EXHIBIT 4.09 CELLEGY PHARMACEUTICALS, INC. NOTICE OF ASSUMPTION OF BIOSYN OPTIONS

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EXHIBIT 4.09

CELLEGY PHARMACEUTICALS, INC.

NOTICE OF ASSUMPTION OF BIOSYN OPTIONS

Dear «Name»:

        As you know, on October 22, 2004, Cellegy Pharmaceuticals, Inc. (" Cellegy ") acquired all the outstanding shares of capital stock of Biosyn, Inc. (" Biosyn ") and assumed all outstanding options and warrants to purchase Biosyn common stock in an exchange transaction (the " Exchange "). This letter confirms the information set forth in the Stock Option Assumption Agreement (" Option Assumption Agreement ") that was previously sent to you regarding one or more outstanding options to purchase Biosyn common stock (" Biosyn Options ") held by you prior to the Exchange. As a result of the Exchange, your Biosyn Options are no longer exercisable for Biosyn common stock. Instead, your Biosyn Options are exercisable for shares of Cellegy common stock under the terms set forth in the Option Assumption Agreement.

        The tables below summarize your Biosyn Options immediately before and after the Exchange. These options may have been granted to you pursuant to Biosyn's 1999 Stock Option Plan (the " Plan ") or they may have been granted to you other than pursuant to the Plan.

        To exercise your assumed Biosyn Option(s), you must send to Cellegy at the address listed on the attached Exercise Notices (i) an executed and completed Exercise Notice for each Biosyn Option that you intend to exercise and (ii) the full purchase price of the Cellegy common stock that you wish to acquire upon exercise of the Biosyn Option in accordance with the Exercise Notice.

        If you are an employee of Cellegy, you should execute and deliver to Cellegy the Exercise Notice attached to this letter as Exhibit A . If you are not an employee of Cellegy, you should execute and deliver to Cellegy the Exercise Notice attached to this letter as Exhibit B .

         Please note that pursuant to the terms of the Exchange, you will not be able to sell any shares of Cellegy common stock that you acquire upon exercise of your assumed Biosyn Options until January 20, 2005.

        If you have any questions about your assumed Biosyn Option(s), please call Virginia Alsup at Cellegy at 650-616-2200.

EXHIBIT A

NOTICE OF EXERCISE
(For Employees of Cellegy Pharmaceuticals, Inc.)

CELLEGY PHARMACEUTICALS, INC.

Attention: Corporate Secretary

I hereby elect to purchase the number of shares of Common Stock of CELLEGY PHARMACEUTICALS, INC. (the "Company") as set forth below:

Type of Option:

o

Incentive Stock Option

o

Non-qualified Stock Option

1.

Delivery of Purchase Price . Option Holder hereby delivers to the Company the Aggregate Purchase Price, to the extent permitted in the Stock Option Agreement (the "Option Agreement") as follows (check as applicable and complete):

o

in cash (by check) in the amount of $                        , receipt of which is acknowledged by the Company;

o

through a "same-day-sale" commitment, delivered herewith, from Option Holder and the NASD Dealer named therein, in the amount of $                  .

2.

Lock-Up; Legend . Option Holder hereby agrees that the Shares are subject to a lock-up agreement between the Company and Option Holder and that Option Holder may not sell or otherwise transfer, or enter into any agreement to sell or transfer, or enter into any other economic arrangement that transfers to another, in whole or in part, any of the economic consequences of ownership of the Shares (other than to donees of Option Holder who agree to be similarly bound) prior to January 20, 2005. Option Holder hereby agrees that the Company may place appropriate restrictive legends on any stock certificates representing the Shares and may impose stop-transfer instructions with respect to the Shares to effect the foregoing.

3.

Tax Consequences . OPTION HOLDER UNDERSTANDS THAT OPTION HOLDER MAY SUFFER ADVERSE TAX CONSEQUENCES AS A RESULT OF OPTION HOLDER'S PURCHASE OR DISPOSITION OF THE SHARES. OPTION HOLDER REPRESENTS THAT OPTION HOLDER HAS CONSULTED WITH ANY TAX CONSULTANT(S) OPTION HOLDER DEEMS ADVISABLE IN CONNECTION WITH THE PURCHASE OR DISPOSITION OF THE SHARES AND THAT OPTION HOLDER IS NOT RELYING ON THE COMPANY FOR ANY TAX ADVISE.

4.

Entire Agreement . The Option Agreement and the Stock Option Assumption Agreement that was previously delivered to Option Holder in connection with the Company's acquisition of Biosyn, Inc. ("Option Assumption Agreement") are incorporated herein by reference. This Exercise Notice, the Option Agreement and the Option Assumption Agreement constitute the entire agreement and understanding of the parties and supersede in their entirety all prior understandings and agreements of the Company and Option Holder with respect to the subject matter hereof.

Spousal Consent

        I acknowledge that I have read the foregoing Notice of Exercise (the " Notice ") and that I know its contents.