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OFFER OF EMPLOYMENT

Executive Employment Agreement

OFFER OF EMPLOYMENT
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This Executive Employment Agreement involves

AMICUS THERAPEUTICS INC

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Title: OFFER OF EMPLOYMENT
Governing Law: New Jersey     Date: 5/17/2006

OFFER OF EMPLOYMENT
, Parties: amicus therapeutics inc
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<PAGE>
                                                                    EXHIBIT 10.9

NEW ENTERPRISE ASSOCIATES                        2490 Sand Hill Road
                                                Menlo Park, California 94025
                                                 Tel: 650.854.9499
                                                Fax: 650.854.9397
                                                www.nea.com

   November 9, 2004
 
   HIGHLY CONFIDENTIAL
   TO BE READ BY ADDRESSEE ONLY
 
   Mr. Matthew R. Patterson
   1701 Jackson Street #709
   San Francisco, CA 94109
 
   Dear Matt:
 
   It has been a pleasure for all of us to meet and interact with you about
   opportunities with Amicus Therapeutics, and to discuss your role in making it
   a formidable biotechnology company. We are delighted, pending the..outcome of
   reference checks, to convey this offer to join the company as its Executive
   Vice President (EVP) Business Operations, and am confident that you will be
   an outstanding and successful leader in the company. We believe Amices'
   growth potential is tremendous and we sincerely and enthusiastically look
   forward to working with you.
 
   As we have discussed, you will be part of a team that will provide the
   leadership and strategic direction of Amicus. To that end, you will be
   employed on an "at-will" basis and will be responsible for the following;
   business development, human resources, IT and Facilities, intellectual
   property, business planning and strategy, product launch planning and program
   management. As Amicus succeeds, you will assist in appropriately growing the
   company and delegate various roles to additional executives you help hire.
 
   It is as exciting time to join Amicus, given the opportunities that the
   company is addressing. In your role, you will report to the CEO. Your
   individual compensation package, as outlined below, includes a variety of
   features which we believe will make your transition easier, both personally
   and professionally. Our overriding interest is to make sure you are intensely
   focused on, and handsomely rewarded for, the company's success.
 
   THE COMPENSATION PACKAGE
 
   Your starting salary will be at an annualized rate of Two Hundred arid Fifty
   Thousand Dollars ($250,000), minus customary deductions for federal and state
   taxes and the like, payable on regular company pay days. Your salary level
   will be reviewed annually.
 
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<PAGE>

Mr. Matthew R. Patterson
November 9, 2004
Page 2

throughout your employment with the company during the company's regular
performance review process.

Once you agree to join Amicus, you will receive a sign-on bonus of Twenty-Five
Thousand Dollars ($25,000), minus customary deductions for federal and states
taxes and the like.

In addition, you will be eligible for an annual performance bonus target of
Fifty Thousand Dollars ($50,000), minus customary deductions for federal and
states taxes and the like, payable in cash, based on the achievement of
company-wide and individual performance goals.

You will initially be granted an incentive stock option to purchase One and One
Half Percent (1.50%) of Amicus' current (B Round) fully diluted stock or
[724,101] shares, This option will have an exercise price equal to the current
fair market value of the company's common stock ($0.085) and will vest in the
following manner over the four (4) year period commencing on your start date:
(i) Twenty -five Percent (25%) of this grant will vest after twelve months and
(ii) the balance of the grant will vest ratably over the following thirty six
(36) months, subject to the terms of the Amicus Therapeutics 2002 Equity
Incentive Plan and a written agreement, which will in


 
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