OFFER OF EMPLOYMENT

Exhibit 10.1

[CYTRX LETTERHEAD]

Dear Dr. Wieland:

     On behalf of CytRx Corporation (the “Company”), I am pleased to offer you the position of Vice President, Clinical and Regulatory Affairs of CytRx Corporation. Speaking for myself, as well as the other members of the Company’s management team, we are all very impressed with your credentials and we look forward to your future success in this position.

     Your responsibilities will be those assigned to you from time to time by your supervisor, Dr. Jack Barber, including but not limited to those described in Schedule 1.

     You will be paid a bi-weekly salary of $7,916.66, less all applicable deductions, which is equivalent to a gross sum of $190,000 on an annualized basis. Your salary will be payable pursuant to the Company’s regular payroll policy. You will also be eligible for a discretionary bonus opportunity, payable in cash, stock or any combination thereof. Any salary change and bonus will be determined by the Board of Directors of the Company based upon your personal performance, the Company’s financial performance, achieving your milestones and other factors. The determinations of the Board of Directors of the Company with respect to such bonus and any salary review shall be final and binding.

     The Company will provide you with the opportunity to participate in the standard benefits plans currently available to other similarly situated employees, including medical, dental and vision insurance, subject to any eligibility requirements imposed by such plans. In addition, you will be entitled to two (2) weeks vacation your first year, in addition to the Company’s standard paid holidays, as such holidays may change from time to time.

     In connection with the commencement of your employment, the Board of Directors of the Company will grant you an option to purchase 100,000 shares of CytRx Common Stock (NASDAQ: CYTR) with an exercise price equal to the fair market value at the close of business on your first day of employment. This option shall vest over a three-year period, with one-third of the option shares vesting on each of the first three anniversaries of the first day of your employment. Vesting will, of course, depend on your continued employment with the Company. The option will be a non-qualified stock option and will be subject to the terms of the Company’s stock option plan and the Stock Option Agreement between you and the Company, a copy of which you will be required to execute as a condition of the grant. In addition, you will be required to comply with any Company policies governing securities trades by Company personnel.

     As an employee of the Company, you will have access to certain Company confidential information and you may, during the course of your employment, develop certain information or inventions, which will become the property of the Company. As a condition of your employment, you will be required to sign the Company’s Confidential Information and Invention Assignment Agreement, a copy of which is enclosed for your review and execution (the “Confidentiality Agreement”), prior to or on your Start Date (as defined below). We wish to impress upon you that we do not wish you to bring with you any confidential and proprietary material of any former employer or to violate any other obligation to