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OFFER OF EMPLOYMENT

Executive Employment Agreement

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This Executive Employment Agreement involves

AMICUS THERAPEUTICS INC

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Title: OFFER OF EMPLOYMENT
Date: 5/17/2006

OFFER OF EMPLOYMENT, Parties: amicus therapeutics inc
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                                                                   EXHIBIT 10.10
[AMICUS THERAPEUTICS LOGO]

June 3, 2005

Dr. Pedro Huertas
283 Simon Willard Road
Concord, MA 01742

Dear Pedro:

      On behalf of Amicus Therapeutics, Inc. (the "Company"), I am pleased to
confirm our offer to you for the position of Chief Development Officer reporting
to me. Your start date will be mutually agreed upon but no later then July 1,
2005.

      In consideration for all your services to be rendered to the Company your
annual base salary will be $275,000, to be paid semi-monthly in accordance
with the Company's payroll practices. Upon the completion of mutually agreed
upon individual goals and objectives as well as the achievement of specific
Company goals, you will be eligible to receive a bonus target of 25% of your
base salary, minus customary deductions. Once you agree to join Amicus, payable
with your first paycheck, you will receive a sign on bonus of $25,000 minus
customary deductions.

      Subject to approval by the Board of Directors, you will receive an
incentive stock option to purchase 724,101 shares of the Company's common stock.
The option will become exercisable over a four-year period as follows: 25% on
the first anniversary of the date of grant, and 75% in equal monthly increments
thereafter. The exercise price of the option will be the fair market value of
the Company's common stock on the date of grant. Shares issuable upon exercise
of the option will be subject to certain transfer restrictions including the
right of first refusal.

      Given that you currently reside over 50 miles from our location in
Cranbury NJ, you will be eligible to be initially reimbursed for reasonable
relocation expenses up to $25,000 to facilitate your move.

      If you are terminated without Cause, you will be eligible for a
continuation of six (6) months salary, an additional six (6) months of option
vesting, plus payment of a bonus payment equal to the bonus earned in the
preceding year. "Cause" means for any of the following reasons: (i) willful or
deliberate misconduct by you that materially damages the company; (ii)
misappropriation of company assets; (iii) conviction of or a plea of guilty or
"no contest" to, a felony; or (iv) any willful disobedience of the lawful and
unambiguous instructions of the CEO of the company; provided that the CEO has
given you written notice of such disobedience or neglect and you have failed to
cure such disobedience or neglect within a period reasonable under the
circumstances.

<TABLE>
<S>                       <C>                           <C>                  <C>                  <C>  
675 U.S. Highway One      North Brunswick, NJ 08902     T: 732-745-9977      F: 732-745-9769      www.amicustherapeutics.com
</TABLE>
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Dr. Pedro Huertas
June 3, 2005
Page #2 of 3

      If there is a Change in Control Event and you resign for Good Reason or
are terminated withou


 
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