CONTRIBUTION AGREEMENT

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Exhibit 4.8

CONTRIBUTION AGREEMENT

This CONTRIBUTION AGREEMENT (as the same may be amended, restated,

supplemented or otherwise modified from time to time, this "Agreement") dated as

of December 13, 2004 is by and between Flavin Ventures, LLC, a Delaware limited

liability company ("Flavin Ventures"), and the Michael T. Flavin Revocable

Trust, an Illinois trust (the "Trust").

WITNESSETH:

WHEREAS, Advanced Life Sciences, Inc., an Illinois corporation

("ALS"), is undergoing a recapitalization and reorganization as of the date

hereof (the "Recapitalization"); and

WHEREAS, in connection with the Recapitalization, the Trust

transferred to Holdings 400,000 shares of common stock, no par value, of ALS

and, in exchange, Holdings delivered to the Trust 400,000 shares of common

stock, $.01 par value per share, of Holdings (the "Holdings Shares"), pursuant

to that certain ALS Exchange Agreement dated as of the date hereof among

Holdings, the Trust and Karen Stec (the "Exchange Agreement"); and

WHEREAS, the Trust desires to contribute the Holdings Shares to Flavin

Ventures as a Capital Contribution (as defined in the Limited Liability Company

of Flavin Ventures, LLC dated as of September 30, 2002, referred to herein as

the "LLC Agreement").

NOW, THEREFORE, in consideration of such benefits and for other good

and valuable consideration, the receipt and sufficiency are hereby acknowledged,

Flavin Ventures and the Trust hereby agree as follows:

Section 1. CONTRIBUTED ASSETS. The Trust hereby conveys, grants, assigns

and transfers the Holdings Shares to Flavin Ventures as a Capital Contribution,

which Capital Contribution shall be governed by the terms of the LLC Agreement.

Section 2. FURTHER ASSURANCES. If at any time the members of Flavin

Ventures determine that any further deeds, bills of sale, assignments or

assurances in law or any other things are necessary or desirable to vest,

perfect or confirm, of record or otherwise, in Flavin Ventures, the right, title

or interest in the Holdings Shares, the Trust shall execute and deliver all such

proper deeds, bills of sale, assignments and assurances in law and do any an