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TAX INDEMNITY AGREEMENT

Indemnification Agreement

TAX INDEMNITY AGREEMENT | Document Parties: VANDA PHARMACEUTICALS INC. You are currently viewing:
This Indemnification Agreement involves

VANDA PHARMACEUTICALS INC.

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Title: TAX INDEMNITY AGREEMENT
Date: 11/8/2007
Industry: Biotechnology and Drugs     Sector: Healthcare

TAX INDEMNITY AGREEMENT, Parties: vanda pharmaceuticals inc.
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Exhibit 10.21

TAX INDEMNITY AGREEMENT

     This Tax Indemnity Agreement (this “ Agreement ”) is made as of this 7 day of November, 2007 by and between Vanda Pharmaceuticals Inc. (the “ Company ”) and Al Gianchetti (the “ Executive ”).

      WHEREAS , the Compensation Committee of the Company’s Board of Directors has determined that the Company should enter into tax indemnity agreements with certain of its executives to reimburse certain excise taxes, interest and penalties they may be obligated to pay in connection with a change of control of the Company, so that the Company may preserve the financial incentives the Company created by granting stock options to those executives, and so that the Company may also continue to provide motivation for those executives to stay with the Company and act in its best interests.

      NOW, THEREFORE, in consideration of the foregoing, and for other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged and agreed to, the parties hereto agree as follows:

      1.     Gross-Up Payment. If it is determined that any payment or distribution of any type to the Executive or for his benefit by the Company, any of its affiliates, any person who acquires ownership or effective control of the Company or ownership of a substantial portion of the Company’s assets (within the meaning of section 280G of the Internal Revenue Code of 1986, as amended (the “ Code ”), and the regulations thereunder) or any affiliate of such person, whether paid or payable or distributed or distributable pursuant to the terms of this Agreement or otherwise (the “ Total Payments ”), would be subject to the excise tax imposed by section 4999 of the Code or any interest or penalties with respect to such excise tax (such excise tax and any such interest or penalties are collectively referred to as the “ Excise Tax ”), then the Executive shall be entitled to receive an additional payment (a “ Gross-Up Payment ”) in an amount calculated to ensure that after the Executive pays all taxes (and any interest or penalties imposed with respect to such taxes), including any Excise Tax, imposed upon the Gross-Up Payment, the Executive retains an amount of the Gross-Up Payment equal to the Excise Tax imposed upon the Total Payments.

      2.     Determination by Accountant . All determinations and calculations required to be made under this Agreement shall be made by an independent accounting firm selected by the Executive from among the largest five accounting firms in the United States (the “ Accounting Firm ”). The Accounting Firm shall provide its determination (the “ Determi


 
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