Exhibit 10.1

FIRST AMENDMENT FORBEARANCE AGREEMENT

THIS FIRST AMENDMENT TO THE FORBEARANCE AGREEMENT (this “ Amendment ” ), dated as of December 23, 2005, is entered into among CURATIVE HEALTH SERVICES, INC. , a Minnesota corporation formerly known as Curative Holding Co. (“ Holdings ”), EBIOCARE.COM, INC. , a Delaware corporation (“ eBioCare ” ), HEMOPHILIA ACCESS, INC. , a Tennessee corporation (“ Hemophilia Access ”), APEX THERAPEUTIC CARE, INC. , a California corporation (“ Apex ”), CHS SERVICES, INC. , a Delaware corporation (“ CHS ”), CURATIVE HEALTH SERVICES OF NEW YORK, INC. , a New York corporation (“ CHSNY ”), OPTIMAL CARE PLUS, INC. , a Delaware corporation (“ Optimal Care ”),  INFINITY INFUSION, LLC , a Delaware limited liability company (“ Infinity ”), INFINITY INFUSION II, LLC , a Delaware limited liability company (“ Infinity II ”), INFINITY INFUSION CARE, LTD. , a Texas limited partnership (“ Infinity Infusion ”), MEDCARE, INC. , a Delaware corporation (“ Medcare ”), CURATIVE PHARMACY SERVICES, INC. , a Delaware corporation (“ CPS ”), CURATIVE HEALTH SERVICES CO. , a Minnesota corporation formerly known as Curative Health Services, Inc. (“ CHSC ”), CRITICAL CARE SYSTEMS, INC. , a Delaware corporation (“ CCS ”) (Holdings, eBioCare, Hemophilia Access, Apex, CHS, CHSNY, Optimal Care, Infinity, Infinity II, Infinity Infusion, Medcare, CPS, CHSC and CCS are sometimes collectively referred to herein as the “ Borrowers ”nd individually as a “ Borrower ”), CURATIVE HEALTH SERVICES III CO. (“ Guarantor ”) Minnesota corporation, and GENERAL ELECTRIC CAPITAL CORPORATION , a Delaware corporation (“ GE Capital ”), as Agent and Lender.

RECITALS:

A. Pursuant to that certain Forbearance Agreement dated December 1, 2005 by and between Borrowers and GE Capital (the “ Forbearance Agreemen t ”), GE Capital agreed to forbear on certain of its rights and obligations under an Amended and Restated Credit Agreement, dated April 23, 2004, as amended by (i) that certain First Amendment to Amended and Restated Credit Agreement and Collateral Documents dated as of May 3, 2004, (ii) that certain Second Amendment to Amended and Restated Credit Agreement dated as of June 30, 2004, (iii) that certain Third Amendment to Amended and Restated Credit Agreement dated as of October 20, 2004 and (iv) that certain Fourth Amendment to Amended and Restated Credit Agreement dated as of December 31, 2004 (as so amended, the “ Credit Agreement ”);

B. The parties hereto have agreed to amend certain terms of the Forbearance Agreement upon the terms and conditions and other requirements set forth herein.

NOW, THEREFORE, in consideration of the foregoing, the terms and conditions set forth in this Amendment, and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, GE Capital, the Borrowers and Guarantor agree as follows:

1.   Definitions :  Unless otherwise defined herein, all capitalized terms herein shall have the meanings assigned to such terms in the Forbearance Agreement.

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