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OFFER OF EMPLOYMENT

Executive Employment Agreement

OFFER OF EMPLOYMENT | Document Parties: LIGAND PHARMACEUTICALS INC | John L. Higgins You are currently viewing:
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LIGAND PHARMACEUTICALS INC | John L. Higgins

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Title: OFFER OF EMPLOYMENT
Governing Law: California     Date: 1/16/2007
Industry: Biotechnology and Drugs    

OFFER OF EMPLOYMENT, Parties: ligand pharmaceuticals inc , john l. higgins
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                                                                    EXHIBIT 10.1



                               [LIGAND LETTERHEAD]


10 January 2007


John L. Higgins
820 Stanford Avenue
Menlo Park, California 94025

Dear John:

                  Ligand Pharmaceuticals Incorporated (the "Company") is pleased
to offer you employment on the following terms:

                1.       POSITION. Your title will be President and Chief
Executive Officer and Director, and you will report to the Company's Board of
Directors (the "Board"). This is a full-time position. While you render services
to the Company, you will not engage in any other employment, consulting or other
business activity (whether full-time or part-time) that would create a conflict
of interest with the Company or your duties, in each case as determined by the
Board. By signing this letter agreement, you confirm to the Company that you
have no contractual commitments or other legal obligations that would prohibit
you from performing your duties for the Company. Upon hire and assuming your
compliance with all Company policies applicable to directors, you will be
elected a director of the Company to serve until the next annual meeting and
while you are serving as the Company's President and Chief Executive Officer,
the Company will make all reasonable efforts to cause you to be elected by our
stockholders to our Board of Directors.

                2.       CASH COMPENSATION. The Company will pay you a starting
salary at the rate of $400,000 per year, payable in accordance with the
Company's standard payroll schedule. This salary will be subject to adjustment
pursuant to the Company's employee compensation policies in effect from time to
time. In addition, you will be eligible to be considered for an incentive bonus
for each fiscal year of the Company. The bonus (if any) will be awarded against
your performance of the Company, and you personally. Company performance targets
and other objective or subjective criteria will be established by the Company's
Board of Directors or its Compensation Committee, in consultation with you. Your
target bonus will be 50% of your annual base salary, with a maximum of 75%. Any
bonus for the fiscal year in which your employment begins will be prorated,
based on the number of days you are employed by the Company during that fiscal
year. The bonus for a fiscal year will be paid after the Company's books for
that year have been closed and will be paid only if you are employed by the
Company at the fiscal year end. The determinations of the Company's Compensation
Committee or its Board of Directors with respect to your bonus will be final and
binding.

                3.       RELOCATION BENEFITS. The Company will pay you $100,000
in a lump sum upon hire to defray the costs of relocating your residence to San
Diego. You agree to reimburse this amount to the Company if you voluntarily
terminate your employment without good reason within one year of the start date
of your employment.

<PAGE>


                4.       EMPLOYEE BENEFITS AND OFFICER INDEMNIFICATION. As a
regular employee of the Company, you will be eligible to participate in the
standard package of Company-sponsored benefits including health insurance,
401(k), employee stock purchase plans and other benefits offered to all senior
executives. The Company will purchase and pay the premiums on a term life
insurance on your life with you as owner and beneficiary. In addition, you will
be entitled to four weeks of paid vacation in accordance with the Company's
vacation policy, as in effect from time to time. We will also provide a standard
indemnification agreement for you as an executive officer, in accordance with
our bylaws.

                5.       RESTRICTED STOCK GRANT. Subject to the approval of the
Company's Board of Directors or its Compensation Committee, you will be granted
150,000 shares of the Company's common stock under the Company's 2002 Stock
Incentive Plan, subject to a right of repurchase or "vesting" and other
customary restrictions (the "Restricted Stock"). The purchase price per share
will be equal to the fair market value of the Company's Common Stock at the
close of business on the date of grant, and will be paid in future services
rendered by you to the Company over the next two years with no out of pocket
cost to you. You shall have full stockholder rights to these shares, regardless
of whether they are vested, including voting rights and the right to receive any
applicable dividends, splits and the like. You will vest in 50% of the
Restricted Stock after 12 months of continuous service after the date of grant,
and the balance will vest at the end of your second year of continuous service
after the date of grant. You will be eligible for future restricted stock awards
and/or option awards at the discretion of the Compensation Committee during the
term of this Agreement.

                6.        SEVERANCE BENEFITS. The Company will enter into a
Severance Agreement with you that will include the terms of this Section 6. If
the Company terminates your employment for any reason other than Cause or
Permanent Disability or you terminate for Good Reason and there has not been a
Change of Control in the prior 12 months, then you will be entitled to the
following benefits:

                        (a)   The   Company   will   continue   to pay your base
         salary for a period of eighteen   months   following   the   termination of
         your employment. Your base salary will be paid at the rate in effect at
         the time of the termination   of your   employment and in accordance with
         the Company's standard payroll procedures.   However,   your severance
         payments will in no event start before the earliest date permitted by
         Section 409A(a)(2)of the Internal Revenue Code. If the commencement of
         the severance payments must be delayed, as determined by the Company,
         then the deferred installments will be paid to you in a lump sum on the
         earliest   practicable   date   permitted   by   Section 409A(a)(2).   The
         amount of the   salary continuation   payments under this Subsection (a)
         will be reduced by the amount of any severance pay or pay in lieu of
         notice that you receive from the Company under a federal or state
         statute (including,   without   limitation,   the WARN Act).

                        (b)   If you elect to continue your health insurance
         coverage under the Consolidated Omnibus Budget Reconciliation Act
         ("COBRA") following the termination of your employment, then the
         Company will pay the same portion of your monthly premium under COBRA
         as it pays for active

<PAGE>

         employees until the earliest of (i) the close of the eighteen-month
         period following the termination of your employment, (ii) the
         expiration of your continuation coverage under COBRA or (iii) the date
         when you become eligible for substantially equivalent health insurance
         coverage in connection with new employment or self-employment.

                         (c)   accelerated vesting of any outstanding, unvested
         stock or options

If the Company terminates your employment for any reason other than Cause or
Permanent Disability or you terminate for Good Reason, and within 12 months
after a Change of Control, then you will be entitled to the following benefits:

                        (d)   The   Company   will pay you a lump sum amount equal
         to two times (i) your   annual   base   salary   plus (ii) the average of
         your annual bonuses for your   period of   service.   Your base salary
         will be paid at the rate in effect at the time of the termination of
         your   employment and in accordance   with the Company's   standard
         payroll   procedures. However,   your severance   payments will in no
         event start before the earliest date permitted by   Section 409A(a)(2)of
         the Internal Revenue Code. If the


 
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