AMENDMENT NO. 1 TO COLLABORATION AND LICENSE AGREEMENT

Collaboration Agreement

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Title: AMENDMENT NO. 1 TO COLLABORATION AND LICENSE AGREEMENT
Date: 3/10/2005
Industry: Biotechnology and Drugs Sector: Healthcare

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Exhibit 10.7

AMENDMENT NO. 1 TO

COLLABORATION AND LICENSE AGREEMENT

This Amendment No. 1, effective as of the last day entered below, amends

the Collaboration and License Agreement (the "Agreement"), dated January 22,

1999, between Professor Jay N. Cohn ("LICENSOR") and NITROMED, INC.

("NitroMed").

In consideration of the terms and conditions set forth in the Agreement,

and other good and valuable consideration, the receipt and sufficiency of which

are hereby acknowledge

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