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DURECT CORPORATION EXECUTIVE CHANGE OF CONTROL POLICY

Change of Control Agreement

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This Change of Control Agreement involves

DURECT CORPORATION

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Title: DURECT CORPORATION EXECUTIVE CHANGE OF CONTROL POLICY
Date: 9/30/2008
Industry: Biotechnology and Drugs     Sector: Healthcare

DURECT CORPORATION EXECUTIVE CHANGE OF CONTROL POLICY, Parties: durect corporation
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Exhibit 10.51

DURECT CORPORATION

EXECUTIVE CHANGE OF CONTROL POLICY

This Executive Change of Control Policy (the “ Policy ”) is effective as of April 7, 2004, as amended on September 25, 2008.

POLICY GOALS

A. It is expected that the Company from time to time will consider the possibility of an acquisition by another company or other change of control transaction. The Board of Directors of the Company (the “ Board ”) recognizes that such consideration can be a distraction to officers of the Company and can cause these individuals to consider alternative employment opportunities. The Board has determined that it is in the best interests of the Company and its stockholders to assure that the Company will have the continued dedication and objectivity of its officers, notwithstanding the possibility, threat or occurrence of a Change of Control (as defined below) of the Company.

B. Accordingly, the Board believes that it is in the best interests of the Company and its stockholders to provide officers with an incentive to continue their employment and to motivate such individuals to maximize the value of the Company upon a Change of Control for the benefit of its stockholders by providing them with certain benefits upon a Change of Control that provide them with enhanced financial security and incentive notwithstanding the possibility or occurrence of a Change of Control.

POLICY

1. ELIGIBILITY. This Policy shall be applicable to each individual who is an employee of the Company holding a position of Vice President (or equivalent position) or higher as of the effective date of a Change of Control or who held such a position with the Company within 90 days of such date but whose employment terminated under the conditions specified in Section 3 below (each, an “ Officer ”); provided, however, that the terms of this Policy will not apply to any Officer who is party to one or more agreements with the Company providing for specified benefits to the Officer upon or in connection with a Change of Control unless such Officer expressly consents (by executing the acknowledgment provided below) to becoming a participant eligible to receive benefits under this Policy and thereby expressly waiving and forfeiting any rights or claims he or she has or may have under any such prior agreement(s). Once acknowledged below, the terms of this Policy shall constitute the entire agreement between the Officer and the Company as to the subject matter covered by the Policy and such terms may thereafter be amended only by a written agreement signed by the Officer and, following approval by the Company’s Board or a Committee thereof, a duly authorized officer of the Company.

2. AT-WILL EMPLOYMENT . Unless otherwise agreed to expressly by the Company and an Officer through a separate written agreement which remains in effect after the Officer becomes eligible to receive benefits under this Policy, each Officer’s employment is and shall continue to be on an at-will basis, meaning that either the Officer or the Company (or its successor) can terminate their employment relationship with each other at any time for any or no reason. Nothing in this Policy shall give an Officer any benefits whatsoever in the event the Officer’s employment terminates in a manner that is not in connection with a Change of Control.

3. SEPARATION BENEFITS UPON INVOLUNTARY TERMINATION FOLLOWING CHANGE OF CONTROL . If, in connection with and within 90 days prior to a Change of Control, or within twenty-four (24) months following the effective date of a Change of Control, the Officer’s employment with the Company (or its successor) is terminated by the Company or the successor without Cause or the Officer experiences a Constructive Termination (in each case as defined below), then subject to Sections 3(c), 4 and 5 below the Officer will be entitled to the following benefits:

(a) Vesting Acceleration. The remaining unvested portion of any such stock options or shares of stock held by the Officer as of the effective date of the employment termination shall automatically be accelerated so as to become completely vested and exercisable (and any such right of repurchase or forfeiture provision shall lapse in full) as of the effective date of such termination; and

(b) Cash Benefits. The Officer will be entitled to payment of an amount equal in aggregate to his or her then-current annual base salary, payable in equal installments (on the Company’s normal payroll schedule and subject to applicable withholdings) over the 12 months following the date of employment termination; provided however that this Section 3(b) shall be subject to Section 5(c) below; and provided further that the Company’s obligations to make any payments under this Section 3(b) is subject to Section 3(c) below.

(c) Conditions to Payment of Benefits. Notwithstanding anything else to the contrary contained herein, no Officer shall be entitled to payment of any benefits provided under this Section 3 or otherwise under this Policy unless and until (1) the Company (or its successor) shall have received from the Officer an effective release releasing the Company (or its successor) from any and all claims Officer may have against such entities related to or arising in connection with his or her employment, the terms of such employment and termination thereof, and (2) the Officer is in compliance and continues to be in compliance with the covenants contained in Section 4 below (the “ Covenants ”), which Covenants shall be acknowledged and agreed to by the Officer upon his or her executing this Policy in the


acknowledgment signature block below. Each Officer further acknowledges and agrees that any breach by him or her of the Covenants at any time during the period specified in Section 4 below will cause irreparable damage to the Company and that in the event of such breach the Company shall have, in addition to any and all remedies of law, the right to an injunction, specific performance or other equitable relief to prevent the violation of his or her obligations hereunder, without showing or proving actual damages or exhausting any Company remedy in the form of money damages and without having to post a bond or any other security. In addition, in the event of any breach of the Covenants by the Officer, the Company will be entitled without further liability to cease any and all payments yet to be made to the Officer under Section 3(b) above.

4. COVENANTS. During his or her employment with the Company, the Officer agrees to devote his or her full time and best efforts to the business of the Company, and the Officer further agrees that during his or her employment with the Company and for any period thereafter for which he or she is receiving or has received payment of cash severance under Section 3(b) above (but in any event not exceeding two years), he or she will not, directly or indirectly, act as a partner, joint venturer, consultant, officer, director, employee, agent, independent contractor or stockholder of any company or business organization (including any unit or division of any company or organization) whose business is the development and marketing of products and services that are directly competitive with the products and services being developed and marketed by the Company immediately prior to the Change of Control; provided, however , that the record or beneficial ownership by the Officer of 5% or less of the outstanding publicly traded capital stock of any such company shall not be deemed, in and of itself, to be in violation of the Covenants set forth in this Section 4.

5. TAXES.

(a) General Withholding Tax Obligations. The Officer shall be responsible for any income, excise or other taxes imposed on the Officer under applicable law with respect to the benefits provided hereunder, including without limitation delivering to the Company (or its successor) any amounts necessary to timely satisfy any applicable withholding tax obligations. The Officer’s receipt of any benefit hereunder is conditioned on his or her satisfaction of any applicable withholding or similar obligations that apply to such benefit, and any cash payment owed hereunder will be reduced to satisfy any such withholding or similar obligations that may apply.

(b) Limitation on Payments. In the event that the benefits provided for under this Policy (x) constitute “parachute payments” within the meaning of Section 280G of the Internal Revenue Code of 1986, as amended (the “ Code ”), and (y) but for this Section 4(b) would be subject to the excise tax imposed by Section 4999 of the Code (or any corresponding provisions of state income tax law), then such benefits shall be either (1) delivered i


 
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