord contributed payment, including, without limitation, the Tenant Improvements made pursuant to the Work Letter without Landlord’s prior written consent, which consent Landlord may withhold in its sole and absolute discretion.

     19.12. Tenant shall pay to Landlord the Construction Management Fee on the Tenant Improvements. In addition, Tenant shall pay to Landlord an amount equal to one and one-half percent (1.5%) of the cost to Tenant of all Alterations (other than Tenant Improvements) installed by Tenant or its contractors or agents to cover Landlord’s overhead and expenses for plan review, coordination, scheduling and supervision thereof but only for those Alterations requiring Landlord’s consent. For purposes of payment of such sum, Tenant shall submit to Landlord copies of all bills, invoices and statements covering the costs of such charges, accompanied by payment to Landlord of the fee set forth in this Section. Tenant shall reimburse Landlord for any extra expenses incurred by Landlord by reason of faulty work done by Tenant or its contractors.

     19.13. Upon Landlord’s written request, within sixty (60) days after final completion of any Alterations performed by Tenant with respect to the Property, Tenant shall submit to Landlord documentation showing the amounts expended by Tenant with respect to such Alterations, together with supporting documentation reasonably acceptable to Landlord.

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     19.14. Tenant shall require its contractors and subcontractors performing work on the Property to name Landlord and its affiliates and lenders as additional insureds on their respective insurance policies.

20. Repairs and Maintenance .

     20.1. Subject to Landlord’s obligations hereunder, Tenant, at its sole cost and expense, shall maintain and keep the Property (other than the Diversified Space), all improvements thereon, and all appurtenances thereto, including but not limited to sidewalks, parking areas, curbs, roads, driveways, lighting standards, landscaping, sewers, water, gas and electrical distribution systems and facilities, drainage facilities, and all signs, both illuminated and non-illuminated that are now or hereafter on the Property, in good condition and in a manner consistent with the Permitted Use. Tenant shall make all repairs, replacements and improvements, including, without limitation, all HVAC, plumbing and electrical repairs, replacements and improvements required, and shall keep the same free and clear from all rubbish and debris, excluding, however, the foundation, slab, structural portions of the walls and roof (not including the membrane), and structural steel aspects of the Buildings. All repairs made by Tenant shall be at least equal in quality to the original work, and shall be made only by a licensed, bonded contractor approved in advance by Landlord (which shall not be unreasonably withheld, conditioned or delayed); provided , however , that such contractor need not be bonded or approved by Landlord if the non-structural alterations, repairs, additions or improvements to be performed do not exceed Fifty Thousand Dollars ($50,000) per occurrence or an aggregate amount of One Hundred Thousand Dollars ($100,000) in any twelve (12) month period. Tenant shall not take or omit to take any action, the taking or omission of which shall cause waste, damage or injury to the Property. Tenant shall indemnify, defend (by legal counsel acceptable to Landlord) and hold harmless Landlord from and against any and all Claims (as defined below) arising out of the failure of Tenant or Tenant’s Agents to perform the covenants contained in this Section. “ Tenant’s Agents ” shall be defined to include Tenant’s officers, employees, agents, contractors, invitees, customers and subcontractors. For the avoidance of doubt, as used in this Article 20 and in Section 11.1 , the Diversified Space shall exclude all building systems within the Diversified Space and any demising, exterior or load bearing walls (other than the interior surface of such walls within the Diversified Space).

     20.2. Tenant shall maintain the lines designating the parking spaces in good condition and paint the same as often as may be necessary, so that they are easily discernable at all times; resurface the parking areas as necessary to maintain them in good condition; paint any exterior portions of the Buildings as necessary to maintain them in good condition; maintain the roof and landscaping in good condition; maintain sightly screens, barricades or enclosures around any waste or storage areas; and take all reasonable precautions to insure that the drainage facilities of the roof are not clogged and are in good and operable condition at all times

     20.3. There shall be no abatement of Rent and no liability of Landlord by reason of any injury to or interference with Tenant’s business arising from the Tenant’s making of any repairs, alterations or improvements in or to any portion of the Property, or in or to improvements, fixtures, equipment and personal property therein (unless the necessity for any of the same is due to Landlord’s gross negligence or willful misconduct).

     20.4. During the Term, Landlord shall, at Landlord’s sole cost and expense, be responsible for any and all repairs and replacements to the foundation, slab, structural portions of the walls and roof (not including the membrane), and structural steel aspects of the Buildings only. Notwithstanding the foregoing, Tenant shall be responsible for, and shall pay, all costs and expenses of such repair and replacement if such repair or replacement results from anything done by Tenant or Tenant’s Agents or any breach by Tenant under this Lease. For purposes of clarity, except as provided in the preceding sentence, Landlord shall not be responsible for any repairs or replacements to the roof, the exterior walls or any other portions of the Property. Except for the foregoing and except as otherwise provided in this Lease, Landlord shall not be required to maintain or make any repairs or replacements of any nature or description whatsoever to the Property unless the necessity for such repairs or replacements is due to Landlord’s gross negligence or willful misconduct. Except as otherwise provided in this Lease, Tenant hereby expressly waives the right to make repairs at the expense of Landlord as provided for in any Applicable Laws in effect at the time of execution of this Lease, or in any other Applicable Laws that may hereafter be enacted, and waives its rights under Applicable Laws relating to a landlord’s duty to maintain its premises in a tenantable condition. Notwithstanding the

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foregoing, if Tenant shall fail, where such failure shall continue for a period of ten (10) days after written notice thereof from Landlord to Tenant, to maintain or to commence and thereafter to proceed with diligence to make any repair required of it pursuant to the terms of this Lease, Landlord, without being under any obligation to do so and without thereby waiving such default by Tenant, may so maintain or make such repair and may charge Tenant for the actual and documented costs thereof. Any expense reasonably incurred by Landlord in connection with the making of such repairs may be billed by Landlord to Tenant monthly or, at Landlord’s option, immediately, and shall be due and payable within thirty (30) days after such billing.

     20.5. Landlord and Landlord’s agents shall have the right to enter upon the Property or any portion thereof in accordance with the terms and conditions of Section 34.2 , for the purposes of performing any repairs or maintenance Landlord is permitted or required to make pursuant to this Lease, and of ascertaining the condition of the Property or whether Tenant is observing and performing Tenant’s obligations hereunder, all without unreasonable interference from Tenant or Tenant’s Agents.

     20.6. Tenant shall, upon the expiration or sooner termination of the Term, surrender the Property (other than the Diversified Space) to Landlord in as good of a condition as when received, ordinary wear and tear and damage by casualty excepted. Landlord shall have no obligation to alter, remodel, improve, repair, decorate or paint the Property (other than the Diversified Space) or any part thereof, other than pursuant to the terms and provisions of this Lease.

     20.7. Tenant shall, at its sole cost and expense, perform the maintenance and repair obligations of the Parcel 3 Owner (as defined in the REA) pursuant to, and in accordance with, Section 4.1 of the REA.

     20.8. Landlord shall not be liable for any failure to make any repairs or to perform any maintenance that is an obligation of Landlord unless such failure shall persist for an unreasonable time after Tenant provides Landlord with written notice of the need of such repairs or maintenance. Notwithstanding any provision in this Lease to the contrary, if Tenant provides notice to Landlord of an event or circumstance which requires the action of Landlord with respect to the provision of repairs as set forth in Section 20.4 of this Lease, and Landlord fails to provide such action as required by the terms of this Lease within thirty (30) days after the date of such notice from Tenant (or if such repair is reasonably expected to require longer than thirty (30) days to complete, if Landlord shall fail to commence in a meaningful way such repair within said thirty (30) day period and diligently prosecutes such repair to completion), then Tenant may provide Landlord with a second written notice stating in bold and all caps 12 point font that “Landlord’s failure to commence repair of the damage described below within ten (10) business days after Landlord’s receipt of this second notice shall entitle Tenant to repair such damage.” If Landlord does not commence in a meaningful way such repair within such ten (10) business day period, then Tenant shall have the right to take such action, and if such action was required under the terms of this Lease to be taken by Landlord, then Tenant shall be entitled to reimbursement by Landlord of Tenant’s reasonable actual and documented costs and expenses in taking such action. Notwithstanding the foregoing, in case of an emergency (where there is an imminent threat of injury to persons or damage to property), Tenant shall only be required to provide Landlord five (5) business days notice of the need to make such repairs stating in bold and all caps 12 point font that “EMERGENCY: Landlord’s failure to commence its repairs of such damage within five (5) business days after Landlord’s receipt of this notice shall entitle Tenant to repair such damage,” and if Landlord does not commence in a meaningful way such repair within such five (5) business day period, then Tenant shall have the right to take such action. In the event Tenant takes such action, and such work will affect the building systems and equipment, structural integrity of the Buildings or exterior appearance of the Buildings, Tenant shall use only those contractors used by Landlord in connection with the Landlord’s Construction Work for such work unless such contractors are unwilling or unable to perform such work or their pricing is unreasonable, in which event Tenant may utilize the services of any other qualified contractor which normally and regularly performs similar work in comparable first-class, institutional quality, office buildings in the San Diego, California area whose pricing is reasonable. If Tenant is entitled to reimbursement by Landlord of Tenant’s reasonable actual and documented costs and expenses in taking any action pursuant to this Section 20.8 , Tenant shall so notify Landlord in writing (the “ Reimbursement Notice ”), which Reimbursement Notice shall specify in detail such costs and expenses. Within thirty (30) days after Landlord’s receipt of a Reimbursement Notice, Landlord shall pay to Tenant any undisputed portion of such costs and

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expenses and shall notify Tenant in writing of those costs and expenses specified by Tenant in the Reimbursement Notice which Landlord disputes (the “ Disputed Amounts ”) and the reasons for such dispute. Any amounts which are not so identified by Landlord as Disputed Amounts within said thirty (30) day period shall be considered to be undisputed. To the extent Landlord fails to reimburse Tenant for the actual and documented costs and expenses specified in the Reimbursement Notice within thirty (30) days after demand therefor, Tenant shall be entitled to offset the sum of the amount of any undisputed portion of such costs and expenses against Basic Annual Rent payable by Tenant under this Lease together with interest at the interest rate of eight percent (8%) per annum from the date of expiration of said thirty (30) day period until the earlier of (a) the date that Landlord reimburses Tenant such amount and (b) the date of offset (up to a maximum offset each month of fifteen percent (15%) of the Basic Annual Rent payable for the Premises) until the full pre-judgment offset amount (plus such interest) has been so offset. If Tenant obtains a final judgment against Landlord for the Disputed Amount and if Landlord fails to pay such judgment within thirty (30) days after the date such judgment is rendered, Tenant shall be entitled to offset such judgment against Basic Annual Rent payable by Tenant under this Lease together with interest at the interest rate of eight percent (8%) per annum from the date Landlord failed to timely reimburse Tenant for such costs and expenses until the earlier of (x) the date that Landlord has reimburses Tenant such amount and (y) the date of offset (up to a maximum offset each month of fifteen percent (15%) of the Basic Annual Rent payable for the Premises) until the full amount of such judgment (plus such interest) has been so offset. If Landlord obtains a final judgment against Tenant for the Disputed Amount, Tenant shall pay to Landlord such judgment within thirty (30) days after the date such judgment is rendered.

     20.9. This Article 20 relates to repairs and maintenance arising in the ordinary course of operation of the Property (other than the Diversified Space) and any related facilities. In the event of fire, earthquake, flood, vandalism, war, terrorism, natural disaster or similar cause of damage or destruction, Article 24 shall apply in lieu of this Article 20 .

     20.10. Notwithstanding anything above to the contrary, if during the Term, any portion of the Property which is Tenant’s responsibility hereunder to repair cannot be repaired other than at a cost which is in excess of fifty percent (50%) of the cost of replacing such item(s), then such item(s) shall be replaced by Tenant (subject to Landlord’s prior approval of the plans and specifications and the cost of any such replacement), and Landlord shall reimburse Tenant a prorata share of the cost thereof based upon a fraction, the numerator of which is the number of months of the useful life of such replacement item beyond the expiration of the Term (including any Extended Term, if applicable), and the denominator of which is the total number of months of the useful life of such replacement (as such useful life is specified pursuant to Federal income tax regulations or guidelines for depreciation thereof); provided , however , for purposes of calculating the useful life of such replacement, the useful life of such replacement shall not exceed seven (7) years from the date that such replacement is made.

21. Liens .

     21.1. Subject to the immediately succeeding sentence, Tenant shall keep the Property free from any liens arising out of work performed, materials furnished or obligations incurred by Tenant. Tenant further covenants and agrees that any mechanic’s lien filed against the Property for work claimed to have been done for, or materials claimed to have been furnished to, shall be discharged or bonded by Tenant within ten (10) days after the filing thereof, at Tenant’s sole cost and expense.

     21.2. Should Tenant fail to discharge or bond against any lien of the nature described in Section 21.1 , Landlord may, at Landlord’s election, pay such claim or post a bond or otherwise provide security to eliminate the lien as a claim against title, and Tenant shall immediately reimburse Landlord for the actual, documented and reasonable costs thereof as Additional Rent.

     21.3. In the event that Tenant leases or finances the acquisition of office equipment, furnishings or other personal property of a removable nature utilized by Tenant in the operation of Tenant’s business (which Tenant shall have the right to do), Tenant warrants that any Uniform Commercial Code financing statement executed by Tenant shall, upon its face or by Exhibit thereto, indicate that such financing statement is applicable only to removable personal property of Tenant located within the Premises. In no event shall the address of the Property be furnished on a financing statement without qualifying language as to applicability of the lien only to removable personal property located in an identified suite leased by Tenant. Should any

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holder of a financing statement executed by Tenant record or place of record a financing statement that appears to constitute a lien against any interest of Landlord, Tenant shall, within ten (10) days after filing such financing statement, cause (a) a copy of the lender security agreement or other documents to which the financing statement pertains to be furnished to Landlord to facilitate Landlord’s ability to demonstrate that the lien of such financing statement is not applicable to Landlord’s interest and (b) Tenant’s lender to amend such financing statement and any other documents of record to clarify that any liens imposed thereby are not applicable to any interest of Landlord in the Property.

22. Indemnification and Exculpation .

     22.1. Subject to Section 22.6 below, Tenant agrees to indemnify, defend and save Landlord harmless from and against any and all demands, claims, liabilities, losses, costs, expenses, actions, causes of action, damages or judgments, and all reasonable expenses (including, without limitation, reasonable attorneys’ fees, charges and disbursements) incurred in investigating or resisting the same (collectively, “ Claims ”) arising from injury to or death of any person or damage to any property occurring within or about the Property arising directly or indirectly out of Tenant’s or Tenant’s employees’, agents’ or guests’ use or occupancy of the Property or a breach or default by Tenant in the performance of any of its obligations hereunder, unless caused solely by Landlord’s willful misconduct or gross negligence.

     22.2. Landlord agrees to indemnify, defend and save Tenant harmless from and against any and all Claims arising from injury to or death of any person or damage to any property occurring within or about the Diversified Space that arise directly out of Landlord’s obligations under the Diversified Lease after the Effective Date, unless (a) caused by Tenant’s acts or omissions, or (b) arising from Tenant’s performance, or Tenant’s failure to perform, any of Tenant’s obligations under this Lease.

     22.3. Notwithstanding any provision of Section 22.1 to the contrary, but subject to Section 22.5 below, Landlord shall not be liable to Tenant for, and Tenant assumes all risk of, damage to personal property or scientific research, including, without limitation, loss of records kept by Tenant within the Property and damage or losses caused by fire, electrical malfunction, gas explosion or water damage of any type (including, without limitation, broken water lines, malfunctioning fire sprinkler systems, roof leaks or stoppages of lines), unless any such loss is due to Landlord’s gross negligence, willful misconduct and/or willful disregard of written notice by Tenant of need for a repair that Landlord is responsible to make for an unreasonable period of time. Tenant further waives any claim for injury to Tenant’s business or loss of income relating to any such damage or destruction of personal property as described in this Section 22.2 .

     22.4. Landlord shall not be liable for any damages arising from any act, omission or neglect of any third party other than the gross negligence or willful misconduct of any of Landlord’s officers, employees, agents, general partners, members, and Lenders (“ Landlord Parties ”).

     22.5. Tenant acknowledges that security devices and services, if any, while intended to deter crime, may not in given instances prevent theft or other criminal acts. Landlord shall not be liable for injuries or losses caused by criminal acts of third parties, and Tenant assumes the risk that any security device or service may malfunction or otherwise be circumvented by a criminal. If Tenant desires protection against such criminal acts, then Tenant shall, at Tenant’s sole cost and expense, obtain appropriate insurance coverage. Notwithstanding any contrary provision of this Lease, neither Landlord nor Tenant shall be liable to the other party for any consequential damages, loss of business or profit for a breach or default under this Lease; provided that this sentence shall not limit Landlord’s damages if, as a result of Tenant’s breach of this Lease: (a) Landlord does not or is unable to lease the Premises to another party, or (b) a third party is unable to occupy the Premises on the date specified in such third party’s lease.

     22.6. Tenant shall not be required to indemnify and hold Landlord harmless from any Claim to any person, property or entity resulting from the grossly negligent acts or omissions or willful misconduct of the Landlord Parties in connection with the Landlord Parties’ activities in, on or about the Property, and Landlord hereby agrees to so indemnify and holds Tenant harmless from any such Claims.

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     22.7. The provisions of this Article 22 shall survive the expiration or earlier termination of this Lease.

23. Insurance; Waiver of Subrogation .

     23.1. Landlord shall maintain insurance for the Property (including the Diversified Space) in amounts equal to full replacement cost (exclusive of the costs of excavation, foundations and footings, and without reference to depreciation taken by Landlord upon its books or tax returns) or such lesser coverage as Landlord may elect, provided that such coverage shall not be less than ninety percent (90%) of such full replacement cost or the amount of such insurance Landlord’s lender, mortgagee or beneficiary (each, a “ Lender ”), if any, requires Landlord to maintain, providing protection against any peril generally included within the classification “Fire and Extended Coverage,” together with insurance against sprinkler damage (if applicable), vandalism and malicious mischief. Landlord, subject to availability thereof, shall further insure, if Landlord deems it appropriate, coverage against flood, environmental hazard, earthquake, loss or failure of building equipment, rental loss during the period of repairs or rebuilding, workmen’s compensation insurance and fidelity bonds for employees employed to perform services. Notwithstanding the foregoing, Landlord may, but shall not be deemed required to, provide insurance for any improvements installed by Tenant or that are in addition to the standard improvements customarily furnished by Landlord, without regard to whether or not such are made a part of or are affixed to the Buildings. Any costs incurred by Landlord pursuant to this Section 23.1 shall constitute a portion of Insurance Costs.

     23.2. In addition, Landlord shall carry public liability insurance with a single limit of not less than Ten Million Dollars ($10,000,000) for death or bodily injury, or property damage with respect to the Property (including the Diversified Space). Any costs incurred by Landlord pursuant to this Section 23.2 shall constitute a portion of Insurance Costs.

     23.3. Tenant shall, at its own cost and expense, procure and maintain in effect, beginning on the Commencement Date or the date of occupancy, whichever occurs first, and continuing throughout the Term (and occupancy by Tenant, if any, after termination of this Lease) comprehensive public liability insurance with limits of not less than Five Million Dollars ($5,000,000) per occurrence for death or bodily injury and not less than Two Million Dollars ($2,000,000) for property damage with respect to the Property (including the Diversified Space).

     23.4. Tenant shall, at its sole cost and expense, procure and maintain in effect, beginning on the Commencement Date or the date of occupancy, whichever occurs first, and continuing throughout the Term all insurance required to be maintained by the Parcel 3 Owner (as defined in the REA) in connection with the Parcel 3 Land (as defined in the REA) pursuant to Section 6 of the REA.

     23.5. The insurance required to be purchased and maintained by Tenant pursuant to this Lease shall show, as an additional insured in respect of the Property, Landlord, BioMed Realty, L.P., BioMed Realty Trust, Inc., Tenant, any management company retained by Landlord to manage the Property, any ground lessor and any mortgagee of Landlord required to be named pursuant to its mortgage documents. All public liability and property damage policies shall contain a provision that Landlord, although named as an insured, nevertheless shall be entitled to recovery under said policies for any loss occasioned to it, its servants, agents and employees by reason of the negligence of Tenant. Said insurance shall be with companies having a rating of not less than policyholder rating of A and financial category rating of at least Class XII in “Best’s Insurance Guide.” Tenant shall obtain for Landlord from the insurance companies or cause the insurance companies to furnish certificates of coverage to Landlord. No such policy shall be cancelable or subject to reduction of coverage or other modification or cancellation except after thirty (30) days’ prior written notice to Landlord from the insurer. All such policies shall be written as primary policies, not contributing with and not in excess of the coverage that Landlord may carry. Tenant’s policy may be a “blanket policy” that specifically provides that the amount of insurance shall not be prejudiced by other losses covered by the policy. Tenant shall, at least twenty (20) days prior to the expiration of such policies, furnish Landlord with renewals or binders. Tenant agrees that if Tenant does not take out and maintain such insurance, Landlord may (but shall not be required to) procure said insurance on Tenant’s behalf and at its cost to be paid by Tenant as Additional Rent.

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     23.6. Tenant assumes the risk of damage to any fixtures, goods, inventory, merchandise, equipment and leasehold improvements, and Landlord shall not be liable for injury to Tenant’s business or any loss of income therefrom, relative to such damage, all as more particularly set forth within this Lease unless caused by Landlord’s gross negligence or willful misconduct. Tenant shall, at Tenant’s sole cost and expense, carry such insurance as Tenant desires for Tenant’s protection with respect to personal property of Tenant or business interruption.

     23.7. In each instance where Tenant’s insurance is to name additional insureds, Tenant shall, upon Landlord’s written request, also designate and furnish certificates evidencing the same to (a) any Lender of Landlord holding a security interest in the Property or any portion thereof, (b) the landlord under any lease whereunder Landlord is a tenant of the real property upon which the Buildings are located if the interest of Landlord is or shall become that of a tenant under a ground lease rather than that of a fee owner, and (c) any management company retained by Landlord to manage the Property.

     23.8. Landlord and Tenant each hereby waive any and all rights of recovery against the other or against the officers, directors, employees, agents and representatives of the other on account of loss or damage occasioned by such waiving party or its property or the property of others under such waiving party’s control, in each case to the extent that such loss or damage is insured against under any fire and extended coverage insurance policy that either Landlord or Tenant may have in force at the time of such loss or damage. Such waivers shall continue so long as their respective insurers so permit. Any termination of such a waiver shall be by written notice to the other party, containing a description of the circumstances hereinafter set forth in this Section 23.8 . Landlord and Tenant, upon obtaining the policies of insurance required or permitted under this Lease, shall give notice to the insurance carrier or carriers that the foregoing mutual waiver of subrogation is contained in this Lease. If such policies shall not be obtainable with such waiver or shall be so obtainable only at a premium over that chargeable without such waiver, then the party seeking such policy shall notify the other of such conditions, and the party so notified shall have ten (10) days thereafter to either (a) procure such insurance with companies reasonably satisfactory to the other party or (b) agree to pay such additional premium. If the parties do not accomplish either (a) or (b), then this Section 23.8 shall have no effect during such time as such policies shall not be obtainable or the party in whose favor a waiver of subrogation is desired refuses to pay the additional premium. If such policies shall at any time be unobtainable, but shall be subsequently obtainable, then neither party shall be subsequently liable for a failure to obtain such insurance until a reasonable time after notification thereof by the other party. If the release of either Landlord or Tenant, as set forth in the first sentence of this Section 23.8 , shall contravene Applicable Laws, then the liability of the party in question shall be deemed not released but shall be secondary to the other party’s insurer.

24. Damage or Destruction .

     24.1. Subject to Section 24.2 , In the event of a partial or complete destruction of the Premises or a Building by fire or other perils, Landlord shall commence and proceed diligently with the work of repair, reconstruction and restoration of the Premises and such Building, as applicable, and this Lease shall continue in full force and effect.

     24.2. Notwithstanding the terms of this Article 24 , Landlord may elect not to rebuild and/or restore the Premises and the Buildings and instead terminate this Lease by notifying Tenant in writing of such termination within sixty (60) days after the date of damage, such notice to include a termination date giving Tenant ninety (90) days to vacate the Premises, but Landlord may so elect only if the Premises or any Building shall be damaged by fire or other casualty or cause or be subject to a condition existing as a result of such a fire or other casualty or cause, and one or more of the following conditions is present: (i) in the reasonable judgment of a contractor selected by Landlord and reasonably approved by Tenant, repairs cannot reasonably be completed within one hundred eighty (180) days of the date of damage (when such repairs are made without the payment of overtime or other premiums); (ii) the holder of any mortgage on the Premises or the Buildings, or ground or underlying lessor with respect to the Premises or the Buildings (a) shall require that the insurance proceeds or any portion thereof be used to retire the mortgage debt due to an impairment of such holder’s collateral, and the remaining proceeds are insufficient to repair the damage and as a result thereof the deficiency of insurance proceeds exceeds the “Maximum Amount,” as that term is defined below, and Landlord elects not to commence repair to the Premises or the Buildings within one (1) year of such damage or

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destruction, or (b) shall terminate the ground or underlying lease, as the case may be; (iii) the dollar amount of the damage or condition arising as a result of such damage which is not fully covered by Landlord’s insurance policies (and that would not be fully covered by Landlord’s insurance policies if Landlord had carried the coverage required under this Lease) including any deductible amount, is equal to or greater than Two Hundred and Fifty Thousand Dollars ($250,000) (the “ Maximum Amount ”), which Maximum Amount shall, as of the date of termination of this Lease, be equal to the product of (a) the Maximum Amount and (b) a fraction, the numerator of which is the number of full months remaining in the Term, or when appropriate the Extended Term then applicable, as of the date of the termination of this Lease, and the denominator of which is 180 (or, if applicable, 60 during an Extended Term) and Landlord elects not to commence repair to the Premises or the Buildings within one (1) year of such damage or destruction; or (iv) the damage occurs during the last twenty-four (24) months of the Term, as such Term may have been extended by Tenant pursuant to this Lease; provided , however , that if Landlord does not elect to terminate this Lease pursuant to Landlord’s termination right as provided above, and the repairs of such damage cannot, in the reasonable opinion of a contractor selected by Landlord and reasonably approved by Tenant, be completed within twelve (12) months after being commenced, Tenant may elect, not later than ten (10) business days after the date of such damage, to terminate this Lease by written notice to Landlord effective as of the date specified in the notice. At any time, from time to time, after the date occurring thirty (30) days after the date of the damage, but in no event more than once every forty-five (45) days, Tenant may request that Landlord provide Tenant with a certificate from the architect or contractor described above setting forth such architect’s or contractors’ reasonable opinion of the date of completion of the repairs and Landlord shall respond to such request within fifteen (15) business days.

     24.3. Landlord shall give written notice to Tenant of its election not to repair, reconstruct or restore the Premises or the Buildings within sixty (60) days following the date of damage or destruction.

     24.4. Upon any termination of this Lease under any of the provisions of this Article 24 , the parties shall be released thereby without further obligation to the other from the date possession of the Premises is surrendered to Landlord, except with regard to (a) items occurring prior to the damage or destruction and (b) provisions of this Lease that, by their express terms, survive the expiration or earlier termination hereof.

     24.5. In the event of repair, reconstruction and restoration as provided in this Article 24 , all Rent to be paid by Tenant under this Lease shall be abated proportionately based on the extent to which Tenant’s use of the Premises is impaired during the period of such repair, reconstruction or restoration, unless Landlord provides Tenant with other space during the period of repair that, in Tenant’s reasonable discretion, is suitable for the temporary conduct of Tenant’s business; provided , however , that the amount of such abatement shall be reduced by the proceeds of lost rental income insurance actually received by Tenant with respect to the Premises.

     24.6. Notwithstanding anything to the contrary contained in this Article 24 , should Landlord be delayed or prevented from completing the repair, reconstruction or restoration of the damage or destruction to the Premises or the Buildings after the occurrence of such damage or destruction by Force Majeure, then the time for Landlord to commence or complete repairs shall be extended on a day-for-day basis.

     24.7. If Landlord is obligated to or elects to repair, reconstruct or restore as herein provided, then Landlord shall be obligated to make such repair, reconstruction or restoration only with regard to those portions of the Premises and the Buildings that were originally provided at Landlord’s expense. The repair, reconstruction or restoration of improvements not originally provided by Landlord or at Landlord’s expense shall be the obligation of Tenant. In the event Tenant has elected to upgrade certain improvements, Landlord shall, upon the need for replacement due to an insured loss, construct the improvements to the standard that existed prior to such damage, unless Tenant again elects to upgrade such improvements and pay any incremental costs related thereto, except to the extent that excess insurance proceeds, if received, are adequate to provide such upgrades, in addition to providing for basic repair, reconstruction and restoration of the Premises and the Buildings.

     24.8. In addition to its termination right in Section 24.2 above, Tenant shall have the right to terminate this Lease if any damage to the Buildings or the Premises: (a) occurs during

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the last twelve (12) months of the Term of this Lease (including the last twelve (12) months of any Extended Term, if applicable); (b) Tenant is unable to occupy more than twenty-five percent (25%) of the Premises; and (c) in the reasonable judgment of a contractor selected by Landlord and reasonably approved by Tenant, such repairs cannot reasonably be completed within twenty-five percent (25%) of the remaining term of this Lease (including any Extended Term, if applicable).

25. Eminent Domain .

     25.1. Total Taking — Termination . In the event the whole of the Premises, or such part thereof so that reconstruction of the Premises will not result in the Premises being reasonably suitable (as reasonably determined by Landlord and Tenant) for Tenant’s continued occupancy for the uses and purposes permitted by this Lease, shall be taken for any public or quasi-public purpose by any lawful power or authority by exercise of the right of appropriation, condemnation or eminent domain, or sold to prevent such taking, Tenant or Landlord may terminate this Lease effective as of the date possession is required to be surrendered to said authority.

     25.2. Partial Taking . In the event of a partial taking of the Premises, or of drives, walkways or parking areas serving the Premises for any public or quasi-public purpose by any lawful power or authority by exercise of right of appropriation, condemnation, or eminent domain, or sold to prevent such taking, then, without regard to whether any portion of the Premises occupied by Tenant was so taken, Landlord may elect to terminate this Lease as of such taking if such taking is, in Landlord’s sole opinion, of a material nature such as to make it uneconomical to continue use of the unappropriated portion for purposes of renting office or laboratory space.

     25.3. Tenant shall be entitled to any award that is specifically awarded as compensation for (a) the taking of Tenant’s personal property that was installed at Tenant’s expense and (b) the costs of Tenant moving to a new location. Except as set forth in this Article 25 , any award for such taking shall be the property of Landlord.

     25.4. If, upon any taking of the nature described in Sections 25.1 and 25.2 , this Lease continues in effect, then (a) Landlord shall promptly proceed to restore the Premises to substantially their same condition prior to such partial taking and this Lease shall, as to the part so taken terminate as of the date that possession of such part of the Premises is taken and the Basic Annual Rent shall be reduced in the same proportion that the floor area of the portion of the Buildings so taken (less any addition thereto by reason of any reconstruction) bears to the original floor area of the Buildings, and (b) in the event of a partial taking of the Diversified Space, (i) Tenant agrees to sublease to Diversified, at no cost to Diversified, up to 6,600 rentable square feet in the Expansion Premises or in the Existing Parcel 1 and Parcel 2 Buildings in accordance with Diversified’s rights under Article 20 of the Diversified Lease, (ii) Tenant shall be entitled to (1) an abatement of fifty percent (50%) of the Expansion Premises Basic Annual Rent for the portion of the Expansion Premises (if any) occupied by Diversified, and (2) an abatement of fifty percent (50%) of the Basic Annual Rent under the Illumina Lease for the portion of the Premises (as defined in the Illumina Lease) (if any) occupied by Diversified, (iii) Landlord shall pay all costs associated with the relocation of Diversified, including, but not limited to, costs of tenant improvements and moving costs, and (iv) Tenant shall not be entitled to an abatement of any of the operating expenses, including Taxes, Insurance Costs, Utility Costs and all other insurance and utility costs and expenses in connection with the portion of the Expansion Premises or the Premises (as defined in the Illumina Lease) occupied by Diversified

26. Defaults and Remedies .

     26.1. Late payment by Tenant to Landlord of Rent and other sums due shall cause Landlord to incur costs not contemplated by this Lease, the exact amount of which shall be extremely difficult and impracticable to ascertain. Such costs include, but are not limited to, processing and accounting charges and late charges that may be imposed on Landlord by the terms of any mortgage or trust deed covering the Property. Therefore, if any installment of Rent due from Tenant is not received by Landlord within five (5) days after written notice that such payment is due, Tenant shall pay to Landlord an additional sum of three percent (3%) of the overdue Rent as a late charge. The parties agree that this late charge represents a fair and reasonable estimate of the costs that Landlord shall incur by reason of late payment by Tenant. Notwithstanding the foregoing, Landlord shall waive the imposition of such late charge for the

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first late payment of Rent due hereunder in any calendar year of the Term. In addition to the late charge, Rent not paid when due shall bear inte


 
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