SECOND ADDENDUM TO LEASE DATED December 1 st , 2003 BETWEEN UNION SQUARE, L.P. (LANDLORD), AND PROTALEX, INC., (TENANT), FOR 145 UNION SQUARE DRIVE, NEW HOPE, PA 18938

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Title: SECOND ADDENDUM TO LEASE DATED December 1 st , 2003 BETWEEN UNION SQUARE, L.P. (LANDLORD), AND PROTALEX, INC., (TENANT), FOR 145 UNION SQUARE DRIVE, NEW HOPE, PA 18938
Date: 5/3/2007

EXHIBIT 99.1

SECOND ADDENDUM TO LEASE DATED December 1 ^st , 2003 BETWEEN UNION SQUARE, L.P. (LANDLORD),

AND PROTALEX, INC., (TENANT), FOR 145 UNION SQUARE DRIVE, NEW HOPE, PA 18938.

It is agreed between Landlord and Tenant (the “Parties”) that the lease term will extend for the period of one (1) year beyond the existing lease term, commencing on 2-1-08 at 12:01 AM and expiring on 1-31-09 at 11:59 PM.

It is agreed between the Parties that the lease will also have one (1) additional option for a one (1) year extension commencing on 2-1-09 at 12:01 AM and expiring on 1-31-10 at 11:59 PM, if exercised.

It is agreed between the Parties that the rent will increas

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