AMENDMENT #5 TO LEASE

Exhibit 10.22

AMENDMENT #5 TO LEASE

      THIS AMENDMENT #5 TO LEASE (this “Amendment”) is made and entered into as of this 5 day of April, 2006, by and between PRINCIPAL MUTUAL LIFE INSURANCE COMPANY . As landlord (“Landlord”), and AMERICAN HOMEPATIENT, INC. as tenant (“Tenant”).

RECITALS:

     WHEREAS, Landlord and Tenant heretofore entered into that certain Lease (the “Original Lease”) dated October 25, 1995, for the lease of 29, 096 square feet of rentable area on the fourth floor of the Parklane Building (the “Building”) located at 5200 Maryland Way, Brentwood, Tennessee 37027; and

     WHEREAS, Landlord and Tenant amended the Original Lease by Amendment #1 to Lease dated January 2, 1996, thereby adjusting the occupancy date and extending the term of the Original Lease, and

     WHEREAS, Landlord and Tenant further amended the Original Lease by Amendment #2 to Lease dated October 29, 1996, thereby increasing the Leased Premises by 2,166 rentable square feet; and

     WHEREAS, Landlord and Tenant further amended the Original Lease by Amendment #3 to Lease dated June 25, 1997, thereby further increasing the Leased Premises by 14, 377 rentable square feet and extending the term of the Original Lease; and

     WHEREAS, Landlord and Tenant further amended the Original Lease by Amendment #4 to Lease dated November 15, 2002, thereby extending the term, restate the fixed minimum rent, and reduced the Leased Premises by 16,543 rentable square feet to 29,096 rentable square feet, effective January 1, 2003; and

     NOW, THEREFORE, in consideration of the mutual covenants and obligations of the parties as set forth herein, and other good and valuable considerations, the receipt and sufficiency of which is hereby acknowledged, the parties hereto agree as follows:

I. AMENDMENTS TO THE EXISTING LEASE

     1.1. Effective Date. The effective date of this Amendment shall be as of 12:01 a.m. on February 1, 2006 (the “Effective Date”).

     1.2 Definitions . For purposes of this Amendment, the term “Existing Lease” means the Original Lease, as heretofore amended by Amendment #1 to Lease dated January 2, 1996, by Amendment #2 to Lease dated October 29, 1996, and by Amendment #3 to Lease dated June 25, 1997, by Amendment #4 to Lease dated November 15, 2002; and the term “Lease” means the Existing Lease as further amended by this Amendment #5 to Lease. All other capitalized terms used herein and not otherwise defined herein shall have the meanings assigned to such terms in the Existing Lease.

     1.3 Extension of Term . The term of the Lease is extended to July 31, 2010, unless sooner terminated as provided in the Lease.

     1.4 Rent . Effective on the Effective Date, fixed minimum rent for the Leased Premises shall be as follows: