FIRST AMENDMENT TO AGREEMENT AND PLAN OF MERGER

Agreement and Plan of Merger

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This Agreement and Plan of Merger involves

ARNO THERAPEUTICS, INC | LAURIER ACQUISITION, INC

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Title: FIRST AMENDMENT TO AGREEMENT AND PLAN OF MERGER
Date: 7/31/2008

Exhibit 2.2

FIRST AMENDMENT TO AGREEMENT AND PLAN OF MERGER

BY AND AMONG

LAURIER INTERNATIONAL, INC.,

ARNO THERAPEUTICS, INC.

AND

LAURIER ACQUISITION, INC.

THIS FIRST AMENDMENT TO AGREEMENT AND PLAN OF MERGER (the "First Amendment") is made by and between L AURIER INTERNATIONAL, INC., ARNO THERAPEUTICS, INC. AND LAURIER ACQUISITION, INC. (collectively, the “Parties”) , and is dated as of the 12th day of May, 2008.

BACKGROUND

A. The Parties have previously entered into that certain Agreement and Plan of Merger dated as of March 5, 2008. (the “Merger Agreement”).

B. Pursuant to the terms of the Merger Agreement, the Parties agreed that either Parent or Arno (as defined in the Merger Agreement) had the right to terminate the Merger if the Merger shall not have been consummated by April 15, 2008 (the “Outside Date”), subject to the right of Arno to unilaterally extend the Outside Date on Notice to Parent. Arno did, in fact, provide such notice and the Outside Date was previously extended to May 15, 2008.

C. The Parties now desire to extend the Outside Date

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