CONTRACTOR'S AGREEMENT

Independent Contractor Agreement

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This Independent Contractor Agreement involves

SIGA TECHNOLOGIES INC

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Title: CONTRACTOR'S AGREEMENT
Date: 9/27/2005
Industry: BIOTRX

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Exhibit 10.1

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AWARD/CONTRACT 1. THIS CONTRACT IS A RATED ORDER RATING PAGE OF PAGES

UNDER DPAS (15 CFR 350) 1 11

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2. CONTRACT (Proc. Inst Ident.) 3. EFFECTIVE DATE 4. REQUISITION/PURCHASE REQUEST/PROJECT NO.

NO. W81XWH-05-2-0085 22 Sep 2005 W81XWH-5101-M260

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5. ISSUED BY CODE W81XWH 6. ADMINISTERED BY (If other than Item 5) CODE W81XWH

USA MED RESEARCH ACQ ACTIVITY USA MED RESEARCH ACQ ACTIVITY

820 CHANDLER ST ATTN: JUANITA BOURNE

FORT DETRICK MD 21702-5014 301-619-7426

FORT DETRICK MD 21702

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7. NAME AND ADDRESS OF CONTRACTOR (No., street, city, county, state and zip code) 8. DELIVERY

SIGA TECHNOLOGIES INC [ ] FOB ORIGIN [X] OTHER (See below)

DENNIS E. HRUBY, PH.D. ----------------------------------------------

420 LEXINGTON AVE 9. DISCOUNT FOR PROMPT PAYMENT

RM 408 Net 7

NEW YORK NY 10170-0499

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10. SUBMIT INVOICES 0 ITEM

(4 copies unless otherwise

------------------------------------------------------------------------------------ specified)

TO THE ADDRESS SHOWN IN:

CODE 1V4X4 FACILITY CODE

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11. SHIP TO/MARK FOR CODE W23RYX 12. PAYMENT WILL BE MADE BY CODE HQ0345

USA MED RESEARCH AND MATERIEL COM DEFENSE FINANCE AND ACCOUNTING SERVICE

JUANITA LIVINGSTON DFAS-SA/FPA 500 MCCULLOUGH AVENUE

504 SCOTT STREET PHONE: 888-478-5636

FORT DETRICK MD 21702-5012 FAX: 866-636-2715

SAN ANTONIO TX 78215-2100

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13. AUTHORITY FOR USING OTHER THAN FULL AND OPEN 14. ACCOUNTING AND APPROPRIATION DATA

COMPETITION:

[ ] 10 U.S.C. 2304(c)( ) [ ] 41 U.S.C. 253(c)( ) See Schedule

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15A. ITEM NO. 15B. SUPPLIES/ SERVICES 15C. QUANTITY 15D. UNIT 15E. UNIT PRICE 15F. AMOUNT

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SEE SCHEDULE

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15G. TOTAL AMOUNT OF CONTRACT $3,200,000.00

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16. TABLE OF CONTENTS

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(X) SEC. DESCRIPTION PAGE(S) (X) SEC. DESCRIPTION PAGE(S)

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PART I - THE SCHEDULE PART II - CONTRACT CLAUSES

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X A SOLICITATION/ CONTRACT FORM 1 I CONTRACT CLAUSES

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B SUPPLIES OR SERVICES AND PRICES/ COSTS PART III - LIST OF DOCUMENTS, EXHIBITS AND OTHER ATTACHMENTS

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C DESCRIPTION/ SPECS./ WORK STATEMENT J LIST OF ATTACHMENTS

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D PACKAGING AND MARKING PART IV - REPRESENTATIONS AND INSTRUCTIONS

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E INSPECTION AND ACCEPTANCE K REPRESENTATIONS, CERTIFICATIONS AND

OTHER STATEMENTS OF OFFERORS

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F DELIVERIES OR PERFORMANCE

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G CONTRACT ADMINISTRATION DATA L INSTRS., CONDS., AND NOTICES TO OFFERORS

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H SPECIAL CONTRACT REQUIREMENTS M EVALUATION FACTORS FOR AWARD

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CONTRACTING OFFICER WILL COMPLETE ITEM 17 OR 18 AS APPLICABLE

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17. [ ] CONTRACTOR'S NEGOTIATED AGREEMENT 18. [X] AWARD (Contractor is not required to sign this document.)

Contractor is required to sign this document Your offer on Solicitation Number ____________________________

and return copies to issuing office.) REF: See Paragraph A, Page 4

Contractor agrees to furnish and deliver all including the additions or changes made by you which additions or changes

items or perform all the services set forth or are set forth in full above, is hereby accepted as to the items listed

otherwise identified above and on any continuation above and on any continuation sheets. This award consummates the contract

sheets for the consideration stated herein. The which consists of the following documents: (a) the Government's

rights and obligations of the parties to this solicitation and your offer, and (b) this award/contract. No further

contract shall be subject to and governed by the contractual document is necessary.

following documents: (a) this award/contract,

(b) the solicitation, if any, and (c) such

provisions, representations, certifications,

and specifications, as are attached or incorporated

by reference herein.

(Attachments are listed herein.)

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19A. NAME AND TITLE OF SIGNER (Type or print) 20A. NAME AND TITLE OF CONTRACTING OFFICER

REBECCA J. TAMA / CONTRACTING OFFICER

TEL: 301-619-2381 EMAIL:rebecca.tama@det.amedd.army.mil

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19B. NAME OF CONTRACTOR 19C. DATE SIGNED 20B. UNITED STATES OF AMERICA 20C. DATE SIGNED

BY BY /s/ Rebecca J. Tama 22-Sep-2005

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(Signature of person authorized to sign) (Signature of Contracting Officer)

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NSN 7540-01-152-8069 26-107 STANDARD FORM 26 (REV. 4-85)

PREVIOUS EDITION UNUSABLE GPO 1985 O - 469-794 Prescribed by GSA

FAR (48 CFR) 53.214(a)

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W81XWH-05-2-0085

Page 2 of 12

Section 00010 - Solicitation Contract Form

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ITEM NO SUPPLIES/SERVICES QUANTITY UNIT UNIT PRICE AMOUNT

0001

Proposal Log No.: 05189001

COST

Period of Performance: 26 September 2005 through 25 October 2006 (Research

ends 25 September 2006)

PURCHASE REQUEST NUMBER: W81XWH-5101-M260

ESTIMATED COST $3,200,000.00

ACRN AA Funded Amount $3,200,000.00

FOB: Destination

DELIVERY INFORMATION

CLIN DELIVERY DATE QUANTITY SHIP TO ADDRESS UIC

0001 POP 26-SEP-2005 TO N/A USA MED RESEARCH AND MATERIEL W23RYX

25-OCT-2006 COM

JUANITA LIVINGSTON

504 SCOTT STREET

FORT DETRICK MD 21702-5012

FOB: Destination

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W81XWH-05-2-0085

Page 3 of 12

Section 00800 - Special Contract Requirements

ACCOUNTING AND APPROPRIATION DATA

AA: 215204000000748112665801M02IM25GYP1H4IMF1ATD45087G003H4IMP1018064

AMOUNT: $3,200,000.00

CLAUSES INCORPORATED BY FULL TEXT

A. This award is made under the authority of 31 U.S.C. 6305 and 10 U.S.C. 2358.

The recipient's statement of work on pages 11-12 of the proposal dated 5 July

2005 and revised budget dated 15 July 2005 which are incorporated herein by

reference. The Catalog of Federal Domestic Assistance Number relative to this

award is CFDA 12.420.

GOVERNMENT INTERACTION (NOV 2000) (USAMRAA)The active participants in this award

are the U.S. Army Medical Research and Materiel Command (USAMRMC) and its

laboratories identified herein through the U.S. Army Medical Research

Acquisition Activity (USAMRAA). The following Laboratory will be the focus of

cooperative research conducted under this agreement:

LTC Barbara Larcom

AFMS/SGRM

5201 Leesburg Pike, Suite 1401

Falls Church, VA 22041

Barbara.Larcom@pentagon.af.mil

B. ACCEPTANCE OF AWARD: The recipient is not required to countersign this

assistance award. In case of disagreement, the recipient shall notify the Grants

Officer and not assess the grant any costs until such disagreement(s) is

resolved.

C. USAMRAA GENERAL TERMS AND CONDITIONS: This assistance agreement is subject to

the USAMRAA General Terms and Conditions and to any special considerations as

contained in the below mentioned Section titled "Special Terms and Conditions".

These USAMRAA General Terms and Conditions are incorporated by reference with

the same force and effect as if they were given in full text. The full text of

the USAMRAA General Terms and Conditions may be accessed electronically at

http://www.usamraa.army.mil/pages/index.cfm.

D. SPECIAL TERMS AND CONDITIONS

1. RESEARCH TECHNICAL REPORTING REQUIREMENTS

U.S. AIR FORCE SGR REPORTING REQUIREMENTS

USAF SGR reporting requirements for assistant agreement partners include monthly

and final reports as stated below:

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W81XWH-05-2-0085

Page 4 of 12

A. MONTHLY TECHNICAL PROGRESS REPORT: The recipient shall submit a Monthly

Technical Progress Report covering work accomplished during each calendar month

of performance. It shall be brief, factual, and informal, and shall be prepared

in accordance with the sample report format on the following page. It shall

contain the following:

Section I - Recipient and award information

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