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INVESTOR AGREEMENT

Investors Rights Agreement

INVESTOR AGREEMENT | Document Parties: REGENERON PHARMACEUTICALS INC | SANOFI-AVENTIS US LLC You are currently viewing:
This Investors Rights Agreement involves

REGENERON PHARMACEUTICALS INC | SANOFI-AVENTIS US LLC

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Title: INVESTOR AGREEMENT
Governing Law: New York     Date: 2/27/2008
Industry: Biotechnology and Drugs     Law Firm: Skadden Arps     Sector: Healthcare

INVESTOR AGREEMENT, Parties: regeneron pharmaceuticals inc , sanofi-aventis us llc
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Exhibit 10.21
INVESTOR AGREEMENT
By and Among
SANOFI-AVENTIS,
SANOFI-AVENTIS US LLC,
AVENTIS PHARMACEUTICALS INC.,
SANOFI-AVENTIS AMÉRIQUE DU NORD
AND
REGENERON PHARMACEUTICALS, INC.
Dated as of December 20, 2007

 


 
TABLE OF CONTENTS
         
    Page  
1. DEFINITIONS
    1  
 
       
2. REGISTRATION RIGHTS
    7  
 
       
2.1 Required Registration
    7  
2.2 Underwritten Required Registration Required; Priority in Underwritten Offering
    9  
2.3 Priority in Required Registration
    9  
2.4 Revocation of Required Registration
    10  
2.5 Effective Required Registrations
    10  
2.6 Continuous Effectiveness of Registration Statement
    . 11  
2.7 Obligations of the Company
    11  
2.8 Furnish Information
    14  
2.9 Expenses
    14  
2.10 Indemnification
    14  
2.11 SEC Reports
    16  
2.12 Assignment of Registration Rights
    16  
 
       
3. RESTRICTIONS ON BENEFICIAL OWNERSHIP
    17  
 
       
3.1 Standstill
    17  
3.2 Amendment to Aventis Collaboration Agreement
    18  
 
       
4. RESTRICTIONS ON DISPOSITIONS
    18  
 
       
4.1 Lock-Up
    18  
4.2 Limitations Following Lock-Up Term
    19  
4.3 Certain Tender Offers
    20  
4.4 Offering Lock-Up
    20  
 
       
5. VOTING AGREEMENT
    20  
 
       
5.1 Voting of Securities
    20  
5.2 Certain Extraordinary Matters
    21  
5.3 Quorum
    21  
 
       
6. TERMINATION OF CERTAIN RIGHTS AND OBLIGATIONS
    22  
 
       
6.1 Termination of Registration Rights
    22  
6.2 Termination of Standstill Agreement
    22  
6.3 Termination of Restrictions on Dispositions
    23  
6.4 Termination of Voting Agreement
    23  
6.5 Effect of Termination
    23  
 
       
7. MISCELLANEOUS
    23  
 
       
7.1 Governing Law; Submission to Jurisdiction
    23  
7.2 Waiver
    23  
7.3 Notices
    24  


 
         
    Page  
7.4 Entire Agreement
    24  
7.5 Amendments
    24  
7.6 Headings; Nouns and Pronouns; Section References
    24  
7.7 Severability
    24  
7.8 Assignment
    25  
7.9 Successors and Assigns
    25  
7.10 Counterparts
    25  
7.11 Third Party Beneficiaries
    25  
7.12 No Strict Construction
    25  
7.13 Remedies
    25  
7.14 Specific Performance
    25  
7.15 No Conflicting Agreements
    25  
 
       
Exhibit A – Form of Irrevocable Proxy
Exhibit B – Notices
       

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INVESTOR AGREEMENT
      THIS INVESTOR AGREEMENT (this “ Agreement ”) is made as of December 20, 2007, by and among sanofi-aventis, a company organized under the laws of France, with its principal headquarters at 174, avenue de France, 75013 Paris, France (“ sanofi-aventis ”), sanofi-aventis US LLC, a Delaware limited liability company indirectly wholly owned by sanofi-aventis (“ Sanofi US ”) and the successor-in-interest to Aventis Pharmaceuticals Inc. (“ Aventis ”) with respect to the Aventis Collaboration Agreement, with its headquarters at 55 Corporate Drive, Bridgewater, New Jersey 00807, Aventis, a Delaware corporation and an indirect wholly owned subsidiary of the Investor with its headquarters at 55 Corporate Drive, Bridgewater, New Jersey 00807, sanofi-aventis Amérique du Nord, a société en nom collectif organized under the laws of France wholly owned by sanofi-aventis with its principal headquarters at 174, avenue de France, 75013 Paris, France (the “ Investor ”, and, together with sanofi-aventis, Sanofi US and Aventis, the “ Purchaser Parties ”), and Regeneron Pharmaceuticals, Inc. (the “ Company ”), a New York corporation with its principal place of business at 777 Old Saw Mill River Road, Tarrytown, New York 10591.
     WHEREAS, the Stock Purchase Agreement, dated as of November 28, 2007, by and among the Investor, sanofi-aventis US and the Company (the “ Purchase Agreement ”) provides for the issuance and sale by the Company to the Investor, and the purchase by the Investor, of a number of shares of the Company’s common stock, par value $0.001 per share (the “ Common Stock ”), equal to the Share Amount (as defined in the Purchase Agreement) (the “ Purchased Shares ”); and
     WHEREAS, as a condition to consummating the transactions contemplated by the Purchase Agreement, the Purchaser Parties and the Company have agreed upon certain rights and restrictions as set forth herein with respect to the Purchased Shares and other securities of the Company beneficially owned by the Purchaser Parties and their respective Affiliates, and it is a condition to the closing under the Purchase Agreement that this Agreement be executed and delivered by the Purchaser Parties and the Company.
     NOW, THEREFORE, in consideration of the premises and mutual agreements hereinafter set forth, and for other valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto agree as follows:
      1. Definitions. As used in this Agreement, the following terms shall have the following meanings:
          (a) “ Acquisition Proposal ” shall have the meaning set forth in Section 3.1(c).
          (b) “ Affiliate ” shall mean, with respect to any Person, another Person which controls, is controlled by or is under common control with such Person. A Person shall be deemed to control another Person if such Person possesses, directly or indirectly, the power to direct or cause the direction of the management and policies of such Person, whether through the ownership of voting securities, by contract or otherwise. Without limiting the generality of the foregoing, a Person shall be deemed to control another Person if any of the following conditions is met: (i) in the case of corporate entities, direct or indirect ownership of more than fifty percent

 


 
(50%) of the stock or shares having the right to vote for the election of directors, and (ii) in the case of non-corporate entities, direct or indirect ownership of more than fifty percent (50%) of the equity interest with the power to direct the management and policies of such non-corporate entities. The parties acknowledge that in the case of certain entities organized under the Laws of certain countries outside the United States, the maximum percentage ownership permitted by Law for a foreign investor may be less than fifty percent (50%), and that in such case such lower percentage shall be substituted in the preceding sentence, provided that such foreign investor has the power to direct the management and policies of such entity. For the purposes of this Agreement, in no event shall the Investor or any of its Affiliates be deemed Affiliates of the Company or any of its Affiliates, nor shall the Company or any of its Affiliates be deemed Affiliates of the Investor or any of its Affiliates.
          (c) “ Agreement ” shall have the meaning set forth in the Preamble to this Agreement, including all Exhibits attached hereto.
          (d) “ Aventis ” shall have the meaning set forth in the Preamble to this Agreement.
          (e) “ Aventis Collaboration Agreement ” shall mean the Collaboration Agreement, dated as of September 5, 2003, by and between Sanofi US and the Company, as amended by the First Amendment, dated as of December 31, 2004, the Second Amendment, dated as of January 7, 2005, the Third Amendment, dated as of December 21, 2005, the Fourth Amendment, dated as of January 31, 2006, and Section 11.2 of the Purchase Agreement, as the same may be further amended from time to time.
          (f) “ Aventis Stock Purchase Agreement ” shall mean the Stock Purchase Agreement, dated as of September 5, 2003, by and between Aventis and the Company.
          (g) “ beneficial owner ,” “ beneficially owns ,” “ beneficial ownership ” and terms of similar import used in this Agreement shall, with respect to a Person, have the meaning set forth in Rule 13d-3 under the Exchange Act (i) assuming the full conversion into, and exercise and exchange for, shares of Common Stock of all Common Stock Equivalents beneficially owned by such Person and (ii) determined without regard for the number of days in which such Person has the right to acquire such beneficial ownership.
          (h) “ Business Day ” shall mean a day on which commercial banking institutions in New York, New York are open for business.
          (i) “ Change of Control ” shall mean, with respect to the Company, any of the following events: (i) any Person is or becomes the beneficial owner (except that a Person shall be deemed to have beneficial ownership of all shares that any such Person has the right to acquire, whether such right which may be exercised immediately or only after the passage of time), directly or indirectly, of a majority of the total voting power represented by all Shares of Then Outstanding Common Stock; (ii) the Company consolidates with or merges into another corporation or entity, or any corporation or entity consolidates with or merges into the Company, other than (A) a merger or consolidation which would result in the voting securities of the Company outstanding immediately prior to such merger or consolidation continuing to represent

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(either by remaining outstanding or by being converted into voting securities of the surviving entity or any parent thereof) a majority of the combined voting power of the voting securities of the Company or such surviving entity or any parent thereof outstanding immediately after such merger or consolidation, or (B) a merger or consolidation effected to implement a recapitalization of the Company (or similar transaction) in which no Person becomes the beneficial owner, directly or indirectly, of a majority of the total voting power of all Shares of Then Outstanding Common Stock or (iii) the Company conveys, transfers or leases all or substantially all of its assets to any Person other than a wholly owned Affiliate of the Company.
          (j) “ Class A Stock ” shall mean the Class A Stock, par value $0.001 per share, of the Company.
          (k) “ Closing Date ” shall have the meaning set forth in the Purchase Agreement.
          (l) “ Common Stock ” shall have the meaning set forth in the Preamble to this Agreement.
          (m) “ Common Stock Equivalents ” shall mean any options, warrants or other securities (including Class A Stock) or rights convertible into or exercisable or exchangeable for, whether directly or following conversion into or exercise or exchange for other options, warrants or other securities or rights, shares of Common Stock.
          (n) “ Company ” shall have the meaning set forth in the Preamble to this Agreement.
          (o) “ Demand Request ” shall have the meaning set forth in Section 2.1.
          (p) “ Disposition ” or “ Dispose of ” shall mean any (i) offer, pledge, sale, contract to sell, sale of any option or contract to purchase, purchase of any option or contract to sell, grant of any option, right or warrant for the sale of, or other disposition of or transfer of any shares of Class A Stock or Common Stock, or any Common Stock Equivalents, including, without limitation, any “short sale” or similar arrangement, or (ii) swap or any other agreement or any transaction that transfers, in whole or in part, directly or indirectly, the economic consequence of ownership of shares of Class A Stock or Common Stock, whether any such swap or transaction is to be settled by delivery of securities, in cash or otherwise.
          (q) “ Exchange Act ” shall mean the Securities Exchange Act of 1934, as amended, and the rules and regulations of the SEC promulgated thereunder.
          (r) “ Extraordinary Matter ” shall have the meaning set forth in Section 5.2.
          (s) “ Filing Date ” shall mean (i) with respect to any Registration Statement to be filed on Form S-1 (or any applicable successor form), ninety (90) days after receipt by the Company of a Demand Request for such Registration Statement and (ii) with respect to any Registration Statement to be filed on Form S-3 (or any applicable successor form), forty-five (45) days after receipt by the Company of a Demand Request for such Registration Statement.

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          (t) “ Governmental Authority ” shall mean any court, agency, authority, department, regulatory body or other instrumentality of any government or country or of any national, federal, state, provincial, regional, county, city or other political subdivision of any such government or country or any supranational organization of which any such country is a member.
          (u) “ Holders ” shall mean (but, in each case, only for so long as such Person remains an Affiliate of sanofi-aventis) the Investor, Aventis and any Permitted Transferee thereof, if any, in accordance with Section 2.12.
          (v) “ Initiating Holder ” shall have the meaning set forth in Section 2.2.
          (w) “ Interference ” shall have the meaning set forth in Section 2.5.
          (x) “ Investor ” shall have the meaning set forth in the Preamble to this Agreement.
          (y) “ Law ” or “ Laws ” shall mean all laws, statutes, rules, regulations, orders, judgments, injunctions and/or ordinances of any Governmental Authority.
          (z) “ Lock-Up Term ” shall have the meaning set forth in Section 4.1.
          (aa) “ Modified Clause ” shall have the meaning set forth in Section 7.7. (bb) “ Offeror ” shall have the meaning set forth in Section 3.1(c).
          (cc) “ Other Holders ” shall mean any Person having rights to participate in a registration of the Company’s securities.
          (dd) “ Permitted Transferee ” shall mean a controlled Affiliate of sanofi-aventis that is wholly owned, directly or indirectly, by sanofi-aventis; it being understood that for purposes of this definition “wholly owned” shall mean an Affiliate in which sanofi-aventis owns, directly or indirectly, at least ninety-nine percent (99%) of the outstanding capital stock of such Affiliate.
          (ee) “ Person ” shall mean any individual, partnership, firm, corporation, association, trust, unincorporated organization, government or any department or agency thereof or other entity, as well as any syndicate or group that would be deemed to be a Person under Section 13(d)(3) of the Exchange Act.
          (ff) “ Prospectus ” shall mean the prospectus forming a part of any Registration Statement, as supplemented by any and all prospectus supplements and as amended by any and all amendments (including post-effective amendments) and including all material incorporated by reference or explicitly deemed to be incorporated by reference in such prospectus.
          (gg) “ Purchase Agreement ” shall have the meaning set forth in the Preamble to this Agreement, and shall include all Exhibits attached thereto.

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          (hh) “ Purchased Shares ” shall have the meaning set forth in the Preamble to this Agreement, and shall be adjusted for (i) any stock split, stock dividend, share exchange, merger, consolidation or similar recapitalization and (ii) any Common Stock issued as (or issuable upon the exercise of any warrant, right or other security that is issued as) a dividend or other distribution with respect to, or in exchange or in replacement of, the Purchased Shares.
          (ii) “ Purchaser Parties ” shall have the meaning set forth in the Preamble to this Agreement.
          (jj) “ registers ,” “ registered ,” and “ registration ” refer to a registration effected by preparing and filing a Registration Statement or similar document in compliance with the Securities Act, and the declaration or ordering of effectiveness of such Registration Statement or document by the SEC.
          (kk) “ Registrable Securities ” shall mean (i) the Purchased Shares and any shares of Common Stock owned of record by Aventis as of the date of this Agreement, together with any shares of Common Stock issued in respect thereof as a result of any stock split, stock dividend, share exchange, merger, consolidation or similar recapitalization and (ii) any Common Stock issued as (or issuable upon the exercise of any warrant, right or other security that is issued as) a dividend or other distribution with respect to, or in exchange or in replacement of, the shares of Common Stock described in clause (i) of this definition, excluding in all cases, however, (A) any Registrable Securities if and after they have been transferred to a Permitted Transferee in a transaction in connection with which registration rights granted hereunder are not assigned, (B) any Registrable Securities sold to or through a broker or dealer or underwriter in a public distribution or a public securities transaction or (C) Registrable Securities eligible for resale pursuant to Rule 144(k) under the Securities Act.
          (ll) “ Registration Expenses ” shall mean all expenses incurred by the Company in connection with any Required Registration pursuant to Section 2.1 or the Company’s compliance with Section 2.7 (excluding clauses (m), (n) and (r) thereof), including, without limitation, all registration and filing fees, fees and expenses of compliance with securities or blue sky Laws (including reasonable fees and disbursements of counsel in connection with blue sky qualifications of any Registrable Securities), expenses of printing (i) certificates for any Registrable Securities in a form eligible for deposit with the Depository Trust Company or (ii) Prospectuses if the printing of Prospectuses is requested by Holders, messenger and delivery expenses, fees and disbursements of counsel for the Company and its independent certified public accountants (including the expenses of any management review, cold comfort letters or any special audits required by or incident to such performance and compliance), Securities Act liability insurance (if the Company elects to obtain such insurance), the reasonable fees and expenses of any special experts retained by the Company in connection with such registration, fees and expenses of other Persons retained by the Company and the reasonable fees and expenses of one (1) counsel for the Holders of Registrable Securities in each Required Registration, selected by the Holders of a majority of the Registrable Securities to be included in such Required Registration. In addition, the Company will pay its internal expenses (including, without limitation, all salaries and expenses of its officers and employees performing legal or accounting duties), the expense of any annual audit and the fees and expenses incurred in connection with the listing of the Purchased Shares to be registered on each securities exchange,

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if any, on which equity securities issued by the Company are then listed or the quotation of such securities on any national securities exchange on which equity securities issued by the Company are then quoted.
          (mm) “ Registration Rights Term ” shall have the meaning set forth in Section 2.1.
          (nn) “ Registration Statement ” shall mean any registration statement of the Company under the Securities Act that covers any of the Registrable Securities pursuant to the provisions of this Agreement, including the related Prospectus, all amendments and supplements to such registration statement (including post-effective amendments), and all exhibits and all materials incorporated by reference or explicitly deemed to be incorporated by reference in such Registration Statement.
          (oo) “ Required Period ” with respect to a Required Registration shall mean the earlier of (i) the date on which all Registrable Securities covered by such Required Registration are sold pursuant thereto and (ii) one-hundred twenty (120) days following the first day of effectiveness of the Registration Statement for such Required Registration, in each case subject to extension as set forth herein; provided , however , that in no event will the Required Period expire prior to the expiration of the applicable period referred to in Section 4(3) of the Securities Act and Rule 174 promulgated thereunder.
          (pp) “ Required Registration ” shall have the meaning set forth in Section 2.1.
          (qq) “ Sanofi License and Collaboration Agreement ” shall mean that certain License and Collaboration Agreement between the Company, the Investor and Aventis dated as of November 28, 2007, as the same may be amended from time to time.
          (rr) “ sanofi-aventis ” shall have the meaning set forth in the Preamble to this Agreement.
          (ss) “ Sanofi US ” shall have the meaning set forth in the Preamble to this Agreement.
          (tt) “ SEC ” shall mean the United States Securities and Exchange Commission.
          (uu) “ Securities Act ” shall mean the Securities Act of 1933, as amended, and the rules and regulations of the SEC promulgated thereunder.
          (vv) “ Selling Expenses ” shall mean all underwriting discounts and selling commissions applicable to the sale of Registrable Securities pursuant to this Agreement.
          (ww) “ Shares of Then Outstanding Common Stock ” shall mean, at any time, the issued and outstanding shares of Class A Stock and Common Stock at such time, as well as all capital stock issued and outstanding as a result of any stock split, stock dividend, or reclassification of Class A Stock or Common Stock distributable, on a pro rata basis, to all holders of Class A Stock and Common Stock, as applicable.

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          (xx) “ Standstill Limit ” shall mean (i) from the Closing Date until the fourth (4 th ) anniversary of the Closing Date, the lesser of (A) twenty-one percent (21%) of the Shares of Then Outstanding Common Stock, in the case of this clause (A) only, calculated on a fully diluted basis assuming the full conversion into, or exercise or exchange for, shares of Common Stock of all Common Stock Equivalents outstanding (as such Common Stock Equivalents outstanding are calculated from the Company’s most recent Form 10-Q or Form 10-K, as applicable, filed with the SEC), and (B) twenty-five percent (25%) of the Shares of Then Outstanding Common Stock, and (ii) from the fourth (4 th ) anniversary of the Closing Date until the expiration of the Standstill Term, thirty percent (30%) of the Shares of Then Outstanding Common Stock.
          (yy) “ Standstill Parties ” shall have the meaning set forth in Section 3.1. (zz) “ Standstill Term ” shall have the meaning set forth in Section 3.1.
          (aaa) “ Third Party ” shall mean any Person other than the Purchaser Parties, the Company or any of their respective Affiliates.
          (bbb) “ Underwritten Registration ” or “ Underwritten Offering ” shall mean a registration in which Registrable Securities are sold to an underwriter for reoffering to the public.
          (ccc) “ Violation ” shall have the meaning set forth in Section 2.10(a).
2. Registration Rights.
      2.1 Required Registration. If, at any time after the expiration of the Lock-Up Term but no later than the tenth (10 th ) anniversary of such expiration (the “ Registration Rights Term ”), the Company receives from any Holder or Holders a written request or requests (each, a “ Demand Request ”) that the Company file a Registration Statement under the Securities Act to effect the registration (a “ Required Registration ”) of Registrable Securities, the Company shall use all reasonable efforts to file a Registration Statement covering such Holders’ Registrable Securities as soon as practicable (and by the applicable Filing Date) and shall use all reasonable efforts to, as soon as practicable thereafter, effect the registration of the Registrable Securities to permit or facilitate the sale and distribution in an Underwritten Offering of all or such portion of such Holder’s or Holders’ Registrable Securities as are specified in such Demand Request, subject however, to the conditions and limitations set forth herein; provided , however , that the Company shall not be obligated to effect any registration of Registrable Securities upon receipt of a Demand Request pursuant to this Section 2.1 if:
          (i) the Company has already completed three (3) Required Registrations;
          (ii) (A) in the event that the market value of all Registrable Securities outstanding is equal to or greater than $50,000,000, the market value of the Registrable Securities proposed to be included in the registration, based on the average closing price during the ten (10) consecutive trading days period prior to the making of the Demand Request, is less than $50,000,000 or (B) in the event that the market value of all Registrable Securities outstanding is less than

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$50,000,000, (i) less than all such Registrable Securities are proposed to be included in the registration, or (ii) the market value of all such Registrable Securities is less than $25,000,000;
          (iii) the Company shall furnish to the Holders a certificate signed by an authorized officer of the Company stating that (A) within ninety (90) days of receipt of the Demand Request under this Section 2.1, the Company shall file a registration statement for the public offering of securities for the account of the Company (other than a registration of securities (x) issuable pursuant to an employee stock option, stock purchase or similar plan, (y) issuable pursuant to a merger, exchange offer or a transaction of the type specified in Rule 145(a) under the Securities Act or (z) in which the only securities being registered are securities issuable upon conversion of debt securities which are also being registered), or (B) the Company is engaged in a material transaction or has an undisclosed material corporate development, in either case, which would be required to be disclosed in the Registration Statement, and in the good faith judgment of the Company’s Board of Directors, such disclosure would be seriously detrimental to the Company and its stockholders at such time (in which case, the Company shall disclose the matter as promptly as reasonably practicable and thereafter file the Registration Statement, and each Holder agrees not to disclose any information about such material transaction to Third Parties until such disclosure has occurred or such information has entered the public domain other than through breach of this provision by such Holder), provided , however , that the Company shall have the right to only defer the filing of the Registration Statement pursuant to this subsection once in any twelve (12) month period and, such deferral may not exceed a period of more than one-hundred twenty (120) days after receipt of a Demand Request;
          (iv) the Company has, within the twelve (12) month period preceding the date of the Demand Request, already effected one (1) Required Registration for any Holder pursuant to this Section 2.1; or
          (v) at any time during the period between the Company’s receipt of the Demand Request and the completion of the Required Registration, any Holder is in breach of or has failed to cause its Affiliates to comply with the obligations and restrictions of Sections 3, 4 or 5 of this Agreement, and such breach or failure is ongoing and has not been remedied; it being understood that (A) a one-time, inadvertent and de minimis breach of Section 4 shall not be deemed to be a breach of the obligations and restrictions under Section 4 for purposes of this Section 2.1(v) and (B) a de minimis breach of Section 3.1(a) hereof, or an inadvertent breach of Section 3.1(g) hereof arising from informal discussions covering general corporate or other business matters the purpose of which is not intended to effectuate or lead to any of the actions referred to in paragraphs (a) through (e) of Section 3.1, shall not be deemed to be a breach of the obligations and restrictions under Section 3.1 for purposes of this Section 2.1(v).

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      2.2 Underwritten Required Registration Required; Priority in Underwritten Offering. The underwriter for any Underwritten Offering requested pursuant to Section 2.1 shall be selected by a majority in interest of the Holders initiating the Required Registration hereunder (such Holder(s) initiating the registration request, the “ Initiating Holders ”) and shall be acceptable to the Company. The right of any Holder to include its Registrable Securities in the Underwritten Offering shall be conditioned upon such Holder’s participation in such Underwritten Offering and the inclusion of such Holder’s Registrable Securities to the extent provided herein. All Holders requesting the inclusion of their Registrable Securities in such Underwritten Offering shall (together with the Company as provided in Section 2.7(h)) enter into an underwriting agreement in customary form with the underwriter or underwriters selected for such Underwritten Offering. Notwithstanding any other provision of this Section 2, if the managing underwriter for the Underwritten Offering determines in good faith that marketing factors require a limitation of the number of shares of Registrable Securities to be included in such Underwritten Offering, then the Company shall so advise all Holders which requested inclusion of their Registrable Securities in such Underwritten Offering, and the number of shares of Registrable Securities that may be included in such Underwritten Offering shall be allocated among the Holders in proportion (as nearly as practicable) to the amount of Registrable Securities of the Company owned by each Holder; provided , however , that the number of shares of Registrable Securities to be included in such Underwritten Offering shall not be reduced unless all other securities are first entirely excluded from such Underwritten Offering. In the event the Company advises the Holders of its intent to decrease the total number of Registrable Securities that may be included by the Holders in such Required Registration such that the number of Registrable Securities included in such Required Registration would be less than seventy-five percent (75%) of all Registrable Securities which the Holders requested be included in such Required Registration, then Holders representing a majority of the Registrable Securities requested to be included in such Required Registration will have the right to withdraw, on behalf of all Holders of all Registrable Securities requested to be so included, such Required Registration, in which case, such Required Registration will not count as a Required Registration for the purposes of Section 2.1(i), and the Company shall bear all Registration Expenses in connection therewith; provided , that , the right to withdraw a registration and have it not count as a Required Registration may only be exercised once by the Holders (taken collectively).
      2.3 Priority in Required Registration. With respect to any Required Registration of Registrable Securities requested pursuant to Section 2.1, the Company may also (i) propose to sell shares of Common Stock on its own behalf and (ii) provide written notice of such Required Registration to Other Holders and permit all such Other Holders who request to be included in the Required Registration to include any or all Company securities held by such Other Holders in such Required Registration on the same terms and conditions as the Registrable Securities. Notwithstanding the foregoing, if the managing underwriter or underwriters of the Underwritten Offering to which any Required Registration relates advise the Company and the Holders of Registrable Securities that, in its good faith determination, the total amount of securities that such Holders, Other Holders, and the Company intend to include in such Required Registration is in an amount in the aggregate which would adversely affect the success of such Underwritten Offering, then such Required Registration shall include (i) first, all Registrable Securities of the Holders allocated, if the amount is less than all the Registrable Securities requested to be sold, pro rata on the basis of the total number of Registrable Securities held by such Holders; and (ii) second, as many other securities proposed to be included in the Required Registration by the

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Company and any Other Holders, allocated pro rata among the Company and such Other Holders, on the basis of the amount of securities requested to be included therein by the Company and each such Other Holder so that the total amount of securities to be included in such Underwritten Offering is the full amount that, in the written opinion of such managing underwriter, can be sold without materially and adversely affecting the success of such Underwritten Offering.
      2.4 Revocation of Required Registration. With respect to one (1) Required Registration only, the Holders of at least a majority of the Registrable Securities to be included in a Registration Statement with respect to such Required Registration may, at any time prior to the effective date of such Registration Statement, on behalf of all Holders of all Registrable Securities requested to be included therein, revoke the request to have Registrable Securities included therein and revoke the request for such Required Registration by providing a written notice to the Company, in which case such Required Registration that has been revoked will be deemed not to have been effected and will not count as a Required Registration for purposes of Section 2.1(i) if, and only if, the Holders of Registrable Securities which had requested inclusion of Registrable Securities in such Required Registration promptly reimburse the Company for all Registration Expenses incurred by the Company in connection with such Required Registration. Notwithstanding the foregoing sentence, the parties agree and acknowledge that the Holders may revoke any Required Registration (without any obligation to reimburse the Company for Registration Expenses incurred in connection therewith) if such revocation is based on (i) a material adverse change in circumstances with respect to the Company and its subsidiaries, taken as a whole, caused by an act or failure to act by the Company or any of its subsidiaries and not known to any Holder at the time the Required Registration was first made or (ii) the Company’s failure to comply in any material respect with its obligations hereunder, and any such revocation based on an event described in (i) or (ii) above shall be exercisable at any time and shall not be counted as the one (1) revocation of a Required Registration permitted by the first sentence of this Section 2.4.
      2.5 Effective Required Registrations. A Required Registration will not be deemed to be effected for purposes of Section 2.1(i) if the Registration Statement for such Required Registration has not been declared effective by the SEC or become effective in accordance with the Securities Act and the rules and regulations thereunder and kept effective for the Required Period. In addition, if after such Registration Statement has been declared or becomes effective, (i) the offering of Registrable Securities pursuant to such Registration Statement is interfered with by any stop order, injunction, or other order or requirement of the SEC or other governmental agency or court such that the continued offer and sale of Registrable Securities being offered pursuant to such Registration Statement would violate applicable Law and such stop order, injunction or other order or requirement of the SEC or other governmental agency or court does not result from any act or omission of any Holder whose Registrable Securities are registered pursuant to such Registration Statement (an “ Interference ”) and (ii) any such Interference is not cured within sixty (60) days thereof, such Required Registration will be deemed not to have been effected and will not count as a Required Registration. In the event such Interference occurs and is cured, the Required Period relating to such Registration Statement will be extended by the number of days of such Interference, including the date such Interference is cured.

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      2.6 Continuous Effectiveness of Registration Statement. The Company will use all reasonable efforts to cause each Registration Statement filed pursuant to this Section 2 to be declared effective by the SEC or to become effective under the Securities Act as promptly as practicable and to keep each such Registration Statement that has been declared or becomes effective continuously effective for the Required Period.
      2.7 Obligations of the Company. Whenever required under Section 2.1 to effect the registration of any Registrable Securities, the Company shall, as expeditiously as reasonably possible:
          (a) prepare and file with the SEC a Registration Statement with respect to such Registrable Securities sought to be included therein; provided that at least five (5) Business Days prior to filing any R

 
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