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CONVERTIBLE PROMISSORY NOTE

Convertible Promissory Note

CONVERTIBLE PROMISSORY NOTE
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This Convertible Promissory Note involves

DERMISONICS, INC

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Title: CONVERTIBLE PROMISSORY NOTE
Governing Law: Nevada     Date: 1/18/2006

CONVERTIBLE PROMISSORY NOTE
, Parties: dermisonics  inc
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"NEITHER   THIS   PROMISSORY   NOTE   NOR   THE   SECURITIES   INTO   WHICH THIS NOTE IS
CONVERTIBLE   HAVE   BEEN   REGISTERED   UNDER   THE   U.S. SECURITIES ACT OF 1933, AS
AMENDED (THE "SECURITIES ACT") OR ANY OTHER SECURITIES LAWS AND HAVE BEEN ISSUED
IN   RELIANCE UPON THE EXEMPTION FROM SUCH REGISTRATION CONTAINED IN REGULATION S
UNDER   THE   SECURITIES   ACT.   THE SECURITIES REPRESENTED BY THIS CERTIFICATE MAY
NOT   BE   OFFERED, SOLD OR TRANSFERRED WITHIN THE UNITED STATES OR TO, OR FOR THE
ACCOUNT   OR BENEFIT OF, ANY "U.S. PERSON" (AS SUCH TERM IS DEFINED IN REGULATION
S)   EXCEPT IN ACCORDANCE WITH REGULATION S, PURSUANT TO A REGISTRATION UNDER THE
SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM REGISTRATION UNDER THE
SECURITIES   ACT."

                            CONVERTIBLE PROMISSORY NOTE

$50,000.00                                                      December 21, 2005

FOR   VALUE RECEIVED, DERMISONICS, INC., a Nevada corporation having an office at
Four   Tower   Bridge,   200   Bar   Harbor   Drive,   West Conshohocken, Pennsylvania,
19428-2977   U.S.A.   (the   "Company"),   hereby promises to pay to Parmino Finance
Ltd.   at   Zurich, Switzerland, or its duly registered assigns (each a "Holder"),
on   December   21,   2007 ("Maturity"), or earlier upon prepayment of this Note as
provided   herein,   the   principal   sum   of US $50,000.00, together with interest
(computed on the basis of a 364-day year) on the unpaid principal balance at the
rate   of   12%   per   annum,   payable   on the first anniversary of the Note and at
Maturity.

     The   principal   amount of this Note and all accrued interest thereon may be
prepaid   by   the   Company   upon   60 day's prior written notice to the Holder and
payment   of   a   prepayment penalty equal to two months' interest, subject to the
Holder's   conversion   rights.   Upon any prepayment of this Note, all accrued but
unpaid   interest on the principal amount shall be paid to the Holder on the date
of   prepayment.   All   payments hereunder shall be applied first to interest then
to   principal.

      All   payments of principal and interest shall be made in lawful currency of
the   United   States   of America in immediately available funds before 11:00 a.m.
California   time   on   the   due date thereof at the coordinates for the Holder on
file   with   the   Company,   or in such other manner or at such other place as the
Holder   of   this   Note   designates   in   writing.

     Subject to and in compliance with the provisions hereof, the Holder may, on
the   due   date   hereof   or   on any prepayment date hereunder, convert all or any
portion   of   the


                                        1
<PAGE>
outstanding   principal   balance   of   this   Note as of such payment or prepayment
date,   and   all or any portion of the interest accrued hereon to such date, into
shares   ("Conversion   Shares")   of   the   common   stock,   $.005 par value, of the
                                                         -----
Company   (the   "Common   Stock"), at a conversion price equal to the lesser of US
$1.00   or   80% of the average closing bid price per share of Common Stock during
           ---
the 10 trading days immediately prior to any such conversion.   The Holder hereof
shall   communicate   its intention to convert all or any portion of the principal
amount   of   this   Note   and   all or any portion of interest accrued through such
conversion   date   by surrendering this Note, with the Form of Notice of Election
to   Convert   attached   hereto   duly   completed and signed, to the Company at its
address   for   notice   set   forth   elsewhere   herein.

     In   the   event   of   a conversion by the Holder of all or any portion of the
outstanding   principal   balance   of   this Note and all or any portion of accrued
interest   thereon   into   shares   of the Common Stock, the Company will issue and
deliver   to   the Holder, as soon as practical after the Company's receipt of the
Notice   of Election a certificate evidencing the shares of Common Stock issuable
upon   any   such   conversion.

     If   the   Holder   elects to convert less than the entire principal amount of
this Note and interest accrued to the date of such conversion, the Company shall
issue   or   cause to be issued and delivered to the Holder, at its expense, a new
promissory   note   evidencing   the   outstanding amount of principal due hereunder
after   giving   effect   to   the   amount   applied   to   the   conversion, which such
promissory   note   shall, except as to the principal amount thereof, be identical
to   this   Note   in   all   respects.

     The   Company covenants that it will at all times reserve and keep available
out   of   the   aggregate   of its authorized but unissued and otherwise unreserved
Common   Stock,   solely for the purpose of enabling it to issue Conversion Shares
upon conversion of this Note as herein provided, the number of Conversion Shares
which are then issuable and deliverable upon the conversion of the entire amount
due   under   this   Note,   free   from   preemptive   rights   or any other contingent
purchase rights of persons other than the Holder. The Company covenants that all
Conversion Shares so issuable and deliverable shall, upon issuance in accordance
with the terms hereof, be duly and validly authorized, issued and fully paid and
nonassessable.

     Except   as   provided   elsewhere herein, if the Company shall fail to make a
payment of principal or interest when due and such failure shall continue for 10
days   after   notice of such failure; or shall make an assignment for the benefit
of   creditors,   file   a   petition   in   bankruptcy,   be   adjudicated insolvent or
bankrupt,   suffer an order for relief under any federal bankruptcy law, petition
or   apply   to   any   tribunal for the appointment of a custodian, receiver or any
trustee for the Company or any substantial part of its assets, or shall commence
any   proceeding   under   any   bankruptcy,


                                        2
<PAGE>
reorganization,   arrangement,   readjustment   of debt, dissolution or liquidation
law   or   statue   of   any jurisdiction, whether now or hereafter in effect; or if
there   shall   have   been   filed   any   such   petition or application, or any such
proceeding   shall   have   been   commenced   against   the   Company,   which   remains
undismissed,   unstayed   or   unbonded   for a period of 30 days or more; or if the
Company,   by   any   act   or   omission   shall   indicate   consent   to,   approve   or
acquiescence   in any such petition, application or proceeding or the appointment
of   a   custodian, receiver or any trustee for all or any substantial part of its
properties,   or   if the Company shall allow such custodianship, receivership, or
trusteeship   to   continue   undischarged, unstayed or unbonded for a period of 30
days   or   more,   or   the Company violates any term or provision of this Note and
same   remains uncured for a period of 30 days after notice thereof by the Holder
of   this   Note,   then and in any such event, the outstanding principal amount of
this   Note,   together with all accrued and unpaid interest thereon, shall be and
become   immediately   due   and   payable.

     Anything   contained   in   this   Note to the contrary notwithstanding, in the
event   this   Note is placed in default as a result of the Company's inability to
pay the amounts due hereunder when due, the C


 
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