2005 AMENDMENT TO AGILENT/BRUKER ITMS COLLABORATION AGREEMENT

QuickLinks -- Click here to rapidly navigate through this document

Exhibit 10.27

2005 AMENDMENT TO AGILENT/BRUKER ITMS COLLABORATION AGREEMENT
AND AGILENT/BRUKER OEM AGREEMENT ("2005 AMENDMENT")

        This amendment to the agreements referenced above and described in more detail below, effective February 25, 2005 (the "Effective Date of this 2005 Amendment"), represents a definitive agreement between Agilent and Bruker as to the terms stated herein below.

        Hewlett-Packard Company and Bruker Daltonik GmbH ("Bruker") entered into an Agreement titled ITMS Collaboration Agreement, effective as of April 28, 1999 (the "ITMS Collaboration"), which is operating and currently in effect for an extension term as of the Effective Date of this 2005 Amendment. Bruker and Hewlett-Packard Company entered into an original equipment manufacturer agreement ("OEM Agreement"), dated January 1, 1999, also operating and currently in effect for an extension term. Both Agreements have been amended from time to time. Hewlett Packard Company assigned to and Agilent Technologies, Inc. ("Agilent") assumed the rights and obligations of the ITMS Collaboration, the OEM Agreement, various amendments to both agreements, and all purchase agreements attendant thereto.

        For good and valuable consideration deemed paid and received, the parties hereby agree as follows:

        1.     As of the Effective Date of this 2005 Amendment, Agilent will include on Exhibit 1004 to the OEM Agreement its current HPLC Infusion Chip: Product # G4240-61001; the HPLC Analytical Chip: Product #G4240-62001 as well as the HPLC-Chip Cube Interface: Product #G4240A provided that use by Bruker is solely for and with Bruker's ITMS and FTMS products. BRUKER understands that the HPLC Chip Cube Interface shall require use of an Agilent "HPLC-Chip and nanoLC-Pump." Agilent understands that Bruker shall be technically enabled by Agilent (in accordance with Section 4 of the Amendment to the ITMS Collaboration and OEM Agreement dated February 28, 2003) to run Agilent's HPLC-Chip product, accessories, and interfaces with Bruker software. Agilent agrees to include in the OEM agreement successor products and chip versions that replace the present HPLC-Infusion Chip, the HPLC Analytical Chip, and the HPLC-Chip Cube Interface each as described above.

        2.     Bruker shall immediately make Gemini II electronics available to Agilent for testing and evaluation within one week of the Effective Date of this 2005 Amendment, and promptly for any subsequent production deliveries that Agilent shall require or request.

        3.