EXHIBIT 10.35
REGULUS THERAPEUTICS
LLC
EMPLOYMENT
AGREEMENT
This EMPLOYMENT AGREEMENT
(the “ Agreement ”) is made and entered into
effective as of December 29, 2008 by and between Regulus
Therapeutics LLC, a Delaware limited liability corporation (the
“ Company ”), and Kleanthis G. Xanthopoulos,
Ph.D. (the “Executive” ). The Company and
the Executive are hereinafter collectively referred to as the
“ Parties ”, and individually referred to as a
“ Party ”.
The Company desires assurance of the
association and services of the Executive in order to retain the
Executive’s experience, skills, abilities, background and
knowledge, and is willing to engage the Executive’s services
on the terms and conditions set forth in this Agreement.
The Parties previously entered into
a letter agreement dated November 30, 2007 (the “
Prior Agreement ”) and desire to terminate and replace
the Prior Agreement with this Agreement, except as set forth
herein.
The Executive desires to be in the
employ of the Company, and is willing to accept such employment on
the terms and conditions set forth in this Agreement.
AGREEMENT
In consideration of the foregoing
recitals and the mutual promises and covenants herein contained,
and for other good and valuable consideration, the Parties,
intending to be legally bound, agree as follows:
1.
EMPLOYMENT.
1.1
Term. The term of
this Agreement shall begin on the date first set forth above (the
“ Effective Date ”), and shall continue until
terminated in accordance with Section 4 herein.
1.2
Title . The
Executive shall have the title of Chief Executive Officer of the
Company and shall serve in such other capacity or capacities as the
Board of Directors of the Company (the “ Board
”) may from time to time prescribe, but only as consistent
with the customary duties of a Chief Executive Officer.
During the term of this Agreement, unless otherwise agreed by the
Parties, the Executive shall also serve as a member of the
Board. Upon termination of the Executive’s employment
with the Company, for any reason or no reason, the Executive shall
immediately resign as a member of the Board.
1.3
Duties. The
Executive shall report to the Board and shall do and perform all
reasonable services, acts or things necessary or advisable to
manage and conduct the business of the Company and which are
normally associated with the position of Chief Executive Officer,
consistent with the bylaws of the Company and as required by the
Board.
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1.4
Location . The
Executive shall perform services pursuant to this Agreement at the
Company’s offices located in Carlsbad, California, or at any
other place at which the Company maintains an office; provided,
however, that (i) the Company will not relocate the offices
that are the primary location at which the Executive performs
services pursuant to this Agreement by more than thirty miles from
the then current location without the Executive’s prior
written consent and (ii) the Company may from time to time
require the Executive to travel temporarily to other locations in
connection with the Company’s business.
2.
LOYAL AND CONSCIENTIOUS
PERFORMANCE; NONCOMPETITION.
2.1
Loyalty . During
the Executive’s employment by the Company the Executive shall
devote the Executive’s full business energies, interest,
abilities and productive time to the proper and efficient
performance of the Executive’s duties under this
Agreement.
2.2
Covenant not to Compete . Except with the prior written consent of
the Board, the Executive will not, while employed by the Company,
or during any period during which the Executive is receiving
compensation or any other consideration from the Company,
including, but not limited to, severance pay pursuant to
Section 4.1.3 herein, engage in competition with the Company
and/or any of its affiliates, subsidiaries, or joint ventures
currently existing or which shall be established during the
Executive’s employment by the Company (collectively, “
Affiliates ”) either directly or indirectly, in any
manner or capacity, as adviser, principal, agent, affiliate,
promoter, partner, officer, director, employee, stockholder, owner,
co-owner, consultant, or member of any association or otherwise, in
any phase of the business of developing, manufacturing and
marketing of products or services which are in the same field of
use or which otherwise compete with the products or services or
proposed products or services of the Company or any of its
Affiliates.
2.3
Agreement not to Participate in Company’s
Competitors .
During his employment by the Company, the Executive agrees not to
acquire, assume or participate in, directly or indirectly, any
position, investment or interest known by the Executive to be
adverse or antagonistic to the Company, its business or prospects,
financial or otherwise or in any company, person or entity that is,
directly or indirectly, in competition with the business of the
Company or any of its Affiliates. Ownership by the Executive,
as a passive investment, of less than 2% of the outstanding shares
of capital stock of any corporation with one or more classes of its
capital stock listed on a national securities exchange or in the
over-the-counter market shall not constitute a breach of this
paragraph.
3.
COMPENSATION OF THE
EXECUTIVE.
3.1
Base Salary. The
Company shall pay the Executive a base salary of $420,000 per year
(the “ Base Salary ”), less payroll deductions
and all required withholdings, payable in regular bi-weekly
payments or otherwise in accordance with Company policy. Such
Base Salary shall be prorated for any partial year of employment on
the basis of a 365-day fiscal year.
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3.2
Discretionary Bonuses. In addition to the Base Salary, the
Executive will be eligible to receive a yearly discretionary merit
bonus (with a base percentage factor of forty percent (40%)) in
accordance with the Company’s Executive Bonus Plan to be
established by the Company based upon the Executive’s
performance, as determined by the Board in its sole discretion,
against fundamental objectives to be mutually agreed upon by the
Executive and the Board. Any bonus that is earned by the
Executive under the Executive Bonus Plan, or any other bonus plan
approved by the Board, shall be paid to the Executive no later than
the March 15 of the year immediately following the year in
which such bonus was earned.
3.3
Stock Options. The
Company agrees that it will grant to the Executive, pursuant to the
terms of the Company’s 2009 Equity Incentive Plan (the
“ Plan ”) to be established by the Company
following the Company’s conversion to a Delaware corporation,
stock options to purchase shares of the Common Stock of the Company
(each an “ Option ” and collectively, the
“ Options ”) representing five percent (5%) of
the shares of capital stock of the Company outstanding following
the Series A Preferred Stock Financing of the Company (which
is expected to occur in the first fiscal quarter of 2009)
determined on a fully-diluted, as converted to Common Stock basis,
including shares reserved for issuance pursuant to the Plan.
Such Options shall include an “early-exercise” feature,
which will allow the Executive to exercise the Options with respect
to some or all of the unvested shares and such unvested shares
shall thereafter be subject to a repurchase option in favor of the
Company, which repurchase option shall lapse in accordance with the
stated vesting of such unvested Options. To the maximum
extent possible, the Options shall be “incentive stock
options” as such term is defined in Section 422 of the
Internal Revenue Code of 1986, as amended (the “ Code
”). The purchase price of the shares issuable upon
exercise of the Options shall be equal to the fair market value per
share of the Company’s Common Stock on the date of grant, as
determined in good faith by the Board based on a valuation
performed by a qualified independent appraiser using a traditional
appraisal methodology. The Options will be subject to vesting
over a period of four (4) years following the grant date, with
1/4th of the shares subject to such Options vesting on the one
(1) year anniversary of the grant date and 1/48
th of the shares subject to such Options
vesting on a monthly basis thereafter until all the shares subject
to such Options are vested on the fourth anniversary of the grant
date, in each case only so long as the Executive remains
continuously employed by the Company. In the event of a
Change in Control (as defined below), regardless of termination of
the Executive’s employment, the vesting of the Options set
forth in Section 3.3 hereof shall accelerate and vest in
full. The terms and vesting of the Options will be more fully
set forth in the Plan and shall be subject to the Company’s
standard form of stock option agreement.
3.4
Changes to Compensation. It is anticipated that the Executive will
be considered on an annual basis for merit increases in base
compensation consistent with performance and market trends but
subject to Board approval in its sole discretion. Subject to
Section 4.1.3 below, the Executive’s compensation may be
changed from time to time in the Company’s sole discretion
based upon Board approved changes to the Company’s operating
plan after considering relevant business conditions.
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3.5
Employment Taxes .
All of the Executive’s compensation and payments under this
Agreement shall be subject to customary withholding taxes and any
other employment taxes as are commonly required to be collected or
withheld by the Company.
3.6
Benefits . The
Executive shall, in accordance with Company policy and the terms of
the applicable plan documents, be eligible to participate in
benefits under any executive benefit plan or arrangement which may
be in effect from time to time and made available to the
Company’s executive or key management employees.
3.7
Vacations and Holidays. The Executive shall be entitled to
receive three (3) weeks of paid vacation during each calendar
year, and shall be entitled to paid holidays in accordance with the
Company’s policies.
4.
TERMINATION.
4.1
Termination By the Company . The Executive’s employment with
the Company may be terminated under the following
conditions:
4.1.1
Termination for Death or Disability . The Executive’s employment with
the Company shall terminate effective upon the date of the
Executive’s death or Complete Disability (as defined
below). If the Executive’s employment shall be
terminated by death or Complete Disability, the Company shall pay
to the Executive, and/or the Executive’s heirs, the
Executive’s Base Salary and accrued and unused vacation
benefits earned through the date of termination at the rate in
effect at the time of termination, less standard deductions and
withholdings, and the Company shall thereafter have no further
obligations to the Executive and/or the Executive’s heirs
under this Agreement.
4.1.2
Termination by the Company For Cause . The Company may terminate the
Executive’s employment under this Agreement for Cause (as
defined below) or the Executive may resign his employment under
this Agreement without Good Reason (as defined below). If the
Executive’s employment shall be terminated by the Company for
Cause or by the Executive without Good Reason, the Company shall
pay the Executive’s Base Salary and accrued and unused
vacation benefits earned through the date of termination at the
rate in effect at the time of termination, less standard deductions
and withholdings, and the Company shall thereafter have no further
obligations to the Executive under this Agreement.
4.1.3
Termination By The Company Without Cause Or By The Executive With
Good Reason. If
the Company (or its successor) terminates the Executive’s
employment without Cause, or if the Executive terminates his
employment for Good Reason, then the Company shall pay the
Executive’s Base Salary and accrued and unused vacation
benefits earned through the date of termination at the rate in
effect at the time of termination, less standard deductions and
withholdings. In addition, subject to the Executive’s
delivery to the Company of a release and waiver of claims in the
form attached hereto as Exhibit A within the applicable
time period set forth therein, but in no event later than
forty-five (45) days following termination of Executive’s
employment, and permitting such Release and Waiver to
become
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fully effective in accordance with its terms,
(the date Executive’s Release becomes fully effective, the
“ Release Effective Date ”), the Company shall
provide the Executive with the following benefits hereunder, as
applicable (the “ Severance Benefits
”):
4.1.3.1
If the Executive’s termination
occurs prior to and not within one month of a Change of Control,
the Executive shall be entitled to 18 months of his Base Salary in
effect as of the termination date (ignoring any reduction in salary
that is the basis for a the Executive’s termination of
employment for Good Reason), less required deductions and
withholdings, paid in the form of salary continuation on the
Company’s standard payroll dates following termination;
provided, however, no such payments will be made prior to the
Release Effective Date, and on the first regular payroll date
following the Release Effective Date, the Company will pay the
Executive in a lump sum the amount of the salary continuation he
would have otherwise received on and prior to such date but for the
delay due to the Release, with the balance paid thereafter on the
original schedule.
4.1.3.2
If the Executive’s termination
occurs within one month of, or within 12 months following, the
effective date of a Change in Control, the Executive shall be
entitled to 24 months of his Base Salary in effect as of the
termination date (ignoring any reduction in salary that is the
basis for a Good Reason Resignation) and two times the maximum
amount of the discretionary bonus payable for the then-current year
as if all milestones or other performance targets had been
achieved, less required deductions and withholdings, paid in the
form of a lump sum on the first regular payroll date following the
Release Effective Date.
4.1.3.3
The Company shall pay the premiums
(the “ COBRA Premiums ”) for group health plan
continuation coverage (i.e., medical, dental and vision insurance)
under Title X of the Consolidated Omnibus Budget Reconciliation Act
of 1985, as amended (“ COBRA ”), under the same
plans available to active Company employees and under the same
rules, restrictions and regulations applicable thereto for up to 18
months following the Executive&rsquo