FIRST AMENDMENT TO AMENDED AND RESTATED ADVISORY AGREEMENT

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SENIOR HOUSING PROPERTIES TRUST | REIT MANAGEMENT & RESEARCH LLC

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Title: FIRST AMENDMENT TO AMENDED AND RESTATED ADVISORY AGREEMENT
Date: 6/12/2008
Industry: Real Estate Operations Sector: Services

EXHIBIT 10.1

FIRST AMENDMENT TO AMENDED AND RESTATED ADVISORY AGREEMENT

THIS FIRST AMENDMENT TO AMENDED AND RESTATED ADVISORY AGREEMENT (this " Amendment ") is dated as of as of June 11, 2008, by and between SENIOR HOUSING PROPERTIES TRUST , a Maryland real estate investment trust (the " Company "), and REIT MANAGEMENT & RESEARCH LLC , a Delaware limited liability company (the " Advisor ").

RECITAL:

The Company and the Advisor are parties to an Amended and Restated Advisory Agreement, dated as of January 1, 2006 (the " Advisory Agreement ").

The Company and the Advisor wish to amend the Advisory Agreement to adjust the calculation of the Advisory Fee (as defined therein) with respect to certain medical office buildings, clinics and biomedical, pharmaceutical and laboratory buildings which the Company has contracted to buy from HRPT Properties Trust and/or certain of its subsidiaries (" HRPT ") pursuant to various purchase and sale agreements, all dated as of May 5, 2008 (collectively, the " Purch

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