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CONVERTIBLE PROMISSORY NOTE AGREEMENT

Convertible Promissory Note

CONVERTIBLE PROMISSORY NOTE AGREEMENT | Document Parties: BOSTON LIFE SCIENCES INC /DE You are currently viewing:
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BOSTON LIFE SCIENCES INC /DE

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Title: CONVERTIBLE PROMISSORY NOTE AGREEMENT
Date: 3/28/2007
Industry: Biotechnology and Drugs     Sector: Healthcare

CONVERTIBLE PROMISSORY NOTE AGREEMENT, Parties: boston life sciences inc /de
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                                                                    EXHIBIT 10.1

NEITHER THIS NOTE PURCHASE, THE NOTES ISSUED HEREUNDER NOR THEE SECURITIES
ISSUABLE UPON CONVERSION OF THE NOTES HAVE BEEN REGISTERED UNDER THE SECURITIES
ACT OF 1933, AS AMENDED (THE "ACT"), NOR UNDER ANY STATE SECURITIES LAWS AND
NONE OF THE FOREGOING MAY BE PLEDGED, SOLD, ASSIGNED OR OTHERWISE TRANSFERRED
UNTIL A (1) REGISTRATION STATEMENT UNDER THE ACT AND ANY APPLICABLE STATE
SECURITIES LAW HAS BECOME EFFECTIVE WITH RESPECT THERETO, OR (2) RECEIPT BY THE
COMPANY OF AN OPINION OF COUNSEL TO THE COMPANY TO THE EFFECT THAT REGISTRATION
UNDER THE ACT OR APPLICABLE STATE SECURITIES LAW IS NOT REQUIRED IN CONNECTION
WITH THE PROPOSED TRANSFER

                 CONVERTIBLE PROMISSORY NOTE PURCHASE AGREEMENT

     This CONVERTIBLE PROMISSORY NOTE PURCHASE AGREEMENT, dated as of March 22,
2007, is made between the purchasers listed on Schedule 2.1 hereto (each a
"PURCHASER" and collectively, the "PURCHASERS"), and BOSTON LIFE SCIENCES, INC.,
a Delaware corporation (the "COMPANY").

                                    RECITALS

     WHEREAS, the Company requires certain funds for the operation of its
business; and

     WHEREAS, the Purchasers are willing to provide the Company with such funds
through the purchase of the Convertible Notes (as defined below) on the terms
and conditions hereafter provided;

     NOW, THEREFORE, in order to induce Purchasers to purchase the Convertible
Notes and for other good and valuable consideration, the receipt and adequacy of
which are hereby acknowledged, and intending to be legally bound, the Purchasers
and the Company hereby agree as follows:

     1. DEFINED TERMS. When used in this Agreement the following terms shall
have the following meanings (such meanings being equally applicable to both the
singular and plural forms of the terms defined):

     "AFFILIATES" shall mean any corporation, company, partnership, joint
venture and/or firm that controls, is controlled by, or is under common control
with the Company. For purposes of this definition, "control" shall mean (a) in
the case of corporate entities, direct or indirect ownership of at least fifty
percent (50%) of the stock or shares having the right to vote for the election
of directors and (b) in the case of non-corporate entities, direct or indirect
ownership of at least fifty percent (50%) of the equity interest with the power
to direct the management and policies of such non-corporate entities.

     "AGREEMENT" means this Convertible Promissory Note Purchase Agreement, as
it may be amended or modified and in effect from time to time.

     "BUSINESS DAY" means any day other than a Saturday, Sunday, or other day on
which commercial banks in the Commonwealth of Massachusetts are authorized or
required to close.

     "COMMON STOCK" means the common stock, $0.01 par value per share, of the
Company.

     "CONVERTIBLE NOTES" shall have the meaning assigned to such term in Section
2.1 hereof.

<PAGE>

     "EFFECTIVE DATE" means the date of this Agreement.

     "EXCHANGE ACT" means the Securities Exchange Act of 1934, as amended.

     "EVENT OF DEFAULT" shall have the meaning assigned to such term in Article
IX hereof.

     "FIRST COMMERCIAL SALE" shall mean, with respect to each Molecular Imaging
Product, the first commercial sale in a country as part of a nationwide
introduction by the Company, its Affiliates or its or its Affiliates' licensees
or sublicensees.

     "HIGHEST LAWFUL RATE" means the maximum lawful interest rate, if any, that
at any time or from time to time may be contracted for, charged, or received
under the laws applicable to the Purchasers which are presently in effect or, to
the extent allowed by law, under such applicable laws which allow a higher
maximum nonusurious interest rate than applicable laws now allow.

     "LOAN DOCUMENTS" means collectively, this Agreement and the Convertible
Notes.

     "MATURITY DATE" means the earliest to occur of (a) December 31, 2010 and
(b) the date on which a Purchaser declares a Default (as defined in Section 9
below) to have occurred.

     "MOLECULAR IMAGING PRODUCTS" shall mean products approved for sale by the
appropriate U.S. and/or foreign regulatory body containing as the active
ingredient the Company's radio-labeled molecular imaging agents, currently in
development or developed by the Company in the future, including, without
limitation, the ALTROPANE(R) and FLUORATEC molecular imaging agents, for the
diagnosis and monitoring of Parkinson's Disease and Attention Deficit
Hyperactivity Disorder using SPECT or PET camera imaging techniques.

     "NET SALES" shall mean the gross amount received by the Company, its
Affiliates and/or its or its Affiliates' licensees or sublicensees on sales or
other dispositions of Molecular Imaging Products to Third Parties (other than
licensees or sublicensees) in bona fide, arm's-length transactions, less the
following deductions:

     (a) Trade, cash and/or quantity discounts actually allowed and taken
directly with respect to such sales, as reflected in the amount invoiced;

     (b) Tariffs, duties, excises, sales taxes or other taxes imposed upon and
paid directly by the Company with respect to the production, sale, delivery or
use of the Molecular Imaging Product (excluding national, state or local taxes
based on income), as reflected in the amount invoiced;

     (c) Amounts repaid or credited by reason of rejections, defects, recalls or
returns, or because of chargebacks, refunds, rebates, retroactive price
reductions or delayed ship orders;

     (d) Amounts credited for uncollectible amounts on previously sold products;

     (e) Freight, insurance and other transportation charges incurred in
shipping a Molecular Imaging Product to Third Parties, as reflected in the
amount invoiced;

     (f) Deduction of one percent (1%) for distribution and warehousing
expenses; and


                                      -2-

<PAGE>

     (g) Any other reduction or specifically identifiable amounts included in
the gross invoice that are creditable for reasons substantially equivalent to
those listed above.

     Notwithstanding anything in this Agreement to the contrary, "NET SALES"
shall exclude any sales or other disposition of Molecular Imaging Products for
test marketing, clinical trial purposes or compassionate or similar use.

     Net Sales amounts shall be determined from the books and records of the
Company, its Affiliates and/or its or its Affiliates' licensees or sublicensees,
maintained in accordance with generally accepted accounting principles,
consistently applied.

     Sales between or among the Company, its Affiliates or their respective
licensees and sublicensees shall be disregarded for purposes of calculating Net
Sales. In the case of any sale or other disposal of a Molecular Imaging Product
between or among the Company and its Affiliates, licensees and sublicensees, for
resale, Net Sales shall be calculated as above only on the value charged or
invoiced on the first arm's-length sale thereafter to a Third Party.

     In the case of any sale or other disposal for value, such as barter or
counter-trade, of any Molecular Imaging Product, or part thereof, other than in
an arm's-length transaction exclusively for money, Net Sales shall be calculated
as above on the value of the non-cash consideration received or the fair market
price (if higher) of the Molecular Imaging Product in the country of sale or
disposal.

     In the event the Molecular Imaging Product is sold in a finished dosage
form in combination with one or more other active ingredients (a "COMBINATION
PRODUCT"), the Net Sales of the Molecular Imaging Product, for the purposes of
determining royalty payments, shall be determined by multiplying the Net Sales
(as defined above) of the Combination Product by the fraction, 'A/(A+B)' where
'A' is the weighted (by sales volume) average sale price in the relevant country
of the Molecular Imaging Product when sold separately in finished form and 'B'
is the weighted average sale price in that country of the other product(s) sold
separately in finished form. In the event that such average sale price cannot be
determined for both the Molecular Imaging Product and the other product(s) in
the Combination Product, Net Sales for purposes of determining royalty payments
shall be agreed by the Parties based on the relative value contributed by each
component, such agreement not to be unreasonably withheld.

     "OBLIGATIONS" means all unpaid principal of and accrued and unpaid interest
on the Convertible Notes, and all other obligations, interest, fees, charges and
expenses of the Company to the Purchasers arising under the Loan Documents.

     "PRE-COMMERCIAL INCOME" shall mean, with respect to each Molecular Imaging
Product, all license fees, milestone payments and other amounts received by the
Company and/or its Affiliates from Third Parties in connection with or related
to the licensing or sublicensing to such Third Parties of the Company's and/or
its Affiliate's rights under the intellectual property covering the Molecular
Imaging Product. Notwithstanding anything in the foregoing to the contrary,
"Pre-Commercial Income" shall exclude (a) any royalty payments or milestone
payments based upon commercial sales levels, (b) amounts received for research
and development activities undertaken for, or in collaboration with, such Third
Parties, (c) amounts received for debt or equity securities of the Company
and/or its Affiliates, provided that any amounts received in excess of the then
current fair market value of such debt or equity securities shall, to the extent
of such excess, be deemed to be Pre-Commercial Income, and (d) transfer pricing
amounts paid in respect of Molecular Imaging Products supplied to such Third
Parties.


                                      -3-

<PAGE>

     "SECURITIES ACT" means the Securities Act of 1933, as amended.

     "THIRD PARTY" shall mean any person or entity other than the Company or any
of its Affiliates.

     "VALID CLAIM" means a claim of any issued, unexpired United States or
foreign patent, which shall not be disclaimed, nor held invalid or unenforceable
by a court of competent jurisdiction in an unappealed or unappealable decision.

     2. CONVERTIBLE NOTE FACILITY.

          2.1 PURCHASE AND SALE OF CONVERTIBLE NOTES. At each Closing (as
defined below), each Purchaser agrees, severally and not jointly, on the terms
of and subject to the conditions specified in this Agreement, to purchase from
the Company, according to each Purchaser's pro rata share (based upon the
respective "Commitment Percentage" of each Purchaser as set forth on Schedule
2.1 attached hereto), and the Company agrees to sell to the Purchasers,
convertible promissory notes dated as of the date of such Closing in the form
attached to this Agreement as Exhibit A (the "CONVERTIBLE NOTES"); provided,
however, that in no event shall the Purchasers be obligated hereunder to
purchase, in the aggregate, more than a principal amount of Fifteen Million
Dollars ($15,000,000) of Convertible Notes.

          2.2 ADVANCES. From time to time prior to December 31, 2007, and so
long as no Default then exists, the Purchasers shall make advances (the
"ADVANCES") to the Company based upon their respective Commitment Percentage,
and the Company may borrow funds from the Purchasers hereunder. Each request for
an Advance shall be made by the Company in writing, delivered to the Purchasers
at least seven (7) business days prior to the requested date of such Advance
(the "ADVANCE NOTICE") and shall specify the date of such Advance, and the
amount of such Advance. Each Advance shall be in the minimum amount of
$3,000,000. The Purchasers shall, and each Purchaser is hereby authorized to,
record on the schedule attached hereto, or to otherwise record in accordance
with its usual practice, the date and amount of each Advance and the date and
amount of each principal payment hereunder (a "PAYMENT"), provided, however,
that any failure to so record any Advance or Payment shall not in any manner
affect the obligation of the Company to repay any Advance in accordance with the
terms hereof. Each Advance shall be documented by a new Convertible Note to be
issued by the Company, dated as of the date of such Advance.

          2.3 CLOSING. The closing of the issuance and sale of each Convertible
Note issued hereunder and representing an Advance shall be held at the offices
of counsel to the Company at 10:00 a.m. on the date set forth in each Advance
Notice, or at such other time and place as the Company and each Purchaser
mutually agree in writing (each such date, a "CLOSING").

          2.4 PAYMENT OF CONVERTIBLE NOTE PURCHASE PRICE. At each Closing, (i)
the Company shall deliver to each Purchaser a Convertible Note in the amount of
the Advance from each Purchaser at such Closing, and (ii) as payment in full for
the Convertible Note being purchased by each Purchaser at such Closing, each
Purchaser shall pay its respective purchase amount to the Company by wire
transfer of immediately available funds to an account designated by the Company
in the Advance Notice.

          2.5 INTEREST. Interest shall accrue on each Convertible Note from the
date of issuance until such Convertible Note is paid in full or otherwise
converted pursuant to Section 4 hereof. The Company promises to pay interest on
the outstanding principal amount of each Convertible Note (i) until the Maturity
Date, or if earlier, conversion pursuant to Section 4 hereof, at a per annum
interest rate


                                      -4-

<PAGE>

equal to five percent (5%), (ii) from and after the Maturity Date, or during the
continuance of an Event of Default, at a per annum rate equal to ten percent
(10%) or (iii) if less than the rates applicable under both clauses (i) and
(ii), the Highest Lawful Rate. Interest shall be calculated on the basis of a
360-day year for the actual number of days elapsed. Interest shall accrue until
paid in full and all unpaid interest shall be due and payable on the Maturity
Date, unless otherwise converted pursuant to Section 4 hereof.

          2.6 METHOD OF PAYMENT. All payments of principal, interest, and fees
hereunder shall be made on the date when due in immediately available funds in
United States Dollars to the Purchasers at the Purchaser's address specified on
the signature page hereof, or at such other address as shall be directed by the
applicable Purchaser in a writing received by the Company.

          2.7 PREPAYMENTS. The Company may not prepay any amounts under any
Convertible Notes whether principal or interest.

          2.8 USURY SAVINGS CLAUSE. Notwithstanding any other provision herein,
the aggregate interest rate charged with respect to any of the Obligations,
shall not exceed the Highest Lawful Rate. If the rate of interest (determined
without regard to the preceding sentence) under this Agreement at any time
exceeds the Highest Lawful Rate, the outstanding amount under the Convertible
Notes issued hereunder shall bear interest at the Highest Lawful Rate until the
total amount of interest due hereunder equals the amount of interest which would
have been due hereunder if the stated rates of interest set forth in this
Agreement had at all times been in effect. In addition, if when the Convertible
Notes issued hereunder are repaid in full the total interest due hereunder is
less than the total amount of interest which would have been due hereunder if
the stated rates of interest set forth in this Agreement had at all times been
in effect, then to the extent permitted by law, the Company shall pay to
Purchasers an amount equal to the difference between the amount of interest paid
and the amount of interest which would have been paid if the Highest Lawful Rate
had at all times been in effect. Notwithstanding the foregoing, it is the
intention of Purchasers and the Company to conform strictly to any applicable
usury laws. Accordingly, if the Purchasers contract for, charge, or receive any
consideration which constitutes interest in excess of the Highest Lawful Rate,
then any such excess shall be cancelled automatically and, if previously paid,
shall be applied to the outstanding principal amount of the Convertible Notes
issued hereunder or be refunded to the Company.

     3. CONDITIONS PRECEDENT. The obligations of the Purchasers to purchase any
Convertible Notes shall be subject to the following conditions precedent that on
the date of the Closing:

          3.1 Each of the representations and warranties of the Company
contained in this Agreement and the Loan Documents shall be true and correct in
all material respects; and

          3.2 At the time of, and immediately after giving effect to, the
issuance of such Convertible Notes, no Event of Default shall have occurred and
be continuing.

     4. OPTIONAL CONVERSION.

          4.1 CONVERSION TO EQUITY.

               (a) After December 31, 2007, at any time during which Convertible
Notes remain outstanding, up to all of the outstanding principal and accrued
interest under any particular Convertible Note then outstanding may be
converted, at the sole option of the holder thereof and by


                                       -5-

<PAGE>

written notice to the Company, into shares of Common Stock of the Company at a
conversion price equal to $2.50 per share.

               (b) Notwithstanding anything to the contrary contained herein,
each Purchaser shall be prohibited from effecting a conversion pursuant to this
Section 4.1 if at the time of such conversion (i) the Common Stock issuable to
such Purchaser pursuant to such conversion or as a result of such conversion,
when taken together with all shares of Common Stock then held or otherwise
beneficially owned by such Purchaser exceeds 19.9% of the total number of issued
and outstanding shares of Common Stock of the Company immediately prior to such
conversion, (ii) the Common Stock issuable to such Purchaser pursuant to such
conversion or as a result of such conversion, exceeds 19.9% of the total number
of issued and outstanding shares of Common Stock of the Company immediately
prior to su


 
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