FIRST AMENDMENT TO LEASE

Lease Agreement

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AMICUS THERAPEUTICS, INC | CEDAR BROOK 5 CORPORATE CENTER, LP | Cedar Brook 5, Inc

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Title: FIRST AMENDMENT TO LEASE
Date: 8/6/2009
Industry: Biotechnology and Drugs Sector: Healthcare

Exhibit 10.1

FIRST AMENDMENT TO LEASE

FIRST AMENDMENT TO LEASE dated June 11, 2009, by and between CEDAR BROOK 5 CORPORATE CENTER, L.P., having an address at 1000 Eastpark Boulevard, Cranbury, New Jersey 08512 (hereinafter called the “Landlord”); and AMICUS THERAPEUTICS, INC. having an address at 5 Cedar Brook Drive, Cranbury, New Jersey 08512 (hereinafter called the “Tenant”).

WITNESSETH:

WHEREAS, the parties entered into a Lease Agreement dated July 31, 2006 (“Lease”) for a portion of the building known as 5 Cedar Brook Drive, Cranbury, New Jersey 08512; and

WHEREAS, the parties now desire to amend the Lease;

NOW, THEREFORE, the parties hereto covenant and agree as follows:

The termination date of the Lease shall be extended to February 29, 2012.

The parties mutually represent to each other that Jones Lang LaSalle Brokerage, Inc. is th

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